A Study on the Development Strategy of H Valve Company

近年来，中国阀门工业进入快速发展时期，目前已成为亚洲最大的阀门加工中心、全球最大的阀门市场之一。我国虽已成为阀门制造大国，但与阀门制造强国相比还相差甚远。在此背景下，如何加快发展，提升持续竞争力，从而在竞争日益激烈的市场中站稳脚跟、健康成长，成为中小阀门企业需要深思的重要命题。本文以H阀门公司为研究对象，在对企业战略理论进行梳理的基础上，采用PEST分析、波特五力分析模型、SWOT分析等工具，对公司所处行业和外部环境进行研究，并结合公司生产能力、技术水平及主要财务情况等内部环境分析，研究企业发展战略和策略实施等问题，希望对中小阀门企业如何发展起到一定的借鉴作用。 论文通过研究认为,我国阀门行...In recent years, Chinese valve industry has entered a period of rapid development, and currently has become one of the largest valve machining center in Asia as well as the largest valve market in the world. However, although China has been a valve manufacturing country, it is still very far behind those valve manufacturing powers. In this content, it has become an important proposition for small ...学位：工商管理硕士院系专业：管理学院高级经理教育中心（EMBA项目）_高级管理人员工商管理硕士(EMBA)学号：X201015624

我国生物地理学研究进展

生物地理学研究是生物学和地理学交叉非常明显的部门自然地理学学科,它具有很强的基础研究特点,同时研究成果也具有很大的应用潜力。近年来,我国生物地理学基础研究在国家自然科学基金委等部门的支持下,在山地植被与地理环境、干旱半干旱区植被与地理环境、植物区系、植物物候、土壤动物与土壤生态功能、土壤生物结皮等方面开展了全面而深入的研究。同时拓展了传统生物地理学的研究方向,在植物地理学与全球变化、植物地理学与生物多样性保护、植物地理学与生态系统管理等方面也开展了大量研究。尤为可贵的是干旱半干旱区土壤生物结皮研究、典型温带荒漠区原生荒漠植被对水分改变的响应与适应研究取得了令国内外关注的高水平研究成果

pJAK2 polypeptide,an antagonist of suppressors of cytokine signaling-1,can enhance the antitumor effect of dendritic cells

目的:探讨细胞因子信号转导抑制因子-1(SuPPrESSOrS Of CyTOkInE SIgnAlIng1,SOCS1)拮抗物PJAk2多肽(氨基酸序列号为1001-1013)参与树突状细胞(dEndrITIC CEllS,dCS)的体外诱导培养后对dCS抗肿瘤作用的影响。方法:采集健康人外周血,离心获得单个核细胞,用重组人粒细胞巨噬细胞集落刺激因子(rECOMbInAnT HuMAn grAnulOCyTE-MACrOPHAgE COlOny STIMulATIng fACTOr,rHgM-CSf)及重组人白细胞介素-4(rECOMbInAnT HuMAn InTErlEukIn-4,rHIl-4)诱导dCS,第5天分为4组:单纯dCS培养(对照)组、抗原负载(lySATE-dCS)组、多肽修饰(PJAk2-dCS)组和抗原与多肽共培养(lySATE+PJAk2-dCS)组,第6天各组加入肿瘤坏死因子-α(TuMOr nECrOSIS fACTOr-AlPHA,Tnf-α)促成熟。倒置显微镜下观察dCS形态;fCM法检测dCS表型;乳酸脱氢酶(lACTATE dEHydrOgEnASE,ldH)细胞毒实验检测各组细胞毒性T淋巴细胞(CyTOTOXIC T lyMPHOCyTE,CTl)对胃癌细胞bgC-823的靶向杀伤作用;ElISA法检测白细胞介素-12(InTErlEukIn-12,Il-12)和γ干扰素(InTErfErOn-γ,Ifn-γ)的水平。结果:与未加入诱导剂组相比,各组均成功诱导出成熟dCS,均高表达Cd80、Cd83、Cd86和人类白细胞dr抗原(HuMAn lEukOCyTE AnTIgEn dr,HlA-dr),但以lySATE+PJAk2-dCS组的表达水平最高。在10:1~30:1的效靶比范围内,CTl杀伤作用与效靶比呈正相关。当效靶比为30:1时,对照组的CTl杀伤率达(19.77±2.34)%,低于其他3组(P<0.01),而lySATE+PJAk2-dCS组较lySATE-dCS组及PJAk2-dCS组都高(P<0.05)。lySATE+PJAk2-dCS组培养上清液中Il-12及Ifn-γ的分泌水平明显高于对照组(P<0.01)。结论:SOCS1拮抗物PJAk2多肽(1001-1013)可增强dCS对胃癌细胞的抗原递呈及特异性抗肿瘤作用。Objective:To investigate the effect of pJAK2 polypeptide,an antagonist of SOCS1(suppressors of cytokine signaling 1),on antitumor effect of in vitro cultivation-induced DCs(dendritic cells).Methods:Peripheral blood was collected from the healthy volunteers,and the PBMCs(peripheral blood mononuclear cells)were isolated.DCs were induced by rhGM-CSF(recombinant human granulocyte-macrophage colony-stimulating factor)and rhIL-4(recombinant human interleukin-4).On the fifth day,DCs were divided into four groups:control group,Lysate-DCs group,pJAK2-DCs group,and Lysate + pJAK2 DCs group.On the sixth day,TNF-α(tumor necrosis factor-alpha)was added into each group.The morphological features of DCs were observed under an inverted microscope;the phenotypes were detected by FCM(flow cytometry);the killing effect of CTLs(cytotoxic T lymphocytes)on gastric cancer BGC-823 cells was evaluated by LDH(lactate dehydrogenase)cytotoxicity test;the concentrations of IL-12(interleukin-12)and IFN-γ(interferon-γ)were detected by ELISA(enzyme-linked immuno sorbent assay).Results:Mature DCs presented typically morphological and phenotypic features;the DCs in Lysate + pJAK2-DCs group had the highest expression levels of CD80,CD83,CD86 and HLA-DR(human leukocyte antigen DR).When the ratio of effectors to target cells ranged from 10:1 to 30:1,the killing activity of CTLs had a positive correlation with the ratio.When the ratio of effectors to target cells was 30:1,the killing activity of CTLs in the control group was(19.77±2.34)%,which was lowest as compared with the other groups(P < 0.01),meanwhile the killing activity of CTLs in Lysate + pJAK2-DCs group was higher than those in Lysate-DCs and pJAK2-DCs groups(P < 0.05).The levels of IL-12 and IFN-γ secretion in Lysate + pJAK2-DCs group were apparently higher than those in the control group(P < 0.01).Conclusion:An antagonist of SOCS1,pJAK2 polypeptide,can enhance the ability of antigen presentation and specific antitumor effect of DCs on gastric cancer cells.南京军区医学科技创新课题资助项目(编号:10MA068); 福建省自然科学基金面上项目(编号:2010D013); 厦门市科技计划创新项目(编号:3502z20104014

