道路近傍大気中における超微小粒子の挙動<研究成果報告>

Field measurements of size-resolved particle number concentrations of PM2.5 and ultra-fine particles (UFP_s) (< 0.3 μm) were performed using an ultra-fine particle counter (UFPC) at roadside and indoor/outdoor of a building located about 50 m away from the roadside. Similar behavior of both UFP and PM2.5 were found for number concentrations at all measuring sites, and it was made clear that the wind speed influences UFP concentration more significantly than rainfall. In addition, high correlations between UFP concentration and nitrogen monoxide (NO) and elemental carbon (EC) concentrations indicated that the particles emitted from motor vehicles, particularly diesel emission particles, are transported near the building and penetrated into the indoor space of the building. Furthermore, since the indoor/outdoor ratios (I/O ratios) of UFP and PM2.5 increased when a fan ventilator was used, it was thought that UFP and PM2.5 come into the building through the gaps between windows and doors with the walls.textapplication/pdfdepartmental bulletin pape

消化器症状に乏しく，高熱を遷延した非チフス性サルモネラ菌血症の2例

非チフス性サルモネラ属菌（non-typhoidal Salmonella; NTS）感染症は無症状の保菌者から， 嘔吐，下痢，血便などの急性胃腸炎症状を呈する患者，さらには菌血症，骨髄炎，膿瘍，髄膜炎，脳症などの重篤な腸管外合併症を呈する患者まで，その臨床像は多岐にわたる．今回，我々は発熱の遷延にも関わらず，消化器症状や炎症反応の上昇が軽微なNTS菌血症の2小児例を経験した．血液培養により診断が確定したが，後方視的には過去の報告同様に，末梢血好酸球数の著明な低値や腸間膜 リンパ節腫大を認めた．NTS菌血症の小児例の文献検索においても，高熱にも関わらず炎症反応が比較的軽微な患者や消化器症状に乏しい患者も少なからず存在し，非典型的な経過をとる場合があることを念頭におき，疑われる際は血液培養を欠かさず採取すべきである

A CASE OF ILEUS BY THE INFECTION OF TYPE X LARVAE OF THE SUBORDER SPIRURINA AFTER EATING RAW FIREFLY SQUIDS

A 53-year-old male was hospitalized on April 12th, 2002 because of an upper abdominal pain that started in the morning of April 11th and gradually worsened. Ileus was suspected based on an X-ray of the abdomen. A medical interview revealed that the patient had eaten raw firefly squids, 2 days before the hospitalization. The abdominal symptoms disappeared in a few days during which the patient was treated conservatively. A specimen from the patient's sera reacted with the esophageal glands in frozen sections of a type X larva of the suborder Spirurina. The infection of the type X larvae of unidentified splruroid nematodes from squids was considered to be the cause, because those larvae have recently been to reported as the cause of visceral and cutaneous. Although the infection rate in W. scintillans is relatively low, a risk of human infection with type X larvae should be taken into a consideration in the consumption of raw squids

Histopathological findings and clinical effects for acute rejections

国際Banff基準と治療効果には相関を認めた.G2以上の症例には, OKT3及びALGがMPに比べ, 有効率に有意差を認めた.DSGは症例数が少なく, 今後の検討が必要であるWe reviewed 115 cases of acute rejection following renal transplantation. All cases were diagnosed after graft biopsy, and showed histopathological evidence of acute rejection. They were treated with administration of OKT3, 15-deoxyspergualin (DSG), anti-lymphocyte globulin (ALG) or methylprednisolone (MP). All rejections were histopathologically classified according to the Banff working classification. The clinical effects of each drug were evaluated both at 1 month and 1 year following the therapy for rejection, by measurement of serum creatinine level. The effective rate both at 1 month and 1 year was related with the Banff working classification ( p < 0.0001). At 1 month after treatment, there were no significant differences between the OKT3, DSG or ALG group and MP group in cases of borderline change and AR grade I. In cases of grade II and grade III, a significant difference was observed between the OKT3 or ALG group and MP group (p < 0.05). The DSG group showed a slightly better outcome than the MP group, although the difference was not significant. In conclusion, the Banff schema is shown to be valid for classification of acute renal allograft rejection, and it is necessary to determine the treatment for acute rejection according to histopathological classification

