Service Quality Management in Company A: A Six Sigma Theory Perspective

产品与服务质量是满足市场需求和维系组织生存发展的基本条件。质量竞争既是对市场的竞争，更是争夺客户的竞争。当今社会的价格竞争和产品质量竞争已趋于同质化，因此提升服务质量成为体现企业差异化的必然途径，服务质量竞争已经成为企业竞争的焦点。在目前的竞争环境下，服务质量管理理念不仅成为世界上众多优秀公司获得竞争优势的利器，而且成为这些公司生存和发展的文化基础。 随着近年来，中国出口增速减缓与全球海运能力过剩，世界航运市场已变为了买方市场，航运业竞争更趋激烈。货物托运人也向承运人提出更高的要求，承运人需要提供更为良好的服务，来更好地满足托运人的专业化运输需求。A公司作为典型的传统的国际集装箱运输公司，正...Product and service quality are the basic conditions to meet the market demand and maintain survival of organization. Nowadays, price competition and product quality become homogeneous. Therefore improving the quality of service has become an inevitable pathway of reflecting business diversification. Service quality competition has become the focus among enterprises. In the current competitive env...学位：工程管理硕士院系专业：管理学院_工程管理硕士学号：1772013115111

Synthesis, Structure and Electrochemical Performance of Cathodes for Lithium–Sulfur Batteries

目前电动汽车一次充电行驶里程不及传统汽油车的1/3。为满足电动汽车技术发展需求，必须全面提升动力电池的性能。因此，研制具有更高比容量和更优电化学性能的新型正极材料成为发展下一代锂二次电池的关键。单质硫具有高的理论比容量，同时自然界储量丰富、价格低廉和环境友好等优势，是十分理想的下一代锂离子电池正极材料。虽然硫作为锂离子电池正极材料优点突出，但很多限制因素却阻碍了其大规模的实际应用。一方面，由于硫的不导电性，使硫的利用率很低，循环性能差；另一方面，充放电过程中产生的多硫化锂(Sn2-)易溶解在有机电解液中，导致活性材料的流失，及电解液粘度增大，离子迁移困难。同时产生的多硫阴离子(Sn2-)会通过...At present, electric vehicles on a single charge mileage is less than 1/3 of the conventional gasoline vehicles. To meet the demand for the development of electric vehicle technology, it is necessary that raise the overall performance of the power battery. Therefore, development of new type cathode materials with higher capacity and better electrochemical performance becomes the key to progressing...学位：工学硕士院系专业：化学化工学院_应用化学学号：2052010115164

Preparation of BaTiO3 Nanoparticles with Various Particle Sizes and Ferroelectic and Dielectric Properties of 0-3 Type BaTiO3/PVDF Piezoelectric Composite Materials

铁电材料作为一种应用广泛的功能材料，一直以来都受到广泛的关注。随着科技的发展，对铁电组件小型化、集成化的要求越来越高，这就进一步要求作为原料的铁电体晶粒尺寸不断减小。当晶粒尺寸减小时，铁电体的铁电性是否还能保持是一个重要的问题，对这种尺寸效应的研究具有重要的意义。由于钛酸钡(BaTiO3)晶体结构简单并具有高介电常数，在理论上和实践方面研究BaTiO3的的临界尺寸很有意义。本论文采用BaTiO3作为增强材料，压电聚合物聚偏二氟乙烯(PVDF)作为基体，用制备压电复合材料的方法研究钛酸钡纳米颗粒的尺寸效应。压电聚合物基压电复合材料兼具压电陶瓷和聚合物的优点，而且还可以表现出复合材料的新性能，所以...Ferroelectric materials, which are widely used as functional matrials, have been extensively investigated recently for device applications. However, ferroelectric devies should be miniaturized and integrated with the development of nanotechnology, nanoparticles then should be handled and utilized. Whether the ferroelectricity still maitain when the grain size decreases, is the biggest obstacle in ...学位：理学硕士院系专业：化学化工学院化学系_物理化学(含化学物理)学号：2052006115197

Synthesis and Electrochemical Performance of Novel Expanded Graphite Oxide/Sulfur Composite Cathodes for Lithium-Sulfur Batteries

