Clinical Observation on Zaoshu Yinchen Prescription in the Treatment of Nonalcoholic Steatohepatitis

目的探究皂术茵陈方治疗非酒精性脂肪性肝炎的临床效果。方法选择我院2015年5月—2016年2月非酒精性脂肪性肝炎患者132例,随机分组。西医治疗组采用多烯磷脂酰胆碱治疗;皂术茵陈组在西医治疗组基础上给予皂术茵陈方治疗。比较两组患者非酒精性脂肪性肝炎治疗效果;治疗前后丙氨酸氨基转移酶、门冬氨酸氨基转移酶、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇;不良反应发生率。结果皂术茵陈组患者非酒精性脂肪性肝炎治疗效果比西医治疗组高,P〈0.05;皂术茵陈组治疗前后丙氨酸氨基转移酶、门冬氨酸氨基转移酶、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇比西医治疗组好,P〈0.05;两组患者均未出现严重不良反应。结论皂术茵陈方治疗非酒精性脂肪性肝炎的临床效果确切,可有效改善患者病情和肝功能、血脂指标,无明显不良作用,值得推广。Objective To investigate the clinical effect of Zaoshu Yinchen prescription in the treatment of nonalcoholic steatohepatitis. Methods 132 cases of patients with nonalcoholic steatohep＇atitis in our hospital from May 2015 to February 2016 were randomly divided into two groups. The Western medicine treatment group was treated with polyene phosphatidyl choline. The Zaoshu Yinchen group was treated with Zaoshu Yinchen prescription on the basis of Western medicine treatment group. The therapeutic effect, alanine aminotransferase, aspartate aminotransferase, low density lipoprotein cholesterol, high density lipoprotein cholesterol before and after treatment and the incidence of adverse reaction was compared, respectively. Results The therapeutic effect of Zaoshu Yinchen group was higher than that of Western medicine group P 〈 0.05. After treatment, alanine aminotransferase, aspartate aminotransferase, low density lipoprotein cholesterol, high density lipoprotein cholesterol of Zaoshn Yinchen group better than that of Western medicine group P 〈 0.05. There were no serious adverse reactions between two groups. Conclusion The Zaoshu Yinehen prescription in the treatment of nonalcoholic steatohepatitis has exactly clinical effect, can effectively improve the patient＇ s condition and liver function, blood fat index, has no obvious side effects, and is worthy of promotion

The Influence of Team Conflict and Organizational Justice on Counterproductive Work Behavior

反生产行为在职场中随处可见，如消极怠工、迟到旷工、蓄意破坏等，这些负面的工作行为对组织以及其他员工的利益造成巨大损害，严重阻碍了组织的正常运营和发展。如何对员工的反生产行为进行有效地预防和管理？这是考验众多管理者的难题之一，也是近几年管理学界的一个热点研究议题。 本文以中国企事业的团队为研究对象，探讨团队冲突对反生产行为的影响，并分析组织公平感在二者关系中所起的中介作用，以及检验心理资本在团队冲突和反生产行为之间的调节作用。研究采用问卷调查法，共收集到274个样本，并运用SPSS17.0和AMOS20.0统计软件完成量表分析和假设检验。研究结论归纳如下： 1.团队冲突与反生产行为正相关，其...Counterproductive work behavior (CWB) can be seen everywhere in the workplace, such as sabotage, absenteeism, sabotage, etc., these negative work behaviors have caused great damage to the interests of the organization and employees, seriously hindered the normal operation of the organization. How to prevent and manage the employees’ CWBs effectively has become a test problem to both managers and r...学位：管理学硕士院系专业：管理学院_企业管理(含财务管理、市场营销、人力资源管理)学号：1762011115129

The Performance and Origins of Individualism and Collectivism ——A Comparison of the Cultures between China and the United States

价值观是文化的一个重要的组成部分，而个人主义和集体主义是价值观体系的核心内容之一，如何理解中美两国价值观在个人主义和集体主义上的差异表现，受到了国内外许多学者的关注。本文通过分析学者们的定义，探讨了集体主义和个人主义在中美两国的差异表现和产生的根源，并对有效避免文化冲突提出了建议。 回顾一些学者的研究，我们发现，部分中国学者在进行中西文化对比时，采用的是二元对立的比较方式，同时也有一些学者关注到了两种不同文化之间存在的共性。 本文尝试着避免二元对立、采取多样化认识视角的原则，对集体主义和个人主义在中美两国的差异表现以及产生差异的根源进行了探索。本文认为，影响差异的根源主要有三个方面，一是人...Value is a core component of culture, and individualism and collectivism are at the core of values. How should we understand the different performances of individualism and collectivism in the values of China and the United States? This question has attracted the attention of many scholars both at home and aboard. This dissertation analyzes the definitions of individualism and collectivism given b...学位：文学硕士院系专业：外文学院英语语言文学系_英语语言文学学号：1202007115267

