Pharmaceutical Consultation Practice for One Case of Rapidly by Growing Mycobacteria Bloodstream Infections

目的：探讨快速生长分枝杆菌血流感染的诊治方法。方法：通过1例骨折术后快速生长分枝杆菌血流感染的两次会诊实践,对治疗过程中不同阶段需要考虑的药物治疗问题进行总结分析。结果：第一次会诊,根据患者的血药浓度和肌酐清除率,优化了万古霉素给药剂量。第二次会诊,在患者症状和检验结果明显好转情况下,建议医生积极针对快速生长分枝杆菌进行抗感染治疗。建议停用抗结核药,改为克拉霉素联用阿米卡星后,患者病情好转出院。结论：对手术部位疑似、确诊快速生长分枝杆菌感染的病例,积极的干预和正确的诊治是成功的关键。Objective： To investigate the diagnosis and treatment of rapidly growing mycobacteria bloodstream infections. Meth- ods： Based on the two pharmaceutical consultation practice for one case of rapidly growing mycobacteria bloodstream infections after fracture operation, the paper summarized and analyzed the problems in different stages of treatment. Results ： The first consultation op- timized the dosage of vancomycin according to the patient- serum concentration and creatinine clearance rate. The second consultation suggested doctors actively perform anti-infection treatment for rapidly growing mycobacteria after the patient＇ s clinical symptoms and ex- amination results were improved significantly. It is recommended to withdraw anti TB drugs, and the use of clarithromycin combined with amikacin was suitable. The patient was discharged with improved health conditions. Conclusion： Positive intervention and correct diagnosis are the keys for the successful treatment of suspected or definite mycobacteria infection in surgical sites.解放军第一七五医院2016年青年苗圃课题（编号：16Y023

连续电解抛光工艺优化前后的钼丝性能比较

通过对比实验对钼丝的连续电解抛光液及工艺参数进行了优化,并研究连续电解抛光工艺优化前后钼丝的相关性能.结果表明,工艺优化后的钼丝表面形成了连续均匀的氧化膜,整体缺陷减少,表面平整度得到较大的改善,同时抗拉强度、显微硬度、耐蚀性、抗氧化性也有所提高,综合性能明显优于传统工艺得到的钼丝性能

Effects of benzo(a)pyrene exposure on aryl hydrocarbon hydroxylase activities in the liver of Boleophthalmus pectinirostris

研究了苯并 (a)芘 (BaP)胁迫下大弹涂鱼肝脏芳烃羟化酶 (AHH)活性的变化 ,结果显示 :BaP对大弹涂鱼肝脏AHH活性总体表现为显著的诱导作用 (P <0 .0 1) ,其中BaP暴露的浓度及时间是影响AHH活性的重要因素。 0 .0 5mg·L-1浓度的BaP暴露对AHH活性无显著影响 ,而 0 .2mg·L-1和 0 .5mg·L-1浓度组AHH活性则显著被诱导 (P <0 .0 1)。随着暴污时间的延长 ,0 .2mg·L-1浓度组AHH活性被显著诱导 (P <0 .0 1) ,而 0 .5mg·L-1组AHH活性则相对稳定。对AHH活性变化的剂量 效应关系进行回归分析的结果表明 ,0 .5mg·L-1浓度组暴露 7d时 ,AHH活性受到一定程度的抑制。污染解除后 ,0 .5mg·L-1浓度组AHH活性显著降低 ,恢复至与对照组相近 ,表明大弹涂鱼肝脏仍具有较强的生理调节机能 ,同时也表明AHH活性可及时反映环境中BaP的水平。以上这些结果表明AHH适于作为大弹涂鱼受BaP胁迫的生物指标。Changes of aryl hydrocarbon hydroxylase(AHH) activities in the liver of Boleophthalmus pectinirostris with benzo(a)pyrene(BaP) exposure were detected in experimental condition. The results showed that the activities of AHH were significantly induced by BaP(P<0.01). Factors including BaP concentration and exposure time had important effect on AHH activities. The activities of AHH decreased to the control level after BaP was removed. It turned out that the physiological modulatary mechanism was still exist in the liver of B. pectinirostris and the activities of AHH could reflect the level of BaP in the environment. All of the results showed that AHH was suitable to be the bioindicator of BaP exposure.国家自然科学基金资助项目 ( 4 9876 0 2 9

