The Investigation of LiNixCoyMn1-x-yO2 as Cathode Materials and their corresponding Electrolyte Additive for Lithium-ion Batteries

三元正极材料LiNixCoyMn1-x-yO2因具有价格低、热稳定性好、对环境友好以及高电位下比容量高等突出优势成为锂离子电池研究的热点之一，引起了研究者的广泛关注。本论文选择该系列材料为研究内容，主要工作集中在优化合成条件，并成功制备出具有良好电化学性能的LiNi1/3Co1/3Mn1/3O2和LiNi0.4Co0.2Mn0.4O2正极材料，通过多种电化学与谱学手段表征它们的电化学、表面性质、热稳定以及储存等多方面的性能，并重点研究了LiNi1/3Co1/3Mn1/3O2材料首次不可逆损失严重的原因，以及LiNi0.4Co0.2Mn0.4O2粉末在空气中的储存稳定性等. 在实验技术方面，本...Recently, LiNixCoyMn1-x-yO2 material has become one of the promising cathode material systems for their high capacity, low cost, environmental-friendly, good thermal stability and stable cyclic performance in the lithium ion batteries. In this thesis, two kinds of material in this family, such as LiNi1/3Co1/3Mn1/3O2 and LiNi0.4Co0.2Mn0.4O2 with excellent electrolyte performance have been synthesiz...学位：理学博士院系专业：化学化工学院化学系_物理化学(含化学物理)学号：B20042504

Relationship between aldose reductase、sodium/potassium/2 chloride cotransporter type 2(NKCC2)and serum and glucocorticoid inducible protein kinase(SGK) in renal cells

糖尿病肾病(diabeticnephropathy,DN)是糖尿病慢性并发症(DCC)中的一种，它是糖尿病(DiabetesMellitus，DM)致死致残的主要原因。据统计，30%～40%的Ⅰ型糖尿病患者和40%的Ⅱ型糖尿病患者并发糖尿病肾病，可由最初出现蛋白尿发展到高血压、肾病综合症，最终导致肾衰和死亡，DN的3年生存率仅为50%左右。糖代谢的多元醇通路与糖尿病血管病变、肾脏病变、视网膜病变及外周神经病变等糖尿病慢性并发症密切相关。而醛糖还原酶(AldosereductaseAR)是多元醇糖代谢支路的限速酶,因此,AR活性的增高可能是导致DN的主要原因之一。醛糖还原酶是组成多元醇糖代谢支路...Diabetic nephropathy, DN is one of the Diabetic chronic complications, it is the main reason for disability and death caused by diabetes mellitus (DM). According to statistics, 30 percent to 40 percent of the type Ⅰdiabetes patients and 40 percent of the type Ⅱ diabetes patients with diabetic nephropathy, there may be proteinuria hypertension at the first to the development of nephrotic syndrome, ...学位：理学硕士院系专业：生命科学学院生物学系_水生生物学学号：2012005130200

Numerical Pushover Analysis On Reinforced Concrete Inclined Column

随着科技进步，现代建筑的造型越来越多样化，建筑的结构形式越来越复杂，为了适应造型的要求，建筑结构的空间布置方式出现许多新的变化，斜柱就是其中出现最多的一种构件。高层建筑立面的倾斜、收进和挑出都可以运用斜柱达到建筑上的效果，斜柱的出现在一定程度上满足了设计师对造型新颖和功能多样的要求。除此之外，在结构层面上，斜柱结构可以在柱间直接完成转换，传力的途径更加直接，因此可以节省一定材料，有效地提高设计和施工的效率，有一定的经济性。 根据材料不同，混凝土结构中斜柱主要可以分为：钢筋混凝土斜柱、劲性混凝土斜柱和钢管混凝土斜柱三大类。本文在参考前人对普通柱和斜柱研究的基础上，以钢筋混凝土斜柱为主要研究对象...With technology developments, the shapes of modern architecture are more and more diversified, building structure more and more complex. In order to meet the requirements of style, many new changes are bringing to bear in spatial arrangement of the building structure; inclined column is one of the most frequent components that we have seen. Designers can use inclined columns to accomplish inclinat...学位：工学硕士院系专业：建筑与土木工程学院_结构工程学号：2532010115170

Preparation and Characterization of “Water-in-Salt” Polymer Electrolyte for Lithium-Ion Batteries