以棒状石墨为原料,采用改良的HuMMErS法与热处理制备得到膨胀氧化石墨(E-gO),利用在酸性水溶液中归中化学反应的方法合成纳米尺寸的硫颗粒,使其嵌入到膨胀氧化石墨的内部,制备了膨胀氧化石墨-硫复合材料。采用红外光谱,X-射线光电子能谱表征了膨胀氧化石墨表面官能团的存在和种类;X-射线衍射分析结果表明生成的硫属于斜方晶结构;扫描电子显微镜和透射电镜分析证明了材料中硫的均匀分布。恒电流充放电结果表明该复合正极材料的首次放电容量为1 020 MAH.g-1,100周循环之后其容量还保持在650 MAH.g-1左右;材料的倍率性能和库伦效率优异,这可能得益于小尺寸的硫在材料中均匀分布,以及表面官能团对硫的固定化作用。The expanded graphite oxides were prepared by modified Hummers method.The expanded graphite oxide/sulfur(E-GO/S) composites have been successfully prepared by a new chemical reaction method based on comproportionation in the acidic aqueous solution.FT-IR,XPS were characterized the existence of functional groups on the surface of expanded graphite oxide.XRD results showed that the as-prepared sulfur belongs to orthorhombic system.SEM and TEM results indicated the uniform distribution of the sulfur in the composite.The electrochemical test showed that the expanded graphite oxide/sulfur(E-GO/S) composites can deliver the highest discharge capacity of 1 020 mAh.g-1 at the first cycle,after 100 cycles of charge-discharge,the discharge capacity of the composites keep the capacity of ca.650 mAh.g-1,and have the excellent rate performance and coulombic efficiency that may be attributed to the homogeneous distribution of sulfur in the composites and the chemical approach to fix sulfur and the lithium polysulfides via the chemical bonds with the functional groups on the surface of expanded graphite oxide.国家“973”计划(No.2009CB220102); 国家基础科学人才培养计划(No.J1210014)资助项

ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

乳腺癌是威胁女性生命健康的“头号杀手”，而远处转移是乳腺癌患者死亡的主要原因。因此，了解乳腺癌如何发动侵袭和转移，对于有效治疗乳腺癌、延长病人生存期具有重要意义。本研究中，该团队发现ULK1通过结合并磷酸化胞泌蛋白复合体关键亚基Exo70来抑制乳腺癌转移。ULK1对Exo70上Ser47，Ser59和Ser89位点的磷酸化，严重地削弱了Exo70的自身寡聚化和与其它胞外分泌复合体亚基的结合，进而减少了细胞运动伪足形成以及基质金属蛋白酶的分泌，从而抑制乳腺癌细胞的迁移和侵袭。该论文首次揭示了胞外分泌复合体重要成员Exo70在乳腺癌中受到ULK1和ERK1/2的双重磷酸化调控，从而使得乳腺癌细胞可以根据外环境来决定潜伏还是发动侵袭转移，为乳腺癌的治疗提供了新的理论基础。 本论文的通讯作者为占艳艳副教授、郭巍教授和胡天惠教授。医学院博士生毛丽媛、占艳艳副教授、吴斌博士和医学院博士生于强为共同第一作者。【Abstract】Increased expression of protein kinase ULK1 was reported to negatively correlate with breast cancer metastasis. Here we report that ULK1 suppresses the migration and invasion of human breast cancer cells. The suppressive effect is mediated through direct phosphorylation of Exo70, a key component of the exocyst complex. ULK1 phosphorylation inhibits Exo70 homo-oligomerization as well as its assembly to the exocyst complex, which are needed for cell protrusion formation and matrix metalloproteinases secretion during cell invasion. Reversely, upon growth factor stimulation, Exo70 is phosphorylated by ERK1/2, which in turn suppresses its phosphorylation by ULK1. Together, our study identifies Exo70 as a substrate of ULK1 that inhibits cancer metastasis, and demonstrates that two counteractive regulatory mechanisms are well orchestrated during tumor cell invasion.This work was supported by the grants from the National Natural Science Foundation of China (81572589, U1405228, 81472568, and 31770860), the Natural Science Foundation of Fujian grant (2017J06020, 2018J01400, 2017R1036-4, 2017R1036-6, 2016R1034-1, and 2016R1034-4), and the Xiamen Science and Technology grant (3502Z20159013) to Y.-y.Z. and T.H., and National Institute of Health R01 GM111128 to W.G.该论文的研究成果是在国家自然科学基金和福建省基金的资助下，与美国宾夕法尼亚大学和清华大学共同协作完成的

Establishment of a method to quantitatively detect FLT3 internal tandem duplication in acute myeloid leukemia with denaturing high-performance liquid chromatography

目的:建立一种应用变性高效液相色谱技术(dHPlC)相对定量检测急性髓细胞白血病(AMl)患者fMS样酪氨酸激酶3(flT3)基因的内部串联重复(ITd)突变的方法。方法:根据flT3-ITd突变基因多位于14外显子而设计引物,用聚合酶链反应(PCr)方法特异性扩增121例AMl患者flT3-ITd突变基因,再用dH-PlC技术相对定量检测flT3-ITd等位基因突变的情况;与毛细管电泳法(CE)检测突变的结果对比进行该方法的有效性检验;最后与121例样品PCr扩增产物的测序结果进行对比。结果:经dHPlC分析后均能得到特征性的洗脱峰。121例样本中检测到flT3-ITd突变阳性的样本13例,总阳性率为10.7%,阳性突变等位基因的比例不一,分布范围中位数为34.5%(11.4%-80.2%),为21-87 bP单个插入片段。阳性率和突变比例与CE方法检测结果相比较均无显著差异(P>0.05),并与121例样本flT3-ITd扩增PCr产物基因测序结果一致。结论:成功建立了一种应用dHPlC相对定量检测AMl患者flT3-ITd基因突变的方法。AIM: To establish a relatively-quantitative method to detect the internal tandem duplication(ITD) mutation of Fms-like tyrosine kinase 3(FLT3)gene in acute myeloid leukemia(AML) patients using denaturing high-performance liquid chromatography(DHPLC).METHODS: According to the fact that much more FLT3-ITD mutations are located in exon 14,we designed the primers,and use the method of polymerase chain reaction(PCR) to specifically amplify FLT3-ITD mutation gene in 121 cases of AML,and relatively quantified the situation of mutant allelic gene of FLT3-ITD by the method of DHPLC.The effectiveness of DHPLC was verified by the method of capillary electrophoresis(CE).The sequenced results from PCR amplified products of 121 samples were compared.RESULTS: A characteristic of elution peak was detected by DHPLC with 10.7% overall positive rate(13/121) and varied in the proportion of mutant alleles,with a single duplicated insert fragment from 21 bp to 87 bp.The median range of mutant alleles was 34.5%(11.4%-80.2%).No significant difference of the positive rates and mutation proportions between the results with DHPLC and the results with CE method was observed.The results of FLT3-ITD mutant gene of 121 samples were consistent with the results using sequencing method.CONCLUSION: A relatively-quantitative method to analyze AML patients with FLT3-ITD mutation by DHPLC is successfully established

