Comparison of mechanism for copper-excretion between Gandouling Tablets and penicillamine by metabonomics

目的探讨肝豆灵片(大黄、黄芩、黄连、半枝莲等)和青霉胺对大鼠的代谢物,以比较两者排铜机制异同。方法适应性饲养1周后,大鼠被随机分为对照组、模型组、肝豆灵组、青霉胺组。造模结束后,取各组大鼠血清样品分析其核磁共振谱峰。结果模型组大鼠血清乳酸、糖蛋白、肌酸、肌酐、谷氨酰胺、精氨酸的量升高,葡萄糖、甜菜碱、胆碱、磷酸胆碱、脂质的量降低;青霉胺组大鼠血清葡萄糖、甜菜碱、胆碱、胆碱磷酸、脂质的量升高,糖蛋白、乳酸、肌酸、肌酐、谷氨酰胺的量降低;肝豆灵组大鼠血清3-羟基丁酸、亮氨酸、异亮氨酸、缬氨酸、胆碱、胆碱磷酸、葡萄糖、脂质的量升高,谷氨酰胺、乳酸、肌酸、肌酐、精氨酸的量降低。结论青霉胺与肝豆灵均可明显调节铜负荷大鼠的葡萄糖、乳酸、肌酸、肌酐、胆碱、磷酸胆碱、谷氨酰胺和脂质向正常范围回归的趋势。而肝豆灵片还可调节鸟氨酸循环、支链氨基酸、3-羟基丁酸及氨的代谢。AIM To apply metabonomics to the exploration of differences in mechanism for copper-excretion between Gandouling Tablets( Rheum officinale Baill.,Scutellaria baicalensis Georgi,Coptis chinensis Franch.,Scutellaria barbata D. Don,etc.) and penicillamine. METHODS After adaptive breeding for one week,the tested rats were randomly divided into four groups, including control, model, Gandouling Tablets and penicillamine group. After modeling,the sera of all groups were analyzed by1H-NMR spectroscopy. RESULTS The model group showed increased levels of lactate, glutamine, glycoprotein, creatine, creatinine and arginine,together with decreased levels of glucose,betaine,choline,phosphocholine and lipid. Penicillamine group had increased levels of glucose,betaine,choline,phosphocholine and lipid,together with decreased levels of glutamine,glycoprotein,lactate,creatine and creatinine. While Gandouling Tablets increased 3-hydroxybutyrate,leucine, isoleucine, valine, choline, phosphocholine, glucose and lipid, but decreased glutamine,lactate,creatine,creatinine and arginine. CONCLUSION There is a similarity of mechanism for copper excretion between Gandouling Tablets and penicillamine, mainly in the metabolic regulation of glutamine, lactate,creatine,creatinine, glucose, choline, phosphocholine and lipid returning to normal. Moreover,Gandouling Tablets can regulate the metabolisms of ornithine cycle,3- hydroxybutyric acid and branched chain amino acids.国家自然科学基金青年基金资助(81202691);; 安徽省高校自然科学基金重点项目(KJ2012Z228);; 安徽省高校博士后岗位项目(2013年

