1,487 research outputs found
Activatable Ferritin Nanocomplex for Real-Time Monitoring of Caspase-3 Activation during Photodynamic Therapy(PDT)
随着分子影像学的发展,治疗诊断学已成为现在医学研究的热点。目前各种 先进的医学成像技术已被用在医学成像,例如光学成像,磁共振成像(MRI),单 光子发射计算机断层扫描(SPECT),正电子发射断层扫描(PET)和光声成像, 从而促进了分子成像探针和医学成像的发展。分子成像探针结构复杂,能够结合 特定生物标志物并产生成像信号用于疾病的诊断。迄今为止,一些成像探针已应 用到临床,例如18F-FDG,但是探针的低靶向性特点限制了成像探针的应用。因 此,开发由特定的靶向基团和成像配基组成的高度敏感的可活化探针是迫切需要 的,并引起了科学家的广泛关注。最有潜力的可活化探针结构包括酶的底物,...Theranostics has become a hot topic in current medical research with the rapid develepment of medical imaging. Nowadays variety of advanced medical imaging technologies have been utilized in medical imaging, for instance optical imaging, magnetic resonance imaging (MRI), emission tomography (PET), single-photon emission computed tomography (SPECT) and photoacousti...学位:医学硕士院系专业:公共卫生学院_流行病与卫生统计学学号:3272013115055
Synthesis and Modification of High-voltage Lithium Nickel Manganese Oxide Cathode Material for Lithium-ion Batteries
随着锂离子电池的应用从手机、数码相机和笔记本电脑等电子仪器领域扩展至电动汽车、通信技术和移动存储设备等领域,人们对锂离子电池的性能,特别是对功率密度和工作电压,提出了越来越高的要求。锂离子电池工作电压和功率密度等性能,主要由正极材料决定。因此,发展高电压正极材料是发展高能量密度锂离子电池重要的研究方向之一。 LiMn2O4(LMO)具有低成本、低毒性和良好的安全性能等优点,被认为是一种理想的正极材料。然而LMO能量密度低,研究表明当向LMO掺杂一定量的镍形成镍锰酸锂LiNi0.5Mn1.5O4(LNMO)后,其放电平台从4.1V提高至4.7V,与传统的正极材料如LiCoO2、LiMn1/3N...With the lithium ion battery expansion from mobile phones, digital cameras, laptop computers and other small electronics to electric vehicle, communication technology and mobile storage devices field, higher requirements for the performance of lithium ion battery, especially the power density and energy density, have been set to satisfy production and people’s demands. Performance of lithium-ion b...学位:理学博士院系专业:化学化工学院_应用化学学号:2052011015371
The research for full-time faculty’s educational background structure in colleges and universities in China over Two decades
高校教师队伍建设一直是高等教育事业发展过程中备受关注的热点议题,其中教师队伍结构建设问题更是不容小觑。目前高校教师队伍结构的合理优化对于我国高等教育事业的进一步发展提升至关重要。特别是在我国从高等教育大众化向普及化阶段过渡的关键节点,必然需要相应的教师队伍结构调整以更加适应新阶段下我国高等教育事业发展的步伐。高校专任教师学历结构是构成整体教师队伍结构的重要部分,同时学历结构也是反映教师群体学习水平、知识储备及理论根基的重要标志。因此,高校专任教师学历结构的深入优化对于我国高校教师队伍整体水平的提高来说具有重要意义。 本文首先对1995年-2015年二十年间我国高校专任教师学历结构的变化发展情...The building of faculties’ team in colleges and universities has been a concerned issue in the process of the development of higher education, among which that of the team structure cannot be underestimated. At present, the optimization of faculties’ team structure in colleges and universities is vital for the further development and improvement of the higher education in China. The corresponding ...学位:教育学硕士院系专业:教育研究院_比较教育学学号:2572014115181
Study on Probe Techniques and a Multi-functional Inhibitor for Corrosion Control of Reinforcing Steel in Concrete
钢筋混凝土是当今世界最普遍使用的建筑材料,广泛应用于各种基础设施。由钢筋腐蚀引起的钢筋混凝土结构过早失效问题,造成巨大经济损失和社会危害。钢筋混凝土的腐蚀与防护已成为世界性的研究热点和难点。混凝土碳化和氯离子侵蚀是引起混凝土中钢筋腐蚀的主要原因。发展混凝土结构中钢筋腐蚀和防护的电化学探针监测技术对预测和判断钢筋混凝土结构耐久性、安全性和使用寿命,对腐蚀防护措施的选择和优化等具有重要理论和实际意义。使用缓蚀剂是一种简单、经济、有效的腐蚀防护措施,目前常用的缓蚀剂主要为亚硝酸盐类及其它有机复合物,缓蚀效果较好,但其毒性会对环境造成污染。针对钢筋混凝土腐蚀监测和防护中存在的问题,本工作发展了阵列电极...As a most popular and important building material, reinforcement concrete is widely applied in various infrastructures in the world. The corrosion of steel rebar makes the premature failure of reinforcement concrete structures, which induces immeasurable economic losses and grave social harm. The corrosion and protection of reinforcement concrete has become a research hotspot and challenge in the ...学位:理学硕士院系专业:化学化工学院_物理化学(含化学物理)学号:2052010115161
