Characteristics of Polymer Waveguide Sensor Based on Local Surface Plasmon Resonance

以SU-8光刻胶作为波导芯层材料,设计了基于金纳米粒子的局域表面等离子体共振(LSPR)波导传感器。根据Mie理论,建立了金纳米粒子的消光模型,理论分析了纳米粒子半径、待测物折射率等因素对局域表面等离子体共振曲线的影响。分析表明:当待测液体折射率增大时,LSPR共振峰的位置发生红移。随着金纳米粒子半径的逐渐增大,传感器灵敏度增加。共振吸收峰逐渐由单峰变为双峰,其中一个峰位于520 nm波长附近,主要由表面等离子体吸收造成;另一个峰随金纳米粒子半径的增大而逐渐红移,主要由表面等离子体散射造成。A SU-8 polymer waveguide sensor based on local surface plasmonresonance( LSPR) was designed. The extinction model of Au nanoparticles was established. Influence of Au nanoparticle'radius and refractive index of analyte on LSPR curve was analysized. The theoretical analysis results show that the resonance wavelengths of LSPR sensor move to longwave direction when the refractive index of the analyte increases. With the increasing of Au nanoparticles' radius,the sensitivity increases and the resonance absorption peak gradually changes from one peak to two peaks. One of the peaks locates near 520 nm wavelength,mainly caused by surface plasmon absorption. Another peak which is caused by surface plasmon scattering,moves to longwave direction gradually with the increasing of Au nanoparticles' radius.厦门大学校长基金(20720150086);; 国家自然科学基金(61107023);; 教育部博士点专项科研基金(20110121120020)资助项

Analysis of the Incipient Failure During Outburst of Coal and Gas

针对煤矿煤与瓦斯突出动力现象的复杂过程,对突出启动前煤体的初次破坏特征进行了分析。特别是对影响突出发生的煤体初次破坏的几何特征以及层裂拱壳形成的力学原理,通过简化的力学模型做了分析,同时讨论了影响初次破坏特性的主要因素,包括与不同煤体结构相适应的煤体材料不同破坏准则的影响。为进一步认识煤与瓦斯突出的机理,突出的启动、发展演化提供一种思路,进而为突出的预测和防治提供基础

浅议高等院校非经营性国有资产评估

目前,资产评估主要涉及非国有资产以及经营性国有资产评估,很少涉及非经营性国有资产评估。一直以来,对于非经营性国有资产的管理都很宽松,这也导致了非经营性国有资产管理中存在许多漏洞和问题。高等院校的非经营性国有资产一般都是由财政划拨,但是,对于高校非经营性国有资产一直缺乏监督,所以,现在高校国有资产的管理存在许多问题,迫切需要得到解决。对高校非经营性国有资产进行资产评估,不但有助于高校非经营性国有资产的规范化管理,而且还将有助于财政制度的建设。文章主要论述对高校非经营性国有资产进行评估的必要性

New Image Interpolation Method Based on Ramp Edge Model

基于斜坡边缘模型的经典插值方法把所有边缘归为强边缘,导致弱边缘过分增强而失真。针对该问题提出基于斜坡边缘模型的图像插值新方法(nIIbrEd),对强弱边缘采用不同方法,考虑边缘宽度随图像放大而增大的情况,对放大图像进行修复。实验结果证明,nIIbrEd使放大图像的边缘更自然且清晰,取得了更好的纹理效果。Classical interpolation method based on ramp edge model considers all the edges as strong edges,which results in weak edges' distortion.Aiming at this problem,a New Image Interpolation method Based on Ramp EDge model(NIIBRED) is proposed,which uses different methods for strong edges and weak edges.This method considers that the edges generated in the enlarged image do not have the same width,and reconstructs the enlarged image.Experimental results show that NIIBRED can make the enlarged image's edges more natural and clearer,and obtain better texture effects.国家自然科学基金资助项目(60472081);航空科学基金资助项目(05F07001

Induction of IL-6 and IL-8 on U937 cell by ricin

目的 :进一步研究蓖麻毒素是否具有诱生U937细胞分泌细胞因子的作用。方法 :采用MTT法检测了蓖麻毒素对U937细胞的毒性 ,并采用ELISA法测定细胞培养上清中的IL 6和IL 8。结果 :蓖麻毒素对U937细胞的毒性具有时间效应和剂量效应。随着作用时间的延长 ,诱生 2种细胞因子的量逐渐增加 ;随蓖麻毒素剂量的增加 ,诱生 2种细胞因子的量均减少。结论 :蓖麻毒素诱导 2种细胞因子的产生为其抗癌应用或其它作用提供理论依据。Objective:Ricin is a glycoprotein from ricinus communis seeds.In order to study induction of cytokine by ricin.Methods:The toxicity has been detected by MTT method and production of IL 6 and IL 8 has been detected by Kit.Results:It showed that the toxicity of ricin for U937 cell has time responses and dose responses. Both of cytokines have increased as the time is prolonged.Conclusion: Production of cytokines may have a role in the pathogenesis of ricin toxic effect and anticancer.国家自然科学基金!资助 (No .3950 0 1 2 2

