职业生涯规划教育提高学生学习素质的理念与途径

随着高等教育规模扩大,毕业生就业竞争日益激烈,大学生职业生涯规划教育越来越受到广大教育者和学生的关注。但是如何完善职业生涯规划教育,满足大学生和社会需求是一个严峻的课题,该文就职业生涯规划教育提高学生学习素质的理念和途径进行了初步探讨。福建省教育厅B类社会科学研究项目(JBS09102

Biological mechanism underlying the formation of greasy fur

腻苔是一种临床常见的病理性舌苔,主湿浊、痰饮、食积等,在中医临床诊断与治疗中有重要的临床意义与辨证价值,研究腻苔形成的现代生物学机制有重要的理论; 和实践意义。文章从舌表面脱落细胞学、微生态学、相关蛋白与基因表达及物质代谢等方面对腻苔形成的生物学机制进行了综述,并对腻苔与肠道微生态的关系,腻; 苔与现代医学疾病的关系进行了阐述,以期从现代生物医学角度对腻苔形成的物质基础、发生机制、变化规律及与相关疾病的关系作相关阐明,为疾病的中医诊断与; 治疗提供借鉴和帮助。Greasy fur is a common pathological tongue coating and is mainly seen in; the clinical practice in traditional Chinese medicine (TCM), such as in; the dampness turbidity, the phlegm and fluid retention, the dyspepsia or; food accumulation, and so on. Greasy fur shows important clinical; significance and differentiation value in TCM diagnosis and treatment,; there is also great theoretical and practical significance in the; studying of the modern biomedical mechanism underlying the formation of; the greasy fur. Here we summarized the formation mechanism of the greasy; fur from the aspects of the shedding cytology of the tongue surface, the; microecology, the expression of the relative genes and proteins and the; metabolism. The relationship between the greasy fur and the intestinal; microecology, and between the greasy fur and the diseases were also; discussed in this paper. Through summarizing these related research; literatures, we want to elucidate the material basis, the occurrence; mechanism and the changing rules of the greasy fur from the perspective; of the modern biomedicine, and to elucidate its relationship with some; related modern medicine diseases, thus to provide references and; assistance for the disease diagnosis and treatment in TCM clinic.国家重点研发计划重点专项; 教育部新世纪优秀人才支持计划; 国家自然科学基金项

Forward Osmosis Membrane Principle and Its Application Were Reviewed

正向渗透是一项新型的利用半透膜两侧溶液渗透压差作为驱动力的膜分离技术。文章介绍了正向渗透膜分离技术的原理和影响因素,对其在各个领域(包括海水淡化、废水处理、橙汁浓缩、水袋)的研究进展进行了综述。现有的研究表明,可用于正向渗透工艺的膜不同于常规的反渗透膜,需要从膜结构开发适合的膜组件;采用nH3和CO2制备提取液是目前研究中具有应用前途的方式之一,具有产水率高且易于分离浓缩的优点。Forward osmosis(FO) is a novel membrane separation technique which utilizes osmotic pressure differential as the driving force and themechanism features of forward osmosis process are introduced.The research progress in seawater desalination,orange juice concentrate,wastewater treatment,water bag is also reviewed.The research shows that FO membrane is different from RO membrane.Appropriate FO membrane should be developed by consideration of the membrane structure.The processing ammonia and carbon dioxide to prepare draw solution is one of the most promising processes,because of the high water flux and being easily separated

