厦门市某医院体检人群中有机氯农药暴露与胆石症发病的关联性研究

目的探讨厦门市第二医院体检人群中有机氯农药暴露与胆结石发生的关联及其发病危险因素。方法收集2015年2月-8月在医院健康体检人群中经B超确诊的新发胆囊结石患者100例,以同期参加体检的非胆囊结石者为对照,进行1∶2配比的病例对照研究。进行流行病学调查,采用气相色谱联用电子捕获器检测研究对象外周血中有机氯农药水平。应用多因素条件Logistic回归模型分析有机氯农药与胆囊结石发病的关系。结果病例组血清中α-HCH残留水平高于对照组,差异有统计学意义;Logistic回归分析非酒精性脂肪肝、2型糖尿病、血清α-HCH含量增高可能增加胆结石的患病危险,OR值及95%CI分别为5.134(1.952~13.502)、4.754(1.849~12.220)和1.357(1.094~1.854)。结论环境有机氯农药暴露可能是胆囊结石病发生的危险因素。厦门市科技计划项目(3502Z20163006)；厦门市集美区科技计划项目(20142C01)；厦门大学校长基金(20720152012)

Electric-field-induced selective catalysis of single-molecule reaction

随着单分子电学检测技术的迅速发展，分子电子学的研究不再局限于分子电子学器件的构筑及其电学性质的测量，而且扩展到单分子尺度化学反应过程的探索。然而目前相关的研究仍然局限于理论计算方面，在单分子尺度上实时监测和调控化学反应的活性和选择性是化学领域的长期目标和挑战。针对这一挑战，洪文晶教授课题组与程俊教授课题组合作，自主研发了精密科学仪器，将单个有机分子定向连接在两个末端尺寸为原子级的电极之间，解决了化学反应中分子取向控制的问题.理论计算结果证实了定向电场可以有效地稳定化学反应的过渡态，从而降低反应能垒。该研究工作在化学化工学院洪文晶教授、程俊教授、能源材料化学协同创新中心（iChEM）刘俊扬副研究员的共同指导下完成，由硕士研究生黄晓艳、iChEM博士研究生唐淳、博士研究生李洁琼以及兰州大学的陈力川博士作为共同第一作者，化学化工学院师佳副教授、陈招斌高级工程师、夏海平教授和田中群教授，萨本栋微纳研究院杨扬副教授、环境与生态学院白敏冬教授以及兰州大学张浩力教授参与了研究工作的讨论并给予指导，博士后乐家波、博士研究生郑珏婷、张佩（已毕业）、李瑞豪、李晓慧也参与了研究工作。Oriented external electric fields (OEEFs) offer a unique chance to tune catalytic selectivity by orienting the alignment of the electric field along the axis of the activated bond for a specific chemical reaction; however, they remain a key experimental challenge. Here, we experimentally and theoretically investigated the OEEF-induced selective catalysis in a two-step cascade reaction of the Diels-Alder addition followed by an aromatization process. Characterized by the mechanically controllable break junction (MCBJ) technique in the nanogap and confirmed by nuclear magnetic resonance (NMR) in bottles, OEEFs are found to selectively catalyze the aromatization reaction by one order of magnitude owing to the alignment of the electric field on the reaction axis. Meanwhile, the Diels-Alder reaction remained unchanged since its reaction axis is orthogonal to the electric fields. This orientation-selective catalytic effect of OEEFs reveals that chemical reactions can be selectively manipulated through the elegant alignment between the electric fields and the reaction axis.This work was supported by the National Key R&D Program of China (2017YFA0204902), the National Natural Science Foundation of China (21722305, 21703188, 21673195, 21621091, 51733004, 51525303, and 91745103), the China Postdoctoral Science Foundation (2017M622060), and the Young Thousand Talents Project of China. 该工作得到国家自然科学基金委（21722305、21703188、21673195、51733004、51525303、91745103），国家重点研发计划课题（2017YFA0204902），中国博士后面上基金（2017M622060）的资助，以及固体表面物理化学国家重点实验室、醇醚酯化工清洁生产国家工程实验室、能源材料化学协同创新中心的支持

Evaluation on difference of therapeutic efficacy of Jiawei Xiaoyao Granules and Pills in treatment of emotional disorder during perimenopause based on Greene Climacteric Scale

