Epithelial-mesenchymal Transition in Renal Cell Carcinoma: The Role of Hepatocyte Nuclear Factor 4α

【背景及目的】 肾癌（renalcellcarcinoma，RCC）是起源于肾小管上皮细胞的恶性肿瘤，占肾脏恶性肿瘤的80％~90％，近年来发病率呈上升趋势。除传统手术治疗外，缺乏其它的有效治疗方法。上皮间质转化(epithelial-mesenchymaltransition，EMT)是上皮细胞在细胞结构、形态、功能等方面获得间质细胞特性的过程，在肿瘤的发生、浸润、转移过程中具有重要作用，核心为上皮标志物E-cadherin表达降低和间质标志物表达增高。肝细胞核因子4α（hepatocytenuclearfactor4α，HNF4α）是调节多种基因转录的重要核因子，HNF4α参与维护肝细胞...【Background and Objective】 Renal cell carcinoma (RCC) is is the most common malignant tumor arising in the kidney, which originates from renal tubular epithelial cells. Its incidence rate showed an upgrade trend in recent years. The common therapeutic approach is conventional surgery, but it has been lack of other effective therapies for a long time. Epithelial-mesenchymal transition (EMT) is a ...学位：医学硕士院系专业：医学院_外科学学号：2452010115330

The Copyright Protection of Technological measure of Cellphone Application Store, and Limitation Thereof

作为一种新兴的软件分发平台，手机应用商店极大促进了移动互联网的发展，对我们的工作、生活形成越来越大的影响，同时也对传统的著作权制度带来了挑战。手机应用商店中的技术措施在保护著作权的同时，也可能损害了使用者利益和公共利益。技术措施作为著作权保护的一种重要的自力救济方法，研究数字信息时代中手机应用商店的技术措施与公众利益间的关系，分析技术措施著作权保护的不同类别及带来的问题，思考如何使著作权人、使用者和公众利益达到相对均衡，明确技术措施受法律保护的范围及其例外规则，具有一定的理论和现实意义。 本文共分四章。 第一章“手机应用商店技术措施对著作权制度的挑战”：本章简要介绍了技术措施的概念和种类，...As a new software distribution platform, the cellphone application store greatly promotes the development of mobile Internet; what’s more, cellphone application, as the main carrier of the mobile Internet, has a greater influence on our work and our life, but it also brings challenges to the traditional copyright system. Technological measure applied in cellphone store may damage the users’ intere...学位：法律硕士院系专业：法学院_知识产权法学学号：X200912010

A Study on the Governance for Tax Avoidance of the Enterprises in China

本文试图回答三个问题。第一，什么是避税？第二，避税是否可以被规制？第三，怎样规制避税？按照回答这三个问题的逻辑顺序，形成了本文的总体篇章结构，即形式研究框架。 第一章导论，介绍选题意义、进行国内外研究综述并明确避税概念，回答什么是避税的问题。第二章论述避税可规制性，认定避税属于脱法行为并得出企业避税可以通过动态立法或者法律解释渠道被规制的结论，回答了第二个问题。第三章论述了评估企业避税现状的最优方法，并从总体估计、企业规模、避税方法等角度研究了中国企业避税现状。第四章透过现象挖掘本质，对中国企业避税现象的成因进行了探讨。包括企业避税内因及其形成机理，外因及其影响方式。第五章进行了企业避税治理...The dissertation tries to answer three questions, such as (i) what is the tax avoidance? (ii) whether the tax avoidance can be governed by regulations or not? and (iii) how to govern tax avoidance by regulations. Above three questions constitute the general composition of this paper in terms of their consecution. i.e. the research framework in form. It has six chapters as follows: Chapter 1 Intr...学位：经济学博士院系专业：经济学院财政系_财政学(含税收学)学号：2005140287

Research on the Algorithms for Detection and Tracking of Moving Vehicles under Night Illumination

