20,239 research outputs found
歯科用レジン照射器による青色光は摘出ラット大動脈に対して光誘導性血管収縮を誘導す
Aims: Currently, the blue light of resin curing unit is frequently used in dental treatment. However, the influence of the blue light irradiation on oral tissue is not lear. The aim of this study was to elucidate the effect of dental blue light irradiation on vascular smooth muscle.Methods: Isolated rat descending aorta was suspended in a superfusion chamber nd superfused continuously with Krebs-Ringer solution. The changes in isometric orce of blue light irradiation were assessed using vessel strips superfused with the Krebs-Ringer solution alone or the Krebs-Ringer solutions containing 10 µM hentolamine, 100 mM dimethyl sulfoxide, 10 unit/mL superoxide dismutase, or 5 M L-histidine. The reactive oxygen species (ROS) scavenging activity of antioxidants was examined using the electron spin resonance technique espectively.Results: We first demonstrated that the vasoconstriction was induced by irradiated of blue light using dental resin curing unit. The vasoconstriction was inhibited by ncluding in the Krebs-Ringer solution an α-receptor blocker that inhibits the eurotransmitter. This phenomenon was controlled with the addition of ROS cavengers.Conclusions: Blue light irradiation of multiple times in dental treatment might have the potential to accelerate aging of pulpal blood vessel from ischemia through dental pulp vasoconstriction via ROS generation. In addition, prolonged and/or repeated blue light irradiation could cause ROS-induced oxidative stress such as ischemia-reperfusion injury on pulpal blood vessel. Therefore, preintake of ntioxidants is suggested to avoid effects such as aging of dental pulp due to blue light irradiation-induced ROS in dental clinic treatments.神奈川歯科大学201
Association between family history of diabetes and insulin secretion in the patient with type 2 diabetes.
糖尿病家族歴が2型糖尿病(T2D)発症のリスクとなる事はよく知られている。しかし糖尿病家族歴がT2D発症後のインスリン分泌能にどのように影響を与えるについては、あまり検討はされていない。今回、糖尿病家族歴の情報とインスリン分泌能を含めたT2Dの臨床像との関連性について富山大学附属病院第ー内科もしくは、その関連施設に通院中のT2D患者999名において検討した。尚、糖尿病(DM)家族歴の情報については、スコア化し、Familyhistory score (FHS)と命名した。FHSは、0;両親共にDM無し、1;いずれか一方にDM有り,2;両親共にDM有りと定義し、主に、糖尿病診断時年齢(AOD)やインスリン分泌の指標である空腹時血中Cペプチド(F-CPR),CPR index、SUITとの関連性を解析した。重回帰分析の結果より、FHSは、AODやF-CPR,CPR-index, SUITと有意に負の相関を示した。上記の結果より、両親の糖尿病罹患者数が多いと、糖尿病診断時年齢が若年化し、糖尿病発症後のインスリン分泌能が低下する事が明らかになった。糖尿病家族歴の情報は、既報通り、糖尿病発症の予測に役立つだけでなく、糖尿病発症後のインスリン分泌能と関連し、将来のインスリン治療の必要性を予測できる可能性が示唆された
An Analysis of Examples for the Interpretation of the Word iṣṭa in Dharmakīrti\u27s Definition of the Thesis
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