The Investigation of the Signal Properties of Intermolecular Multiple-Quantum Coherences and Corresponding MRI Applications

分子间多量子相干(intermolecularMultipleQuantumCoherence，iMQC)是当前核磁共振领域的热点话题之一。本论文研究了分子间多量子相干信号性质，对iMQC理论进行了扩展，并将其应用于磁共振成像。主要成果如下： 一、本论文研究了化学交换体系的分子间多量子相干表观纵向弛豫行为，采用本小组提出的“量子¾经典”方法推导出其理论表达式。结果表明，在远程偶极场调制作用下，交换体系的纵向弛豫行为表现出与正常纵向弛豫行为不同的多指数特征；将分子间多量子相干技术与化学交换饱和转移效应相结合能够获得更好的成像对比度。 二、本论文将分子间二量子相干技术应用于当前较...Intermolecular multiple-quantum coherence (iMQC) phenomenon is a hot topic in the NMR field. In this thesis, the properties of iMQC signals and their applications are investigated. The results extend the previous iMQC theory and its applications, and are summarized as follows: 1. The apparent longitudinal relaxation behavior of iMQC in the slow chemical exchange system was investigated. ...学位：理学博士院系专业：物理与机电工程学院物理学系_无线电物理学号：1812005140303

引江济淮工程对派河水环境的影响

引江济淮工程是淮河流域水资源战略配置及巢湖和淮河水环境综合治理的重要措施,并列入国家加快推进的172项重大水利工程。引江济淮工程派河段是按照丰、枯水期严格设计的,派河水质不仅直接影响巢湖口的水质,还将间接影响淮河水质。结合派河现状水文、水质条件,采用明槽恒定均匀流公式预测了引江济淮工程对派河规划年水文情势的影响,预测结果表明:工程实施后,派河水位将升高1. 01～2. 32 mm,流速将增大0. 24～0. 33 m/s,流量将增大76～103 m3/s;采用一维稳态稀释、降解综合模型对工程实施后派河国控断面水质的变化进行预测,以枯、丰水期的污染物背景浓度值为基础,考虑了枯、丰水期输水方向的变化,水质预测结果表明工程实施后水质将有较大改善。国家科技重大专项水体污染控制与管理“清水廊道技术标准化与产业推广模式构建”(2017ZX07603-004-04

Advances in preparation of mesoporous silica nanoparticles and its use as different functional drug

近年来,有越来越多的文献报道关于介孔二氧化硅纳米粒（mesoporous silica nanoparticles,MSN）作药物载体的研究。本文结合近几年国内外的相关文献,介绍了由Mobli公司合成的M41S系列,圣巴巴拉大学合成的SBA系列,以及中空介孔二氧化硅纳米粒这3种最常见的MSN的特点及制备方法,并举例介绍了MSN作为药物速释载体的相关研究,同时从p H敏感型、热敏型、光响应型三方面介绍了MSN作为药物控释载体的研究。从相关研究结果可以看出,将MSN作为药物的载体,鉴于其独特的介孔孔径、可调节的纳米孔道结构、易于功能化修饰的表面等特点,可以实现对药物的速释、缓释及控释释放。由此可见,选择将MSN作为药物的载体具有广阔的应用前景。In the past a few years, mesoporous silica nanoparticles (MSN) have attracted more and more attention for their application in drug delivery. The recent relative literature was used for reference to introduce the characteristics and preparation of M41S series MSN (synthesized by Mobil Corporation), the SBA series MSN (synthesized by Santa Barbara University), and hollow mesoporous silica nanoparticles. Examples were presented to introduce the use of MSN as immediate drug delivery carrier. The use of MSN as controlled drug delivery carrier (CDDC) was illustrated via pH-responsive CDDC, temperature-sensitive CDDC, and light-triggered CDDC. MSN showed great properties in immediate/sustained/controlled drug delivery system, in view of their unique mesoporous pore diameter, adjustable nano-channel, and surface easily to be modified. The selection of MSN as drug carrier has a broad application prospect. ? 2017, Chinese Journal of New Drugs Co. Ltd. All right reserved.福建省科技计划重点项目（2013Y0074

Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system

研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.福建省科技计划重点资助项目（2013Y0074

The primary investigation of the value of whole body diffusion weighted imaging in diagnosis of metastatic tumor

背景与目的:随着临床上晚期肿瘤病例的增多,为了解治疗前、后全身转移瘤的大小及数量变化的实际情况,以往多采用分部位进行CT和(或)Mr扫描,少部分有条件的患者采用PET检查,但这些方法可能存在过多地暴露于射线、检查时间过长及经济负担过重等问题。因此,我们探讨磁共振的全身弥散加权成像(WHOlE bOdy dIffuSIOn WEIgHTEd IMAgIng,WbdWI)方法对肿瘤及转移灶的检出准确性及其临床应用的可行性。方法:对68例临床已发现原发肿瘤及多个转移灶或发现多个肿瘤病灶,但原发灶不明确的患者进行WbdWI检查,其中男性49例;女性19例。平均年龄61岁。68例均与CT和(或)MrI的检查结果进行比较,其中17例与PET的检查结果相比较。对病灶的检出率,以病灶长径大小分为:<1CM,≥1~<2CM,≥2~<3CM及≥3CM以上4组进行计数分析,同时,对不同部位间的病灶检出情况进行分析。结果:WbdWI对4组病灶的检出率分别为30%、78%、96%及100%。在各个部位的敏感性和准确性中以骨骼最高。对位于肺部小于1CM的病灶和位于颈部、盆腔小于2CM的淋巴结的诊断存在一定困难。结论:WbdWI对大范围的肿瘤病灶筛查是安全、简便、有效和经济的检查新方法。随着技术参数的进一步完善,WbdWI在发现和诊断全身多发肿瘤方面,具有良好的发展潜力。因此,本技术有望作为一种新的、效果好于PET的全身检查技术。Background and purpose:With the increased number of advanced tumors,it is important to evaluate the actual pre-and post-treatment changes in metastatic diseases,such as tumor size and tumor quantity.Previously,CT and/or MRI scan were usually applied,only a few patients could pay for PET(positron emition tomography).But there were several problems we should face,including redundantly exposure to radiation,too long verification time and heavy financial burden.Therefore we evaluated the application of whole body diffusion weighted imaging in diagnosing of tumor and metastatic tumor.Methods:sixty-eight patients(49 male,19 female,age from 29 to 84 years with mean age of 61 years) with a variety of tumors were investigated by combined CT and/or MRI scan,seventeen patients were compared with positron emition tomograph(PET).All tumors were classified into four groups,according to longest diameter of <1 cm,≥1-<2 cm,≥2-<3 cm and ≥3 cm.At the same time,the positive detection rates between different parts of the lesions were analyzed.Results:The detection rate of the four groups were 30%,78%,96% and 100%,respectively.The skeletal system had the highest sensitivity and accuracy in every part of body.There was difficulty in diagnosing lung cancer with longest diameter less than 1 cm as well as tumors located in neck and pelvic with longest diameter less than 2 cm.Conclusion:Whole body diffusion weighted imaging is secure,convenient,effective and economic for screening wide-ranging tumor focus.After improvement of parameters,WBDWI could be as a new effective whole body examination technique.厦门市科技计划项目(No:3502Z20074017

