High-order Numerical Approximations to Stochastic Partial Differential Equations

随着计算机技术和计算方法的快速发展，人们已发展了许多计算确定性问题的高效数值方法。然而，在很多情形下，方程中的一些参数(如扩散项、边界条件以及求解区域等)带有不确定性。为了准确地对不确定性问题做出证明和检验等，需要设计高精度的数值方法求解随机微分方程。谱元法作为一种高阶的数值方法，结合了谱方法的高精度和有限元法灵活的网格剖分技术，在不可压流体的计算中已取得了很大的成功，并正成为计算随机微分方程的一个有力工具。   本文旨在利用随机Galerkin谱方法求解带有不确定性输入参数的微分方程。研究的算法基于随机方向上的Askey正交(混沌)多项式谱分解和物理空间方向上的谱方法。我们针对...Thanks to the great progress in the development of numerical methods and computer resources, many classical partial differential equations can now be solved very efficiently with high accuracy. However, in many cases, the coefficients, boundary conditions as well as the geometry of the considered partial differential equation may contain uncertainties. In order to provide meaningful predictions to...学位：理学博士院系专业：数学科学学院信息与计算数学系_计算数学学号：1902006015316

抗光老化海洋生物活性物质作用机制研究进展

紫外辐射是导致皮肤光老化的主要因素。近年防止紫外线对皮肤的伤害已被大众所重视,探索预防光老化活性物质成为研究热点。海洋是人类巨大的生物资源和物质资源宝库,特殊的环境条件造就了许多具备化妆品功效的海洋生物活性物质。综述阐述了皮肤光老化的外在表现及机制,总结了海洋多糖、酚类化合物、类胡萝卜素、萜类化合物和类菌胞素氨基酸等海洋生物活性物质抗皮肤光老化的保护机制,为其在光保护海洋功能化妆品中的研究和应用提供理论依据。福建省省属公益类科研院所基本科研专项(2017R1003-13);;福建省海洋与渔业结构调整专项[2015];;闽海洋高新[2016]07

Construction of cDNA library of gills from Pagrus major with the cloning of hepcidin

【中文摘要】 以细菌攻毒的真鲷鳃组织为材料,分离出mRNA,合成双链后,回收500~4 000bp cDNA片段,构建了λZAP表达型cDNA文库。初级文库的容量为1.75×105个重组子,扩增文库的滴度达到1×109pfu.mL-1,随机挑选噬菌斑的插入片断在500~2000bp之间。以hepcidin特异性引物做PCR扩增文库,获得了hepcidin抗菌肽基因cDNA序列,证明所建立的文库可用于免疫相关基因的筛选。本文库可作为筛选真鲷免疫相关基因的重要资源。 【英文摘要】 With the layers of mucus and nonspecific immune defenses,the fish gill is exposed to the external environment and forms the initial barrier to invasion by pathogens.As one of the mucosa-associated lymphoid tissues in teleost fishes,gill contains populations of leucocytes.In order to probe the immune-related genes in red seabream(Pagrus major),the cDNA library of gills was constructed from the red seabream inoculated with several species of pathogenic bacteria.The total RNA was extracted by TRIZOL and mRNA w...福建省重大科技项目(2003I005);; 厦门市高新技术项目(3502Z20021052

皱纹盘鲍内脏脂质对人肝癌细胞HepG2脂质调节作用研究

本研究探讨了皱纹盘鲍(Haliotis discus hannai)内脏脂质(Haliotis discus hannai visceral lipid,HDHL)对人肝癌细胞HepG2的脂质代谢的影响,对HDHL脂肪酸成分、HepG2细胞活性、细胞内胆固醇和甘油三酯含量以及脂肪酸代谢相关mRNA基因的表达情况进行了研究。研究发现HDHL中不饱和脂肪酸占总脂肪酸含量59.50%,其中多不饱和脂肪酸占29.71%。HDHL与HepG2细胞共孵培养24 h及48 h后,浓度为0～240μg/mL的HDHL对HepG2细胞无毒性影响。30～240μg/mL HDHL可显著降低HepG2总胆固醇含量,30～120μg/mL HDHL共孵HepG2细胞后,细胞内甘油三酯含量显著降低。qPCR结果显示HDHL可显著降低HepG2细胞脂肪酸合成相关基因SREBP1c、ACC1、FAS和脂肪酸转运吸收相关基因CD36 mRNA水平的表达,提高线粒体脂肪酸氧化基因CPT1的表达。因此,HDHL可能通过抑制脂肪酸合成和脂肪酸转运,增强线粒体中脂肪酸氧化等途径有效调节细胞脂质代谢,该研究为脂质调节功能食品的开发提供理论依据。海洋公益性行业科研专项(201405016

皱纹盘鲍内脏脂质对人肝癌细胞HepG2脂质调节作用研究

本研究探讨了皱纹盘鲍(Haliotis discus hannai)内脏脂质(Haliotis discus hannai visceral lipid,HDHL)对人肝癌细胞HepG2的脂质代谢的影响,对HDHL脂肪酸成分、HepG2细胞活性、细胞内胆固醇和甘油三酯含量以及脂肪...海洋公益性行业科研专项(201405016