Correlation between Voice Handicap Index-10(VHI-10) and Voice Acoustic Analysis in Patients with Unilateral Arytenoid Dislocation

目的探讨嗓音声学分析与简化嗓音障碍指数(voice handicap index-10,VHI-10)用于单侧环杓关节脱位患者嗓音质量评估的临床意义及其相关性。方法对36例(男性20例,女性16例)单侧环杓关节脱位患者和50例(男性25例,女性25例)嗓音正常者进行嗓音声学分析和VHI-10调查。嗓音声学参数包括基频微扰(jitter)、振幅微扰(shimmer)、基频(F0)和噪谐比(NHR);VHI-10调查记录总分值Tvh。结果 (1)单侧环杓关节脱位组的jitter、shimmer、NHR、F0和VHI-10与对照组比较差异均有统计学意义。(2)男性单侧环杓关节脱位组患者嗓音声学分析参数jitter、shimmer、NHR和F0与VHI-10之间无相关性;女性患者组,除F0与VHI-10之间无相关性外,其余3个jitter、shimmer、NHR与VHI-10之间均有相关性,相关系数分别为0.556,0.719和0.793。结论计算机声学分析的各项参数均可作为衡量单侧环杓关节脱位患者嗓音音质的有效参数。单侧环杓关节脱位对患者生活质量具有显著影响,且不同性别的患者其生活质量所受影响的程度不同。Objective To study the relationship between voice acoustic analysis(VAA)and voice handicap index-10(VHI-10) in patients with unilateral arytenoid dislocation and to investigate the characteristic of the VHI-10. Methods 50 subjects with normal voice and 36 patients with unilateral arytenoid dislocation were tested by VAA and VHI-10. VAA include jitter、shimmer、F0 and NHR. The total score of VHI-10 recorded as Tvh. Results(1)There were significant differences in jitter、shimmer、F0、NHR and VHI-10 between unilateral arytenoid dislocation group and control group.(2)There was no correlation between all acoustic parameters and VHI-10 in male. All acoustic parameters except F0 had significant correlations with VHI-10 in female and the correlation coefficient were 0.556, 0.556 and 0.719. Conclusion The acoustic parameters are effective parameters to measure the voice quality of patients with unilateral arytenoid dislocation. Unilateral arytenoid dislocation significantly affects the quality of life in patients. However, the different of sex will result in the effect on the quality of life in patients inconsistently.国家自然科学基金资助项目(No.81371080

海洋来源放线菌HN-E31次生代谢产物的分离与鉴定

利用反相硅胶柱色谱、Sephadex LH-20凝胶柱色谱、半制备高效液相色谱等分离方法,对采自中国南海的鸟氨酸微菌属放线菌HN-E31发酵液乙酸乙酯萃取部位的化学成分进行分离研究,通过1H NMR、13C NMR和质谱等波谱技术,并参照相关文献数据,对化合物进行结构鉴定。结果共分离得到了12个化合物,分别鉴定为:环(脯-缬)二肽(1)、环(脯-亮)二肽(2)、环(脯-异亮)二肽(3)、环(脯-苯丙)二肽(4)、环(亮-丙)二肽(5)、环(异亮-丙)二肽(6)、苯丙氨酸(7)、3-hydroxyacetyl-indole(8)、3-吲哚甲醛(9)、水杨酸(10)、尿嘧啶(11)和对羟基苯甲醛(12)。上述化合物均为首次从鸟氨酸微菌属放线菌中分离获得。国家自然科学基金项目(31201969);;厦门市海洋与渔业局科研项目(17GYY008NF04)~

Electrochemical Impedance Spectroscopic Studies of the First Lithiation of Si/C Composite Electrode

采用球磨法制备了SI/C复合材料,X射线衍射(Xrd)和扫描电子显微镜(SEM)测试结果显示SI/C复合材料中硅保持着良好的晶体结构且均匀的分散于炭黑基体中.充放电测试结果表明SI/C复合材料首次放电容量高达3393 MAH/g,4周之后可逆容量均保持在1000 MAH/g左右,表现出较好的循环性能.电化学阻抗谱测试结果显示,SI/C复合材料电极在首次嵌锂过程中分别出现了代表接触阻抗、固体电解质相界面界面膜(SEI膜)阻抗、电荷传递阻抗和相变阻抗的圆弧,并详细分析了它们的变化规律.The Si/C composite materials were prepared by ball milling method,and characterized by X-ray diffraction(XRD) and scanning electron microscopy(SEM).The result displayed that Si in the Si/C com-posite materials still maintained a good crystal structure and uniformly dispersed in carbon black matrix.The first discharge capacity was 3393 mAh/g,and 4 cycles later still retained 1000 mAh/g,showing better charge-discharge cycle performance.Electrochemical impedance spectroscopy test indicated that there ap-peared three semicircles respectively representing the impedance of contact problems,solid electrolyte in-terface film(SEI film),charge transfer and phase transformation in the first lithiation,and their evolutive principles were also investigated.中央高校基本科研业务费专项资金(Nos.2010LKHX03;2010QNB04;2010QNB05);中国矿业大学科技攀登计划(No.ON090237);江苏省普通高校研究生科研创新计划(No.CX10B_153Z)资助项

