Hospitalization Expenses of Breast Cancer with Different Payments Based on Gamma Model

目的分析不同支付方式的女性乳腺癌患者住院费用,为合理控制乳腺癌住院费用提供依据。方法收集厦门市某三甲医院2004-2012年入院接受治疗且信息完整的女性乳腺癌患者的人口学、疾病、治疗和住院费用资料,采用Gamma模型分析医保与非医保患者的各项住院费用的差异,并估计边际均值及其95%可信区间。结果共纳入451例乳腺癌住院患者,其中医保患者占71.2%;医保与非医保患者中位住院费用分别为12696.4元和11216.5元,其中药品费分别占40.0%和38.8%,检查费分别占23.2%和22.5%,床位费分别占4.5%和4.3%。在控制协变量的影响后,医保和非医保患者的总住院费用(8889.5元vs 6807.6元)、药品费(1721.2元vs 1290.9元)、检查费(3366.5元vs 2400.6元)和床位费(488.9元vs 299.6元)差异均有统计学意义,医保患者的总住院费用、药品费、检查费和床位费分别是非医保患者的1.31、1.33、1.40和1.63倍。结论基于Gamma模型分析支付方式对乳腺癌住院费用的影响具有一定的科学合理性。医疗支付方式在一定程度上影响女性乳腺癌患者的住院费用,医保患者住院费用高于非医保患者,药品费、检查费和床位费是主要的差异来源。Objective To study the difference of hospitalization expenses between insured and uninsured female breast cancer patients with Gamma model. Methods The female patients with breast cancer in a tertiary hospital in Xiamen from Jan1,2004 to Dec 31,2012 were recruited into our study,whose demographics,disease situation,treatment and hospitalization expenses were collected. Gamma model was applied to analyze hospitalization expenses for insured and uninsured patients under control of other covariates,and to estimate marginal means. Results The study included 451 patients with 71. 2% of which were insured. For insured and uninsured patients,the median cost of hospitalization was 12696. 4 RMB and 11216. 5 RMB,respectively. The proportions of the compositions of hospitalization cost were 40. 0% and 38. 8% for drug cost,23. 2% and 22. 5% for examination cost,4. 5% and 4. 3% for bed cost,respectively. After controlling other covariates,total hospitalization cost(8889. 5 RMB vs. 8889. 5 RM B),drug cost( 1721. 2 RMB vs. 1721. 2 RMB),examination cost( 3366. 5 RMB vs. 3366. 5RMB),and bed cost(488. 9 RMB vs. 488. 9 RMB) between insured and uninsured patients were significantly different. Total cost,drug cost,examination cost and bed cost of insured patients were higher than uninsured patients with 0. 31,0. 33,0. 40,and0. 63 times respectively. Conclusion For its advantage in deal with skewed data,the Gamma model has its own rationality and validity on analysis of hospitalization expense. The hospitalization expense of female breast cancer patients with medical insurance was higher than uninsured patients. Drug cost,examination cost and bed cost made a main contribution of difference.国家自然基金青年项目(71403229);; 厦门市科技计划项目(3502Z20143006

Analysis on 6 Cases of Adverse Drug Reactions Induced by Ammonium Chloride and Licoricl Oral Solution

目的：探讨氯化铵甘草口服溶液不良反应的特点,为临床安全用药提供参考。方法：对本院2014年1月-2016年3月上报的6例氯化铵甘草口服溶液不良反应监测报告进行回顾性分析,对6例患者的年龄、性别、原患疾病,药物使用情况,ADR发生时间、临床表现、治疗与转归,ADR的类型与关联性评价等项目进行统计分析。结果：氯化铵甘草口服溶液不良反应多发生于老年患者;发生时间主要在用药8h内;以累及系统呼吸系统和皮肤为主;6例患者均痊愈,未出现后遗症或导致死亡。6例ADR中一般的ADR 2例,新的一般的ADR 2例,新的严重ADR 2例;关联性评价为可能4例,很可能2例。结论：临床上应重视氯化铵甘草口服溶液的不良反应,应密切观察患者,保证用药安全。Objective： To explore the characteristics of the adverse drug reactions （ADRs） induced by ammonium chloride and licoricl oral solution, to provide the reference for clinical safe medication and prevent adverse reaction. Methods：Restrospectively analysis were used on the ADRs reports of 6 cases of ammonium chloride and licoricl oral solution form January 2014 to March 2016 in our hospital. The application of drug, the age and gender distribution of patients ,occurrence time of ADRs, clinical manifestations ; treatment and outcome ; types and relevance evaluation of ADRs were analyzed respectively. Results：ADRs were mostly happened in the senile patients 8h after the medication. The clinical manifestations were respiratory and skins. 6 patients were all recovered, no occurrence sequel or lead to death. There were 4 cases of new ADR ,4 cases of commom ADR and 2 cases of severe ADR, 4 cases of possible relevance and 2 cases of probale relevance. Conclusion：The ADRs caused by ammonium chloride and licoricl oral solution should be pay more attention to, observed the changes closely to ensure clinical safe mediation