基于视频的车辆自动检测和跟踪是计算机视觉中一个重要的研究领域，同时也是基于视频的智能交通监控系统中的一个重要组成部分，其广泛的应用前景和惊人的商业价值已经引起了国内外学术界和企业界的极大关注。本文针对目前视频交通监控系统存在的不能有效全天候工作的状况，对夜间光照状况下的车辆检测与跟踪做了一定程度的研究。我们提出的道路车辆检测和跟踪算法，可以比较准确地实现运动车辆的分割，消除路面反光和阴影的影响，对多车辆进行有效地实时跟踪，较好地解决了检测失败时的跟踪问题。总起来看，基本上可以满足交通监控系统的实时性、准确性的要求，鲁棒性还有待提高。本文的主要工作包括以下几点：（1）夜间路面反光的消除夜间的车辆...Vehicle detection and tracking based on video sequences is an important research field in computer vision, and also a crucial part of visual traffic surveillance system. In the past decade, visual traffic surveillance has been a popular issue in computer vision with increasing concern for its large-scale application and potential business benefits. Visual traffic surveillance system cannot work...学位：工学硕士院系专业：计算机与信息工程学院计算机科学系_计算机应用技术学号：20022802

Design and Implementation of Teaching Media Resources Management System of Film and Television

随着国家信息实力的不断提高，计算机和网络环境变得越来越受欢迎，近年来，媒体资源管理越来越受到关注，艺术院校作为高等教育系统，在影视类专业教学过程中会积累和收集大量的视频数据和媒体资源，而如何管理和应用这些媒体资源，是我们面临的严峻问题。本文以某大学影视与传媒学院媒体资源管理现状为出发点，设计构建一个适用于影视类教学的媒体资源管理系统。 如何构建适用于影视类教学的媒体资源管理系统并服务于教学是本文研究的核心，系统的设计与实现是综合运用流媒体、视音频编解码、网络传输、内容检索和数据库等技术进行。其中，系统采用C/S系统架构设计，核心功能模块包含：媒资的采集上载、媒资的编目、媒资的存储管理、资源检...Abstract With the continual improvement of nation’s information strength, computer and network gains more and more popularity. In recent years, media resources management has been emphasized and concerned by more and more enterprises and public institutions. Art colleges, as part of higher education system, has gathered and accumulated large amounts of video data and media resources in teaching f...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201223026

Nude Mice with Green Fluorescent Protein Expression-based Human Glioma Animal Model and Expression of PSMB4 in Human Gliomas

胶质瘤是中枢神经系统最常见的肿瘤，占颅内肿瘤的40%～45%，同时也是颅内肿瘤中最难治愈的肿瘤。长期以来都是采用手术切除及放化疗辅助的综合性治疗，但是其治疗效果仍然不佳，5年生存率不足5%。随着分子生物学技术的发展，这就促使人们进一步从分子水平深入探讨胶质瘤发生发展的分子机制，寻求更为有效的治疗措施。 高表达表皮生长因子受体（epidermalgrowthfactorreceptor，EGFR）的人脑恶性胶质瘤能上调血管内皮生长因子(vascularendothelialgrowthfactor，VEGF)和其他血管生成因子表达而促进血管生成，这新生的血管又促进了肿瘤细胞增殖、侵袭和远处转移...Human glioma with a bad prognosis is the most common tumor in the central nervous system, accounting for 40% - 45% intracranial tumors. The main treatment method for glioma includes surgical resection and auxiliary radiotherapy and chemotherapy treatment for a long time, but its efficiency is still poor, with the 5-year survival of less than 5%. With the development of molecular biology techniques...学位：理学博士院系专业：生命科学学院生物学系_细胞生物学学号：2172008015041

Study on the trend of mortality and years of life lost related to lung cancer in Xiamen in ten years

