The association between IgG1,IgG2 subclasses toward human papillomavirus16-like particles in the serum and cervical intraepithelial neoplasia

背景与目的:免疫球蛋白g(IMMunOglObulIn g,Igg)是血清和细胞外液中含量最高的免疫球蛋白,其某个亚类的升高,可能与宫颈上皮内瘤变(CErVICAl InTrAEPITHElIAl nEOPlASIA,CIn)的发生、发展及转归有密切相关。然而对于CIn患者血清人乳头瘤病毒样颗粒(HuMAn PAPIllOMAVIruS VIruS-lIkE PArTIClES,HPV VlPS)Igg1及Igg2抗体变化目前尚不明确。本研究旨在探讨CIn患者血清中HPV16VlPS-Igg1、Igg2亚类抗体的变化及其与不同级别宫颈病变的关系。方法:采用ElISA法检测HPV感染患者HPV感染患者CIn患者及子宫平滑肌瘤或宫颈炎患者血清中HPV16VlPS-Igg和HPV16VlPS-Igg1、Igg2亚类抗体的表达水平。结果:患者血清中HPV16VlPS-Igg和Igg1抗体含量随宫颈病变级别增高而增加,差异有统计学意义(P1),分别为100.00%、87.50%和75.00%,而CInⅡ~Ⅲ组中仅为9.52%,与前3组相比,差异有统计学意义(P1),可能与HPV清除和宫颈病变逆转有关。Background and purpose:The maximum content of immunoglobulin G was found in serum and extracellular fluid.The increase of some immunoglobulin G subclasses may closely correlate with the occurrence,development and the outcome of cervical lesions.However,the changes of IgG subclasses toward human papillomavirus 16-like particles(HPV16VLPs) in the serum of patients are still under investigation.This paper aimed to study this issue and also analyze the relationship between the expression of IgG subclasses and different grades of cervical lesions.Methods:The expression of IgG subclasses in 32 human papillomavirus,30 cervical intraepithelial neoplasia(CINⅠ) ,43 CINⅡ-Ⅲ,24 hysteromyoma and chronic cervicitis were examined by ELISA.Results:The absorbance value of HPV16-IgG,IgG1 increased with the grade of CIN(P1) from control group was 100%,87.50% for HPV infection group,75% for CINⅠ group,compared with that from CINⅡ-Ⅲ patients(9.52%) (P1) in serum from low grade cervical lesions group and normal control group,might indicate the clearance of HPV infection and the regression of cervical lesions

铟硼磷酸盐结构中的交叠生长规律研究

Several indium borophosphates have been reported recently, including KIn[BP2O8(OH)](I) and NaIn[BP2O8(OH)](H). The latter two compounds were synthesized under mild hydrothermal conditions, and have the same molar ratio (M-I:In:B:P:O:H) in molecular formula but with different structure types. Compound I crystallizes in the triclinic system with space group P (1) over bar (No.2), a=0.52638(4) nm, b=0.84791(5) nm, c=0.81469(9) nm, alpha=91.1741(7)degrees, beta=93.061(7)degrees, gamma=79.823(5)degrees, V=0.3573 nm(3), Z=2; while compound II possesses a monoclinic structure with space group P2(1)/n (No.14) with a=0.5177(1) nm, b=1.6815(3) nm, c=0.7684(2) nm, beta=94.10(3)degrees, V=0.6672(2) nm(3), Z=4. Eight- membered-ring and six-membered-ring are formed by alternating borate, phosphate tetrahedra and In-coordination octahedron sharing corners via common oxygen atoms in compound I and H respectively. The polyhedra in the structure are oriented along certain direction to form alternating layered fragments. These two structure types can be considered as intergrowth structures, which consist of the same layered fragments growing in different orientations. Other structure intergrowth possibilities are also expected in similar systems

Syntheses and characterizations of new compounds in main group elements(In) borophosphate and phosphate systems

在现有的非线性光学材料（NLO）中，硼酸盐和磷酸盐占有很大的比例。而尚处于起步阶段的硼磷酸盐的研究，无论对材料开发，还是对结构化学内容的丰富，都有着广泛的研究前景 在本论文中，应用水热法，合成了主族元素铟(In)的硼磷酸盐和磷酸盐新化合物。分别用X－射线粉末衍射及单晶衍射法对晶体结构进行表征，化学分析方法和EDX鉴定化合物所含化学成分，对潜在的具有非线性光学活性的材料，检测其非线性光学性能。 对硼磷酸盐和磷酸盐系统的研究过程中，合成了三种硼磷酸盐新化合物和两种磷酸盐新化合物，并对他们进行结构和性质表征。 三斜晶系 1.KIn[BP2O8(OH)]。无色透明长方柱状晶体，大小:0.4*0...Boroates and phosphates have drawn much attention for their application in non-linear optical material, and borophosphates being explored only in recent years distribute much not only to the structural chemistry,but also to the probing of functional materials , having more interesting potential application. In this thesis,several charaterization methods were employed to explore new Indium boroph...学位：理学硕士院系专业：化学化工学院化学系_物理化学(含化学物理)学号：19992504

