Research on facial spectrum and color characteristics of five-zang disease status

目的:观察疾病状态人群面色光谱色度情况,为疾病状态五脏病评价提供可供依据。方法:采用日产柯尼卡美能达CM-2600d分光测色仪,观测健康组(183例)、疾病组(370例)额部、眉间部、鼻部、下颏、左右颧部、左右眼胞8处明亮度l、红光度A、黄光度b、饱和度C值及波长段(400~700nM)下的面色反射率值等指标,并据中医理论对疾病状态进行五脏病位分析。结果:疾病组l值显著低于健康组,b、C值均显著高于健康组;疾病组各波长段下反射率显著低于健康状态组(P<0.05)。疾病组除左右眼胞外的6个位点间的l、A、b、C值有显著性差异(P<0.05),不同点位有其特异性的色度变化特征。疾病组五脏病各组光谱色度特征比较有显著差异(P<0.05),结果与中医面部脏腑五色理论在一定程度上相符合。结论:运用光谱色度测定方法,可以作为诊断疾病状态五脏病的重要指标。Objective: To observe disease status facial spectrum and color,providing good quantitative basis for disease assessment.Methods: We gathered the facial color information in health(183) and disease groups(370) including L,a,b,C values and reflection of different wavelengths in 400-700nm with CM-2600D spectral photometric color measuring instrument on 8 points including frontal part,glabellas nose,mandible two cheeks and eye cells and analysized disease status five-zang positioning according to the principle of TCM syndrome differentiation.Results: L value of Disease group was lower than health status group and b,C values were higher than health status group,reflection of different wavelengths of disease group were lower than health group(P<0.05).6 points in disease group between loci L,a,b,C values with varying degrees of significant differences(P<0.05).Different point had its own specificity facial complexion variation characteristics.Facial spectrum and color of each five-zang disease group had significant difference through comparion of facial complexion.To a certain extent the result was consistent with TCM facial organs Five-color theory.Conclusion: There existed diagnostic value in distinguishing five-zang disease status in some degree by spectral photometric color measuring technique.国家科技支撑计划(No.2012BAI37B06);国家高技术研究发展计划(863计划)资助项目(No.2008AA02Z407);国家自然科学基金资助项目(No.30873463;No.81173200);国家自然基金青年项目(No.81102558);上海市重点学科(第三期)建设项目(No.S30302;No.S30303)---

磷酸盐氧同位素在有机磷降解研究中的应用

磷的有机化合物广泛分布于土壤和水体中,发挥着重要作用的同时,也给环境带来潜在的污染。研究有机磷化合物的磷循环过程对于防控磷的污染有着重要作用。磷酸盐中的氧同位素作为一种地球化学的示踪剂,近年来被广泛应用于研究磷在自然界中的循环过程。本文总结了磷酸盐中氧同位素的应用原理以及其在有机磷降解和溯源方面的应用,并在此基础上展望本领域下一步的工作重点。中国国家自然科学基金(41173113);;中国环保部公益项目(201509049

A PZT/Si composite transducer for resonant ultrasound spectroscope

提出并设计了一种应用于超声共振检测的PZT/Si复合材料圆片换能器。该换能器是将一小硅片粘贴在PZT压电片上复合而成,硅片中心已有一个应用MEMS技术加工制造的倒金字塔小坑。这使得待测样品很容易安装在超声共振谱检测的平台上,并能提高测量的精确度。文中利用ANSYS对该换能器和单独PZT-4压电片换能器进行比较分析,得出了不同结构在相同电压和外力作用下产生的静态位移结果以及共振频率,并讨论了复合结构参数对换能器工作灵敏度的影响。结果表明,复合换能器的灵敏度仅降低4%~4.8%,可以应用在超声共振谱检测中。In this paper,a PZT/Si composite transducer for resonant ultrasound spectroscope(RUS) measurement is proposed and designed.This composite transducer is made of a PZT piezoelectric disk,where a tiny silicon piece is adhered in its centre.For the silicon piece,a pyramid pit is fabricated by using MEMS technology.By using this composite transducer with a central pyramid pit,the tested sample is easily amounted to RUS stage and measurement accuracy can be improved.In the paper,we use finite element method in ANSYS to analyze the performance of composite transducer,and compare it with that of single PZT plate piezoelectric transducer.The results show that the sensitivity of composite transducer decreases only by 4%~4.8% and can be used in RUS measurement.厦门大学引进人才启动基金资

