33 research outputs found

    铁皮石斛多糖通过上皮-间质转化抗肝纤维化

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    目的探讨铁皮石斛多糖(DOP)对CCl4 诱导肝纤维化(HF)的影响及其作用机制。方法将56 只雄性SD 大鼠随机分为七组:正常组(NG)、模型组(MG)、秋水仙碱组(CG, 0.1mg/ kg)、扶正化瘀组(FG, 0.45g/kg)、低剂量DOP 组(LDG, 0.05 g/kg)、中剂量DOP 组(MDG, 0.1 g/kg)和高剂量DOP 组(HDG,0.2 g/kg),每组8 只。采用皮下注射40% CCl4 橄榄油混合液制备HF 大鼠模型,每3 d 注射1次,共10周。造模第6周结束后,各药物组分别给予秋水仙碱、扶正化瘀和DOP 溶液灌胃处理,NG 和MG 大鼠给予等量0.9 % 生理盐水处理,每天1次,连续4周。各组大鼠肝组织病理学采用苏木精-伊红(HE)、Masson 染色、天狼星红(Sirius red)染色检测;肝功能和肝纤四项指标采用血液生化法检测;肝组织中α-SMA、Col-I、E-cadherin、ZEB1 基因和蛋白的表达分别采用RT-qPCR 法和Western Blot 法检测。结果HE、Masson、Sirius red 染色结果显示MG 大鼠肝脏组织出现典型的HF 病理特征,LDG、MDG 和HDG 大鼠HF 均出现不同程度改善。肝功能检测结果显示,LDG、MDG、HDG 大鼠的血清AST、TBIL、AKP 水平与MG 相比均显著降低(P < 0.05或 < 0.01),血清ALT 水平除LDG 外均显著降低(P < 0.05或 < 0.01)。肝纤四项指标检测结果显示,LDG、MDG、HDG 大鼠的血清HA、LN、PC-Ⅲ、COL-Ⅳ 含量与MG 比较均明显下降(P < 0.05或 < 0.01)。基因、蛋白检测结果显示,LDG、MDG、HDG 大鼠肝组织中α-SMA、COL-I、ZEB1 的相对表达量明显降低(P < 0.05或 < 0.01),而E-cadherin 的相对表达量升高(P < 0.05或 < 0.01)。此外,HA、α-SMA、COL-I、ZEB1、E-cadherin 的表达均存在一定的DOP 剂量依赖性。结论DOP 可通过抑制大鼠肝组织的上皮-间质转化减轻CCl4 诱导的HF 程度

    Digital technology assisted research on consecutive interpreters' notes

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    过去20多年,键盘记录软件和眼动跟踪技术等新技术手段推动了翻译过程研究向纵深发展。在口译研究领域,数字技术同样有着广泛的运用空间。本文试图探索数字技术对交传笔记研究的辅助作用,介绍了Neo smartpen N2智能笔的主要功能,尝试将其运用于交传笔记的数字化,挖掘数字技术对口译过程研究的作用。本文还以一篇交传笔记为例,展示了该智能笔的使用及如何利用ELAN软件对数字化的笔记进行标注和分析,从而探查译员在记录笔记时的困难与决策。本文结果表明,与传统研究手段相比,数字技术可从视频、音频、文本三维度再现口译笔记文本产生过程,为口译过程研究提供强有力的数据支撑,打开更丰富的研究视窗。In the past 20 years, new technologies such as key-logging and eye-tracking technologies have enabled translation process research to go deeper and further. Digital technologies can also be applied in interpreting process research. This paper focuses on how smart pen technology can open up new dimensions in interpreting research, specifically how Neo smartpen N2 can be used in digitizing consecutive interpreters' notes. A case study is introduced using Neo smartpen N2 to record the note-taking process of a professional interpreter and employing ELAN to annotate notes, which are classified into 6 types. It is demonstrated that the smart pen, together with annotation tools like ELAN, makes it possible for researchers to capture the note-taking process and make precise measurements, which offers precious hard data for identifying details in the note-taking process and analyzing note-taking as a resource-management and decision-making process in consecutive interpreting

    Interpreting and Relevance: Cognition and Context

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    本文作者以DanSperber和DeirdreWilson的关联理论为框架研究口译。关联理论是交际和认知的理论,口译作为一种特殊的交际活动,作者认为关联理论中的认知概念对口译活动具有借鉴意义。 引言部分介绍了本文的总体构架。主体共分为四章。 第一章介绍了关联理论的基本概念和论述。关联理论认为,人类交际的模式可分为代码模式和明示-推理模式。人类交际有两重意图:信息意图和交际意图。当交际人的交际意图得到实现时,也就是当听众认识到交际人的信息意图时,即认为交际人已被理解。交际人意图使听者在头脑中的一组假设明白或更明白。为理解交际人的意图,听众自然而然地进行推理。推理需要两个前提:从感观接收到的声...In this thesis, the author attempts to apply Relevance Theory developed by Dan Sperber and Deirdre Wilson to the study of interpreting. Relevance Theory is a theory of communication and cognition. It is believed that the theory is relevant in explaining interpreting as a special act of communication with the cognitive notions it has developed. The thesis starts with an introduction in which th...学位:文学硕士院系专业:外文学院外文系_英语语言文学学号:20010404

