The Regulation of Transforming Growth Factor β Signaling Activity by Nuclear Receptor Nur77

孤儿核受体Nur77是核受体（NuclearReceptors，NRs）超家族中非常重要的一员。它作为细胞内立早基因的产物，能够响应包括各类生长因子在内的多种刺激。同时，Nur77广泛参与到机体的生理以及病理学过程中，如：糖脂代谢，细胞自噬，炎症发生发展以及肿瘤的生长凋亡等过程。转化生长因子（TransformingGrowthFactorβ，TGF-β）信号通路在体内广泛参与包括糖代谢，脂质代谢，胞外基质的更替，细胞的增殖、分化，组织的纤维化以及肿瘤的发生发展等多种生理以及病理过程的调控。对TGF-β信号通路调控的研究一直是TGF-β研究的重点，但是核受体对TGF-β信号调节的活性和机理尚不...Nur77 is a unique member of nuclear receptor superfamily. As a product of immediate early responsive gene, it responds to a variety of stimuli, including various growth factors. Nur77 participates widely in physiological and pathological processes, such as glycolipids metabolism, autophagy, inflammation, and growth and apoptosis of tumor. Transforming growth factor β (TGF-β) signaling pathway broa...学位：理学硕士院系专业：药学院_化学生物学学号：3232012115307

仕事と介護の両立を目指して

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Kinetics of Shear Coagulation of Oppositely Charged Particles : A Trajectory Analysis

Transport properties of aqueous colloidal dispersions are controlled by the coagulation of particles in the dispersions. In order to study the coagulation kinetics and stability of colloid in a shear flow, which are practically important, trajectory analyses with electric double layer force have been used. So far, however, this analysis has not been applied to the heterocoagulation between oppositely charged particles in a shear flow. In the present study, the rate of shear coagulation of oppositely charged particle was calculated using the trajectory analysis. The calculated results indicate that the rate of heterocoagulation increases with decreasing ionic strength and increasing the magnitude of surface potential. The increase of the rate is considered to be due to the increases of the thickness of diffuse double layer and the magnitude of attractive double layer force

Strength of natural soil flocs

To obtain the strength of flocs against breakup is crucial for controlling flocculation in water treatment and predicting transport of colloidal particles in aqueous environments. Recently, the author reported a method to obtain floc strength from a simple experiment of floc breakup subjected to a laminar converging flow. In this study, this method was applied to natural soil flocs. The flocs were formed by coagulation with 0.5 M NaCl (pH 5.4–5.5, pH 6.6) solutions, 0.1 M CaCl2 (pH 6.4–6.9) solutions, or acidified distilled water with dilute HCl (pH 5.6). Obtained floc strengths were 0.3, 0.7 and 4 nN for Na-, Ca-, and H-coagulated flocs, respectively. Also, floc strength did not change with floc size. These values of floc strengths were 1–3 orders smaller than those of flocs formed with polymer flocculants and/or precipitated ferric or aluminum coagulants

ワーク・ライフ・バランス社会の実現と課題

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介護は突然やってくる

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