为提高柔性锂离子电池安全性和循环稳定性能,本实验以自由基聚合结合冷冻干燥得到的聚丙烯酰胺膜为电解质载体,引入21 mol·kg-1 LiTFSI 高浓度电解液,得到“water-in-salt”聚合物电解质。通过聚合物膜的形貌和孔道结构表征,红外光谱分析,离子电导率及电化学稳定窗口测试等对其基本物化特性进行了研究。冷冻干燥得到的聚丙烯酰胺膜内部具有大量微孔结构,有利于电解液的载入。将该吸附了电解液的聚合物电解质膜与锰酸锂(LiMn2O4)正极和磷酸钛锂(LiTi2(PO4)3)负极组装全电池进行充放电性能测试。结果表明,制得的柔性聚合物电解质具有良好的拉伸性能,高离子电导率(20°C,4.34 mS·cm-1)和宽电化学稳定窗口(3.12 V)。以“water-in-salt”聚合物电解质为隔膜组装的LiMn2O4||LiTi2(PO4)3 全电池表现出优异的倍率性能和长循环稳定性。Since the development of wearable and flexible electronic products, the demand of flexible energy storage devices such as batteries and super capacitors is in urgent. To enhance the safety and cycling stability for flexible lithium-ion batteries, “water-in-salt” polymer electrolyte was prepared by introducing 21 mol·kg-1 LiTFSI electrolyte into cross-linked polyacrylamide (PAM) after freeze-drying. A great amount of holes with the size range of 10 ~ 20 μm can be found on the surface and in the bulk of polyacrylamide, which is benefited from the freeze-drying process and acts as a great support for the electrolyte uptake. The “water-in-salt” polymer electrolyte showed good tensile property, high ionic conductivity (4.34 mS·cm-1 at 20℃), and broadened electrochemical stability window (ESW, 3.12 V). Comparing the FTIR spectra of PAM, “water-in-salt” electrolyte (WiSE) and WiSE-PAM, the signal that can be assigned to H-O bending mode transfered from 3186 cm-1 in PAM to higher wavenumber of 3560 cm-1 in WiSE-PAM. Therefore, it can be inferred that the amide group in PAM participates in the Li+ solvation sheath in WiSE-PAM electrolyte, due to the hydrogen bond between amide group and water. On the one hand, the Li+ solvation sheath can transfer through the polymer bone and the liquid in the hole, resulting in high ionic conductivity. On the other hand, due to the hydrogen bond between amide group in PAM bone and free water, the enrichment of free water along the polymer bone can be obtained. Therefore, the free water content on the electrode surface is reduced, resulting in expanded ESW. With this polymer electrolyte, LiMn2O4||LiTi2(PO4)3 full cell showed high initial charge/discharge capacity (68.1/62.1 mAh·g-1) and coulombic efficiency (91.2%) at 1 C. The high capacity retention of 94.2% (with discharge capacity of 58.5 mAh·g-1) could be obtained after 100 cycles. To evaluate the rate capability, the cells were charged and discharged at different current densities varying from 1 C to 30 C. The remarkable capacity of 28.1 mAh·g-1 was still retained even at 30 C. After the rate test, the current was decreased back to 1 C, there was still 99.2% of the initial capacity could be recovered. In addition, when cycling at 10 C rate, 79% of the initial capacity was retained even over 5000 cycles. There results demonstrate that the full cell also showed superior rate capability and long-term cycling stability. This work offers an idea for the electrolyte design with high safety to enable the application of high-performance aqueous lithium-ion batteries in flexible electronics.通讯作者:李劼E-mail:[email protected]:JieLiE-mail:[email protected] Muenster (HI MS), IEK-12,Muenster 481492.四川大学化工学院,四川 成都 6100653.Politecnico di Milano, Department of Energy, Milano 201561. Helmholtz-Institute Muenster (HI MS), IEK-12,Muenster 48149, Germany2. School of Chemical Engineering Sichuan University,Chengdu 610065, Sichuan, China3. Politecnico di Milano,Department of Energy, Milano 20156, Ital

Electrochemical Behavior of Vinyl Ethylene Sulfite as an Electrolyte Film-forming Additive in Lithium Ion Batteries

