【背景及目的】 肾癌（renalcellcarcinoma，RCC）是起源于肾小管上皮细胞的恶性肿瘤，占肾脏恶性肿瘤的80％~90％，近年来发病率呈上升趋势。除传统手术治疗外，缺乏其它的有效治疗方法。上皮间质转化(epithelial-mesenchymaltransition，EMT)是上皮细胞在细胞结构、形态、功能等方面获得间质细胞特性的过程，在肿瘤的发生、浸润、转移过程中具有重要作用，核心为上皮标志物E-cadherin表达降低和间质标志物表达增高。肝细胞核因子4α（hepatocytenuclearfactor4α，HNF4α）是调节多种基因转录的重要核因子，HNF4α参与维护肝细胞...【Background and Objective】 Renal cell carcinoma (RCC) is is the most common malignant tumor arising in the kidney, which originates from renal tubular epithelial cells. Its incidence rate showed an upgrade trend in recent years. The common therapeutic approach is conventional surgery, but it has been lack of other effective therapies for a long time. Epithelial-mesenchymal transition (EMT) is a ...学位：医学硕士院系专业：医学院_外科学学号：2452010115330
