1,3-取代吲唑类低氧诱导因子l抑制剂的设计合成及其抗肝癌活性

低氧诱导因子l（HIF-1）与肿瘤细胞的生长、侵袭和耐药密切相关,在肿瘤细胞内HIF-1高度表达,因此新型的HIF-1抑制剂可作为潜在的抗肿瘤药物。本文合成了9个1,3-取代吲唑衍生物。通过蛋白质印迹（Western Blot）法及实时定量荧光PCR（Real time-PCR）等方法检测了其对HIF-1及其靶基因血管内皮生长因子（VEGF）表达水平的影响,并以3-（5’-羟甲基-2’-呋喃基）-1-苯甲基吲唑（YC-1）为阳性对照药物初步评价了其体外抗肝癌细胞增殖的生物活性。实验发现化合物7b可显著抑制HIF-1及其下游靶基因VEGF的表达,且体外抗肝癌增殖生物活性优于YC-1,半抑制浓度(IC50)值为10.37μmol/L。研究结果表明,3-（5’-羟甲基-2’-呋喃）-1-（1″-对甲苯磺酰基）吲唑具有靶向抑制HIF及良好的抗肝癌活性作用。福建省科技厅项目(2015Y0081,2015J01350);;厦门大学大学生创新创业训练计划项目(2016X0644,20720152005)~

A Thematic Research on the Inheritance and Innovation of the Great Wall

長城文化は，中華民族の貴重な精神的遺産であり，文化的象徴である。長城文化のテーマ要素の進化の流れを定量化することは，長城文化遺産のより良い継承と革新に新たな視点を開き，新たな方法を提供する。本研究では，文献計量法を用いて長城文化のテーマ要素を解析し，分類体系とキーワード共起ネットワーク図を構築した。さらに，社会ネットワーク分析法を用いてテーマ要素間の関係を探り，LDAテーマモデルを用いてテーマの進化を可視化分析した。研究結果によると，長城文化のテーマ要素に関する研究数は年々増加しており，研究の方向性はその構成や特徴の追究から，現代社会における価値や役割の反省へと発展している。具体的には，長城文化のテーマ要素の研究は，人文芸術，文化観光体験，文化遺産保護，イデオロギー，産業振興など12の側面から展開されており，そのテーマの進化過程は歴史文化型，文化景観型，人文体験型など6つのタイプに分類される。departmental bulletin pape

实体水-虚拟水“二维三元”耦合流动理论基本框架

在变化环境下，区域水资源系统演变规律正在发生深刻变化。解决新形势下出现的水问题单单依靠传统的实体 水资源规划、调度和调控手段还不够。虚拟水概念和理论的提出拓展了水文水资源的认知范畴，丰富了水问题的解决手 段。然而，如何搭建虚拟水理论与传统水文水资源认知体系的统一框架，认识自然-经济-社会连续系统中水资源演化的新 规律，目前学界还没有成熟统一的看法。该文首先提出了实体水-虚拟水耦合流动效应的基本理论框架，指出实体水-虚 拟水耦合流动是现代环境下自然-经济-社会水资源系统呈现的新特征。其次，从文明进步和生产力发展角度，论述了人类 社会水文水资源系统的演化历史，将水文水资源系统演进大体分为三个阶段：早期的实体水&ldquo;一维一元&rdquo;自然循环阶段， 近现代的实体水&ldquo;二元&rdquo;水循环阶段和当前的实体水-虚拟水&ldquo;二维三元&rdquo;耦合流动阶段。最后，该文详细论述了实体水 -虚拟水耦合流动过程的路径结构，并针对其流动过程和状态表征提出了定量表达方程，初步构建了实体水-虚拟水耦合 流动基本理论框架。</p

我国北方重点煤电基地发展伴生的水资源压力分析

鉴于煤电基地的快速扩张会给区域水资源保障带来极大的压力，运用生命周期评价方法计算了２００６～ ２０１５年我国北方九大煤电基地煤炭生产和火力发电的水足迹，提出了虚拟水流出伴生的水资源压力指数，评 价了煤电虚拟水外送给当地水资源系统造成的压力，分析了未来煤电基地发展的水资源适配性。结果表 明， 九大煤电基地煤炭生产和火力发电的年均水足迹为１３．４&times;１０８ｍ３，占当地淡水资源可用总量的２２．８％，煤 炭 和电力外送伴生的虚拟水流出总量持续增加，增长率为３０３１．９&times;１０４ｍ３／ａ，近１０年来，水资源压力指数呈现 上升趋势，六个煤电基地达到中度压力等级，造成巨大的水资源压力；２０２０年，九大煤电基地总水足迹为 １５．７&times;１０８ｍ３，区域可供给煤电基地的水资源量为１１．９&times;１０８ｍ３，只有晋北和准东的水资源满足未来基地扩张 需要；晋中、晋东、陕北和鄂尔多斯通过优化调度等增加区域可供水量后可以满足未来生产需要；宁东和哈 密 发展所需的水资源与供给能力严重不适配，应调整发展战略，保障基地用水安全。</div