Transition from tunneling leakage current to molecular tunneling in single-molecule junctions

数十年来，半导体工业一直遵循基于“摩尔定律”所设定的发展蓝图，逐步提升集成电路芯片上晶体管的集成度和运行速度，减小器件尺寸。为探索这一尺寸极限，课题组基于机械可控裂结技术自主开发了具有飞安级电学测量和亚纳米级位移控制灵敏度的科学仪器，在国际上首次获取了一系列具有不同重复单元的寡聚苯乙炔类分子电导随电极间距的演变关系，并发现随着电极间距的缩小，器件电输运由通过分子器件电流占主导逐步转变到由隧穿漏电流占主导。对于本研究中具有最小尺寸的寡聚苯乙炔分子器件，其由于隧穿漏电流所制约的尺寸极限可小至0.66 nm，预示了有机分子器件在未来电子器件小型化方面具有重要的应用潜力。 这一研究工作是在化学化工学院洪文晶教授、萨本栋微纳研究院杨扬助理教授以及英国Durham University的MartinR. Bryce教授共同指导下完成的。能源材料化学协同创新中心iChEM Fellow刘俊扬博士为论文第一作者，博士研究生郑珏婷、李瑞豪和硕士研究生黄晓艳、唐永翔、皮九婵、本科生王飞等参与了研究工作。田中群教授、毛秉伟教授和师佳副教授为论文工作提供了重要指导。【Abstract】The tunneling leakage current will be a major quantum obstacle during miniaturization in the semiconductor industry down to the scale of several nanometers. At this scale, to promote charge transport and overcome the tunneling leakage current between the source and drain terminals, molecular electronic junctions offer opportunities by inserting molecules between these two electrodes. Employing a series of oligo(aryleneethynylene) (OAE) molecules, here we investigate the transition from tunneling leakage current to molecular tunneling in the single-molecule devices using mechanically controllable break junction (MCBJ) technique, and the transition distances of the OAE molecular junctions were determined and even down to 0.66 nm for OAE2 molecular junction, which demonstrates that the intrinsic charge transport properties of a single-molecule device can be outstripped from the tunneling leakage current. Consequently, molecular electronic devices show the potential to push the ultimate limit of miniaturization to the scale of several angstroms.This work was supported by the National Key R&D Program of China (2017YFA0204902). This work was also generously supported by the Young Thousand Talent Project of China, the EC FP7 ITN “MOLESCO” project number 606728, the National Natural Science Foundation of China (nos. 21703188, 21673195, 21503179), and the China Postdoctoral Science Foundation (2017M622060). 该工作获得科技部国家重点研发计划课题（2017YFA0204902），国家自然科学基金委（21673195、21703188、21503179）以及中国博士后科学基金（2017M622060）等项目的资助，也得到了固体表面物理化学国家重点实验室、能源材料化学协同创新中心的支持

《怜悯我吧,上帝》之音乐处理与演唱分析

《怜悯我吧,上帝》是意大利作曲家斯特拉代拉的代表作品。这是一首具有宗教色彩的歌曲,演唱时要注重内心情感的表达,注意装饰音与歌曲旋律音的连贯,声音要清晰灵巧,要控制音量,语感悲切,把握好整个乐曲的节拍

艺术院校声乐教育教学评价初探

艺术院校的声乐教学评价长期以来都是以学生的考试成绩"一锤定音",为了提高教师的教学水平,为了激发学生的学习积极性,文章对艺术院校声乐教育教学的评价提出了看法和见解

高校艺术教育对培养和谐人格、和谐社会建设之价值研究

艺术教育对于培养健康和谐人格、和谐社会的构建有着独特的功能。在高校加强艺术教育能极大地培养大学生的和谐思维、和谐情感、和谐人格,提高大学生的文化艺术修养和文化艺术品格。高校艺术教育以审美教育为核心,以人的全面发展为目标,促进人与自然、人与社会,人与人之间关系的和谐发展,以其独特的功能为和诸社会建设服务