半绝缘InP中深能级缺陷对电学性质的影响和缺陷的控制

综合深能级缺陷和电学性质的测试结果，证明了半绝缘InP单晶材料的电学性能、热稳定性、均匀性等性能与材料中一些深能级缺陷的含量密切相关．通过分析深能级缺陷产生的规律与热处理及生长条件的关系，给出了抑制缺陷产生，提高材料质量的途径．对缺陷的属性与形成机理进行了分析讨论

Investigations on Transition-metal and Main-group-element Borophosphate Systems

总结了作者近几年在硼磷酸盐研究中所合成和表征的 10多个新化合物 ,即元素周期表第 4周期从 Cr至 Ga的元素或氧化物与工业催化剂材料 BPO4 在高温固相反应中 ,分别合成出具有 3种结构类型的新化合物 :新结构类型的三方 Cr2 [BP3 O12 ]、正交 Al PO4 型的 (B,M) [PO4 ](M=Mn,Fe,Co,Ni,Cu,Zn)和新型四方 (Ga,B) PO4 ;用水热法合成出 Na Ga[BP2 O7(OH) 3 ]、Na2 In2 [PO3 (OH) ]4· H2 O和 Na4 Co3 H2 (PO4 ) 4· 8H2 O等新化合物 .同时还讨论了硼磷酸盐化合物研究的最新进展及结构化学的一般规律 .Borophosphates have attracted much attention of scientists in the last few years due to the potential applications of these compounds as functional materials. More than ten new compounds in the related systems have been synthesized and characterized here by either solid state reactions or hydrothermal methods. The new compounds have either new structure types like Cr 2BP 3O 12 which contains new building motif, or with very well known structure type like low cristobalite. The general structural features of these compounds have been discussed together with the literature data, and the new developments of the borophosphate research have also been reviewed here.国家杰出青年基金!(2 0 0 2 510 1);; 国家自然科学基金!(2 970 10 0 4 );; 高等学校骨干教师资助计划;; 福建省自然科学基金!(B981

Studies on the Intergrowth Structures in Indium(In)Borophosphates

Several indium borophosphates have been reported recently,including K In[BP 2 O 8 (OH)]( Ⅰ )and NaIn[BP 2 O 8 (OH)]( Ⅱ ).The latter two compounds were synthesized under mild hydrothermal condit ions,and have the same molar ratio(M Ⅰ ∶In∶B∶P∶O∶H)in molecular formula but with different structure types.C ompound Ⅰ crystallizes in the triclinic system with space group P1(No.2), a =0.52638(4)nm, b =0.84791(5)nm, c =0.81469(9)nm,α=91.1741(7)°,β=93.061(7) °,γ=79.823(5)°, V =0.3573nm 3 ,Z=2;while compound Ⅱ possesses a monoclinic structure with space group P 2 1 / n (No.14)with a =0.5177(1)nm, b =1.6815(3)nm, c =0.7684(2)nm,β=94.10(3)°, V =0.6672(2)nm 3 ,Z=4.Eight-membered-ring and six-membered-ring are formed by alterna ting borate,phosphate tetrahedra and In-coordination octahedron sharing corner s via common oxygen atoms in compound Ⅰ and Ⅱ respectively.The polyhedra in the structure are oriented along certain dire ction to form alternating layered fragments.These two structure types can be co nsidered as intergrowth structures,which consist of the same layered fragments growing in different orientations.Other structure intergrowth possibilities are also expected in similar systems.CSD: Ⅰ ,409583; Ⅱ ,413343.国家杰出 青年基金项目(No．20025101);; 国家科技部863项目(No．2002AA324 070);; 上海市光科技项目(No．02

Studies on Syntheses and Formation of Borophosphates under Room Temperature and Ambient Pressure

