Prader-Willi综合征分子分型诊断方法的初步研究

【目的】探讨Prader—Willi综合征（PWS）的短串联重复序列（STR）连锁分析诊断方法，为遗传咨询提供相关信息。【方法】对一例临床疑似病例经甲基化特异性PCR（MS—PCR）确诊为PWS后．应用15号染色体特定区域的STR进行家系连锁分析，探讨其在PWS分子缺陷类型诊断方面的可行性。【结果】STR连锁分析结果显示该患者为父源缺失型PWS。【结论】STR连锁分析是一种可准确诊断PWS并明确其分子缺陷类型的好方法：国人相关区域的STR位点及其多态信息等有待进一步研究．以完善并最终建立该方法

表面等离激元“热点”的可控激发及近场增强光谱学

金属纳米结构中特定表面等离激元模式的光学激发及其相互作用是发展高分辨、高灵敏、高精度界面光谱学的物理基础.本文综述了我们研究组近期在表面等离激元共振的光学激发、分类识别、近场增强及在界面光谱学中的应用等方面的进展,主要内容包括:1)利用时域有限差分法,分析了金属粒子-基底体系中SPR\"热点\"产生的物理机制及影响因素,讨论了电模式和磁模式下界面\"热点\"的可控激发及\"热点\"转移的影响因素; 2)利用粒子-金膜体系,实现了可见光频率的表面等离激元磁共振,并利用其形成的\"热点\"进行了表面增强拉曼光谱实验,获得了比常规电模式更高的拉曼增强; 3)通过界面SPR\"热点\"增强二次谐波的实验和理论研究,提出并实现了空间分辨率达到1 nm的等离激元增强二次谐波纳米尺; 4)讨论了针尖增强拉曼光谱及针尖增强荧光体系中的空间分辨率、定向发射等关键共性问题的解决方案.相关研究成果可为界面SPR\"热点\"的可控激发及进一步发展表面增强拉曼、针尖增强拉曼、表面等离激元增强二次谐波等各类高灵敏度,高空间分辨率的界面光谱学方法提供新的思路.国家自然科学基金(批准号:21673192,91850119,11474239);;\n国家重点研发计划(批准号:2016YFA0200601,2017YFA0204902)资助的课题~

Stock Investment Decision Support: Models, Technology and System

[[abstract]]隨著台灣人們生活富裕，使得投資理財逐漸受到重視；在眾多金融商品裡，唯具有動態且開放的市場、高獲利以及高變現能力等特性的股票投資最受投資者青睞。在動態且多變化的股票市場中，影響股票價格的因素眾多，投資者為了掌握對個股產生投資影響的重要訊息，往往需蒐集股票市場資訊以利進行投資分析與判斷。而現今股票投資資訊日漸氾濫，導致投資者陷入須耗費大量時間來蒐集與整理投資資訊的困境。因此，為即時且正確地提供投資者相關股票投資決策資訊，如何針對這些龐雜且量大的股票投資資訊進行蒐集、過濾、分析與整理，形成有效的股票決策資訊，已成為股票投資決策重要的研究議題。本計劃主要目的在於研發股票投資之決策支援模式、技術與系統，以協助股票投資者能依據其投資需求提供個人化股票投資決策之相關資訊，並選擇合適的投資個股與其投資時程，進而提昇股票投資者之獲利能力。針對上述研究目的，本計劃將： (i) 提出一股票投資之決策支援模式， (ii) 設計一股票投資之決策支援系統架構， (iii) 發展股票投資決策支援系統之核心方法與技術，以及 (iv) 實作一股票投資之決策支援系統以及驗證其方法(案例示範)。[[abstract]]Investment and financial management has become important due to generally wealthy lifestyle in Taiwan. However, for most of the investors, they favor only the stocks with the characteristics of in a dynamic and open market, high profit and high liquidity among diversified financial products. In the dynamic and changeable stock market, there are a lot of elements that could affect stock prices. To control important information that would influence the investment decision to certain stock, investors must collect stock market information to facilitate the analysis and judgment of the investment. Nowadays, stock investment is getting overloaded with information, this circumstance causes a bottleneck that investors need to spend a great deal of time to collect and organize related investment information. Therefore, how to collect, filter, analyze and organize the complicated and high-volume stock investment information and then to create effective stock decision information for investors has become an important research issue for stock investment decision. This NSC project develops a decision support model, technology and system for stock investment to provide stock investors with information on personalized stock investment decision based on their own investment requirements as well as select suitable investment stocks and relevant investment schedules, and consequently boost stock investors’ profitability. To accomplish the above purpose, the following tasks should be performed: (i) designing a decision support model for stock investment. (ii) designing a decision support system framework for stock investment. (iii) developing core techniques involved in the decision support system for stock investment. (iv) implementing a decision support system for stock investment with an illustrative case.[[note]]NSC100-2410-H327-003-MY

