2D/3D级联卷积在分割CT肺动脉上的应用研究

医学影像分割是计算机辅助诊断的重要组成部分。针对CT影像的三维特性,提出了一种基于2D/3D级联卷积的Unet网络结构用来分割肺动脉。该结构相比基于传统2D卷积的方法,关联了第三维度信息,提高了分割准确度和泛化能力,相比基于传统3D卷积的方法提高了准确度和执行效率。实验对多套肺动脉增强CT数据集做了验证,分割准确率达到85.7%,高于传统2D和3D Unet网络,同时执行效率较3D Unet提高近30%,在CT影像分割上做到了效率和准确度的兼顾。国家自然科学基金(编号:61001144,61102137,61327001,61671399)~

630nm和514.5nm两种波长激光束对人体胃、肺癌细胞株的HpD光敏化光剂量的研究

本工作使用630nm和514.5nm两种波长激光束对不同分化程度的人胃、肺癌细胞株进行HpD光敏化光剂量的比较研究。实验数据显示,514.5nm波长光对体外培养单层癌细胞的光敏杀伤力是630nm光的2—3倍。分析结果还表明,分化程度越低的癌细胞受光敏化的效率越高

LIN总线及其在智能家居控制系统中的应用

LIN总线是新近出现在汽车行业的一种串行通信总线。其协议对硬件的依赖程度低,可以基于普通单片机的通用串口等硬件资源以软件方式实现,成本低廉,因此可广泛应用于汽车行业以外对实时性要求不高的其他领域。本文概要介绍了LIN总线协议,并介绍了其在智能家居控制系统中的应用

Local Interconnect Network Bus and Its Application in Control System of Smart Home

介绍了LIN总线协议,及其在智能家居控制系统中的应用。LIN总线是新近出现在汽车行业的一种串行通信总线,其协议对硬件的依赖程度低,可基于普通单片机的通用串口等硬件资源以软件方式实现,成本低廉,可广泛应用于汽车行业以外对实时性要求不高的其他领域。利用LIN总线在智能家居系统中构建内部网络,以实现对各电器节点的控制,相较于传统控制方式具有诸多优势,将更为用户所接受。The LIN bus protocol and its application in controlling system of the smart home were introduced.The LIN bus is a new serial communication bus,which is emerging in existing automotive industry with features of protocol less depend upon hardware,implementing low cost software model by using hardware source of standard UART/SCI interface of simple MCU,widely used in other fields with less real time demand etc..Using LIN bus to build internal network of the smart home and implement controlling node of every electrical apparatus will be well received by users for many advantages over the conventional controlling mode

Application of single poise counterweight method in adjusting grinding uniformity of silicon wafer

为提高硅片研磨的均匀性,提出了一种通过改变调节砝码位置的新方法。对单砝码配重法的原理、步骤及物理模型进行了详细的论述,并基于lAbVIEW软件对该方法进行了可视化。在精密研磨抛光机上进行实验,并用膜厚仪进行均匀性测量。结果表明:在给定的条件下使9.9 CM硅片的均匀性从单靠自重研磨的20μM提高到用配重法调节后的3μM,显著提高了硅片研磨的均匀性。单砝码配重法为解决硅片研磨均匀性问题提供了一种既精确又简便的方法。To improve the grinding uniformity of silicon wafer,this paper proposed a new approach by changing the position of poise.The principle,procedure and physical model of the single poise counterweight method were described in detail,and then the visualization of this method basing on LabVIEW software was realized.Experiment was carried out on a precision grinding and polishing machine,and the thickness uniformity was measured on the thickness monitor.Experimental results show that the uniformity of three inches silicon wafer is improved from 20 μm to 3 μm comparing to conventional deadweight grinding,so the grinding uniformity of silicon wafer is enhanced markedly.Therefore,the single poise counterweight method provides a precise and convenient way to solve the grinding uniformity problem of silicon wafer.航空科学基金(20110868001