Analysis of the Effect of Economic Growth on the Development of Life Insurance Under the Background of Inflation
从2013年普通型寿险费率改革的实施,到2015年2月16日万能险费率改革正式启动,以及2015年10月1日分红险费率改革的正式启动,我国保险费率逐步走向市场化的进程加快。市场化的费率受利率、通货膨胀等的宏观因素影响较大。寿险本身具有类似于长期储蓄的性质,可以对财产进行时间、空间上的再分配,这使得通货膨胀对其影响通过实际利率的作用更加明显。 通货膨胀本身对于经济增长也有不可忽视的影响,对于不同的经济发展水平,通胀对经济增长的影响为正或为负也未可定论。因而其对于经济增长对寿险的引致效应也是值得探索的。通过界定通货膨胀的区间值,可以试图找出在不同区间内,经济增长对寿险的引致效应是否不同,从而提出...From 2013 in ordinary life insurance rate reform implementation, to 2015 February16, universal insurance rate reform was officially launched, and in October1 2015participating insurance rate reform was officially launched, insurance premium rate in China gradually market-oriented process accelerated. Market rate is affected by interest rate, inflation and other macroeconomic factors. Life itself h...学位:保险硕士院系专业:经济学院_保险硕士学号:1562013115216
The Tenure of Office and Regional Economy Growth —Based on Provincial Panel Data of China from1990 to 2014
针对改革开放以来我国在经济上取得的显著成就,许多文献从技术、物质资本、开放政策、外商投资、基础设施等角度对我国的经济增长进行探索。不可忽视的是,由于我国中央集权与地方分权的政治体制,我国的地方官员在促进辖区经济增长中扮演着重要的角色。国内外已有学者对我国省级官员与辖区经济之间的关系进行研究,大部分文献集中于从晋升激励的角度对官员促进辖区经济增长的动力来入手,且使用的方法大同小异。本文基于1990年以来各省经济环境的区别,关注省级官员的异质性,利用1990年至2014年我国省级数据对省级官员与辖区经济增长的关系进行实证检验。由于官员对经济增长的影响需要一个传导机制,官员对经济增长的影响不会有一个...Since the reform and opening up, China has made remarkable achievements in economy, according to many economic literatures, a lot of scholars explore the growing of Chinese economic from many angle, such as technology, open policies, foreign investment and so on. Since Chinese political system is made up of centralization and decentralization, local officials play an important role in promoting ec...学位:经济学硕士院系专业:经济学院_政治经济学学号:1532014115212
Phosphorylated nuclear receptor Nur77 protects melanoma cells from glucose starvation-induced cell death
孤儿核受体Nur77是立早基因NR4A1编码的产物,是一个转录因子。它可以通过依赖转录活性或不依赖转率活性的方式参与调控细胞的许多生命活动过程。 本文首次阐明,在无糖培养的情况下,Nur77通过磷酸化修饰靶向线粒体,进而帮助黑色素瘤细胞应对代谢压力。在无葡萄糖的情况下,黑色素瘤细胞中的ERK2被激活,发挥其激酶的磷酸化作用,通过磷酸化Nur77,促进Nur77转运并定位到线粒体内部。线粒体是细胞能量代谢的重要场所。Nur77的线粒体定位会影响黑色素瘤细胞的能量代谢,从而应对葡萄糖饥饿产生的能量压力。因此,Nur77可以一定程度地维持黑色素瘤细胞在应激状态下的还原力水平,即NADPH和GSH水...Orphan nuclear receptor Nur77 is translated by an immediate-early gene encoded by NR4A1. At the same time, it’s a transcription factor. Nur77 participates in various fundamental cellular processes such as growth, proliferation, differentiation, migration and apoptosis through several mechanisms, including: (i) via a transcriptional dependent pathway; (ii) interaction with various proteins; (iii) s...学位:理学硕士院系专业:生命科学学院_细胞生物学学号:2162014115249
Conductive poly(3,4-ethylenedioxythiophene) synthesized by horseradish peroxidase and its application
导电高分子聚二氧乙撑噻吩(PEDOT,poly-(3,4-ethylenedioxythiophene))近年来引起了很多人研究兴趣,主要是由于PEDOT具有较低的能带隙、优良的导电性(10~105S/cm)、显著的电致变色特性以及环境热稳定性,成为当前引人注目的商业化应用型导电聚合物。 目前常用的化学法聚合聚二氧乙撑噻吩/聚苯乙烯磺酸盐((poly-(3,4-ethylenedioxythiophene)/poly(styrenesulfonate),PEDOT/PSS),由于使用大量的强酸和极强的氧化剂,不仅回收处理困难并且污染环境,所以本研究采用辣根过氧化物酶(Horseradishp...The conductive polymer, poly-(3,4-ethylenedioxythiophene)(PEDOT), has drawn much attention in recent years due to the features of its low band-gap, great conductivity, pronounced electrochromic activity, and long-term stability. PEDOT has shown great promise as one of the most feasible and commercial inherently conductive polymers(ICP). At present, PEDOT is commonly synthesized by chemical approa...学位:工学硕士院系专业:化学化工学院_生物化工学号:2062010115150
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