Design and Implementation of the Taxation Portal Platform Based on SOA

面向服务的体系结构（Service-OrientedArchitecture，SOA）是一个组件模型，它将应用程序的不同功能单元（称为服务）通过这些服务之间定义良好的接口和契约联系起来。接口是采用中立的方式进行定义的，它应该独立于实现服务的硬件平台、操作系统和编程语言。这使得构建在各种这样的系统中的服务可以一种统一和通用的方式进行交互。 门户（Portal）是一个通过把基于WEB的资源聚集一处使用户可以单点访问那些资源的WEB站点。用户与门户交互，而门户通过Portlet与各种后台应用程序交互，可以将它们都聚合到一个浏览器窗口（门户页面）中以呈现给用户。Porlet是可再用的Web模块，它们...Service-oriented architecture (Service-Oriented Architecture, SOA) is a component model; it’s a different application functional unit (called services) between these services through well-defined interfaces and contracts linked. Interfaces are defined in a neutral manner; it should be independent of implementation services, hardware platforms, operating systems and programming languages. This make...学位：工程硕士院系专业：软件学院_工程硕士(软件工程)学号：X201123104

カンポウヤクノカッセイサンソショウキョノウヒョウカニカンスルケンキュウ

論文内容要旨学位取得大学:山形大学 ; 学位記番号:工博甲第277号 ; 学士の種類:課程 ; 学位の種別 ; 博士(工学) ; 学位授与年月日:2009-03-3

1,3-取代吲唑类低氧诱导因子l抑制剂的设计合成及其抗肝癌活性

低氧诱导因子l（HIF-1）与肿瘤细胞的生长、侵袭和耐药密切相关,在肿瘤细胞内HIF-1高度表达,因此新型的HIF-1抑制剂可作为潜在的抗肿瘤药物。本文合成了9个1,3-取代吲唑衍生物。通过蛋白质印迹（Western Blot）法及实时定量荧光PCR（Real time-PCR）等方法检测了其对HIF-1及其靶基因血管内皮生长因子（VEGF）表达水平的影响,并以3-（5’-羟甲基-2’-呋喃基）-1-苯甲基吲唑（YC-1）为阳性对照药物初步评价了其体外抗肝癌细胞增殖的生物活性。实验发现化合物7b可显著抑制HIF-1及其下游靶基因VEGF的表达,且体外抗肝癌增殖生物活性优于YC-1,半抑制浓度(IC50)值为10.37μmol/L。研究结果表明,3-（5’-羟甲基-2’-呋喃）-1-（1″-对甲苯磺酰基）吲唑具有靶向抑制HIF及良好的抗肝癌活性作用。福建省科技厅项目(2015Y0081,2015J01350);;厦门大学大学生创新创业训练计划项目(2016X0644,20720152005)~

生物胺对雌性锯缘青蟹生殖神经内分泌的调控作用

采用活体注射和体外培养方法 ,进行生物胺调控雌性锯缘青蟹生殖神经内分泌的研究。结果表明 ,锯缘青蟹于实验的第 1天 ,第 5天 ,第 1 0天 ,分别注射 1 0 0 μl剂量为 1 μg/g体重的 5羟色胺 (5 HT)、章鱼胺 (OA)和多巴胺 (DA) ,第 1 5天解剖 ;其中 5 HT对卵巢发育具有显著的促进作用 ,OA和DA的作用不明显。离体条件下 ,将脑、胸神经团、视神经节分别与卵巢小块进行联合培养 ,每个实验组分别加入PBS与 1 μg/g体重的5 HT、OA、DA、HA(组胺 )和NE(去甲肾上腺素 ) ,发现卵巢发育的促进作用与 5 HT刺激了脑和胸神经团的分泌活动有关 【英文摘要】 The possibility that biogenic amines affect ovarian development in the female mud crab, Scylla serrata, was investigated. Females were administered 1μg/g body weight of 5-hydroxytryptamine (5-HT)?octopamine (OA) or dopamine (DA) on days 1, 5 and 10 and were sacrificed on day 15. Crabs given 5-HT showed significant increases in ovarian index and oocyte size over the concurrent controls, while OA and DA did not significantly affect either the ovarian index or oocyte size. In vitro study indicates that none ...福建省重中之重“福建省海洋生物优良种质和生物活性物质的应用基础研究”项目资助 1 998— 2 0 0 2年;; 高等学校博士学科点专项科研基金项目资助 ,2 0 0 1 0 3 84 0 1 0

In vitro study of neuroendocrine regulation over the testicular development in mud crabs Scylla serrata

The reproductive endocrine activities of neuroendocrine organs and androgenic glands (AG) in male Scylla serrata were investigated with co-incubation technology. In vitro studies show that: (1) the AG in Stage Ⅲ can significantly accelerate the development of seminiferous tubules and spermic matu- ration; (2) the brain, thoracic ganglia and optic ganglia have no direct influence over the testicular devel- opment; (3) the brain and thoracic ganglia can significantly promote the growth of the AG cells and hig...This work was supported by the National Natural Science Foundation of China (No.30300269) and the Fujian Province Key Foundation Re-search Program (1998-2002)

锯缘青蟹视神经节存在雄激素受体

国家自然科学基金资助项目 ( 3 0 3 0 0 2 69

Effects of biogenic amines on the testicular development in mud crabs Scylla serrata

英文摘要】 The regulation of three biogenic amines over the reproductive neuroendocrine activity of the male Scylla serrata was investigated by in vivo injection and in vitro incubation. The testicular index, the ratio of the mature sections in testes, and the ratio of Type B cells in androgenic gland were taken as the quantitative indexes. The in vivo injections indicated that: 5-HT can significantly promote the testicular development and the secretion of the androgenic gland in S. serrata; DA can inhibit the testicu..

第十八届美国理论与应用力学大会总结

1会议概况2018年6月5—9日,第18届美国理论与应用力学大会(18th U.S. National Congress of Theoretical and Applied Mechanics, USNCTAM2018)在美国芝加哥召开.本次大会由美国力学国家委员会和中国力学学会联合主办,旨在探讨和交流近四年世界范围内在理论和应用力学领域的基础研究、创新技术的最新进展,吸引了来自世界各地的近千名专家学