养正消积胶囊辅助GP方案治疗晚期非小细胞肺癌临床研究

目的观察养正消积胶囊辅助GP方案治疗晚期非小细胞肺癌(NSCLC)的临床疗效。方法采用随机数字表法将89例晚期NSCLC患者分为对照组44例及观察组45例。2组均采用GP方案;观察组并予养正消积胶囊,每次4粒,每日3次,口服。2组均21d为1个周期,连续治疗2个周期,随访1年。观察2组治疗前后Ki67、Bax、Bcl-2蛋白表达及肿瘤标志物[血管内皮生长因子(VEGF)、骨桥蛋白(OPN)、癌胚抗原(CEA)、糖类抗原199(CA199)]、中医症状评分、生活质量评分,比较2组客观缓解率(ORR)、疾病控制率(DCR)、无进展生存时间(PFS),监测不良反应。结果观察组ORR、DCR明显优于对照组(P<0.05)。与本组治疗前比较,观察组治疗后、随访1年VEGF、OPN、CEA、CA199水平明显降低(P<0.05);对照组治疗后上述指标明显降低(P<0.05),随访1年CEA水平明显降低(P<0.05)。与本组治疗前比较,2组治疗后Ki67、Bcl-2蛋白表达明显降低,Bax蛋白表达明显升高(P<0.05);2组治疗后比较,观察组Ki67、Bcl-2蛋白表达低于对照组(P<0.05),Bax蛋白表达高于对照组(P<0.05)。与本组治疗前比较,2组治疗后中医症状评分(神疲乏力、胃纳少馨、腰膝无力、夜尿频多、头晕目眩)、生活质量评分(躯体功能、认知功能、社会功能、情绪功能)明显改善(P<0.05);2组治疗后比较,观察组上述评分改善明显优于对照组(P<0.05)。观察组PFS明显长于对照组(P<0.05),不良反应明显低于对照组(P<0.05)。结论养正消积胶囊辅助GP方案治疗晚期NSCLC可有效降低患者肿瘤标志物水平,改善生存质量,减少吉西他滨和顺铂的不良反应,提高疗效。福建省卫生厅中医药科研专项课题(wst201210

Determination of rutin and quercetin in hypericum japonicum by capillary electrophoresis with

建立了毛细管电泳电化学分离检测田基黄中生物活性成分芦丁和槲皮素的方法。考察了检测电极电位、缓冲液浓度、pH、运行电压和进样时间对分离的影响。以40 cm长,50μm内径的石英毛细管作为分离通道,运行缓冲液为25 mmol/L硼砂(pH 9.2)溶液,分离电压12 kV,0.3 mm直径的铂圆盘电极为检测电极,检测电位1.00 V(vs.Ag/AgCl),芦丁和槲皮素在10 min内得到良好分离。在上述实验条件下,芦丁和槲皮素分别在8.2×10-6~5.2×10-4mol/L与6.8×10-6~7.2×10-4mol/L范围内与峰面积呈良好线性关系,检出限分别为9.0×10-7mol/L(S/N=3)和4.7×10-7mol/L(S/N=3)。方法已应用于田基黄药材提取物成分分析。Abstract: A method based on capillary electrophoresis with amperometric detection was established for the separation and determination of rutin and quercetin in hypericum japonicum． Detection potential， buffer concentration and pH，separation voltage and injection time were investigated to acquire the optimum condition． An uncoated silica capillary column ( 50 μm i． d． × 40 cm) was used as the separation channel，the two analytes could be well separated within 10 minutes by using 25 mmol /L sodium borate buffer( pH9． 2) and 12 kV as the separation voltage． The detection electrode was a platinum disk electrode ( 0． 3mm i． d． ) and the detection potential was 1． 00 V ( vs． Ag /AgCl) ． Under the optimized experimental conditions mentioned above，there was a good linear relationship for rutin ranging from 8． 2 × 10 － 6 mol /L to 5． 2 × 10 － 4 mol /L as well as 6． 8 × 10 － 6mol /L to 7． 2 × 10 － 4mol /L for quercetin． The detection limits for rutin and quercetin were 9． 0 × 10 － 7mol /L ( S /N = 3) and 4． 7 × 10 － 7mol /L ( S /N = 3) ，respectively． The method has been successfully used for the assay of bioactive compounds in hypericum japonicum extracts．广西壮族自治区自然科学基金项目(0640038)资

