Research and Implementation of Automatic Singing Transcription

音乐记谱是音乐人辨识音乐旋律并寻求乐谱表达的一种智力行为，而哼唱自动记谱则是利用计算机技术将哼唱信号转换为一系列连续独立的音符，并且识别出音符的音高以及时长信息，从而来模拟人的这种记谱行为。随着多媒体技术的发展和音乐的数字化进程，在音乐传播的过程中能够自动得到音乐的乐谱信息将帮助人们更好地欣赏音乐。 目前的哼唱自动记谱研究大多基于信号处理或模式分类的方法，却往往忽略了音乐的表现和感知与音乐内容识别计算模型的关系，造成自动记谱效果一直不太理想。本文旨在通过对音乐听觉特征分析，结合信号处理方法与音乐乐理知识规则，对哼唱自动记谱展开了以下几个方面的研究： 1.针对音高估计算法常见的倍频估算错误，...Music notation is a kind of intelligent behavior that musicians identify the melody and express them in musical scores. Automatic singing transcription refers to the analysis of a music signal in order to produce a parametric representation of the sounding notes with the pitch and duration. It is a technology to simulate the manually notation. With the development of multimedia and the procession ...学位：工程硕士院系专业：信息科学与技术学院_计算机技术学号：3152010115317

Development and stability test of compound ketoconazole ointment

目的 制备复方酮康唑软膏并考察其稳定性。方法 以酮康唑、莫匹罗星和糠酸莫米松为主药，以聚乙二醇（PEG）为基质制备软膏；利用影响因素试验考察软膏中药物的稳定性。结果 PEG400和PEG3350的比例为2：1时，软膏的黏度最佳，易于涂展。制成软膏后，高温下糠酸莫米松和莫匹罗星稳定性良好；酮康唑有少许分解，加入0.5%的抗坏血酸棕榈酸酯（L-A）后，酮康唑的含量明显提高。加速试验发现，放置6个月后软膏的颜色无变化，3种药物的含量均在98%以上。结论 本实验成功制备了新型复方酮康唑软膏，药物稳定性良好。Objective To prepare compound ketoconazole ointment and perform the stability study.Methods Ketoconazole, mupirocin and mometasone furoate were used as active pharmaceutical ingredients （API）. PEG mixture was used as matrix to prepare the ointment.Stability of the API in the ointment was evaluated by the stress tests.Results The optimal ratio of PEG400 to PEG3350 for the ointment matrix was 2：1. Mometasone furoate and mupirocin in the ointment were stable to the high temperature（40℃）while ketoconazole had some degradation. The stability of the API was improved by addition of 0.5% of L-A. During the accelerate test, the ointment had no color change and the API percentages were above 98%. Conclusion The novel compound ketoconazole ointment was successfully prepared and the formulation stability was excellent.福建省自然科学基金项目（2010J01218

薪酬-职务倒挂是否具有“黑色嫉妒”效应?——基于国有企业薪酬激励对企业行为的影响研究

合理的薪酬契约是管理层激励的重要机制之一。本文以2007-2016年A股国有企业为样本,研究薪酬激励中薪酬-职务倒挂安排对企业投资行为和社会责任行为的影响。结果表明,由于我国A股国有企业的隐性激励机制的存在,薪酬-职务倒挂并未导致\"黑色嫉妒\"效应,虽然薪酬-职务倒挂短期内抑制了企业投资水平,但降低的部分主要来自于抑制企业过度投资;同时,薪酬-职务倒挂企业会通过提供就业岗位的形式承担更多的社会责任。进一步研究表明:(1)薪酬-职务倒挂对投资水平的抑制主要存在于地方国企;(2)当CEO任期较短时,薪酬-职务倒挂的企业增加投资的意愿较弱。本文结论为国有企业制定合理的薪酬契约提供了一定的借鉴意义。国家自然科学基金(71572163、71532012、71422008、71372074);国家自然科学基金重大项目(71790601);;\n“国家万人计划”青年拔尖人才和校长基金创新团队项目(20720171003)的支

Dynamic Investigation of Inhibitory Effects of Black Tea and Green Tea Polyphenols on Porcine Pancreatic α-amylase

