Application of Fuzzy Control in Intelligent Traffic Lights Monitoring System

为了解决拥挤的城市交通问题,针对交通灯监控系统中可变的交通状况,提出一种基于模糊算法的监控系统。应用模糊算法,通过模糊控制实现交通灯的控制,使道路通畅。对监控系统进行分析,合理选择模糊控制器的结构,根据动态的车流量,通过模糊算法分配当前车道的通行时间,并全面考虑同时通行的各种车道组合。该监控系统提高了车辆通行效率,使道路更为通畅。与传统的固定配时系统相比,它更适于当前纷繁复杂的交通状况。In order to solve the crowded transportation problem of cities,in view of the variable traffic condition in the traffic lights monitoring system,proposed to use the fuzzy algorithm and the fuzzy control to realize the control of the traffic lights.Making the analysis to the monitoring system,selected the fuzzy controller structure in reason.It assigned the pass time of each traffic lane through the fuzzy algorithm according to the dynamic volume of vehicle.In the paper it has considered all kinds of traffic lanes combination pass through in the same time.The monitoring system enhanced the efficiency of vehicles traffic,caused the path to be more unobstructed.Compared with the traditional fixed timing systems,it is more suitable to the complexity of current traffic conditions

Enantiomeric Separation of Mandelic Acid and Its Analogues by High Performance Liquid Chromatography with 2,6-Di-O-Pentyl-β-Cyclodextrin Coated Symmetry C_8 Column

利用合成的 2 ,6 二 O 戊基 β 环糊精涂渍SymmetryC8色谱柱 ,研究了扁桃酸及其类似物等 6种外消旋对映体的反相高效液相色谱拆分。优化了色谱分离条件 ,探讨了扁桃酸的手性拆分机理。结果表明 ,采用优化后的甲醇 水或甲醇 0 5 %三乙胺 乙酸缓冲液流动相等色谱条件 ,扁桃酸、扁桃酸甲酯、苯基甘氨酸、苯基琥珀酸和安息香等 5种外消旋对映体达到或接近基线分离 ,其中前 4种对映体均为 (S) 构型先出峰。该法可用于实际样品的对映体纯度测定。国家自然科学基金资助项目(Nｏ.20272048,203900505

睡眠相关痛性勃起发病相关风险的评估

目的睡眠相关痛性勃起（SRPE）是一种以夜间睡眠中反复被伴有疼痛的阴茎勃起中断而觉醒为临床特征的罕见睡眠障碍，目前病因尚不明确。本研究目的在于探讨可能相关的危险因素对SRPE的发病的影响。方法通过问卷调查的方式，我们对前来泌尿男科就诊的SRPE患者或非SRPE患者进行信息采集。通过Logistic回归分析评估年龄、职业、每晚睡眠开始时间、每周性交频率、心理状态、勃起功能障碍、慢性前列腺炎病史、前列腺增生病史、腰椎疾病史、中枢神经系统疾病史、 高血压病史、糖尿病病史及家族史等是否为SRPE发病的影响因素。结果290名受试者完成了研究，其中对照组145名，病例组145名。单因素Logistic回归分析发现，慢性前列腺炎病史、脑力劳动、职业、中枢神经系统疾病史、晚睡、性生活频率、焦虑状态可能与SRPE发病相关。将上述因素纳入到多因素回归分析模型中后发现，性生活≥2次/周（OR 95%CI = 0.326（0.179，0.592）及晚睡（24时后入睡）（OR 95%CI = 0.494（0.265，0.918）可能是SRPE的保护因素；慢性前列腺炎史（OR 95%CI = 3.779（2.082，6.859）可能是SRPE的危险因素。然而，中枢神经疾病史、职业影响在多因素分析中的统计学差异不显著。结论：慢性前列腺炎、 焦虑状态可能是SRPE的独立危险因素；性生活≥2次/周及适当地推迟睡眠时间可能是独立保护因素

Preparation of mesoporous silica nanoparticles in different pore size and its use in the solidification of sirolimus loaded self-microemulsifying drug delivery system

研究制备了不同孔径的介孔二氧化硅纳米粒及西罗莫司自微乳。使用扫描电镜、透射电镜、小角度X-射线衍射、氮气吸附-脱附表征制得的介孔二氧化硅纳米粒,发现其为有序的纳米孔道结构,孔径分别为6.3、8.1和10.8 nm,通过粒径测定仪测得西罗莫司自微乳粒径为20.6±1.3 nm。通过搅拌法制备载西罗莫司自微乳介孔二氧化硅纳米粒。研究发现,当西罗莫司自微乳与介孔二氧化硅纳米粒质量比2∶1时为最佳比例,载药量约为0.83%,且固体粉末流动性良好。采用差示扫描量热法表明,西罗莫司以非晶体或无定形存在于载体材料中,重分散性良好。孔径大小对于载西罗莫司自微乳介孔二氧化硅纳米粒在250 m L水中2 h的释放终点并没有显著影响,但对于最初40 min释放结果影响较大。综上,介孔二氧化硅纳米粒有望成为一种新型的自微乳吸附剂。The mesoporous silica nanoparticles (MSN) in different pore size and sirolimus (SRL) loaded self-microemulsifying drug delivery system (SMEDDS) were prepared. The results in morphology were collected by scanning electron microscope, transmission electron microscope, small-angle X-ray diffraction, and N2 adsorption-desorption. The results showed that the prepared MSN has ordered nanochannels with a pore size of 6.3, 8.1, 10.8 nm, respectively. The particle size of SRL-SMEDDS were measured by particle sizing system, which was 20.6 ± 1.3 nm. The stirring method was developed to prepare SRL-SMEDDS-MSN. It was found that the optimal ratio of SRL-SMEDDS to MSN was 2: 1, while the drug loading rate was near 0.83%, and the flow properties of SRL-SMEDDS-MSN were of good condition. The differential scanning calorimetry results proving a molecular or amorphous dispersed state of SRL in MSN while the suspension experiment has shown great reconstitution properties of SRL-SMEDDS-MSN. There is no significant influence on maximum drug release rate of different pore size of SRL-SMEDDS-MSN in 250 mL water within 2 h, while the results of the first 40 min have an obvious difference. Above all, MSN might provide a new strategy for the solidification of SMEDDS.福建省科技计划重点资助项目（2013Y0074