通过发表OA论文来提高学术影响力

1、生物物理所OA论文发表及学术影响力分析；2、与科研相关的OA；3、如何发表OA论文；4、开放科技资源介

黄芩素对MC3T3-E1体外成骨分化及对口腔常见菌的抑菌作用

目的研究不同浓度黄芩素对MCT3-E1增殖及生物学行为的影响，以及其对口腔常见菌的抑菌作用，并探讨其相关机制。方法将MC3T3-E1细胞分别培养在0、6、12、18、24 μmol/L的黄芩素浓度下，通过CCK-8实验检测黄芩素处理后MC3T3-E1的增殖活性；对成骨诱导培养后的MC3T3-E1进行ALP活性检测；RT-PCR法检测RunX2、BMP2、Osterix基因的表达差异。K-B纸片法检测黄芩素处理24 h对大肠杆菌，金黄色葡萄球菌，血链球菌的抑菌效果。结果黄芩素可在一定程度降低细胞增殖活力，但不影响其继续增殖。18 μmol/L的黄芩素可以提高MC3T3-E1的ALP活性，并有效上调BMP2与Osterix的表达，下调RunX2的表达，能有效抑制金黄色葡萄球菌与血链球菌的增殖（P<0.05）。结论适宜浓度的黄芩素（18 μmol/L）对MC3T3-E1细胞成骨分化有促进作用，并且可有效抑制口腔常见菌（金黄色葡萄球菌与血链球菌）的增殖

经济全球化与中国文学

中国文学面临的冲击林兴宅:我们回顾20世纪90年代以来,中国的文学受到三次冲击。第一次是市场化或者叫商品化的冲击,最明显的变化就是文学边缘化,整个中心转移了,企业家充当了社会主流角色,文学退到社会的边缘再一个变化就是文学和商品的实现连在一起,精品文学慢慢失去社会的关注,而一些流行的、时尚的文学作品地位却在上升。第二次冲击是网

数字微流控技术及其在生物分析中的应用

数字微流控技术是一种基于微电极阵列来实现离散液滴精确控制的新型液滴操纵技术。这种基于介电润湿现象实现的液滴电操纵体系,相比于传统微流控芯片具有自动化、可寻址、可动态配置、易集成等特点。该文介绍了数字微流控技术液滴驱动原理,总结了芯片的结构和常用的制作方法,举例阐述了现阶段该技术在生物分析化学领域的应用,并对其应用前景做了展望。国家自然科学基金资助项目(21735004,21435004,21775128,21705024,21521004);;长江学者和创新研究团队项目(IRT13036

Hypoglycemic action of acidic polysaccharide in leaf of Gynura divaricata and its effect on related indexes