研究了具有不饱和双键和亚硫酸酯双官能团的乙烯基亚硫酸乙烯酯(VES)作为锂离子电池电解液成膜添加剂对中间相碳微球(CMS)和lIfEPO4电极电化学性能的影响.结果表明:在1MOl/llIClO4/PC电解液体系中,少量的VES(5%)能够在电化学过程中先于PC在CMS表面还原,形成稳定的SEI膜,明显抑制PC和溶剂化锂离子共嵌入石墨层间,改善了电池的循环性能.此外,电解液1MOl/llIClO4/PC+5%VES(V∶V)在lIfEPO4电极中展现出良好的电化学稳定性.A film-forming additive, vinyl ethylene sulfite (VES) with both vinylene group and sulfite group, affects the electrochemical performance of carbonaceous mesophase spherules (CMS) and LiFePO4 electrode.The results indicated that a small amount of VES (5%) could be reduced prior to the propylene carbonate (PC) solvent on the surface of CMS electrode in PC-based electrolyte to form a stable solid electrolyte interphase (SEI) layer, so co-intercalation of PC and solvated lithium ions to graphite could be suppressed.Furthermore, the electrolyte of 1 mol/L LiClO4/PC+5%VES (V∶V) exhibited excellent electrochemical stability in the LiFePO4 electrode.国家自然科学基金(Nos.20473068;29985310);国家“973”计划(No.2007CB209702)资助项

Electrochemical Behavior of Vinyl Ethylene Sulfite as an Electrolyte Film-forming Additive in Lithium Ion Batteries

A film-forming additive, vinyl ethylene sulfite (VES) with both vinylene group and sulfite group, affects the electrochemical performance of carbonaceous mesophase spherules (CMS) and LiFePO4 electrode. The results indicated that a small amount of VES (5%) could be reduced prior to the propylene carbonate (PC) solvent on the surface of CMS electrode in PC-based electrolyte to form a stable solid electrolyte interphase (SEI) layer, so co-intercalation of PC and solvated lithium ions to graphite could be suppressed. Furthermore, the electrolyte of 1 mol/L LiClO4/PC+5%VES (V:V) exhibited excellent electrochemical stability in the LiFePO4 electrode

Y型聚乙二醇干扰素琢-2b注射液治疗HCV基因2/3型慢性丙型肝炎患者疗效和安全性的多中心随机对照试验研究

目的以标准剂量的聚乙二醇干扰素(Peg IFN)α-2a联合利巴韦林作为阳性对照,评价新型试验药物Y型Peg IFNα-2b注射液联合利巴韦林治疗2型/3型慢性丙型肝炎(CHC)患者的疗效和安全性。方法采用多中心、随机开放、阳性药对照的Ⅲ期临床试验,筛选符合要求的2型/3型CHC患者,按照2:1的比例随机分配到Y型Peg IFNα-2b组和Peg IFNα-2a组,同时口服利巴韦林,疗程24 w,停药随访24 w。采用Abbott Real Time HCV Genotype II检测HCV基因型,采用Cobas Taq Man实时定量PCR法检测血清HCV RNA水平。详细记录不良事件。主要疗效指标为持续病毒学应答(SVR),并进行非劣效检验。结果本试验实际入组2型/3型CHC患者255例,实际治疗241例。全分析集(FAS)数据显示,158例试验组和83例对照组患者SVR分别为85.4%(95%CI 79.94%~90.94%)和79.5%(95%CI 70.84%~88.20%,P=0.2402);对符合方案分析集(PPS)人群分析显示,试验组和对照组患者SVR分别为87.9%(95%CI 82.45%~93.27%)和85.9%(95%CI 77.82%~94.01%,P=0.7060),率差的95%可置信区间均符合非劣效标准;对PPS人群分析显示,85.8%受试者获得了早期病毒学应答(RVR),RVR的阳性预测值为90.1%;试验组和对照组不良事件发生率相似,分别为95.6%和95.2%,严重不良事件发生率分别为3.8%和3.6%。结论应用Peg IFNα联合利巴韦林治疗2型/3型CHC患者,新型试验药物Y型Peg IFNα-2b具有与对照药物Peg IFNα-2a相似的疗效和安全性。国家科技部“十二五”重大专项(编号:2012ZX10002-003)；“重大新药创制”十二五科技重大专项(编号:2012ZX09303019)