兰索拉唑肠溶微丸胶囊的制备

目的:制备兰索拉唑肠溶微丸胶囊。方法:采用流化床包衣技术,在空白丸芯上依次包以主药层、隔离层和肠溶层,制备成兰索拉唑肠溶微丸,将肠溶微丸装入普通胶囊制成兰索拉唑肠溶微丸胶囊,并考察3批制剂的载药率及在人工肠液和人工胃液中的释放情况。结果:所制微丸圆整度高,外观亮泽,载药均匀、载药率高(平均值在96%以上),包衣效果好;其在人工肠液中45min的体外累积释放率大于(94.3±0.76)%,在人工胃液中2h的释放量小于(6.2±1.6)%。结论:所制兰索拉唑肠溶微丸胶囊工艺可行,重现性良好,质量稳定可靠,具有良好的体外释药性和耐酸力

中国大学章程——应运而生吗?

出生、存活、长大,十岁、五十岁、一百岁,中国大学终于开始补办出生证了。对于一所高等学府来说,章程犹如“宪法“,不仅承载着大学精神、彰显着大学使命,更是大学作为一个社会组织运行发展的制度屏障,规制着高等教育内外部的活动边界和发展准则。近年来,国家开始大力推进大学章程的创建工作,以使其成为构建现代大学制度建设、实施依法治校的基本保障。目前,教育部率先核准了中国人民大学、东南大学、东华大学、上海外国语大学、武汉理工大学和华中师范大学六所高校的章程,这是

疫苗市场概况和发展趋势

疫苗是公共卫生领域最大的成就之一,疫苗的接种是预防和控制传染病最经济有效的手段。目前,全球共批准预防性疫苗77种,用于预防41种疾病。全球疫苗市场总额近年来稳步增长,2017年达到277亿美元。国际疫苗四大巨头葛兰素史克、默沙东、辉瑞和赛诺菲巴斯德在不断的并购整合下,占据全球90%的销售额。我国疫苗市场发展迅速,2017年市场总额达224亿元,且疫苗品种不断丰富。但我国疫苗产业水平与发达国家仍存在明显差距。需加大疫苗研究投入、合理布局、完善监管制度以推动技术创新,实现我国从疫苗大国迈向疫苗强国

金属矿千米深井高应力特性岩爆发生规律与防治措施研究

针对大红山铁矿进入千米深井开采后,在巷道、竖井和大断面硐室的基建开挖过 程中发生的多次不同程度的岩爆动力地压现象等严重的地压灾害问题,首先对千米深部 采区的高地应力特性进行了研究,得到了其深部高地应力处于超过亚临界深度的状态,但 还没有达到临界深度的总体评价结果;其次采用模糊综合评价法获得了不同岩性在不同 埋深的岩爆倾向性,得到了深部采区岩体总体上具有中等岩爆倾向性,在最深-40 m 水 平的局部,大理岩、片岩和磁铁矿的岩爆倾向性趋于强烈的结论;其次全面统计了基建过 程中发生的岩爆案例,获得了岩爆发生与埋深、地应力、岩性等的关系与规律,得到了岩爆 数量随埋深的增加呈指数关系增加的规律;最后提出了易爆岩层巷道与硐室的岩爆动力 地压灾害的防护措施.国家自然科学基金项目（51674218）国家重点研发计划项目（016YFC0600702）

社会系统工程与国家治理体系现代化

2014年3月30日,中国人民大学国家发展与战略研究院社会系统工程研究中心成立暨“社会系统工程与国家治理体系现代化“学术研讨会在中国人民大学逸夫会堂第一会议室举行,来自十余所高校和学术团体的专家、学者和一些媒体的代表参加了会议。现把会议主要发言内容选载如下