Rescaling and Scalar Politics in the‘One Belt, One Road'Strategy

目前,"一带一路"已成为中国的核心发展战略之一。借鉴尺度重构和尺度政治理论,分析"一带一路"战略的内涵、影响和风险。研究发现"一带一路"战略重构了现有的国家角色和地域形式,催生了以跨国基础设施为基础、以资本和经贸合作为支撑的新尺度。该尺度一方面被国际和国内的资本和权力关系不断重构,另一方面也在重构着现有的权力关系和资本积累过程。还从尺度政治视角出发探讨了"一带一路"战略中的风险因素。在国际层面,中国既面临着基于多边国际关系和地方抵抗的尺度上推力量,也面临着基于旧有边界和尺度化表达的尺度下推因素。在国内,"一带一路"战略既面临着地方政府基于政策争夺和地方保护主义产生的重复建设问题,也存在疆独势力等通过国际联系复杂化地方趋势的风险。为了更好地推行"一带一路"战略,中国必须积极应对这些尺度政治的挑战,深入研究尺度政治的机制和破解之道,努力化解海外投资、国际合作和地方治理中的风险。‘One Belt, One Road'(OBOR) was proposed by President Xi Jinping in 2013 when he visited Kazakhstan and Indonesia. It is now the core regional development strategy in China. A series of studies(mainly in Chinese) have been conducted to provide the contextual knowledge or suggestion for this strategy. However,a theoretical examination of OBOR remains at the very superficial level among existing scholarship. This study aims to analyze the nature and impacts of OBOR from the perspective of rescaling and scalar politics,with a balanced consideration on the political geographical mechanisms and potential risks for promoting OBOR. It is argued that OBOR reshapes the roles and territoriality of Chinese state and produces a number of new geographical scales based on construction of international infrastructure, capital flows and trade cooperation. Specifically, the state power is re-territoralized through forming new international organizations and investing in the international infrastructure; the importance of some large cities are also highlighted as the nodes of OBOR. In other words, the inter-national processes are embedded in sub-national regions or new state spaces, confirming the previous theories on‘localization'. The rescaling strategies enable China to gain more influence on Eurasian geo-political and economic processes and more space to accelerate its capital accumulation.This echoes Lefebvre's arguments that the spatial fix of urban growth is based on scalar fixes. Therefore, it is interesting to note that the scale and power relations are mutually constructed. On the one hand, scale is produced and reconstructed by both international and domestic political powers and capitals; on the other hand,the rescaling processes have great impacts on the existing power relations and capital accumulation. The perspective of scalar politics suggests that there are some potential hindrance and risks behind this new initiative.At the international level, China is not only facing complex up-scaling forces related to the multilateral and international relations and local unrests, but also confronting the down-scaling forces based on the existing boundary and scalar discourses. At the domestic level, OBOR may lead to excessive competition, over accumulation and repeated construction due to local protectionism determined by the political promotion system in China. Some potential risks may also be caused by Xinjiang separatists, who can get supports easier than with the further opening of China to the rest of the world in the OBOR strategy. China must cope with these scalar politics actively in order to promote "one belt one road" strategy. This research has much policy implication for Chinese government to smooth the mechanisms of scalar politics on internationalization and reduce the potential risks of oversea investment, inter-national cooperation and regional governance. This aticle also furthers the understanding of scale in human geography by integrating discussions of rescaling and scalar politics from different sub-disciplines.国家自然科学基金项目(40701041;51208444);; 教育部人文社会科学研究基金项目(12YJAGJW007;11YJCZH058);; 中央高校基本科研业务费(20720140519)资助~

注射模变动设计系统

注射模变动设计系统是新一代注射模CAd系统的主要研究目标之一。它分析了传统注射模CAd系统的不足，指出了不足之处存在的主要原因在于没有提供高级变量驱动的产品模型和模型之间的关联机制，提出了变动产品模型与变动设计的概念，并提出了注射模变动设计系统的总体结构，最后总结了系统的关键技术

Optimized Kernel-Based Conformal Predictor for Online Fault Detection

为了提高相符预测器的计算效率,在算法中引入基于核的度量学习.将其学习过程分解成2部分:先通过提高75%的训练样本的类可分性获得1个优化核;然后在优化的核空间中采用k近邻方法设计奇异度函数,并使用剩下的25%的样本实现标准的相符预测器算法.将新算法应用于田纳西-伊斯曼过程的多类故障诊断问题,实验结果表明,在保证高的预测效率的同时,新算法可以显著降低计算时间.In order to improve the computational efficiency of conformal predictora,procedure of adaptive kernel-based distance metric learning was incorporated in the algorithm.The learning process was divided into two stages.Firstlya,n op-timized kernel was obtained by increasing the class separability of 75% of the training samples.Secondlyt,he k nearest neighbor classifier was used to design a nonconformity measure function in the optimized kernel space.And then the stan-dard conformal predictor algorithm was conducted on the remaining 25% of the training samples.The new method was ap-plied to the multiple fault diagnosis of Tennessee Eastman process.The results show that the new algorithm provides substan-tial reductions in computational timea,nd ensures high predictive efficiency as well.厦门大学985二期工程信息创新平台资助项目(0000-x07204);厦门市科技计划资助项目(3502Z20083028

Design of stand-alone solar lighting system based on super capacitor energy-storage

介绍了一种基于超级电容模块储能的独立太阳能照明系统的设计,包括储能模块、充电、稳压输出电路和光控微波探测延时电路,对设计的系统进行性能测试,取得了很好的预期效果,随着超级电容性能的提升和太阳电池性价比的不断提高,离网型太阳能照明系统有广阔的市场。A design of stand-alone solar lighting system based on super capacitor energy-storage module was introduced,including energy-storage module,charging circuit,regulator output circuit and microwave detection-delay circuit of optical control.And by testing the design of the system performance,good expectations were achieved.As the super capacitor performance develops and cost-effective solar cells continuously improve,the stand-alone solar lighting system has a broad market.福建省重大科技项目资助(2006H0092

Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network

Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects

Study on process of solvent sublation of butyl acetate in waste water

溶剂气浮是一种基于气泡的分离技术。具有一定表面活性或疏水性的溶质在水相中被吸附在气泡表面，然后被置于水相顶部的一层有机溶剂层所捕收。该技术具有很多优势，如较高的分离效率和较低的二次污染等。因此，这项技术已被广泛应用于许多领域。探索溶剂气浮过程中的传质机理并研究对特定体系适用的工艺参数，是为进一步应用奠定良好基础的重要工作。本文主要从气泡直径对乙酸丁酯废水溶剂气浮的影响展开，考察了小直径气泡在模拟体系和实际青霉素废水体系中的不同作用，并进行了初步的数学模拟计算。采用溶剂气浮法，对乙酸丁酯(BA)模拟废水(0.40%, φ)进行了分离研究。考察了气浮时间、气体体积流速、油水相体积比等对乙酸丁酯溶剂气浮分离效率的影响，重点考察了不同尺度的气泡对溶剂气浮过程的影响。结果表明，当油水体积相比为1:25时，气体流速为20 mL/min，平均直径为0.6 mm的气泡，并与气体流速为1.67 mL/min，平均直径为0.2 mm的气泡进行对比，两者气浮最终分离效率均可达到60%，但分离时间、总通气量及溶剂对水相的二次污染均有较大差别。对含乙酸丁酯的青霉素废水实际体系进行了溶剂气浮研究，考察了气浮时间、气体体积流速、油水相体积比等对分离效率的影响。结果表明，由于青霉素实际废水体系的复杂性，各种工艺参数在溶剂气浮乙酸丁酯模拟废水中的气浮规律尤其是小直径气泡的气浮规律，在实际体系中出现了较大变化。小直径气泡的分离效率出现了较大幅度的下降，气浮效果不如大气泡气浮。利用数学模型模拟计算了不同分离机理在乙酸丁酯模拟废水溶剂气浮过程中的作用。结果表明，乙酸丁酯模拟废水的溶剂气浮分离过程是各种机理综合作用的结果，适当改变工艺条件，可以使某些机理作用更加有利

Web环境中的HTTP状态管理

如何在ＡＳＰ中利用Ａｐｐｌｉｃａｔｉｏｎ和Ｓｅｓｓｉｏｎ对象管理ＨＴＴＰ的状态，跟踪用户在Ｗｅｂ环境中的工作期，并给出了一个应用实例

AlGaInP/GaInP MQW MOVCD Epitaxial Layer Optical Characteristics of Test

利用金属有机物化学气相沉积(MOCVd)生长了不同周期的四元合金半导体材料AlgAInP/(gAInP多量子阱(MQW)外延片,通过实验找到了在周期数和阱/垒宽度比等结构参数上生产AlgAInP/gAInP MQW的比较理想的结果.对常温下AlgAInP/gAInP MQW外延片的光学性质进行深入的分析和实验研究,发现当阱/垒宽度比A=0.56时,出光强度趋于饱和,当周期数目n=20时,fWHM减小到11.9 nM,可在一定程度上达到改善MQW结构设计和提高材料生长质量的目的.The paper Use MOCVD grew the different cycles of epitaxial layer of A1GaInP/GaInP multiple quantum wells.Through the experiment,found the production of the A1GaInP/GaInP MQW structure parameters in a more satisfactory results.In this paper, normal temperature of A1GaInP/GaInP MQW optical properties of epitaxial films had an in-depth analysis and experimental study.Found that when well/barrier width a=0.56,the light intensity tended to saturation;when the number of cycles AT=20,FWHM reduced to 11.9 nm.To some extent to improve the design of MQW structure and improve the quality of materials growth purposes

石油化工行业全员安全素质模型实践到全民安全素养提升体系建设

石油化工行业全员安全素质模型实践，指的是在石油化工行业内以安全为战略导向进行安全培训产品的研发，使安全问题得到重视，从而逐步提高安全培训工作的质量和针对性。安全素质模型可以帮助石化企业员工明确培训要求。企业按照素质模型涉及的素质要求设置各种培训课程，确保受训者能学到安全技能并将其应用到实践工作中，以提高培训效率，降低培训成本，增强培训的实效性。</jats:p