优化预测运动矢量的快速运动估计算法

提出了一种优化预测运动矢量的快速运动估计算法.在对预测运动矢量研究的基础上,根据序列图像中运动矢量的中心-中值偏置分布特性和矢量间的时空相关性,结合运动矢量的相似度分析,选用中心、中值和时间相关的三个矢量作为基本预测矢量.设置相似门限来减少由三个空间相邻块预测矢量带来的大量冗余信息,对算法中关键的门限技术进行了改进.实验结果证明,本文算法对各种类型的运动序列都有很强的自适应性,在保持搜索准确度的同时,可大幅度提高运动估计的速度,其平均搜索速度是FS的208倍,明显优于PMVFAST的146倍、MVFAST的77倍、DS的55倍,提高了视频压缩中现有的运动估计算法的性能. (A new Optimizing Predictive Motion Vector Fast Motion Estimation Algorithm (OPM-VFMEA) is proposed. Based on the center-median-biased distributed characteristic of the motion vector of real-world sequences and the high space-time correlation of adjacent block's motion vector, combined with similar analysis of the motion vectors, the center, median, forward vector are selected as the basic predictive motion vector to predict the current one, then the similar threshold is set to reduce the redundant information from the three space adjacent block motion vectors. In addition, the adaptive threshold to enable half-stop is also represented. Experiment results show that the algorithm is able to adapt to all types of video sequences and can offer a high performance of PSNR. The search speed of the algorithm is faster than that of the existing well-known algorithms. For case examined, it is about 208 times faster than that of FS in average, which is superior to that of 146 times for PMV-FAST, 77 times for MVFAST and 55 times for DS. Therefore, the algorithm improves the performance of existing motion estimation algorithms.)国家自然科学基金资助项目(No.60472081);航空科学基金资助项目(No.05F07001

Determination of 19 Organophosphorous Pesticides Residues in Milk Drink and Milk Powder by Gas Chromatography-Negative Chemical Ionization-Mass Spectrometry

将气相色谱-负离子化学源质谱法(GC-NCIMS)应用于牛奶饮品和奶粉中19种有机磷农药残留的同时分析。牛奶饮品和奶粉经乙腈提取剂超声提取、Florisil硅藻土和中性氧化铝双净化剂同时净化及正己烷-乙酸乙酯(体积比1∶1)混合洗脱剂洗脱后,以三苯基磷酸酯为内标物,采用GC-NCI MS的选择离子监测方式(SIM)定性与定量分析。当牛奶饮品和奶粉的加标浓度水平为20、100、500μg/kg时,平均加标回收率为64.5%~129%,相对标准偏差为2%~20%;除喹硫磷的方法检出限(MDL)为2.4μg/kg外,其余18种有机磷农药的MDL均小于1.0μg/kg;线性范围为10~500μg/kg,相关系数均大于0.9988,此分析方法成功地应用于牛奶饮品和奶粉中多种痕量有机磷农药残留的分析。A rapid method was developed for the determination of 19 organophosphorous pesticides residues in commercial milk drink and milk powder.Under optimized conditions,the pesticides were extracted from milk drink or milk powder with acetonitrile in an ultrasonic bath and cleaned up on a Florisil and neutral alumina column,and were determined by gas chromatography with negative chemical ionization mass spectrometric detection in the selected ion monitoring mode with triphenyl phosphate as internal standard.The recoveries for all the pesticides studied ranged from 64.5% to 129% with a relative standard deviation range of 2%-20%.The detection limit of the method was less than 1.0 μg/kg for most of the pesticides except for the quinolphos.The linear ranges of the calibration curves ranged from 10 μg/kg to 500 μg/kg with correlation coefficients of 0.998 8.The proposed method was successfully applied to the analysis of these compounds in milk drink and milk powder