Proteomic Analysis of Rice Cultivar Jiafuzhan in the Responses to Xanthomonas campestris pv.oryzicola Infection

作者简介: 陈芳育(1978-) , 男, 讲师。E-mail : cfy307@ sohu. com * 通讯作者(Corresponding author) : 陈亮( 1963-) , 男, 教授, 博士生导师, 研究方向: 细胞与分子生物学。E-mail: chenlg@ xmu. edu. cn[中文文摘]运用双向电泳分析高抗水稻品种“佳辐占”受强毒力细菌性条斑病病原菌侵染2d后的叶片蛋白质组变化,共发现38个蛋白质发生差异表达,其中32个上调,5个下调,1个新增。用MALDI-TOF-MS分析和数据库检索鉴定出其中的33个差异表达蛋白质,并将它们分为4个功能类群,即信号转导相关蛋白、防卫相关蛋白、代谢相关蛋白和蛋白质稳定相关蛋白。这些蛋白分别参与了信号识别、信号传递、抗氧化、糖代谢、细胞壁加固、植保素合成等抗病生理反应。研究表明,水稻对细菌性条斑病病原菌的侵染存在着一个复杂的抗病信号应答和代谢调控网络,其作用机理可以通过差异表达的蛋白质(酶)反映出来,其中差异表达的8个R蛋白和3个PR蛋白可能与水稻对细菌性条斑病的抗病性密切相关。本研究为进一步揭示水稻对细菌性条斑病的抗性机理及相关抗病基因的功能克隆提供了依据。[英文文摘]Rice bacterial leaf streak( BLS) caused by the pathogen Xanthomonas oryzae pv. oryzicola ( Xooc) is one of the major rice diseases in South China. Here we focus on proteomics as a tool for the discovery of differentially expressed proteins closely related to the disease resistance. The leaves of rice cultivar Jiafuzhan (Oryzae sativa L. ) highly resistant to the disease, were infected by"89773-1- 1" strain of the Xooc with strong pathogenicity. Total proteins were extracted from the leaves sampled at two days after inoculation, and separated by two- dimensional electrophoresis. It was found that there were thirty- eight proteins expressed differentially, of which thirty-two were up-regulated, five down-regulated and one was "new". Of the thirty- eight responsive proteins, thirty-three were identified by MALD-I TOF-MS and database searching.Based on the predicted function, we grouped them into four clusters: signal transduction, defensive responses, substance metabolism and protein stabilization, which were involved in many resistant physiological react ions, including signal recognition and transduction, antioxidant react ion, carbonhydrate metabolism, cel-l wall reinforcement and phytoalexin biosythesis. In turn a complex signal transduct ion and metabolic regulative network in the resistant responses to the infection of Xooc was outlined in this work, and the molecular mechanism was revealed by differentially expressed protein/enzyme patterns during Xooc infection. In this study, eight R proteins and three pathogenesis- related(PR) proteins which might relate closely to the disease-resistance were found. This result provides us the basic information to further reveal the resistant mechanism and conduct functional cloning of the resistan-t related genes in rice to BLS.生物农药与化学生物学教育部重点实验室( 福建农林大学) 开放课题基金项目( KF0411

一种被动采样器

本实用新型公开了一种被动采样器。它包括上盖板、固定支架、固定器和不锈钢皿，所述的固定器由上方的环形固定板和下方的打孔支撑板组成，打孔支撑板上固定有不锈钢皿，不锈钢皿的上方开口与环形固定板内的环形孔相适应并固定连接，不锈钢皿的开口处固定遮盖有一层不锈钢网，不锈钢皿底板为石英滤膜底板，所述的上盖板、环形固定板和打孔支撑板三者通过若干根固定杆固定连接，所述的不锈钢皿中填充有石英棉层，所述的固定支架与上盖板固定连接。本实用新型的被动采样器可以捕集大气干沉降颗粒物，该大气干沉降颗粒物可以用于测定样品的OC/EC比值(碳组份表征)，同时分离捕集对应CO2产物，用于14C分析