基于光纤传送网的5G移动通信前传关键技术

移动前传网络是C-RAN（集中式/云无线接入网）技术中的重要部分。随着现代无线接入网络的发展演进,用户带宽需求的快速增长对网络的传输速率提出了更高的要求。文章回顾了移动前传网络的基本内容,分析了前传网络需要满足的各项需求,并对当前提出的各种前传网络的解决方案进行了详细的介绍

不同海拔梯度高寒草地地上生物量与环境因子关系

以新疆天山南坡的巴音布鲁克高寒草地为研究对象,沿海拔每升高100 m设置1块样地,共9个样地,研究了海拔梯度变化条件下高寒草地地上生物量与环境因子的关系.研究表明: 紫花针茅、羊茅群落分布在海拔2,460～2,760 m,地上生物量为52.2～75.9 g&middot;m-2,线叶嵩草+紫花针茅群落分布在海拔2,860 m,地上生物量为53.2 g&middot;m-2,线叶嵩草、天山羽衣草、细果苔草群落分布在海拔2 960～3 260 m,地上生物量为62.1～107.4 g&middot;m-2;7-8月平均相对湿度对群落总的地上生物量影响较大;海拔与禾本科的地上生物量呈显著负相关,与莎草科呈显著正相关;7-8月平均气温是决定禾本科和莎草科功能群地上生物量的主导因子,回归方程分别为Y=13.467X-97.284和Y=171.699-15.331X;海拔与平均气温和Ph值呈极显著负相关(P＜0.01),与平均相对湿度呈极显著正相关(P＜0.01),与速效N含量和土壤含水量呈显著正相关(P＜0.05)

Seperation and determination of cimetidine by capillary electrophoresis with electrochemiluminescence

建立了以三联吡啶钌为发光体系的毛细管电泳电化学发光(CE-ECL)检测系统,并应用于分离和测定西咪替丁片剂中西咪替丁的含量。考察了检测电位,三联吡啶钌(Ru(bpy)32+)的溶液浓度,缓冲液的pH和溶液浓度,分离电压、进样电压与进样时间等因素对分离检测的影响。结果表明:在检测电位1.18V,Ru(bpy)32+溶液浓度为5 mmol/L,磷酸盐缓冲液(PBS)25 mmol/L(pH 7.8),进样时间10 s,进样电位10 kV,运行电位15 kV下,测得西咪替丁线性范围为2.8×10-6~4.0×10-4mol/L,检出限为1.2×10-7mol/L(S/N=3)。对1.0×10-5mol/L的西咪替丁标准溶液连续测定5次,电化学发光强度和迁移时间的RSD分别为3.9%和1.5%。方法已应用于西咪替丁片剂中西咪替丁含量的测定。Abstract: A sensitive and simple method based on capillary electrophoresis( CE) with electrochemiluminescence ( ECL) detection has been developed for the separation and determination of cimetidine in cimetidine tablets． The effects of detection potential，the concentration of tris ( 2，2 '-bipyridyl) ruthenium( Ⅱ) ，the acidity and the concentration of the running buffer，separation voltage，injection voltage，injection time and so on were investigated to acquire the optimum conditions． The detection electrode was a platinum microelectrode with a diameter of 90 μm at a detection potential of 1. 18 V ( versus Ag /AgCl) ． Cimetidine could be well separated within 6 min in a 50 cm length fused-silica capillary at a separation voltage of 15 kV in a 25 mmol /L PBS buffer ( pH 7. 8) ． The injection voltage and injection time are 10V and 10s． The response was linear over about three orders of magnitude ranging from 2. 8 μmol /L to 400 μmol /L for cimetidine． The detection limit ( S /N = 3) is 1. 2 × 10 － 7mol /L． Ｒelative standard deviations ( ＲSD) of no more than 4. 0% were obtained for both migration time and electrophoretic peak area． The proposed method was successfully applied to the analysis of active ingredients in cimetidine tablets with satisfactory assay results．广西壮族自治区自然科学基金(0640038)资