Essence of tongue diagnosis of HE Meng-yao

岭南,指中国五岭以南的地区,相当于现在广东、广西及海南全境。因气候炎热潮湿,人群多脾胃虚弱,病多阳虚、痰湿。从晋代以后,当地医家以中原医学为基础; ,结合岭南特殊气候和人群体质特点,逐渐形成独具风格的岭南医学流派。何梦瑶作为岭南名医之一,其医术高明,医学著作颇丰,极大地促进了岭南医学的发展。; 《医碥》是其代表作之一,亦是其学术思想的精髓,为现代研究何梦瑶学术思想和岭南医家流派的主要古籍。其中所记载的舌诊方法,至今仍具有临床实用意义。Lingnan, Chinese refers to the south of the five ridges area, which is; equivalent to the current Guangdong province, Guangxi province and; Hainan province. All due to the hot and humid climate, majority of local; people are with spleen and stomach deficiency, most of the clinical; manifestation are yang deficiency and dampness. After the Jin dynasty,; based on the traditional Chinese medicine of central plains, the local; doctors gradually formed their unique medical schools, combining with; the characteristics of the local climate and peoples constitutions. As; one of the famous specialists in the south of the five ridges, HE; Meng-yao, greatly promote the development of local medical health level.; Yibian is one of his famous masterpieces, which is also the essence of; the his medicine. Records of tongue diagnosis in this book are still; practical in clinical.国家自然科学基金资助项目; 福建中医药大学校管课题; 福建省科技计划引导性项

皂术茵陈方治疗非酒精性脂肪性肝炎的临床观察及其对肠道菌群的影响

目的评价皂术茵陈方调节肠道菌群治疗非酒精性脂肪性肝炎(NASH)的临床疗效及其作用机制。方法选取福建中医药大学附属厦门市中医院肝病中心门诊就诊的NASH患者80例,采用随机数字表法分为治疗组(40例)和对照组(40例)。治疗组予中药皂术茵陈方治疗,对照组予以枯草杆菌二联活菌肠溶胶囊治疗,两组疗程均为12周。评价治疗前后两组患者的症状、体征积分以及血清ALT、AST活性;检测两组患者血清内毒素水平以及肠道菌群变化。结果治疗12周后,治疗组的临床总有效率达87.5%(35/40),较之对照组的65%(26/40)有统计学意义(χ~2=7.966,P<0.05);两组患者ALT、AST活性以及血清内毒素水平较治疗前均有明显下降(P<0.05),且以治疗组的ALT、AST活性下降值大于对照组(t=2.254,t=2.325,P<0.05);两组患者肠道菌群中的双歧杆菌、乳酸杆菌、拟杆菌数量较治疗前显著升高,而肠球菌、肠杆菌显著降低(P<0.05)。结论皂术茵陈方具有改善肝功能、治疗NASH的临床疗效,其作用机制与调节肠道菌群紊乱、恢复肠道微生态平衡、减轻肠源性内毒素血症相关。国家自然青年科学基金资助项目(No.81503529);;福建中医药大学临床专项校管课题基金(No.XB2016080

Clinical Research of Kangshi Kangxian Recipe Treating on Hepatic Fibrosis of Chronic Hepatitis B