    Enlightenment of Interlanguage's Fossilization for Oral Foreign Language Enhancement Teaching

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    从中介语和石化的角度对学生语言水平停滞不前的普遍状况作出解释,阐述了外语强化教学的意义、目标、方式和原则,希望对探索系统、科学、合理、有效的外语强化教学模式有所启示。Interpreting training is now being pursued by educational institutions at various levels,yet students' unsatisfactory English proficiency is undermining the efforts to produce qualified interpreters.This paper explains the language issue from the perspective of interlanguage and fossilization.It further analyzes the significance,objective,method and several principles of a language enhancement course.国家社科基金项目“口译职业资格认证测试的理论体系和运作模式研究”(09BYY073

    An Exploratory Study of Fluency in English Output of Chinese Consecutive Interpreting Learners

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    文章对中国口译学习者汉英交替传译产出的流利度发展进行探索性研究。在实验中有18名口译硕士生在集中授课之初和结束时将同一个汉语篇章译为英语。8名英语母语人士对其译文的流利度评分,9项指标被用来对流利度做客观测量。本研究提出并回答了3个研究问题,包括学生口译流利度变化情况、流利度得分与流利度指标的关系以及对无声停顿分界点的讨论。This paper describes an exploratory study aimed at investigating fluency development in English productions of Chinese consecutive interpreting learners.Eighteen students' interpreting of the same passage was collected at the beginning and the end of an intensive training period.Their interpreting production was scored for fluency by eight native speakers of English and analyzed manually in terms of nine temporal measures of fluency.Three research questions were answered,covering learners' fluency development,predictors of native speakers' ratings,and the justification of cut-off point for silent pauses

    汉英口译课堂内纠错决策模型

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    在口译中,语言是交际信息和意图最根本的实现手段,因此口译教学应当重视与语言准确性相关的语言错误,思考如何正确看待错误和采用适当的纠错策略。本文分析了汉英口译课堂纠错涉及的五个主要问题并提出一个纠错决策过程模型,涵盖了纠错主体、纠错时机、纠错类型和纠错方式等重要方面。国家社科基金项目“口译职业资格认证测试的理论体系和运作模式研究”(编号09BYY073)对本研究的支

    Implementing Monitoring in the Interpreting Classroom

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    学生进步的必要条件是了解自身与学习目标间的差距并在学习中作相应调整以达到该目标。口译监控在口译教学中起对学生学习“把关“的作用,也是培养学生监控能力尤其是自我实时监控能力从而促进学生自主学习、保证口译质量的途径。文中提出口译监控的定义和理论框架,指出口译监控在口译教学中的三大目的,并从监控要素、监控主体、监控时机和信息反馈形式等方面讨论了口译监控在教学中的实施。It is necessary for students to know the gap between their current level of performance and as- pired learning goals if progress is to be made.Interpreting monitoring in interpreting training is a means of "gate-keeping"and a way of developing students' monitoring expertise,which is indispensible for developing learning autonomy and ensuring quality of interpreting.This paper first proposes a definition and a theoretical framework,and then elaborates three main aims,followed by discussions on various aspects of interpreting monitoring including the elements of monitoring,actors and timing of monitoring,types of feedback,etc.全国翻译专业学位研究生教育指导委员会项目(MTIJZW201311

    木糖异构酶基因xylA表达载体构建

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    以大肠埃希菌 MG1655的基因组为模板,通过PCR扩增获得木糖异构酶基因xylA。利用敲除编码对基因转录起负调控作用的lacIq基因的大肠埃希菌/谷氨酸棒杆菌穿梭质粒pEC-XK99E,酶连后转化大肠埃希菌BL21和谷氨酸棒杆菌ATCC 13032。成功构建出了具有大肠埃希菌BL21表达活性的木糖异构酶表达载体Ptrc-xylA

    海流引起海底管道悬空的数值模拟

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    海底管道悬跨将影响管道的安全运营。在海底管道稳定性设计中,需要合理分析具有初始嵌入深度的海底管道产生悬空的物理机制。本文对海流作用下铺设于砂质海床上的海底管道悬空进行了数值模拟。求解不可压缩流体N-S方程,分析了海流作用下管道周围的流场特性,研究了管道两侧的压力分布特性和海床表面剪应力的分布特点。在管道绕流流场分析的基础上,通过对土体渗流方程的求解,得到了管道周围砂质海床内的渗流场以及渗流水力梯度场的分布情况。与海床表面剪应力计算结果进行比较分析发现,管道下方渗流出口处土体的流土渗透破坏将诱导管道发生悬

    在大肠杆菌中表达酮酸脱羧酶产异戊醇

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    Keto acid decarboxylase is the key enzyme for biological synthesis of isoamyl alcohol, rarely existed in E. coli. Keto acid decarboxylase gene kivD(rbs) obtained from Lactococcuslactis subsp.Lactis genome DNA through reaction of PCR, was inserted into E
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