基于领域本体的中医语义推理诊断系统

本文基于本体理论建立中医系统知识库,并在此基础上开发智能诊断系统。为了在诊断推理中与用户输入的症状相匹配,文中采用统计学中的TfIdf结合语义思想的方法进行相似度计算排序解决,该系统为中医临床医生提供一个诊疗决策的优良工具

Discussion on the Treatment of Hypertension from Retained Fluid

根据古代文献关于"饮病"和现代医学关于高血压病的认识,"饮病"与高血压病无论从临床表现还是从发病机制上都有着密切的相关性。近年来,"痰饮"成为高血压病发病的重要病因之一,并贯穿于高血压病发病的始终。五苓散、苓桂术甘汤等具有"化饮"功效的方剂在治疗高血压病的临床实践中已取得较好疗效,但始终缺乏从饮论治高血压病的辨治纲要。因此,将"饮邪"引入高血压病的致病因素之中,对其做系统性、理论性的探讨,并总结出一套治则治法,对指导临床实践具有一定的帮助。According to the ancient literature on the"retained fluid disease"and modern medicine on the understanding of hypertension,"retained fluid disease"and hypertension disease from clinical manifestations or from the pathogenesis are closely related. In recent years,"phlegm"has become one of the important causes of hypertension,and always runs through the occurrence of hypertension. Wuling Powder and Linggui Zhugan Decoction have"dispersing retained fluid"effect of the prescription in the treatment of hypertension in clinical practice to obtain good curative effect,but always a lack of debate on the treatment of hypertension from the theory of"retained fluid disease"treatment program. Therefore,put the"drink evil"into the category of hypertension disease,on the system,theoretical study,and sums up the prevention and treatment,to guide the clinical practice has certain help.2013~2015福建省中医药科研项目计划(课题名称:五苓散健脾-利水-温阳通脉多靶点途径调控高血压大鼠RAAS表达的机制研究)(编号:wzln201309);; 2013年夏门市科技局高校、科研院所科技创新项目(课题名称:柴苓降压剂的开发研究)(编号:3502Z20134052

