Reactivity Ratio of Methyl Acrylate with Methacrylates For Group TransFer Copolymerization

丙烯酸甲酯和甲基丙烯酸酯基团转移无规共聚的竞聚率⒇邹友思林东海张景辉潘容华（厦门大学化工系，厦门大学核磁共振实验室，厦门，361005）单体竞聚率作为一个定量数据，对于不同投料比下共聚物组成的预计和控制，共聚反应动力学和机理研究均有重要作用。丙烯酸...Statistical group transFer copolymerization of methyl acrylate(MA) with methacrylates have been perFormed For three binary systems. The copolymer compositions were determined by 1H NMR spectroscopy and the results were evaluated by the extented Kelen Tudos method. The monomer pairs concerned are (1) methyl acrylate (MA) and ethyl methacrylate(EMA), (2) MA and butyl methacrylate(BMA), (3) MA and i butyl methacrylate(iBMA). The reactivity ratios were Found to be γ MA =14.41, γ EMA = 0.01 ; γ MA =13.96, γ BMA =0.23; γ MA =8.66, γ iBMA =0.08. It was Found that acrylate is much more reactive than methacrylate For GTP and anionic copolymerization.国家自然科学基

丙烯酸酯和甲基丙烯酸酯基团转移共聚研究

研究了三种丙烯酸酯分别和四种甲基丙烯酸酯的基团转移共聚，用１ＨＮＭＲ法测定共聚物组成，扩展的ＫｅｌｅｎＴｕｄｏｓ法测定竞聚率，结果为γＭＡ＝９２３、γＭＭＡ＝００６；γＥＡ＝１４１５、γＭＭＡ＝００１；γＢＡ＝７５１、γＭＭＡ＝００２；γＭＡ＝１４４１、γＥＭＡ＝００１；γＭＡ＝１３９６、γＢＭＡ＝０２３；γＭＡ＝８６６、γｉＢＭＡ＝００８，表明基团转移聚合同阴离子聚合有明显的相似之处

Data processing method of time-of-flight 3D imaging camera

飞行时间法三维成像摄像机测量结果存在中心点偏移、距离歧义性和混合像素等问题,且易受曝光时间和主动光源影响.为提高测量结果的有效性和准确性,对测量数据进行了如下处理:对摄像机进行校正,减小了球面距离到三维坐标转换过程中引入的误差;采用2个不同光源调制频率交替进行测量,根据2次测量结果差值消除距离歧义性;过度曝光时测量幅值随曝光时间增大而减小,据此提出了一种基于感兴趣区域的快速自动曝光控制方法;边界混合像素以单点或单线形式出现,根据某像素邻域内各像素位置分布情况判定该像素是否为混合像素;由测量幅值判定噪声大小,根据对主动光源成像时测量幅值很大、偏移值很小的特点辨别主动光源.实验结果表明:以上方法能有效提高数据可靠性和准确性.Measurement results of time-of-flight 3D imaging camera have problems of center offset,range ambiguity and mixed-pixel,and they are sensitive to exposure time and vulnerable to active light source.The measurement data were processed to improve the effectiveness and accuracy of measurement results.The camera was calibrated so that the error was decreased thanks to the transformation from spherical distances to Cartesian coordinates.The ambiguity was eliminated according to the difference between two measurements taken with two different light modulation frequencies alternately.The amplitude decreases with increasing exposure time due to excessive exposure,accordingly,a rapid auto-exposure control method based on region of interest was proposed.Boundary mixed pixels are in form of a single point or a single line,accordingly,the location distribution of each pixel in its neighborhood was a used to determine whether the pixel was a mixed pixel.Noise was determined according to the amplitude,meanwhile,the active light source was identified according to the characteristics that the amplitude was very small and the offset was very big when the active light source was measured.The experimental results showed that the data reliability and accuracy were improved with the above methods.国家自然科学基金重点资助项目(60534070);国家自然科学基金资助项目(60302013

历代医家论治冻疮学术思想探析

冻疮为冬日常见病,虽多数病情轻微,但影响美观,且反复发作,因此冻疮防治研究仍具较强临床需要。本研究通过查阅、整理历代医家对冻疮的论述发现历代医家对冻疮认识全面,治法丰富,不仅外治法用药简便、剂型丰富、分阶段用药,预防亦有明显特色。研究结果不仅给冻疮临床治疗提供借鉴,且对进一步相关药物开发提供基础。全国第六批老中医药专家学术经验继承工作(No．国中医药人教发〔2017〕29号)国家中医药管理局第四批全国中医优秀人才项目(No.2017124)厦门市科技惠民计划项目(No.3502Z20174028)厦门大学医学院创新训练项目(No.2017Y0856

Y型聚乙二醇干扰素琢-2b注射液治疗HCV基因2/3型慢性丙型肝炎患者疗效和安全性的多中心随机对照试验研究

目的以标准剂量的聚乙二醇干扰素(Peg IFN)α-2a联合利巴韦林作为阳性对照,评价新型试验药物Y型Peg IFNα-2b注射液联合利巴韦林治疗2型/3型慢性丙型肝炎(CHC)患者的疗效和安全性。方法采用多中心、随机开放、阳性药对照的Ⅲ期临床试验,筛选符合要求的2型/3型CHC患者,按照2:1的比例随机分配到Y型Peg IFNα-2b组和Peg IFNα-2a组,同时口服利巴韦林,疗程24 w,停药随访24 w。采用Abbott Real Time HCV Genotype II检测HCV基因型,采用Cobas Taq Man实时定量PCR法检测血清HCV RNA水平。详细记录不良事件。主要疗效指标为持续病毒学应答(SVR),并进行非劣效检验。结果本试验实际入组2型/3型CHC患者255例,实际治疗241例。全分析集(FAS)数据显示,158例试验组和83例对照组患者SVR分别为85.4%(95%CI 79.94%~90.94%)和79.5%(95%CI 70.84%~88.20%,P=0.2402);对符合方案分析集(PPS)人群分析显示,试验组和对照组患者SVR分别为87.9%(95%CI 82.45%~93.27%)和85.9%(95%CI 77.82%~94.01%,P=0.7060),率差的95%可置信区间均符合非劣效标准;对PPS人群分析显示,85.8%受试者获得了早期病毒学应答(RVR),RVR的阳性预测值为90.1%;试验组和对照组不良事件发生率相似,分别为95.6%和95.2%,严重不良事件发生率分别为3.8%和3.6%。结论应用Peg IFNα联合利巴韦林治疗2型/3型CHC患者,新型试验药物Y型Peg IFNα-2b具有与对照药物Peg IFNα-2a相似的疗效和安全性。国家科技部“十二五”重大专项(编号:2012ZX10002-003)；“重大新药创制”十二五科技重大专项(编号:2012ZX09303019)

应用于工控系统的软硬件平台技术

本文介绍了一种用于工业控制的计算机软硬件综合设计方法——软硬件平台技术，阐述了其基本原理、设计思想、实现方法、技术特点及其优越性