Research on Life Distribution Model of Cancer Patients Under Random Censoring Life Test——based on the Survey of Tumor Patients in a Hospital in Fujian Province from 2003 to 2007

本文基于福建省某医院对2003-2007年肿瘤患者的调查,按住院人数统计,对顺位前三类癌症患者的寿命分布模型进行了研究。研究发现:(1)40-50岁是女性子宫肿瘤发病的高峰期,并且有逐年增长的趋势;(2)剔除女性患子宫肿瘤人数的影响,肿瘤发病的高峰期转移到60-70岁这个年龄段,表现出其它肿瘤多发于老年人,而且肺癌、胃癌、肝癌患者人数尤为突出;(3)肺癌、胃癌、肝癌患者的寿命分布属同一分布族,并且均能通过随机截尾数据下的H-P检验。Based on the survey of tumor patients in a hospital in Fujian Province from 2003 to 2007,this paper studied life distribution of cancer patients whose number is at top three.We find: Firstly,high-incidence period of uterine tumor is in 40 to 50 years old women,and incidence rate is increasing in recent years.Secondly,after removing the effect of uterine tumor,high-incidence period of the tumor is in 60 to 70 years old people and the number of patients suffering from lung cancer,gastric cancer,liver cancer are more than others.Lastly,the life distributions of lung cancer,gastric cancer and liver cancer belong to the same distribution family and the null hypothesis is not rejected by H-P test under random censored data.福建省自然科学基金计划项目“保险精算中修匀方法的研究及应用”(S0650038)的资

Nitrile-Modified 2,5-Di-tert-butyl-hydroquinones as Redox Shuttle Overcharge Additives for Lithium-Ion Batteries

Nitrile-modifled 2,5-di-tert-butyl-hydroquinones were synthesized and investigated as redox shuttle overcharge additives for LiFePO4/Li cells. The cyanoethylation reaction was utilized to synthesize the target molecules 2,5-di-tert-butyl-l,4-di（β-cyanoet

High temperature micro pressure sensor based on model identification

高温压力传感器应用在很多领域,由于高温将使放大电路工作失效,因而采用将放大电路与传感器件分离的设计方案是解决高温测量的方法之一。介绍一种将放大电路与传感器件分离的基于模型识别技术的微型电容式压力传感器。传感器件由MEMS工艺来实现,信号激励与信号处理由计算机来完成。对电路的工作过程进行了计算机仿真和试验,并给出了微型高温压力传感器的MEMS工艺设计流程。High temperature pressure sensor is applied in many fields. However, the amplifying circuit may be invalidate at high temperature. One way to solve this problem is to separate the amplifying circuit and sensor. A kind of high temperature micro pressure sensor based on model identification using this method is introduced, which is realized by MEMS process. Signal stimulation and disposal are accomplished by computer. The circuit is simulated and tested. And the MEMS process of the high temperature micro pressure sensor is designed

Hige Temperature Pressure Microsensor Based on Model Identification

【中文文摘】高温测量是急需解决的测量问题之一。介绍一种将放大电路与信号传感器件分离的基于模型识别技术的高温微型电容式压力传感器。电阻电容信号滤波网络和信号的模型识别组成一个微型传感系统,在对滤波网络进行激励和模型识别后就可以得到变化的电容值。这种MEMS技术制作的硅玻璃键合的电容式压力传感器,可以在小于300℃环境下工作。此高温测量系统既满足高精度测量的要求,也避免了在高温环境中进行信号放大的难题。 【英文文摘】Measuring in high temperature is a problem in dire need of sloving.A kind of high temperature capacitive pressure microsensor based on model identification is introduced.The microsensor is made of RC signal filter and signal model identification.Can get a capacitor after inspiring the filter and model identification.It can work in a condition less than 300 ℃ .The high temperature measuring system with high precision avoids the trouble of amplifying signal in high temperature

Research on the Financing Structure Design and Policies Suggestion to Promoting Private Enterprise to Participate in Comprehensive Watershed Management PPP Model