Design of USB host controller

讨论在SOPC(SySTEM On A PrOgrAMMAblE CHIP)系统中设计uSb主机接口设备的一般方法,着重阐述主机控制器的驱动程序开发。利用XIlInX公司的Edk软件在Ml405开发板上搭建一个基于POWErPC的片上系统,设计Ez-HOST的uSb主机控制器的lInuX驱动程序,使系统具有uSb主机功能,能够和各种uSb设备进行通信,实现SOPC系统上基于lInuX的uSb接口的扩展,对于开发其他uSb主控制器驱动具有一定借鉴意义。The general development method of USB host interface based on SoPC system is discussed,and the driver program development of host controller is introduced in detail.A PowerPC-based system on chip is built up by using Xilinx′s EDK software in the ML405 development board.Linux driver program of USB host controller of EZ-Host is designed.The system is capable of communicating with a variety of USB devices,achieves extension of the Linux-based USB interface.The design is helpful to the development of other USB host drivers.福建省重大专项项目(2007HZ0003

Effect of Ethanol Extract from Camellia Oleifera Abel. on Blood Glucose in Type 2 Diabetic Mice

目的筛选油茶（Camellia oleifera Abel.）降低2型糖尿病小鼠血糖的有效部位。方法采用腹腔注射烟碱、链脲霉素诱导的2型糖尿病小鼠模型,应用超声提取法分别获得油茶叶、果、籽的乙醇提取物,筛选降低血糖的有效部位。结果阳性药罗格列酮每日灌胃剂量10mg/kg·BW,连续灌胃21d后,降低了2型糖尿病小鼠血糖。分别灌胃油茶叶、油茶果、油茶籽乙醇提取物,按每日剂量100mg/kg·BW连续灌胃21d后,均在一定程度上降低2型糖尿病小鼠血糖,油茶籽乙醇提取物对口服葡萄糖耐受试验（Oral glucose tolerance test,OGTT）作用最明显。与对照组相比,1μM和2μM的阳性药罗格列酮均能明显促进3T3-L1前脂肪细胞分化;油茶籽乙醇提取物在0.5μg·m L-1和1μg·m L-1浓度下也体现出促进分化的活性。结论油茶籽乙醇提取物降低了2型糖尿病小鼠的血糖,促进了3T3-L1前脂肪细胞的分化,但其具体作用机制尚需深入研究。OBJECTIVE To investigate effective parts possessing property of lowering blood glucose in type 2diabetic mice from Camellia oleifera Abel. METHODS Leaf,fruit and seed ethanol extract of C. oleifera were obtained through ultrasonic extraction,and were subsequently subject to type 2 diabetic mice model induced by intraperitoneal injection of streptozocin and nicotine. RESULTS In accordance with the positive drug rosiglitazone by intragastric administration once daily dose of 10 mg / kg·BW,continuous intragastric administration for 21 days,blood glucose in type 2 diabetic mice was reduced. In accordance with a daily dose of 100 mg / kg·BW leaf,fruit and seed ethanol extract of C. oleifera,continuous intragastric administration for 21 days respectively,in a certain extent,blood glucose in type 2 diabetic mice was reduced. Moreover,effect of seed ethanol extract on blood glucose and oral glucose tolerance test（ OGTT） is the most obvious. Compared with control group（ treated with insulin）,1μM and 2μM of positive drug rosiglitazone can significantly promote differentiation of 3T3-L1 pre-adipocytes,C. oleifera seed ethanol extract as the most effective part for lowing blood glucose at 0. 5μg·m L~（-1） and 1μg·m L~（-1）concentration also promoted 3T3-L1 pre-adipocyte differentiation. CONCLUSION It was suggested that C. oleifera seed ethanol extract lowered blood glucose in type 2 diabetic mice and enhanced differentiation of 3T3-L1 pre-adipocytes,but the specific mechanism needs further study.福建省教育厅中青年教师教育科研项目杰青项目JA14421;福建省教育厅中青年教师教育科研项目JA13425; 厦门市科技局科技计划高校创新项目3502Z20143026;厦门市科技局科技计划项目3502Z20144031; 福建省自然科学基金计划资助项目2015J01065; 福建省科技厅自然科学基金青年创新项目2014D008; 福建省卫生系统中青年骨干人才培养项目基础项目2015-ZQN-JC-45; 厦门市卫生和计划生育委员会资助研究经费; 厦门医学高等专科学校科研基金Z2013-12;Z2013-2

分子内扭转电荷转移的胶束效应

研究了水溶液中对二甲氨基苯甲醛(DMABA)分子内扭转电荷转移(TICT)的胶束效应。胶束能促进DMABA的TICT过程,并导致DMABA的总荧光量子产率提高和TICT荧光峰的显著蓝移,DMABA的TICT荧光强度与正常荧光带的强度之比与DMABA的浓度之间有线性关系,胶束存在时该直线的斜率提高,认为DMABA的TICT激发态涉及两个DMABA分子,并且影响DMABA的TICT激发态相对布居的主要因素是其与相应的三重态和基态的能隙.讨论了DMABA的TICT激发态的可能结构及胶束效应的本质