水飞蓟素固体分散体的制备及5种成分的溶出度

目的制备水飞蓟素固体分散体,并评价5种成分的溶出度。方法以F68与PVPk30为联合载体,溶剂熔融法制备固体分散体。再考察联合载体比例、药物-载体比例对水飞蓟宾、异水飞蓟宾、水飞蓟宁、水飞蓟亭、花旗松素溶出度的影响。结果最佳条件为联合载体比例1∶3,药物-载体比例1∶5。固体分散体中5种成分的溶出度显著高于原料药和物理混合物(水飞蓟素-载体)中。结论固体分散体可显著提高水飞蓟素中有效成分的溶出度。福建省自然科学基金项目(2015J01491

Literature Research on TCM Syndromes Distribution Characteristics of Menopausal Syndrome

目的研究围绝经综合征的中医证候分布特点,为规范本病的诊断和治疗提供依据。方法检索中国期刊全文数据库、中文科技期刊数据库、中国生物医学文献数据库、中国中医药数据库、万方数据资源系统1991-2011年发表的有关围绝经期综合征文献,进行文献整理分析。结果纳入分析文献191篇。围绝经期综合征常见中医证候有49个,其中肝肾阴虚、肾阳虚、肾阴虚、肾阴阳两虚、心肾不交、肝郁气滞、脾肾阳虚最多见;提取常见症状共65个,包括月经紊乱、头晕耳鸣、失眠、烘热汗出、腰膝酸软、心悸、易怒、纳呆等;病位以肾、心、肝、脾为主;病性以虚为主;脉象以细数、沉细、弦细为主,舌象以舌淡或舌红,苔薄或少苔为主。结论围绝经期综合征的中医证候分布比较集中,本研究为下一步临床科研工作奠定了基础。Objective To analyze TCM syndromes distribution characteristics of menopausal syndrome,provide evidence for further research.Methods The articles related to menopausal syndrome in CNKI Chinese Academic Journal database,Chinese Science and Technology Journal database,China Biological Medicine database,Chinese medicine database,Wanfang database during 1991-2011 were retrieved and analyzed.Results A total of 191 articles were included in the analysis,49 syndromes were found in menopausal syndrome,in which the common syndromes were liver and kidney yin deficiency,kidney yang deficiency,kidney yin deficiency,kidney yin and yang deficiency,heart and kidney deficiency,liver depression,spleen and kidney yang deficiency.We extracted a total of 65 common symptoms,including menstrual disorders,dizziness and tinnitus,insomnia,hot flashes sweeting,waist and knees,palpitations,irritability,poor appetite and so on.The common positions were kidney,heart,liver and spleen.The common disease characteristic was the deficiency-based.The common pulse were fine rapid,sunken fine,string-like fine.The common tongue were pale or red,the tongue fur were mainly moss thin or less moss.Conclusion The menopausal syndrome of TCM syndromes distribution characteristics were more concentrated,and this research laid a foundation for further clinical research work.国家高技术研究发展计划(2008AA02Z407);国家自然科学基金(30873463);上海市重点学科项目(S30302、S30303