与西药相比,传统中药及其提取物具有经济、安全的优点,同时还可避免西药的许多副作用[1]。中药材白子草又名白背三七,为菊科(COMPOSITAE)三七属(gynurA CASS.)植物白子菜〔gynurA dIVArICATA(lInn.)dC.〕的干燥叶,具有清热、舒筋、止血、祛痰等功效[2]。在民间,白子菜的茎和叶可药食两用,用于治疗高血压、糖尿病和高血脂症等[3],其化学成分复杂,目前已分离获得多糖类[3]、黄酮类[4-6]、生物碱[4,7-8]和脂肪酸[9]等成分。Gynura divaricata acidic polysaccharide( GDAP) was extracted and purified from dry leaf of Gynura divaricata( Linn.) DC.Effects of successive lavage GDAP for 0,7,14 and 21 d with daily dose of 15,37 and 60 mg·kg- 1on blood glucose content of diabetic model mice were analyzed,and differences in SOD activity and MDA content in serum and glycogen content in liver of mice were compared.The results show that with prolonging of successive administration time and increasing of GDAP daily dose,blood glucose content of diabetic model mice generally appears the decreasing trend.With successive administration for 14 and 21 d,blood glucose content of different GDAP treatment groups is generally lower than that of CK group( 0.9% Na Cl injection with daily dose of 10 m L·kg- 1) but higher than that of T1group( metformin with daily dose of 200 mg·kg- 1).In which,after successive administration GDAP for 21 d with daily dose of 37 and60 mg·kg- 1,blood glucose content of diabetic model mice is significantly or extremely significantly lower than that of CK group but significantly or extremely significantly higher than that of T1 group,while SOD activity in serum of diabetic model mice is significantly higher and its MDA content is significantly lower than those of CK group,but there is no significant difference with those of T1 group.Glycogen content in liver of diabetic model mice of different GDAP treatment groups is higher than that of CK group,but lower than that of T1 group.It is suggested that GDAP is the main hypoglycemic components in polysaccharide of G.divaricata leaf, and it has dose-effect relationship in hypoglycemic activity.Hypoglycemic mechanism of GDAP is probably related to improving antioxidant enzyme ability in the body,enhancing activity of scavenging oxygen free radicals,relieving liver damage,and increasing glycogen storage capacity.福建省自然科学基金资助项目(2012J01400

十一种壳聚糖衍生物的紫外吸收特性

通过对O-氰乙基壳聚糖、N-苄基壳聚糖等11种壳聚糖衍生物的紫外吸收特性的研究发现,在稀溶液体系中,这些衍生物的紫外吸收光谱都可以覆盖整个UV-B区(280~320 nm),其中N-羟基苄基壳聚糖、N-苯基乙烯基甲基壳聚糖甚至可以覆盖至UV-A区(>320 nm);大部分衍生物吸收强度可达中等以上,N-苯甲醛西佛碱壳聚糖、N-羟基苄基壳聚糖、N-苯基乙烯基甲基壳聚糖、辛基氨基甲酸酯基壳聚糖、萘基氨基甲酸酯基壳聚糖达到强吸收。而在浓溶液体系中,虽然由于浓度过高不能得到完整的谱图,但是可以通过其出峰位置的移动来说明其聚集态的变化。液晶临界浓度附近,峰的位置移动较大,而将液晶态冻结下来的N-苄基壳聚糖薄膜的紫外光谱已经可以覆盖大部分的UV-A区

环孢素治疗中重度干眼症的对照研究

【目的】观察0．2％（2g/L）环孢素滴眼液对中重度干眼症的效果。【方法】将中重度干眼症134例随机分为对照组（65例）和实验组（69例）。对照组应用10g/L羧甲基纤维素钠，4次／d，实验组应用10g/L羧甲基纤维素钠和2g／L环孢素滴眼液，4次/d。两组均连续用药1个月。用药前后均进行荧光素染色检查、泪液分泌检查（STT）、泪膜破裂时间检测（BUT）、结膜印迹细胞检查。【结果】两组比较在治疗前差异无统计学意义（P〉0．05），治疗后实验组SIT、BUT比对照组的结果有统计学意义（P〈0．01），实验组治疗前后结果比较有统计学意义（P〈0．01）。对照组的治疗前后比较差异无统计学意义（P〉0．05）。【结论】2g/L环孢素滴眼液治疗中重度干眼确有良好的效果

甲状腺相关眼病患者眼眶脂肪抵抗素的表达

【目的】通过检测抵抗素在甲状腺相关眼病患者及对照组眼眶脂肪组织和脂肪细胞中的表达，为进一步探讨抵抗素与甲状腺相关眼病的相关性打下基础。【方法】通过体外原代培养获得前脂肪细胞，前脂肪细胞在分化液的作用下转化为成熟脂肪细胞。用RT-PCR法检测眶脂肪组织、前脂肪细胞及成熟脂肪细胞中抵抗素mRNA的表达，并进行免疫组化检测抵抗素蛋白的表达。【结果】前脂肪细胞中无抵抗素mRNA及蛋白的表达。成熟脂肪细胞及眶脂肪组织中有抵抗素mRNA及蛋白的表达。免疫组化结果显示抵抗素蛋白位于成熟脂肪细胞胞浆中。【结论】甲状腺相关眼病患者眶脂肪中抵抗素mRNA及蛋白表达丰富，说明甲状腺相关眼病患者眶脂肪增多是因成熟脂肪细胞所占比例增加、脂肪细胞分化增强所致