目的掌握厦门市居民2004-2013年肺癌死亡趋势及寿命损失情况,为政府部门制定干预政策提供参考依据。方法从厦门市死因监测系统收集整理2004年1月1日-2013年12月31日厦门市居民肺癌死亡资料进行统计分析。结果2004-2013年间厦门市居民肺癌死亡率逐年增加(P<0.05),总死亡率27.32/10万;男性死亡率是女性的2.90倍;65岁开始死亡率急剧增高,在75~79岁年龄组达到高峰;2013年死亡率比2004年增长35.32%。10年肺癌造成的寿命损失年(PYLL)共52 970人年,寿命损失率(PYLLR)为3.06‰,平均减寿年数(APLL)为11.20年;男性PYLL值为38 605人年,比女性多24 240人年,但APLL男性比女性约少1年,分别为10.95年和11.91年。结论厦门市居民肺癌死亡率呈不断上升趋势,主要危及中老年人群,男性死亡率始终高于女性,应采取必要的干预措施。Objective To learn the trend of mortality and years of life lost related to lung cancer in Xiamen from 2004 to 2013 and to provide the basis for the government setting up intervention policies. Methods The death data related to lung cancer of residents in Xiamen from Jan 1,2004 to Dec 31,2013 were collected from "Xiamen Municipal Death Surveillance System" to be and they were counted and analyzed. Results The total mortality of lung cancer in Xiamen from 2004 to 2013 was 27.32 per 100,000,of which male was 2.90 times as female. The mortality rose sharply after 65 years old and peaked in the group of 75~79 years old.Over the last ten years,the total mortality rate of lung cancer in Xiamen rose year by year(P<0.05),increasing about 35.32% in 2013 than that in 2004. The potential years of life lost(PYLL),the rate of PYLL,and the average years of life lost(AYLL)due to lung cancer in Xiamen during the last ten years were 52 970 per person per year,3.06‰,and 11.20 years,respectively. The value of PYLL in male was 38 605 per person per year,24 240 per person per year more than that in female. However,the APLL in male was one year less than that in female,which were 10.95 years and 11.91 years,respectively. Conclusion The mortality of lung cancer in residents of Xiamen has increasing trend in the last ten years. It is more harm for group with middle and elderly age. The mortality in male is always higher than that in female. So it's necessary to adopt some effective intervening measures.福建省卫生厅青年课题项目(项目编号:2014-2-78

新《企业所得税法》实施后税收征管存在的问题及对策

新《企业所得税法》实施后,异地非法人分支机构的税收管理难度加大,国税、地税部门之间出现新一轮税收管辖权的争执和矛盾,企业所得税征管面临新情况、新问题。新形势下,税务机关应当采取措施加强对异地非法人分支机构的企业所得税征管,改革现行企业所得税税收管理体制,进一步加强税收宣传,强化业务培训,落实执法追究,以堵塞税收流失漏洞

厚颌鲂的年龄结构及生长特性

以鳞片作为鉴定年龄的材料,对龙溪河厚颌鲂(Megalobrama pellegrini)种群开展年龄结构与生长特性的研究。结果表明,厚颌鲂鳞片年轮结构呈疏密切割型,年轮特征显著,可用于年龄鉴定,3~4月是年轮形成高峰时间。种群由0~7龄共8个龄组组成,以低龄个体为主,1~3龄个体占83.14%,体长分布主要集中在130~250 mm间(77.71%)。体质量分布主要集中在50~250 g(64.33%)。群体总性比为♀∶♂=1∶1.03,符合1∶1理论比值。体长和鳞径呈直线关系,体长和体质量呈幂函数关系

Preparation of Aluminum Titanate Film by Sol-gel Method and Its Fused Salt Corrosion Resistance

以钛酸四丁酯和硝酸铝为原料,乙醇为溶剂,通过溶胶-凝胶法在碳化硅基片上制备钛酸铝薄膜。借助dSC-Tg、Xrd、fE-SEM和SEM研究了钛酸铝干凝胶在热处理过程中的热重效应与相变化、薄膜的晶相组成、显微结构及其抗硝酸钠熔体腐蚀性能。结果表明:制备的钛酸铝薄膜表面均匀、致密,晶粒尺寸在100nM左右,具有良好的抗硝酸钠熔体腐蚀性能。Aluminum titanate ( AT) film coated on the surface of SiC substrate was prepared via Sol-gel method,using tetrabutyl titanate and aluminum nitrate as raw materials,ethanol as solvent.The weight loss and phase transformation of AT xerogel during the heat treatment,the crystal composition and microstructure of the AT film and its corrosion resistance to fused sodium nitrite salt were studied by means of DSC-TG,XRD,FE-SEM and SEM.The results show that the prepared AT film is uniform and dense with the crystal size of about 100 nm,and has good corrosion resistance to fused sodium nitrite.国家自然科学基金(No.50762005;No.50962006);中国科学院特种无机涂层重点实验室开放基