目的:在前期加味逍遥丸治疗围绝经期情绪障碍具有比较优势的基础上,基于grEEnE量表探讨其颗粒剂和丸剂不同剂型间疗效差异。方法:经筛选后患有情绪障碍的围绝经期女性75例随机等分为A、b、C3组,分别对应采用帕罗西汀、加味逍遥丸和加味逍遥颗粒剂治疗8周。所有患者在治疗前后各进行1次grEEnE及其子因子评定,并在观察期结束时进行TESS评定。结果:grEEnE总分差及其焦虑、抑郁因子分差:3种治疗方法均能改善,且相互间无显著差异;grEEnE性因子和血管因子分差:后二组均优于A组(P<0.01);TESS评分:与A组比较,b、C组均有统计学意义(P<0.01),评分均小于A组,且后二组间无显著差异。结论:加味逍遥的2种剂型间疗效无显著差异,考虑到帕罗西汀的不良反应,治疗该病加味逍遥的2种剂型都值得推荐。Objective: To investigate the difference in therapeutic efficacy between Jiawei Xiaoyao Granules and pills based on the preliminary research of treating emotional disorder during perimenopause with Jiawei Xiaoyao Pills and Greene Climacteric Scale.Methods: 75 female patients with emotional disorder during perimenopause were slected and randomly divided into 3 groups as group A, B and C.Patients in the 3 groups were treated with paroxetine, Jiawei Xiaoyao Pills and Jiawei Xiaoyao Granules respectively for 8 weeks.Greene and Greene factors assessment were carried out in all the patients before and after treatment, and the TESS assessment was carried out at the end of the observation period.Results: The three therapies all could improve the gap in total score of Greene and its factors as anxiety and depressed, and the difference among these three groups was no significant.The factors of Greene and gap in score of vascular factors of group B and C was better than that of group A(P<0.01).The difference in TESS score between group A and group B and C was significant(P<0.01), while the difference between group B and group C was not significant.Conclusion: The difference in curative effect between the two formulations was not significant.Because of the adverse reactions of paroxetine, in the treatment of emotional disorder during perimenopause, the two formulations of Jiawei Xiaoyao Powder were worth to be recommended.国家自然科学青年基金项目(No.81302960)~

基于MMOGA的某超高速包装机推手机构动平衡优化

为了改进某型超高速包装机推手机构的动态性能,对该机构进行动平衡优化。基于多刚体动力学理论,建立该推手机构的动力学模型,分析出主要产生惯性载荷的零部件。建立该部件的数学模型,推导出摆动力和摆动力矩方程。基于微型多目标遗传算法（MMOGA）,综合考虑摆动力和摆动力矩的均方根值,以杆件的质量、质心位置等为变量,对该部件进行动平衡优化。根据变量的较优值,重新设计长臂推手的结构。优化后推手机构的摆动力与摆动力矩分别减小了23. 6%和29. 5%,且长臂推手的固有频率远离了260 Hz（激振频率）。上述结果表明,经过优化,该型包装机推手机构的动力学性能得到了较明显的改善,避免了长臂推手的共振现象

语义WIKI分析研究

随着全球E-Research和中国科学院信息化工作发展，科研数字知识环境正在形成，各类研究对象（数据、文献、设施、过程、机构、人员、政策等）等数字信息资源以不同的组织方式，散落在各种不同机构，如科研机构、基金会、科研管理部门、图书馆等。智能语义Wiki系统的研究，正是在这一背景下提出，对于解决数字知识资源的动态发现、以及为广大科研人员提供知识集成、知识推理和知识获取是一个新的尝试。该项目以语义Web技术为基础，对智能语义Wiki进行分析研究。同时以科研本体作为数字知识资源的基本知识组织形式，能够根据不同的应用环境，灵活动态地组织不同来源的数字知识资源。整个研究过程包括了对语义Wiki的特性分析，然后通过调研从标注机制、导航机制和检索机制等三个方面展开深入研究，同时针对有代表性的语义Wiki项目进行了比较和分析，并开发原型系统进行验证

抗菌性纳米材料在水处理中的应用现状

杀菌消毒是水处理中至关重要的一个环节,传统的含氯氧化剂在消毒的同时会产生严重危害人体健康的消毒副产物,抗菌性纳米材料以其独有的特性不仅具有良好的杀菌消毒效果,而且不产生对人体有害的副产物。从纳米材料的抗菌原理、基本方法、常用材料种类等几方面对近5年来抗菌性纳米材料在水处理中的应用现状进行了讨论,分析了其目前存在的问题和发展前景,并在此基础上提出了一些新的看法

铌酸锂晶体中写入晶格周期与衍射效率的关系

为了得到衍射效率高的光子晶格,采用光诱导光子晶格的方法,在LiNbO3∶Fe（掺铁铌酸锂）晶体中写入一维光子晶格。对写入晶格周期的密度的最小值,以及晶格周期与衍射效率之间的关系进行了研究,并对用不同波长的激光器写入时的情况进行了对比。实验结果表明,写入周期最小时为入射波长的一半,此时两束入射光形成驻波。发现双光束夹角在20°以内时衍射效率比较高,大于25°时衍射效率比较低。得出结论是:要得到衍射效率高的光子晶格,双光束夹角应在20°以内,并使用短波长激光器作为辐照光源

Determination of organophosphorus and carbamate insecticide residues in food and water samples by solid phase extraction coupled with capillary liquid chromatography

A method was established for the simultaneous separation and determination of one organophosphorus and three carbamate insecticide residues in food and water samples by solid phase extraction (SPE) followed by analysis using a home-made capillary liquid chromatogram. Various parameters possibly affecting the efficiencies of capillary liquid chromatography (CLC) and SPE were investigated in detail, such as type of SPE column, pH value of samples, type and volume of elution solvent, flow rate of loading sample, salt effect, loading volume, detection wavelength, and type and ratio of mobile phases. Under the optimized experimental conditions, the four insecticides were separated completely within 6 min. The limits of detection and limits of quantification were 0.35-1.20 μg/kg and 1.17-4.00 μg/kg, respectively. Satisfactory recoveries of the SPE-CLC method were achieved for spiked food samples of tomato, cucumber and apple ranging from 72.41% to 107.15% with the relative standard deviations (RSDs) no more than 8.12%, and for spiked tap/lake water samples ranging from 71.45% to 109.25% with the RSDs no more than 9.28%. The method can meet the requirements for multi-residue analysis of insecticides