CDK5-dependent BAG3 degradation modulates synaptic protein turnover

阿尔茨海默病（AD）是严重威胁人类健康的重大神经系统疾病，AD的发生发展与衰老密切相关，目前临床治疗方法十分有限。因此迫切需要从AD致病早期入手，发现和鉴定导致AD神经功能紊乱的机制和靶点，为AD的早期防治提供基础。张杰教授及其团队从高通量磷酸化蛋白质组学入手，系统研究了CDK5在神经细胞中的磷酸化底物，鉴定出了在蛋白质量控制中发挥重要功能的BAG3蛋白是CDK5的全新底物。课题组从磷酸化蛋白质组学入手，发现和阐明了细胞周期蛋白激酶5（CDK5）通过调控BAG3在维持突触蛋白水平调控中的作用机制，及其在阿尔茨海默病（AD）发生发展中的机理。 该研究是多个团队历时8年合作完成的，香港中文大学的周熙文教授、美国匹兹堡大学的Karl Herrup教授、美国Sanford-Burnham研究所的许华曦教授、美国梅奥医学中心的卜国军教授，厦门大学医学院的文磊教授、张云武教授、赵颖俊教授、薛茂强教授，军事医学科学院的袁增强教授等都参与了该工作。 厦门大学医学院2012级博士生周杰超等为文章的第一作者，张杰教授为通讯作者。Background Synaptic protein dyshomeostasis and functional loss is an early invariant feature of Alzheimer’s disease (AD), yet the unifying etiological pathway remains largely unknown. Knowing that cyclin-dependent kinase 5 (CDK5) plays critical roles in synaptic formation and degeneration, its phosphorylation targets were re-examined in search for candidates with direct global impacts on synaptic protein dynamics, and the associated regulatory network was also analyzed. Methods Quantitative phospho-proteomics and bioinformatics analyses were performed to identify top-ranked candidates. A series of biochemical assays were used to investigate the associated regulatory signaling networks. Histological, electrochemical and behavioral assays were performed in conditional knockout, shRNA-mediated knockdown and AD-related mice models to evaluate its relevance to synaptic homeostasis and functions. Results Among candidates with known implications in synaptic modulations, BCL2-associated athanogene-3 (BAG3) ranked the highest. CDK5-mediated phosphorylation on Ser297/Ser291 (Mouse/Human) destabilized BAG3. Loss of BAG3 unleashed the selective protein degradative function of the HSP70 machinery. In neurons, this resulted in enhanced degradation of a number of glutamatergic synaptic proteins. Conditional neuronal knockout of Bag3 in vivo led to impairment of learning and memory functions. In human AD and related-mouse models, aberrant CDK5-mediated loss of BAG3 yielded similar effects on synaptic homeostasis. Detrimental effects of BAG3 loss on learning and memory functions were confirmed in these mice, and such were reversed by ectopic BAG3 re-expression. Conclusions Our results highlight that neuronal CDK5-BAG3-HSP70 signaling axis plays a critical role in modulating synaptic homeostasis. Dysregulation of the signaling pathway directly contributes to synaptic dysfunction and AD pathogenesis.This work was supported by the National Science Foundation in China (Grant: 31571055, 81522016, 81271421 to J.Z.; 81801337 to L.L; 81774377 and 81373999 to L.W.); Fundamental Research Funds for the Central Universities of China-Xiamen University (Grant: 20720150062, 20720180049 and 20720160075 to J.Z.); Fundamental Research Funds for Fujian Province University Leading Talents (Grant JAT170003 to L.L); Hong Kong Research Grants Council (HKUST12/CRF/13G, GRF660813, GRF16101315, AoE/M-05/12 to K.H.; GRF16103317, GRF16100718 and GRF16100219 to H.-M,C.); Offices of Provost, VPRG and Dean of Science, HKUST (VPRGO12SC02 to K.H.); Chinese University of Hong Kong (CUHK) Improvement on Competitiveness in Hiring New Faculty Funding Scheme (Ref. 133), CUHK Faculty Startup Fund and Alzheimer’s Association Research Fellowship (AARF-17-531566) to H.-M, C. 该研究受到了国家自然科学基金、厦门大学校长基金、福建省卫生教育联合攻关基金等的资助

自适应FFT软件包的分析

FFT算法在计算机科学中具有广泛的应用，自适应FFT软件包，以其良好的可移植性而备受研究人员和用户的青睐，本文通过对FFTW，UHFFT，SPIRAL这三个不同的自适应FFT软件包详细的分析，分别介绍了这三个软件包的结构和特点。通过对这三个软件包的对比，为用户了解和选择使用自适应FFT软件包提供了借鉴。文章在最后总结了目前自适应FFT软件包的一般方法，为下一步开发自适应FFT软件包提供了思路。中国计算机学

基于多模干涉器的三维模式转换分束器的设计

采用三维结构光子器件可以实现多维度的空分复用,即并行处理多路信号,从而增加传输容量,提高集成密度。文章根据三维多模干涉耦合器的自成像原理,设计了一种易于集成的三维模式转换分束器。该分束器可以将输入的基模光场转换为3个基模光场和3个一阶模光场输出。用聚合物材料设计并优化得到多模波导的长、宽和高分别为3 398.17、50.00和29.37μm。模拟结果显示,在1 550nm波长时的总传输效率为85.5%,其中基模输出光场的传输效率为28.9%,最大不均衡性为0.010dB;一阶模输出光场的转换效率为56.6%,最大不均衡性为0.004dB

异构平台上基于OpenCL的FFT实现与优化

快速傅立叶变换作为20世纪公认的最重要的基础算法之一,在大规模科学计算处理、数字信号处理、图形图像仿真等众多领域有着广泛的应用。OpenCL是首个面向异构系统通用的并行编程标准,为软件开发人员提供了统一的面向异构系统的并行编程环境。首先,在异构平台Cell和GPU上使用OpenCL实现了基于2的幂一维FFT,并对其进行了测试和分析,在Cell平台上当数据规模适中时它能够达到SDK性能的65%,当数据规模继续增大时,相对性能有所降低。此外,针对Nvidia Fermi平台,手工调优了小因子的FFT,使其性能接近于CUFFT的140%

混合固态发酵降解甘蔗渣产糖产乙醇研究

The effects of fermentation and direct conversion of ethanol were investigated by single and mixed culture of Trichoderma reesei CICC40359 and Penicillium decumbens LSM-1 with sugarcane bagasse. Fungi biomass, total sugars concentration, enzyme solid-sta

The invention relates to a Zn2 + selective microelectrode applied to a non-destructive micrometric system and a preparation method thereof

本发明涉及一种微电极，特别是一种应用于非损伤微测系统的Zn2+选择性微电极及其制备方法。电极包括锥形玻璃微电极管，锥形玻璃微电极管腔内填充有膜后灌充液，锥形玻璃微电极管尖端部注有Zn2+液态离子交换剂LIX，电极通过Ag/AgCl丝与非损伤微测系统连接。本发明通过非损伤微测系统可以实现对被测样品表面微观区域Zn2+浓度、流速及其运动方向等信息的实时、动态、无损检测，为生物和非生物材料表面Zn2+的微观过程和机制研究提供新的方法