结合当前政府相关金融创新的鼓励政策,设计出民营企业参与流域综合治理PPP项目的三种融资方案,并进行优劣势的比较,认为民营企业参与PPP项目的最重要障碍是自身信用和融资能力。在上述基础上,提出在可以授予特许经营权抵押融资的前提下,政府及金融机构应给予民营企业鼓励与政策支持,共同参与流域综合治理PPP项目。Combined with the relevant government finance incentives policies, this paper designs three financing options for private enterprise to participate in the comprehensive watershed management PPP project, compares the advantages and disadvantages, and shows that the most important obstacle to private enterprise to participate in PPP projects is the own credit and financing capacity. Then, proposes that under finance franchise mortgage, financial institutions should give private enterprises encouragerment and policy support, and joint participation in the integrated watershed management PPP project

基于模型预测控制的光储发电系统VSG频率控制方法

随着光伏发电装机规模大幅提升，电力系统转动惯量不断降低，虚拟同步发电机（virtual synchronous generator，VSG）技术被广泛采用以应对日益严峻的电网稳定性问题。为进一步提高VSG技术对系统稳定性的改善作用，提出基于模型预测控制的VSG频率控制方法。该方法首先在同步发电机转子运动方程和逆变器下垂控制方程基础上建立VSG可优化的离散模型，再通过模型预测控制（model predictive control，MPC）预测VSG转子角频率的运动轨迹，并将最优的预测控制输入向量的第一项作为下一时刻控制器的反馈输入。将VSG转子角频率增量转化为转矩增量的反馈回路，实现对频率偏差的实时预测补偿，提升VSG并网逆变器的无差调频能力和运行性能。最后，在MATLAB软件上搭建含光储系统的时域仿真模型，验证了所提方法能更有效地抑制频率越限，减少系统频率的恢复时间

Study on Water Environmental Capacity of Reservoired River in Jiulong River Basin

针对九龙江流域湖库化问题,确定湖库化河段判定标准,提出综合电站的概念,基于大量的实测数据进行水质模型的降解系数值k参数率定,以此为基础,提出湖库化河段水环境容量计算方法,对九龙江流域湖库化后的水环境容量核算开展研究,确定了流域河流湖库化对水环境容量计算的影响,湖库化河段的水环境容量,为流域的水环境容量总量控制和管理、决策提供科学的依据.According to the problem of reservoired in Jiulong River basin,the judgment standard of reservoired river was determined,and the concept of integrate hydropower station was presented.Then,the parameter value of degradation coefficient K was calibrated with water quality model based on a large number of measured data of water quality.On this basis,calculation method of water environmental capacity for reservoired river was proposed.Finally,research was carried on water environmental capacity accounting of reservoired river in Jiulong River basin.The results show the effect of reservoired on water environmental capacity calculation,and the water environmental capacity of reservoired river,which provided scientific basis for the total emission control,management and decision-making of water environmental capacity in Jiulong River basin.福建省环保资助项目(ZLT0903); 福建省科技重大专项(2013YZ001-1