双段消能摇摆结构体系弹性地震反应的简化分析模型及参数分析

双段消能摇摆结构体系是基于单段摇摆结构体系应用于高层建筑的发展,由两段串联的摇摆结构、主体结构、刚性连杆以及位移型阻尼器组成,可以减小高层建筑结构在地震作用下的动力响应,控制主体结构变形更加均匀,并削弱结构高阶振型的影响,提高结构的抗震性能。基于双段消能摇摆结构体系的刚度组成,建立了双自由度简化分析模型,并结合有限元分析模型进行验证。提出了影响双段消能摇摆结构体系弹性地震反应的无量纲控制参数,结合参数分析的结果,给出了无量纲控制参数的建议范围。研究表明,双自由度简化分析模型可以准确模拟双段消能摇摆结构体系的弹性地震反应,并较准确地反映了主体结构刚度、阻尼器刚度对结构弹性动力响应的影响,降低结构的计算成本;相比于单段摇摆结构,双段摇摆结构能够减小高层建筑下段结构的弹性地震反应,提高高层建筑的抗震性能

梅花鹿<italic>DLX5</italic>基因克隆及表达分析

为研究梅花鹿（Cervus nippon）DLX5基因的结构和功能，进一步探究其与梅花鹿茸角骨化机制间的关系，采用RT-PCR技术对梅花鹿DLX5基因进行克隆，获得包含全部编码区的cDNA序列，对该基因的氨基酸序列进行生物信息学分析并构建系统进化树，通过KEGG富集分析其信号通路，运用实时荧光定量RT-PCR检测该基因在鹿茸生长不同时期的表达情况。结果表明：梅花鹿DLX5基因编码区长为870 bp，共编码289个氨基酸。DLX5蛋白为可溶性的不稳定蛋白，有2个保守结构域，主要定位于细胞核。梅花鹿DLX5蛋白与许多不同物种来源的DLX5蛋白氨基酸序列有较高相似度，比较保守。DLX5蛋白二级结构中无规则卷曲占比最大（78.89%），其后依次是α-螺旋、延伸链，占比分别为16.96%和4.15%。DLX5基因主要的作用通路为TGFβ信号通路、MAPK信号通路和Wnt信号通路等。实时荧光定量RT-PCR结果表明，DLX5基因在鹿茸生长后期（三杈茸）表达量显著增高，这种上调表达暗示了其在鹿茸骨化过程中发挥重要作用，说明其可能是鹿茸骨化相关候选基因

Q460高强钢焊接H形柱轴心受压极限承载力参数分析

为了研究现行钢结构设计规范是否仍适用于高强钢中厚板焊接H形柱的设计,采用数值积分法与有限单元法对Q460钢轴心受压柱的极限承载力进行了参数分析。试件的主要参数分别为翼缘宽厚比（3.47.0）与柱长细比（10130）。数值积分法计算采用作者编制的电算程序,并与通用有限元程序ANSYS的计算结果进行了对比。数值模型考虑了1/1 000柱长的初始弯曲及相应截面的残余应力分布简化模型。计算结果表明:考虑相同初始缺陷的有限单元法与数值积分法所得计算结果吻合较好;Q460高强钢焰割边焊接H形柱与普通强度钢柱相比,其极限承载力对初始几何缺陷的敏感性降低,柱的稳定系数有所提高。通过对比参数分析结果与现行规范,发现当翼缘宽厚比不小于7时,中厚板Q460高强钢焰割边焊接H形柱绕弱轴稳定系数仍可沿用《钢结构设计规范》（GB 50017—2003）中b类截面柱子曲线;当翼缘宽厚比小于7时,应采用c类截面柱子曲线