塞克硝唑片治疗滴虫阴道炎的随机对照多中心临床研究

【目的】评价口服塞克硝唑片治疗滴虫阴道炎的有效性和安全性。【方法】采用多中心、随机双盲、平行对照设计，入选滴虫阴道炎患者144例，塞克硝唑片组与替硝唑片组各72例，对其临床疗效和滴虫清除率进行比较，并观察用药后不良事件和实验室检查异常的发生情况。【结果】用药后塞克硝唑片组痊愈率和有效率分别为61％和94％；替硝唑片组痊愈率和有效率分别为51％和94％，两组之间比较差异无统计学意义（P〉0．05）。塞克硝唑片组滴虫清除率为96％；替硝唑片组滴虫清除率为97％，两组比较差异无统计学意义（P〉0．05）。144例病例中无不良事件与严重不良事件发生；塞克硝唑片组实验室检查异常发生率为0，替硝唑片组实验室检查异常发生率为4％，两组之间比较差异无统计学意义（P〉0．05）。【结论】口服塞克硝唑片治疗滴虫阴道炎安全、有效

类泛素蛋白及其中文命名

泛素家族包括泛素及类泛素蛋白,约20种成员蛋白.近年来,泛素家族领域取得了迅猛发展,并已与生物学及医学研究的各个领域相互交叉.泛素家族介导的蛋白质降解和细胞自噬机制的发现分别于2004和2016年获得诺贝尔奖.但是,类泛素蛋白并没有统一规范的中文译名. 2018年4月9日在苏州召开的《泛素家族介导的蛋白质降解和细胞自噬》专著的编委会上,部分作者讨论了类泛素蛋白的中文命名问题,并在随后的\"泛素家族、自噬与疾病\"(Ubiquitinfamily,autophagy anddiseases)苏州会议上提出了类泛素蛋白中文翻译草案,此草案在参加该会议的国内学者及海外华人学者间取得了高度共识.冷泉港亚洲\"泛素家族、自噬与疾病\"苏州会议是由美国冷泉港实验室主办、两年一度、面向全球的英文会议.该会议在海内外华人学者中具有广泛影响,因此,参会华人学者的意见具有一定的代表性.本文介绍了10个类别的类泛素蛋白的中文命名,系统总结了它们的结构特点,并比较了参与各种类泛素化修饰的酶和它们的生物学功能.文章由45名从事该领域研究的专家合作撰写,其中包括中国工程院院士1名,相关学者4名,长江学者3名,国家杰出青年科学基金获得者18名和美国知名高校华人教授4名.他们绝大多数是参加编写即将由科学出版社出版的专著《泛素家族介导的蛋白质降解和细胞自噬》的专家

Determination of Five Polybrominated Diphenyl Ether Residues in Deep-Sea Fish Oil Using Gas Chromatography-Negative Chemical Ionization/Mass Spectrometry

建立了气相色谱-负离子化学电离质谱法(GC-NCI/MS)同时分析深海鱼油食品中5种多溴联苯醚残留的分析方法。深海鱼油食品用正己烷超声提取、中性与酸性硅胶色谱柱净化和正己烷洗脱后,以PCB103为内标物,采用GC-NCI/MS的选择离子监测方式(SIM)分析;同时探讨了5种多溴联苯醚的NCI/MS特征离子的断裂机理。当空白深海鱼油食品的加标浓度为20.0和100.0μg/kg时,加标回收率为88.6%-111.3%,相对标准偏差为3.8%-13.5%,方法的检测限为0.77-1.34μg/kg,线性范围为1.0-500.0μg/kg,相关系数均大于0.999 2。此方法已成功地应用于深海鱼油食品中5种痕量多溴联苯醚残留的同时分析。Polybrominated diphenyl ethers(PBDEs) are a kind of brominated flame retardants(BFRs),which refer to compounds used in some plastics to impede or even suppress the combustion process.As the emission or disposal of plastics,PBDE residues have been found in both environment and biota.In this work,an analytical method was developed for the simultaneous determination of 5 PBDE residues in deep-sea fish oil.PBDEs were extracted from deep-sea fish oil with n-hexane,cleaned up on a silical gel column,and determined by using gas chromatography-negative chemical ionization/mass spectrometry(GC-NCI/MS) in the selected ion-monitoring(SIM) mode,with PCB103 as the internal standard.Meanwhile,the characteristic ion and fragmentation mechanism of some PBDEs in NCI/MS were evaluated.Recovery studies were performed at 20.0 and 100.0 μg/kg fortification levels for each PBDE,and the recoveries ranged from 88.6% to 111.3% with relative standard deviations between 3.8% and 13.5% for different PBDEs.The limits of detection(LOD) were from 0.77 to 1.34 μg/kg for different PBDEs.The developed method was linear over the range assayed,1.0-500.0 μg/kg,with correlation coefficients larger than 0.999 2.The developed method has also been successfully applied to the determination of PBDEs in several deep-sea fish oil samples and the three most abundant PBDEs(PBDE-47,PBDE-99 and PBDE-100) were found