Current status of vaccine development against leishmaniasis

利什曼病是由利什曼原虫引起的一种人兽共患寄生虫病,分布于全球90多个国家,每年新发利什曼病患者130多万,有2万~3万例死亡,给全球尤其是发展中; 国家带来沉重的社会经济及医疗负担。目前针对利什曼病的防治措施主要为控制传染源和药物治疗,但均无法消除利什曼病。疫苗接种是行之有效的并具社会经济效; 益的控制利什曼病的防治手段。因此,利什曼病疫苗的研发具有十分重要的现实意义。本文重点就利什曼原虫致病机制及各类利什曼病疫苗的研究现状进行综述。Leishmaniasis is a zoonotic disease caused by Leishmania parasites.; Currently, leishmaniasis has affected 12 million people in over 90; countries, with 1.3 million reported cases each year and 20 -30 thousand; deaths. The disease causes a large social and economic burden; particularly in developing countries. Current strategies for; leishmaniasis control include controlling the source of infection and; drug treatment, both of which, however, cannot eliminate the disease.; Effective vaccination would be an ideal approach to control; leishmaniasis. Here, we review the pathogenic mechanism of Leishmania,; the existing vaccines for veterinary use, and human vaccine development; efforts against the disease

攻“关”——厦门海关大厦投标案笔记

以“本原”为构想基点 ,求异为解题路向 ,基于属性、全图、整合、视空、功能、技术层面的演析 ,对厦门海关大厦本体进行了书写

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In Situ FTIR Spectrocopic Studies of CO and CN~- Adsorbed on Electrode of Nanometer Thin Film of Palladium in Alkaline Solutions

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In situ FTIR spectrocopic studies of CO and CN- adsorbed on electrode of nanometer thin film of palladium in alkaline solutions

The adsorption and coadsorption of CO and CN- on electrode of nanometer thin film of palladium (nm-Pd/GC)was studied by using in situ FTIR spectroscopy. The results demonstrated that the nm-Pd/GC electrode exhibited abnormal infrared effects (AIREs) in alkaline solutions as in acid solutions. The characters of AIREs, i.e.,the inversion of the direction of IR band, the augmentation of FWHM and the significant enhancement of IR absorption by adsorbed species were observed in all cases of adsorption and co-adsorption of CO and CN-. It has been illustrated that strong interaction is existed between adsorbed CO and CN- on nm-Pd/GC surface. The study has contributed towards understanding the surface processes of chemisorption as well as to reveal the origin of nanometer size-effects of thin film materials

精子DNA甲基化异常与男性不育

DNA甲基化/去甲基化是表观遗传学最重要的内容并可以控制基因的表达和印迹,越来越多的研究显示DNA甲基化异常与不育男性精子发生异常、特定肿瘤的发生、神经系统疾病、Rett综合征等有关.文章通过总结近来的相关研究资料来阐述精子发生过程中的DNA甲基化状态的改变,探讨精子DNA的甲基化异常与男性不育之间的联系,旨在为男性不育的治疗提供新的临床思路