Predation Strategies of Four Common Crabs on Sea Urchins Mesocentrotus nudus with Different Sizes

[Objectives] Mesocentrotus nudus is a key species in maintaining the stability of the kelp ecosystem and a valuable economic sea urchin species in northern China. However, little researches focus on its population ecology, and the factors impacting the population dynamics are still not clear. Gaetice depressus, Hemigrapsus sanguineus, Portunus trituberculatus and Charybdis japonica are four common crab species off the coast of China and are potential predators of M nudus. In order to explore the predation strategies and predation intensities of four crab species and the predation selectivities of C. japonica on different sizes of M. nudus, three different groups of body sizes of M nudus individuals, e.g., small sized (12 - 15 mm), medium sized (19-22 mm) and large sized (30 - 33 mm in diameter) were selected as the research objects. [Methods] Two sets of experiments were conducted in the laboratory. In the predation strategies and predation intensities experiment, each species of crabs was divided into two groups separately containing small and medium sized sea urchins, while the predation selective experiment contains a C. japonica and three sizes of urchins in a single experimental group. The data was analyzed using Excel and Spss16.0,and the significance was inspected using one-way ANOVA and Kruskal-Wallis in both sets of experiment, and Ivlev indexes were calculated to examine the predation selectivity of C. japonica on small and medium sized sea urchins. [Results] The results showed that four crab species could prey on the small sized sea urchin individuals, of which, the P. trituberculatus and C. japonica showed higher predation intensity on sea urchins (8.67 1.53 and 9.33 1.15, respectively, Table 2); whereas only P. trituberculatus and C. japonica consumed the medium sized sea urchins (Table 2). As for the predation strategies, four crab species presented diverse kinds of strategies on different sizes of sea urchins but showed similar predation behavior when encountering difficulties of crushing the urchins (Fig. 1). The predation and selection pattern of C. japonica belong to a kind of passive selection, and the selectivity was closely related to the size of its cheliped. Crabs with smaller cheliped had relatively high selective feeding index on small sized sea urchins (Fig. 2), while individuals with bigger cheliped showed no significant differencein predation rate for small and medium size sea urchins (one-way ANOVA, P > 0.05) (Fig. 2). [Conclusion] This study reveals that G. depressus, H. sanguineus, P. trituberculatus and C. japonica are all potential predator of sea urchin M. nudus. Moreover, they can adapt their hunting strategies according to the preys with different body size, predation capacity is a key factor to the prey selectivity of C. japonica

西藏羌塘盆地鸭湖地区天然气水合物成藏条件

近年来中国陆域冻土区天然气水合物调查研究结果表明，气源条件是制约羌塘盆地天然气水合物找矿突破的关键因素。为明确鸭湖地区天然气水合物成藏潜力，基于近年来的钻探调查成果，从陆域冻土区天然气水合物成藏系统理论出发，系统分析了影响天然气水合物成藏的冻土、气源、储集、构造等地质因素。分析结果显示，鸭湖地区局部具有较好的冻土、地温、气源、储集、构造及水源条件，具备一定的天然气水合物成藏潜力，继续寻找充足的烃类气源是下一步天然气水合物调查的主要方向。同时，选取钻探调查获取的地温梯度、气体组分等参数，结合音频大地电磁测深（AMT）冻土厚度调查成果，对鸭湖地区天然气水合物稳定带的厚度和底界深度进行了预测。结果显示，当甲烷为85%、乙烷为9%、丙烷为6%时，天然气水合物稳定带厚度与冻土厚度分布变化基本一致，稳定带厚度400~630m，底界深度400~680m。当甲烷为98%、乙烷为2%时，天然气水合物稳定带厚度急剧减薄，大部分地区仅有0~30m，最厚仅有150m，局部地区稳定带底界最深仅为240m。结合气测录井结果，认为渐新世唢呐湖组比上三叠统土门格拉组更具备天然气水合物成藏潜力，土门格拉组自身具备较强的生排烃能力，可作为寻找常规油气或页岩气的一个重要层位

Measurement of integrated luminosity of data collected at 3.773 GeV by BESIII from 2021 to 2024

We present a measurement of the integrated luminosity e+e- of collision data collected by the BESIII detector at the BEPCII collider at a center-of-mass energy of Ecm = 3.773 GeV. The integrated luminosities of the datasets taken from December 2021 to June 2022, from November 2022 to June 2023, and from October 2023 to February 2024 were determined to be 4.995±0.019 fb-1, 8.157±0.031 fb-1, and 4.191±0.016 fb-1, respectively, by analyzing large angle Bhabha scattering events. The uncertainties are dominated by systematic effects, and the statistical uncertainties are negligible. Our results provide essential input for future analyses and precision measurements