HMPAO脳血流シンチでEarly Postischemic Hyperperfusionを呈した左内頸動脈狭窄の1例

福井赤十字病院 放射線科71歳男.右片麻痺と失語が突然に発症し,MRIのT2画像では明らかな異常を認めなかったが,拡散強調画像で左大脳半球のwater-shed areaに高信号域の散在が認められた.発症2日後のMRI拡散強調像でも同様の所見で,病変部はT2強調像でも明瞭な高信号を示した.発症日の脳血管造影では左内頸動脈起始部に90%の狭窄を認めた.以上から,左内頸動脈狭窄に関連した左大脳半球の広範な虚血とwater-shed infarctionと診断した.HMPAOによる脳血流シンチグラフィを発症2日後に施行し,左大脳半球の広範な高集積と左基底核の集積低下が認められ,発症5日後のIMP脳血流シンチグラフィでも左大脳半球に同様の所見を認めた.臨床症状は徐々に改善し,発症12日後のMRIでは発症2日後の所見とほぼ同様の所見で,左大脳半球の脳血流シンチグラフィで早期に高集積を認めた部分は梗塞には陥っていなかった原著論文/症例報

魚類寄生微胞子虫類はヒトに対して病害性がない

[Abstract]Recently, serious problems associated with the food-poisoning of a myxosporean parasite Kudoa septempunctata infecting olive flounder Paralichthys olivaceus have made suspicious on a probable pathogenicity of fish-infecting microsporidians as well. The present study aims to reveal whether the two microsporidians，an unidentified microsporidian from rainbow trout Oncorhynchus mykiss and Microsporidium seriolae from cultured yellowtail Seriola quinqueradiata, could give a health damage on humans. Both poisonous taste tests with trout and yellowtail flesh infected with the microsporidians exhibited no onset of food-poisoning except one person showing some diarrhea 1-2days after the consumption of the trout microsporidian. However, judging by an upset stomach of the person prior to the test, the onset seems to be caused not by the parasites but by his original health condition. These results strongly suggested that the fish-infecting microsporidians did not affect the human health

XRCC4遺伝子欠損によるヒト大腸癌幹細胞マーカー発現変化及びX線、炭素線に対する感受性増強

Here we report the role of XRCC4 in cancer stem cell (CSC) properties and radiosensitivity of CSCs to X-ray and carbon ion beam. FACS analysis showed that the CSCs (CD133+, CD44+/ESA+) were significantly altered in XRCC4 KO cells compared to HCT116-WT cells. The number of colony and spheroid formed from CSCs were significantly higher compared to that from non-CSCs in XRCC4 KO cells, but extremely decreased compared to HCT116-WT cells. The proportion of CSCs was more extremely increased in XRCC4 KO cells compared to HCT116-WT cells after X-ray irradiation. Survival fraction analysis showed that the doses at D10 levels of CSCs sorted from XRCC4-KO and HCT116-WT cells were 1.4 and 4.2 Gy for X-ray and 1.0 and 1.9 Gy for carbon ion beam, respectively. A much more large number and large-sized gamma-H2AX foci were observed in CSCs sorted from XRCC4 KO cells compared to that from HCT116-WT cells, after 24 h carbon ion beam compared to X-ray irradiation. In conclusion, lack of XRCC4 significantly altered expression of CSC markers, radiosensitized CSCs to both X-ray and carbon ion beam, suggesting that XRCC4 may play a pivotal role in modulating cancer cell stemness.第72回日本癌学

PULC(Probability of Uncomplicated Local Control)の臨床的有用性に関しての検討─遅発反応のDVHの解析─

Ｈ１３年度ＨＩＭＡＣ共同利用研究成果発表

PULC(Probability of Uncomplicated Local Control)の臨床的有用性に関しての検討─遅発反応のDVHの解析─

Ｈ１３年度ＨＩＭＡＣ共同利用研究成果発表

A case of retroperitoneal abscess accompanying pregnancy

A 40-year-old pregnant woman, who suffered a continuous episode of fever and anemia since the 26th week of pregnancy, was referred to our clinic for evaluation of her left flank pain and tumor. As retroperitoneal tumor was suspected by retrograde pyelography, sonography and CT, translumbar tumorectomy was performed under general anesthesia. The histological diagnosis was retroperitoneal abscess