New town development in an entrepreneurial city : the case of Shanghai

The new town programme has been a widely adopted urban development strategy since the post-2000s in large Chinese cities such as Beijing and Shanghai. This study argued that the current trends of new town development in China need to be understood in light of its own political economy and urban contexts, particularly China’s shift to a socialist-market economy, participation in the global economy, and the rise of Chinese entrepreneurial cities. Using two new towns in Shanghai as case studies, this dissertation attempts to interpret Shanghai’s new town development from the perspective of urban entrepreneurialism, and contribute to the understanding of how the new town programme adds on the ‘entrepreneurial city’ nature to Shanghai. This dissertation is essentially a qualitative study based on data from planning and policy documents, media information, field trip observation, and interviews. Employing the concepts relating to the urban entrepreneurialism and entrepreneurial city theory, the development of the two new towns in Shanghai was examined in three domains: entrepreneurial urban policy and planning, entrepreneurial urban development practices and space production, and entrepreneurial governance. The major analytical elements include development objectives and planned functions of new towns, cultural or entertainment oriented mega-projects development, the fostering of cultural and creative industries, the roles of the state and types of state intervention, and financing mechanisms. This study found that the new town programme in Shanghai is an entrepreneurial urban development strategy to facilitate the building of Shanghai into a global city with international competitiveness, by equipping the metropolitan areas with new urban spaces and new growth capacities. Within the domain of entrepreneurial urban policy and planning, a number of policies were identified to promote industrial development and upgrading, and new planning practices were adopted for place promotion. Within the domain of entrepreneurial urban development practices, it is found that cultural or entertainment oriented mega-projects development was widely adopted, with entrepreneurial objectives such as raising land value and attracting affluent residents and consumers. Within the domain of entrepreneurial governance, a pro-growth coalition formed between the local governments and the government affiliated development corporations was found to be the most influential driving force in promoting the new town development, with their landownership, land selling power, and planning power. The new town programme has added on the entrepreneurial city nature to Shanghai by invoking innovative strategies and state-dominated entrepreneurial urban governance. Innovative entrepreneurial strategies were observed in five fields: producing new type of urban space for living, working, consuming, etc.; new methods for space production to creative locational competitiveness; opening new markets by providing attractive places for consumption; finding new sources of supply by land development and attracting human capital; and redefining urban hierarchy by developing regional nodal city and logistics hub. Urban governance in the new towns were found to be state-dominated in which the local governments themselves are entrepreneurs in pursuit of their own economic and political interests, instead of forming partnerships between the state and the market and facilitating private participation in the development process.published_or_final_versionUrban Planning and DesignDoctoralDoctor of Philosoph

Stability analysis of uncertain genetic regulatory newtworks

Genetic regulatory network (GRN) is a fundamental research area in systems biology. This thesis studies the stability of a class of GRN models. First, a condition is proposed to ensure the robust stability of uncertain GRNs with SUM regulatory functions. It is assumed that the uncertainties are in the form of a parameter vector that determines the coefficients of the model via given functions. Then, the global asymptotic stability conditions of uncertain GRNs affected by disturbances and time delays are further explored. The conditions are obtained by solving a convex optimization problem by exploring the sum of squares (SOS) of matrix polynomials and by introducing polynomially parameter-dependent Lyapunov-Krasovskii functionals (LKFs). Moreover, based on the uncertain GRNs with guaranteed disturbance attenuation, it is shown that estimates of the sought stable uncertainty sets can be obtained through a recursive strategy based on parameter-dependent Lyapunov functions and the SOS. Second, the stability conditions of GRNs described by piecewise models are considered. Depending on whether the state partitions and mode transitions are known or unknown as priori, the proposed networks are divided into two categories, i.e., switched GRNs and hybrid GRNs. It is shown that, by using common polynomial Lyapunov functions and piecewise polynomial Lyapunov functions, two conditions are established to ensure the global asymptotic stability for switched and hybrid GRNs, respectively. In addition, it is shown that, by using the SOS techniques, stability conditions in the form of LMIs for both models can be obtained. Third, the multi-stability of uncertain GRNs with multivariable regulation functions is investigated. It is shown that, by using the Lyapunov functional method and LMI technology, a criterion is established to ensure the robust asymptotical stability of the uncertain GRNs, and such condition can be extended to deal with the multi-stability problem. Moreover, it is shown that by using the square matrix representation (SMR) and by adopting polynomially parameter-dependent Lyapunov functions, a condition in the form of LMIs for robust stability for all admissible uncertainties can be obtained. Examples with synthetic and real biological models are presented in each section to illustrate the applicability and effectiveness of the theoretical results.published_or_final_versionElectrical and Electronic EngineeringDoctoralDoctor of Philosoph