Damage to mangroves from extreme cold in early 2008 in southern China

通讯作者Author for correspondence (E-mail: [email protected])2008年初,我国南方19个省经历了50年一遇的持续低温雨雪冰冻天气。极端气候对华南沿海各省的红树林区造成不同程度的危害。2008年3月,在我国南方各省红树林区的10个代表性地点,对这次寒害造成的红树植物伤害程度进行了系统的调查。结果表明:冬季低温对红树林的影响极为显著,特别是在低纬度的海南、广西和广东湛江,由于极端低温正值夜间退潮,对红树林的影响更为显著;在纬度较高的福建,本地红树种类秋茄(Kandelia obovata)、桐花树(Aegiceras corniculatum)和白骨壤(Avicennia marina)及引种的木榄(Bruguiera gymnorrhiza)等,由于长期适应于冬季较低的气温或在种植前经过抗寒锻炼,具有较强的抗寒能力。各地主要红树植物中,广布种秋茄、桐花树和白骨壤最为耐寒,其耐寒性均大于红树科的木榄、海莲(Bruguiera sexangula)和红海榄(Rhizophora stylosa)。海桑(Sonneratia caseolaris)对温度的敏感性最强,抗寒能力最低,因此,即使在其原产地海南也受到较为严重的寒害,在纬度更高的引种地出现大面积受害甚至全部死亡,而从孟加拉国引种的无瓣海桑(Sonneratia apetala)却显示出一定的抗寒能力。同一地点的红树植物幼苗的抗寒能力低于大树。此次寒害也造成了苗圃场的种苗大量死亡,成熟的植株提前落花落果,这势必会影响后继一两年内红树林的自然更新和人工造林。因此,在未来红树林造林或人工引种中,一定要考虑到红树植物的抗寒能力。国家自然科学基金(30671646和30700092);厦门大学“闽江学者”启动基

China's Position in Intra-product Trade and Its Trade Direction:Evidence from Electronics

对中国电子机械类产品内贸易的实证研究表明,中国仍然处于产品生产的低端环节或价值链的低附加值部分,但已经出现产品生产环节或价值链环节的攀升现象。从贸易地理方向上看,中国电子机械类产品内贸易已经从明显的三角贸易模式逐步转为融入到全球生产网络体系中去,具有明显的全球价值分割的特征。鉴于全球产品内贸易的深入发展,欧美不断引发针对中国的贸易争端是不公正的。This paper investigates China's role in the international production in electronics empirically. The evidence shows that although China is still in the lower end of global value chains, the position of China is somehow improved. By analyzing its direction of foreign trade, the paper concludes that as far as electronics is concerned, China, used to be an assembly and export base of advanced Asian economies, is now more and more involved in the global production network. Due to the expansion of intra-product trade and China's special position in this process, quite a number of trade disputes among EU, US and China are misplaced.教育部人文社科重点研究基地重大项目(2006JDXM207);; 福建省高等学校社会科学研究项目(JA06004S)的部分研究成果

Experimental and Numerical Research on the Particles Movement in the Internally Circulating Fluidized Bed

通过冷态试验与数值模拟研究了不同布风下装有∧字型布风板的内旋流流化床的流动特性，并进行了对比．气固两相数值模拟结果表明，固相流场产生了大尺度旋流，而且与试验观察到的现象相似．对固相颗粒速度分析表明非均匀布风使内旋流流化床的底部和顶部产生了气、固两相强烈的横向和纵向运动．相比较来说，对称的非均匀布风扩散能力要比均匀布风的扩散能力强

A method for preparing interspecific hybrid seedlings between scallops and purple scallops in the Gulf of Mexico

本发明涉及经济海产贝类优良苗种制备技术领域，特别是一种可显著提高雌雄同体型扇贝种间杂交后代比例的墨西哥湾扇贝与紫扇贝种间杂交苗种制备方法。以连续选育墨西哥湾扇贝和紫扇贝的自交品系作为种贝；通过人工控制培育条件使两种贝性腺趋于同步成熟；催产紫扇贝种贝获得浓度大于106个/ml的高浓度精液；对上述性腺发育成熟的墨西哥湾扇贝种贝进行诱导催产，大量获得未受精或受精率低的卵子，将其与获得的紫扇贝高浓度精液进行种间杂交，规模化制备种间杂交一代苗种。本发明利用收集的大量墨西哥湾扇贝未受精或受精率低的卵，并用紫扇贝高浓度精液授精的方式进行种间杂交，该方法能够显著提高墨西哥湾扇贝和紫扇贝种间杂交效率