目的:研究红茶和绿茶抑制剂对猪胰腺α-淀粉酶催化水解淀粉的抑制效果和特异性。方法:实验在25℃和PH6.9条件下进行。混合0.7 Ml不同浓度的淀粉和0.2 Ml红绿茶(7.5 g/l),添加0.1 MlPPA(0.04 g/l),进行5 MIn孵化反应。通过SMArTSPEC PluS SPECTrOPHOTOMETEr不间断540 nM波长下,测量PPA催化生成的麦芽糖的吸光度增加值。通过动力曲线的直线段斜率获得反应速度,动力学参数(VMAX和kS)由lInEWEAVEr-burk图求出,抑制类型通过统计学分析确定。结果:无抑制剂和红茶抑制剂的最大反应速度(VMAX)之间的差异具有统计学意义(P<0.05),无抑制剂和绿茶抑制剂的酶-底物解离常数(kS)之间的差异具有统计学意义(P<0.05)。红茶抑制剂解离常数(kI)值高于绿茶(P<0.05)。结论:红茶抑制为非竞争抑制型,绿茶抑制为竞争抑制型。红茶抑制剂既能与自由酶活化中心位点结合,也能与酶-底物上的位点结合,而绿茶抑制剂仅能与活化中心位点结合。Objective: To study the effectiveness and specificity of black tea and green tea inhibition of starch hydrolysis that was catalyzed by porcine pancreatic α-amylase(PPA).Methods: Kinetic experiments were carried out at 25℃and pH 6.9.Starch(0.7 mL) with different concentration and black tea and green tea(0.2 mL,7.5 mg/mL) were mixed together and the reaction was initiated by adding PPA(0.1 mL,0.04 mg/mL) to the incubation medium for 5 min.The increase of absorbance resulting from the PPA liberated maltose was measured continuously at 540nm using SmartSpec Plus Spectrophotometer.The initial velocity was determined from the slope of linear part of the kinetic curves.Kinetic parameters(Vmax,Ks) were calculated using Lineweaver-Burk plots.The type of inhibition was determined by statistical analysis.Results: There were significant differences between maximum velocity(Vmax) in the absence and presence of black tea inhibitor(P<0.05) and between the dissociation constants of enzyme-substrate(Ks) in the absence and presence of green tea inhibitor(P<0.05).The dissociation constant of black tea inhibitor(Ki) was much higher than that of green tea inhibitor.Conclusion: Acording to the statistical analysis,the black tea inhibition was belong to non-competitive inhibition type,and the green tea inhibition was belong to competitive inhibition type.The black tea inhibitor could bind either to the active site or to the other site of enzyme-substrate to give rise to enzyme-inhibitor and enzyme-substrate-inhibitor complexes,and the green tea inhibitor could only bind to the active site

Talent recommendation system in big data era

1人才推荐系统的应用背

On Teaching Reform and Practice at Biochemical Engineering Experiments

本文从工科专业实验课教学的重要性入手,阐述了进行生物工程专业实验课教学改革的必要性和重要意义,介绍了生物工程实验教学改革的相关体会。This article,based on the importance of the engineering experiments teaching,expounds the necessity and importance of the reform in Biochemical Engineering Experiments Teaching,and also introduces the experience about Biochemical Engineering Experiments Teaching reform

基于系统可靠性的主动配电网置信容量评估

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洗涤剂中的十二烷基苯磺酸钠对海洋藻类生长的影响王宪，李文权，郑爱榕，韩涛生，连卫中（厦门大学海洋学系）关键词lAS，布氏双尾藻，悬浮物前言随着工农业生产的发展，洗涤剂的使用范围越来越广，用量日趋增大。藻类是水生生态系统的初级生产者，通过各种途径进入水...福建省自然科学基

海洋储碳机制及区域碳氮硫循环耦合对全球变化的响应

海洋作为地球表面最大的活跃碳库,其碳收支在很大程度上决定了全球气候变化的走向.然而,海洋碳循环是一个多时空尺度的过程,相关的碳收支估算存在很大的; 不确定性,其控制过程与机理更是一个颇具挑战性的难题(胡敦欣等, 2015),特别是海洋储碳机制,是研究全球变化及应对的核心内容之一.国家重点研发计划专项全球变化及应对项