Study on the Relationship between Structure of Supramolecular Ion Material and Performance of Humidity Sensing

相对湿度是许多领域的关键参数，环境湿度与人们的生活密切相关，因此对湿度进行测量和控制是各个领域中值得关注的问题之一. 在前期的研究中，作者制备了一种新型的超分子离子材料（SIM），它是由基于咪唑的双阳离子（如1,10-双（3-甲基咪唑-1-基）癸烷，C10(mim)2）和电活性二阴离子（如2,2\'-连氮基-双（3-乙基苯并噻唑啉-6-磺酸），ABTS）组成的，发现其对湿度具有敏感且快速的响应. 在此基础上，本文制备了6种不同碳链（C4，C6，C8，C10，C12，C14）的咪唑基化合物，发现其中3种（C10，C12，C14）可与ABTS形成水稳定的SIM. 循环伏安法、计时电流法以及石英晶体微量天平表征了这些超分子离子材料的湿度传感性能，发现基于C12的SIM具有最佳的湿度传感性能. 同时，SEM结果显示随着碳链的增加，离子材料的厚度变薄并且形态变得不规则. 因此，作者认为疏水作用和材料比表面积均会影响湿度传感的灵敏度. 本研究为发展新的湿度响应的离子传感材料奠定了基础.Humidity measurement and control is one of the most notable issues in various areas, such as climate, industry, agriculture, electronics, especially human comfort and health. In our previous study, we have found that a new kind of supramolecular ionic material (SIM), consisting of an imidazolium-based dication (e.g., 1,10-bis(3-methylimidazolium-1-yl) decane, C10(mim)2) and electroactive dianionic (e.g., 2,2\'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid), ABTS), shows ultrasensitive and ultrafast response towards humidity sensing. Herein we prepared six kinds of imidazolium-based dications with different carbon chain lengths (i.e., C4, C6, C8, C10, C12, C14), and found that three of them (i.e., C10, C12, C14) could form water-stable SIM with ABTS. Cyclic voltammetry, chronoamperometry and quartz crystal microbalance were used to characterize the humidity sensing performance of these supramolecular ionic materials. The results show that the C12-based SIM has the best humidity sensing performance compared with the other two kinds of SIM. Moreover, SEM images show that the thickness of the ionic material became thinner with the increase of the carbon chain length. We, thus, conclude that both the hydrophobic interaction and the specific surface area of SIMs would contribute to the performance of humidity response. This paper would lay the foundation for the development of new ionic compound for humidity sensing.This research was supported by the National Natural Science Foundation of China (No. 21475138).作者联系地址：1. 湘潭大学化学学院，环境友好化学与应用教育部重点实验室，湖南 湘潭 411105；2. 北京分子科学国家实验室，中国科学院化学研究所活体分析化学重点实验室，北京 100190Author's Address: 1. Key Laboratory of Environmental Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, China; 2. Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, the Chinese Academy of Sciences, Beijing 100190, China通讯作者E-mail：[email protected]

毕赤酵母分泌表达嵌合HEV表位的HBcAg颗粒

在毕赤酵母分泌表达嵌合有HEV受体相关表位12A10的HBcAg蛋白,经甲醇诱导后的培养液上清通过切向流浓缩、更换缓冲液后,进行疏水层析纯化.CsCl等密度梯度离心测得分泌的重组颗粒的密度为1.32 g/mL.透射电镜观察显示,纯化的重组颗粒为均一的直径30 nm左右的空心颗粒.小鼠免疫实验表明,纯化颗粒免疫8周后鼠血清中的特异性12A10抗体滴度可达到1.6×105,并且重组颗粒较好地呈递了HEV受体相关的非免疫优势表位.本文的结果为毕赤酵母胞外分泌表达其它大尺度的重组蛋白颗粒提供了参考,为研究携带表位多肽的疫苗载体提供了范例

第十八届美国理论与应用力学大会总结

1会议概况2018年6月5—9日,第18届美国理论与应用力学大会(18th U.S. National Congress of Theoretical and Applied Mechanics, USNCTAM2018)在美国芝加哥召开.本次大会由美国力学国家委员会和中国力学学会联合主办,旨在探讨和交流近四年世界范围内在理论和应用力学领域的基础研究、创新技术的最新进展,吸引了来自世界各地的近千名专家学

关于“经济发展方式转变进程中的财税政策”的探讨(笔谈)

转变经济发展方式是当前中国的热门话题,而上海在城市发展中又肩负着率先转变的重要任务,在这一意义和背景下,2010年4月24日由上海金融学院学院主办、上海金融学院公共经济管理学院承办的“《中国城市财政发展报告2009/2010:促进‘两个中心’建设的上海城市财政》首发式暨‘经济发展方式转变进程中的财税政策’论坛“在我校举行。与会专家围绕经济发展方式转变进程中的财税政策的“趋势与目标“、“机遇和挑战“、“实施方略“和“地方实践“等四个专题进行研讨,各抒己见,智慧交锋。现将其真知灼见整理摘要与读者分享,以期待更多学者共同关注当前经济发展方式转变进程中的财税政策