Concentration Protile of Etchant Measured by Microelectrode Technique in the Process of Chemical Micromachining

利用微圆盘电极技术,测定了KBr、L-胱氨酸和硫酸组成的刻蚀溶液体系中Pt电极表面电化学氧化产生的刻蚀剂Br2浓度分布,为约束刻蚀剂层技术(CELT)中刻蚀体系的选择和优化提供更直观的依据.GaAs表面CELT微加工实验证明了用微圆盘电极测得的表面刻蚀剂的浓度分布趋势与微加工实验所得到的结果一致.A carbon-disk microelectrode was used to investigate the surface concentration profile of etchant Br2, which was electrogenerated on the Pt working electrode. The steady state reducing currents of Br2 at different distances away from the Pt electode was measured. The concentration profile was estimated from the current-distance variation curves as a function of different sampling times. Experimentally determined concentration profiles are in good agreement with those estimated from the microetching results. The microelectrode technique has offered a good method to choose suitable etching solution for chemical micromachining.国家高新技术发展规划(863项目)(2002AA404170);; 福建省自然科学基金计划资助项目(E0520001

Genomic organization and tissue-specific expression analysis of hepcidin-like genes from black porgy (Acanthopagrus schlegelii B.)

【英文摘要】Hepcidin is an antimicrobial peptide and putative iron regulatory hormone previously described in mice and humans. Dozens of fish hepcidins have been isolated and characterized so far. Here we present seven hepcidin-like cDNA sequences named AS-hepc1–7, amplified from the normal commercially cultured fish (black porgy) by RACE–PCR. Sequence analysis reveals that these seven potential hepcidin peptides have highly conserved sequences with other known hepcidins, but they are different from each other in constitution and characteristics of predicted mature amino acids. Based on the study, it is deduced that AS-hepc1–7 represent different variants of a family of hepcidin genes in black porgy. To understand the organization of these hepcidin-like genes, we sequenced AS-hepc2 DNA, AS-hepc3 DNA, AS-hepc4 DNA, AS-hepc7 DNA and AS-hepc2 upstream region; and all of the four genomic DNAs consisted of two introns and three exons, the same organization as other reported hepcidins. The tissue-specific gene expression of hepcidins in normal black porgy was evaluated using RT–PCR and dot blot approaches. RT–PCR showed that transcripts of hepcidin-like mRNAs were present in each tested tissue of normal juvenile black porgy, including liver, spleen, kidney, heart, brain, stomach, intestine, gill, skin and blood, but abundant hepcidin-like mRNA transcripts were only detected in the liver, kidney, spleen, intestine and stomach by dot blot assay. In addition, using dot blot and Northern blot approach, a significant increase of hepcidin mRNA transcription was observed in the liver within 48 h after immersion in a suspension of live bacteria, which suggested that the expression pattern of hepcidin-like genes in black porgy might be different in the liver from the other tissues as previously reported in several hepcidin studies

金属Cu表面三维齿状微图形的复制加工——约束刻蚀剂层技术 (CELT)的应用

主要介绍了一种Cu的CELT加工的化学刻蚀体系和捕捉体系 ,并通过控制刻蚀时间、刻蚀电流、刻蚀剂浓度、捕捉剂浓度等实验参数和优化电化学模板的制作工艺 ,以规整的齿状结构为模板 ,在Cu的表面实现了三维微结构的复制加工 ,得到了与齿状结构模板互补的三维微结构 ,用SEM和AFM对实验结果进行了表征 ,表征结果证明约束刻蚀剂层技术在金属三维加工方面的可行性和潜在优势。金属Cu由于具有优良的导热导电性能以及很好的延展性 ,在微系统 (也称微机电系统 )中应用广泛 ,因此对Cu的刻蚀加工对微系统技术的发展具有重要的意义。约束刻蚀剂层技术 (ConfinedEtch antLayerTechnique简称CELT)作为一种新型的微加工技术[1] ,能够加工复制出复杂三维结构 ,到目前为止 ,该技术已成功应用于Si、GaAs等材料微结构的复制加工[2 ,3]

第十八届美国理论与应用力学大会总结

1会议概况2018年6月5—9日,第18届美国理论与应用力学大会(18th U.S. National Congress of Theoretical and Applied Mechanics, USNCTAM2018)在美国芝加哥召开.本次大会由美国力学国家委员会和中国力学学会联合主办,旨在探讨和交流近四年世界范围内在理论和应用力学领域的基础研究、创新技术的最新进展,吸引了来自世界各地的近千名专家学

Concentration protile of etchant measured by microelectrode technique in the process of chemical micromachining

A carbon-disk microelectrode was used to investigate the surface concentration profile of etchant Br-2, which was electrogenerated on the Pt working electrode. The steady state reducing currents of Br-2 at different distances away from the Pt electode was measured. The concentration profile was estimated from the current-distance variation curves as a function of different sampling times. Experimentally determined concentration profiles are in good agreement with those estimated from the microetching results. The microelectrode technique has offered a good method to choose suitable etching solution for chemical micromachining