在常温常压条件下直接合成了硼磷酸盐NaCd(H2O)2[BP2O8·]0.8H2O(Hexagonal,P6122,a=0.97130(14)nm,c=1.6136(3)nm,V=1.31836(40)nm3,Z=6)和NaZn(H2O)2[BP2O8]·H2O(Hexagonal,P6122,a=0.95404(2)nm,c=1.47780(3)nm,V=1.16488(5)nm3,Z=6)。用粉末XRD表征了合成产物。用扫描电镜观察了不同温度下形成的产物的形态。通过实时XRD监测方法研究了常温常压下硼磷酸盐NaZn(H2O)2[BP2O8·]H2O的形成过程。NaCd(H2O)2·0.8H2O and NaZn(H2O)2·H2O have been synthesized under room temper-ature and ambient pressure. The two borophosphates were characterized by powder X-ray diffraction. Their morphology were observed by SEM. The formation procedure of NaZn(H2O)2·H2O was studied by in situ powder X-ray diffraction.国家自然科学基金委杰出青年基金(No.20025101);; 国家自然科学基金委重点基金(50332050);; 上海市光科技发展基金(No.022261015);; 国家科技部863计划课题(No.2002AA324070)

Hydrothermal Synthesis and Characterizations of Na_6In_4[P_7O_(24)(OH)_5]·4H_2O

A new sodium indium phosphate Na 6In 4[P 7O 24(OH) 5]·4H 2O was synthesized under a mild hydrothermal condition and its structure was determined by means of single-crystal X-ray diffraction methods. The title compound crystallizes in a hexagonal system, space group P6 3, with a= 0.950 23(5) nm, b=0.950 23(5) nm, c=1.694 2(2) nm, α=90°, β=90°, γ=120°, V=1.324 8(2) nm 3, Z=8, structure refined to R=0.052 8 and wR=0.116 5 for 2 134 independent observed reflections. The three-dimensional network structure consists of helical chains formed by apex-sharing polyhedra. The connection of the chains results in 4- and 8-polyhedral rings and cages centered by three indium metal connecting oxygen atoms formed by three 4-rings. The three-connected oxygen atom is firstly observed in indium phosphate systems.国家自然科学杰出青年基金 (批准号 :2 0 0 2 5 10 1);; 上海市光科技发展基金 (批准号 :0 2 2 2 610 15 );; 国家科技部“八六三”计划 (批准号 :2 0 0 2 AA3 2 40 70 )资

New Indium(III) Phosphate CsIn[PO_3(OH)]_2 with a New Type of Structure

水热法合成了新结构类型化合物CsIn[PO3(OH)]2,并通过单晶X--射线衍射表征结构。标题化合物空间群为P121/c1(No.14),晶体学参数为:Mr=439.69,mP56,a=0.53286(6)nm,b=0.91653(7)nm,c=1.47839(14)nm,β=93.849(9)°,V=0.7204(1)nm3,Z=4,Dx=4.054g·cm-3,μ=8.713mm-1,F(000)=800,R1=0.0325,wR2=0.0874。在该化合物中,2个InO6八面体和4个PO4四面体形成交连的六元环柱,并沿a轴方向形成近六方密堆积并连接成Cs+离子占据的十二元环结构隧道,六元环和十二元环连接构筑了三维网络结构。与类似化学计量比化合物Na2In2[PO3(OH)]4·H2O比较,标题化合物中十二元环的形成明显取决于隧道阳离子的大小,其拓扑构造可看作扩展的6,3-网格连接,化合物RbIn[PO3(OH)]2与之同构。A cesium indium hydrated phosphate, CsIn2, was synthesized under mild hydrothermal conditions, and the crystal structures were characterized by single crystal X-ray diffraction method. CsIn2 has a new type of crystal structure. Crystallographic data are as following: Mr=439.69, monoclinic, mP56, P1 21/c 1 (No.14) , a=0.532 86(6) nm, b=0.916 53(7) nm, c=1.478 39(14) nm, β=93.849(9)°, V=0.720 4(1) nm3, Z=4, Dx=4.054 g·cm-3, μ=8.713 mm-1, F(000)=800, R1=0.032 5, wR2=0.087 4 for 116 variables and 1 502 contributing unique reflections. The structure is characterized by 6-membered column with cross-section formed by two InO6 octahedra and four PO4 tetrahedra. The condensation of the column forms an almost hexagonal close-packing array along a axis, resulting in close packing of 12-membered-ring channels occupied by Cs+ cations. The connections of the columns and channels result in a three-dimensional network structure. The formation of the 12-membered ring in these structures seems clearly governed by the cation size by comparing to Na2In24·H2O with the similar stoichiometry. The topological construction of the title structure can be considered as an augmented 6,3-net. RbIn2 is isotypic to the Cs compound. CSD: 391266.国家自然科学基金资助项目(No.50332050);; 国家杰出青年基金资助项目(No.20025101);; 国家科技部“863”计划(No.2002AA324070);; 上海市科委光科技项目(No.D11161015)资