我国油料产业形势分析与发展对策

油料安全事关国计民生，保障油料有效供给是我国必须坚守的国家粮食安全底线。站在全球视角，对2011/2012—2020/2021年度我国油料供需形势、生产形势及市场形势进行分析，明确我国油料产业在生产、加工、贸易等方面面临的挑战，并针对性地提出了统一科学谋划与增强政策扶持精准度相结合，强化科技支撑与耕地资源保护相结合，提高农户油料种植收益与增强自然灾害抵御能力相结合，坚持大宗油料品牌建设与特色油料资源开发相结合，稳定当前农业合作伙伴关系与扩宽油料进口来源相结合，实施差异化市场监管与引导居民科学消费相结合等发展对策，以期为促进油料生产、保障植物油有效供给、降低植物油对外依存度，维护国家粮油安全提供参考。 Oilseed security is related to national economy and people′s livelihood, and ensuring the effective supply of oilseeds is the bottom line of national food security that China must adhere to. From a global perspective, the supply and demand situation, production situation and market situation of oilseeds in China for the period of 2011/2012-2020/2021 were analyzed, further the challenges faced by China′s oilseed industry in terms of production, processing and trade were clarified, and six development countermeasures ,including the combination of unifying scientific planning and enhancing the accuracy of policy support, the combination of strengthening scientific and technological support and protecting arable land resources, the combination of improving farmers′ income from oilseed planting and enhancing natural disaster resistance, the combination of insisting on the brand building of bulk oilseed and developing characteristic oilseed resource, the combination of stabilizing the current agricultural industry cooperative partnership and expanding sources of oilseed imports, and the combination of implementing differentiated market supervision and guiding residents′ scientific consumption,were put forward, in order to provide a reference for promoting oilseed production, ensuring effective supply of vegetable oil, reducing external dependence of vegetable oil and maintaining national food and oil security

中药多组分缓释制剂体外释放评价体系的研究进展

目的：为找到更适合中药多组分的评价方法提供思路。方法：以＂中药多组分＂＂体外释放＂＂同步释药＂＂多指标＂＂Synchronized＂＂Release in vitro＂＂TCM multicomponent＂＂Multi-index＂等为关键词,组合查询2004年1月-2016年6月在PubMed、Elsevier、Springer Link、中国知网、万方、维普等数据库中的相关文献,对中药已知成分作为评价指标、中药指纹图谱在药物体外释放中的应用,以及中药化合物组、吸波面积法、质量权重系数法等方法在中药多组分缓释制剂体外释放中的应用进行综述。结果与结论：共检索到相关文献210篇,其中有效文献42篇。对于成分复杂的中药制剂,溶出度的测定选择其中某种已知的指标成分进行;选择中药组分制剂中的一种或几种药效成分的释放度作为评价指标,可反映中药组分制剂中特定成分的释放特征;以指纹图谱相关峰为指标,可更全面地评价中药多组分缓释制剂的体外释放行为;选择中药多组分制剂中的几种有效成分并结合中药制剂的指纹图谱进行评价中药多组分制剂的释药行为,既可反映多个成分的含量变化,又可反映中药复方整体的含量变化;基于中药化合物组的整体谱特征,采用卡尔曼滤波法,计算获得溶出介质中化合物的含量,能很好地反映中药多组分的释药行为;吸波面积法能考察中药所有成分的释放情况,对复方药物溶出度及体内药动学的研究有指导意义;质量权重法可为中药组分的整体性研究提供参考,但必须明确各成分在整体组分中所占的质量权重系数才能整合反映整体性质。福建省自然科学基金资助项目（No.2015J01491

改良分子信标-双重实时荧光PCR快速检测SARS病毒

目的建立改良分子信标-双重实时荧光PCR检测SARS病毒的方法,用于SARS的早期诊断和动物溯源。方法利用改良分子信标技术、装甲RNA和双片段双色荧光技术,根据GenBank公布的SARS病毒聚合酶基因1b的阅读开放框架结构的保守序列,自行设计一对引物和探针,以部分临床标本的酶联吸附实验结果和传统细胞培养方法作为对照,建立分子信标检测SARS病毒的方法。对368份临床标本(咽漱液、血液、粪便、尿液)、52份细胞培养液和50份动物标本进行荧光PCR扩增。结果分子信标检测SARS病毒的方法灵敏度为10～100个拷贝ml,与流感病毒等呼吸道病毒无交叉反应。分子信标检测368份临床标本,20份阳性。其中确诊病例阳性率为21.27%(1047),确诊病例的咽漱液阳性率为43.48%,还分别从粪便和血清中检测到SARS病毒。52份细胞培养液,29份阳性,阳性率为55.77%。50份动物标本,23份阳性,阳性率为46%。结论改良分子信标-双重实时荧光PCR检测SARS病毒方法灵敏度高、特异性强,可用于SARS的临床早期诊断和动物溯源