基于多组分评价的雷公藤提取物固体分散体的制备及体外表征

目的制备雷公藤提取物(ETW)固体分散体(ETW-SD),提高其体外溶出度。方法通过溶剂-熔融法,以聚乙二醇6000(PEG 6000)、泊洛沙姆188(F68)为载体制备ETW-SD。以雷公藤甲素、雷公藤内酯酮、雷公藤次碱、雷公藤红素以及雷公藤内酯甲为评价指标,通过体外溶出度、电子扫描电镜(SEM)、差示热量扫描(DSC)和X-射线衍射(XRD)对ETW-SD进行表征。结果 ETW-SD的最优处方为ETW-PEG 6000-F68(1∶2∶1)。与原料药相比,在60 min内雷公藤内酯酮、雷公藤甲素的溶出度分别提高了3.32倍,雷公藤次碱提高了2倍,而雷公藤红素和雷公藤内酯甲的溶出度均达到83%以上。福州总医院院立课题(2016L02);;福建省科技计划重大项目(2012I1001

雷公藤减毒增效工艺的研究进展

目的:为更安全使用雷公藤提供参考。方法:检索中国知网,从制备工艺上对雷公藤减毒增效的技术手段进行文献综述。结果:雷公藤减毒增效的制备工艺主要有传统的炮制减毒、超临界流体萃取技术和加压溶剂提取技术。制剂新技术制备的如胃漂浮缓释片、微乳凝胶等均能明显缓解患者的不良反应,减毒效果明显。结论:不同的制备方法可为研究更加安全有效的雷公藤制剂提供理论依据。福建省科技计划项目(No.2012I1001

小潮气量机械通气期间肺开放策略对肺损伤标志物的影响

【目的】探索外科手术中小潮气量机械通气期间应用间断肺复张手法（RM）联合中等水平呼气末正压（PEEP）构成的肺开放策略（OLS）对血浆中肺损伤标志物晚期糖基化终产物可溶性受体（sRAGE）及Clara细胞蛋白（CC16）浓度的影响。【方法】本研究纳入行择期腹腔镜结直肠癌切除术的患者100例，随机（1∶1）分为开放策略组（OLS）和非开放策略（NOLS）组。两组均使用小潮气量机械通气；OLS组机械通气期间间断给予RM并设置PEEP为6~8cmH2O，NOLS组不予RM及PEEP。麻醉诱导前（T1）、术毕后即刻（T2）及术后第3天（T3）分别取血检测血浆sRAGE、CC16浓度。【结果】在T1、T2、T33个时间点，血浆sRAGE、CC16浓度组间均无统计学差异（>0.05）。所有患者中，T2、T3sRAGE浓度高于T1，T3sRAGE浓度高于T2，T3CC16浓度高于T1、T2，均有统计学差异（<0.05）。【结论】术中小潮气量机械通气期间，应用间断RM联合中等水平PEEP的肺开放策略不能改变术后三天内血浆肺损伤标志物sRAGE和CC16的水平

三维CT影像资料测量国人心尖区心肌变薄的解剖学验证

背景:在常规心脏三维CT成像检查中可见国人心脏心尖部心肌存在变薄的影像改变,但未见文献报道。认识该影像征象的相关解剖及影像特征,可为临床相关学科的应用及研究提供客观基础。目的:确定国人心尖区心肌最薄点的存在,测量其厚度及位置关系。方法:解剖学观察12个体外心脏标本并利用游标卡尺测量心尖部最薄点厚度及左室心肌最厚处的厚度。选取2009-01/12在厦门大学附属中山医院CT室进行检查的69例无明确心脏疾患患者的三维CT资料,利用三维成像技术显示心尖部结构。测量心尖最薄点、左室心肌最厚处的厚度及心尖最薄点至冠状动脉前降支的距离。结果与结论:解剖学观察显示体外心脏标本心尖部存在心肌变薄区,厚度为(1.74±0.32)mm,左室心肌最厚处为(13.07±1.48)mm;三维CT可清楚显示心尖部心肌最薄区,厚度为(1.27±0.31)mm,左室心肌最厚处为(12.02±1.66)mm;心尖部最薄点到左冠状动脉前降支的距离为(13.70±3.78)mm。统计结果显示解剖学心尖部最薄点厚度与三维CT测量值差异有显著性意义(P<0.05)。结果证实国人心尖区心肌变薄是一种正常解剖结构,标本解剖学及活体三维CT影像学均可清楚显示