目的观察康氏抗纤方治疗慢性乙型肝炎肝纤维化的临床疗效,探讨其对肝组织N-花生四烯酸氨基乙醇(; arachidonoylethanolamine,AEA) 、2-花生四烯酸甘油( 2-arachidonoylglycerol,2-AG); 、大麻素受体1( cannabinoid receptor 1,CBR1) mRNA、大麻素受体2( cannabinoid receptor; 1,CBR2); mRNA含量变化的影响。方法将110例慢性乙型肝炎肝纤维化患者按随机数字表法分为治疗组和对照组,每组55例。治疗组予中药康氏抗纤方联合恩替卡韦分; 散片治疗,对照组用恩替卡韦分散片单药治疗,两组均治疗48周。判定两组临床疗效,检测血清ALT水平,HBV; DNA、HBsAg、HBsAb定量,肝组织病理、肝硬度变化,肝组织AEA、 2-AG含量和CBR1、CBR2; mRNA表达水平。结果与对照组比较,治疗组的临床总有效率、HBsAg阴转率、肝组织纤维化分期疗效有效率均高于对照组(chi~2 =; 4.453,4.152,6.364,均P < 0.05); 。与本组治疗前比较,治疗后两组患者肝纤维化瞬时弹性测定值、AEA、2-AG含量及CBR1、CBR2 mRNA表达均降低(均P <; 0.05),且治疗组降低更明显(均P < 0.05); 。肝组织病理显示:治疗后治疗组肝小叶结构基本完整,肝细胞轻度水样变性,汇管区纤维组织无增生,局部少量淋巴细胞浸润,炎症及纤维化较对照组明显改善。; 结论康氏抗纤方具有提高慢性乙型肝炎肝纤维化患者的临床总有效率、HBsAg阴转率、肝组织纤维化分期疗效有效率,其作用机制可能与调节内源性大麻素系统; 有关。Objective To observe the clinical effect of Kangshi Kangxian Decoction (; KSKXD) in treating on patients of hepatic fibrosis of chronic hepatitis; B ( CHB),and to explore the mechanisms of KSKXD by regulating the; contents of arachidonoylethanolamine ( AEA),2-arachidonoylglycerol (; 2-AG),cannabinoid receptor 1 ( CBR1 mRNA) and cannabinoid receptor 2 (; CBR2 mRNA) in the liver tissue. Methods Totally 110 patients with; hepatic fibrosis of CHB were assigned to the treatment group and the; control group according to random digit table,55 cases in each group.; The treatment group was treated with Chinese herb KSKXD combined with; Entecavir,and the control group was treated with Entecavir. Both of the; two groups were treated for 48 weeks. The clinical efficacy of the two; groups was determined. The serum ALT levels,HBV DNA, HBsAg and HBsAb; quantification,liver pathological changes,liver stiffness; changes,contents of AEA and 2-AG,mRNA expression of CBR1 and CBR2 in the; liver tissue were detected. Results The total effective rate,HBsAg; negative conversion rate,hepatic fibrosis staging and curative effect; rate of the treatment group were higher than those of the control group; (chi~2 = 4.453,4.152,6.364,allP <0.05). After treatment,the; instantaneous elasticity of liver fibrosis,the contents of AEA and; 2-AG,the mRNA expressions of CBR1 and CBR2 in the liver tissue in the; two groups were decreased compared to those of the same group before; treatment (P < 0.05),and the treatment group had better effect than that; of the control group (P < 0.05). The pathological changes in the; treatment group after treatment indicated the liver lobules; integrity,mild hydropic degeneration of liver cells,periportal fibrous; tissue hyperplasia,local small lymphocytic infiltration,which fibrosis; and inflammation were better than those of the control group.; Conclusions KSKXD was effective in the treatment of hepatic fibrosis of; CHB, which improved total effective rate,HBsAg seroconversion rate and; liver fibrosis stage efficiency. And its mechanism maybe related to the; regulation of the endocannabinoid system.国家自然科学基金资助项目; 福建省科技计划引导性项目; 厦门市科技惠民项目; 福建中医药大学临床专项校管课题基

The Lead Isotope Ratios Study of Aerosol in Antarctica

通过对电感耦合等离子体质谱(ICP-MS)的工作条件和参数进行优化,建立了ICP-MS测定铅同位素比值的精确方法,测量了2007—2009年南极中山站采集到的气溶胶样品中208Pb/206Pb、207Pb/206Pb和206Pb/207Pb的比值。结果表明,南极大气气溶胶中铅同位素比值在逐年缓慢地发生线性变化,线性相关系数为0.996 2;气溶胶铅同位素示踪揭示南极附近国家(除南非)释放的铅可能成为南极大气中铅的重要来源。By optimizing the operating parameters,a methodology for a precise and accurate determination of lead isotope ratios based on inductively coupled plasma mass spectrometry(ICP-MS) has been developed.The developed method has been applied to determine the lead isotope ratios(208Pb/206Pb,207Pb/206Pb and 206Pb/207Pb) in aerosol samples collected at the Antarctic Zhongshan Station during 2007—2009.The result indicated that lead isotope ratios of the Antarctica aerosol samples(208Pb/206Pb Vs 207Pb/206Pb) increased linearly year by year from 2007 to 2009 with a linear correlation coefficient of 0.996 2.Moreover,the lead isotopic composition of the aerosol in Antarctica collected at the Zhongshan Station was close to the values of the countries surrounding Antarctica(except South Africa),suggesting that the important source of lead in Antarctica atmosphere mignt be the lead released in these countries.国家自然科学基金项目(40676062);国家海洋局海洋-大气化学与全球变化重点实验室开放基金项目(hxjcht008