周期与非周期传输线网络的物理与拓扑性质

传输线电缆是一种生活中很常见的一维波导, 除了在工程上有广泛应用外, 也可以被应用于基础研究领域的一些理论验证性实验中. 例如, 因为传输线和量子电路具有相同的波动方程形式, 传输线被广泛应用于量子图的研究中. 另一方面, 传输线网络方程还和零能紧束缚模型的方程形式相似, 所以可以用传输线网络来验证基于紧束缚模型理论所预言的物理性质, 例如安德森局域化、能带结构、拓扑性质等. 本文从传输线网络方程出发, 回顾传输线在上面提到的几个研究方向中的具体应用. 这些研究方向分别为: 一维、二维、三维网络中的安德森局域化研究; 周期性以及准周期性网络中的能带结构; 传输线网络中角动量依赖的拓扑传输的验证. 本文详细阐述了这些工作的研究思路以及结果, 展现了传输线在基础研究领域的广泛应用潜力.Transmission line is a common kind of one-dimensional waveguide. In addition to being widely used in engineering, the transmission lines can be used in proof-of-principle experiments in basic scientific research. For example, the wave equations governing the transmission line and quantum wire are equivalent, so transmission lines are widely used in the research of quantum graphs. The transmission line network equations are similar to the equations of zero-energy tight binding model, so the transmission line network can also be used to study some physical properties predicted by the theories based on tight binding model, and examples include Anderson localization, band dispersions, topological properties, etc. According to the transmission line network equations, we review some applications of transmission lines in the research fields mentioned above. We will discuss Anderson localization in one-, two-, and three-dimensional networks, the band structures of periodic and quasiperiodic networks, and the angular moment-dependent topological transport in transmission line network. We introduce the methods and results in detail to show the potential of transmission lines in basic scientific research

全人照護及其教育訓練與評值

&lt;p&gt;目的：全人照護是對病人身體、心理、社會層面及靈性全面照護的態度與行為，需要醫療院所投注多專 業、跨領域且有效率又有品質的整合服務，才能滿足病人「一站式服務、一次購足」的需求。本文之目的在於詮釋全人照護之真諦、內涵、教育訓練與評值。&lt;/p&gt; &lt;p&gt;方法：藉由闡釋全人照護的素養與能力，強調推廣全人照護需要多面向的教育訓練加以養成，並發展以能力為基礎的評值方法。&lt;/p&gt; &lt;p&gt;結果：醫療人員需要終身持續學習有關全人照護的核心知識與技能、醫療專業照護、同理心與心理支持、就醫行為和家庭照護，以及生命關懷及和臨終照護，並佐以適合及一致性的評值標準，方能系統性的推廣全人照護。&lt;/p&gt; &lt;p&gt;結論：本文探討全人照護的真諦、如何推動全人照護及如何實施全人照護之教育訓練與評值，作為醫療院所推動全人照護之參考。&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt;&lt;p&gt;Objective: Holistic care is an approach that involves consideration of the physical, emotional, social, and spiritual wellbeing of a patient. It involves multidisciplinary, interprofessional integrated teams with members who educate, cooperate with, and respect each other to offer one-stop fulfillment of patient needs. This article explains the core values and intentions of holistic care and the relevant education, training, and assessments.&lt;/p&gt; &lt;p&gt;Methods: By explaining the competencies of holistic care, this article argues that the promotion of holistic care necessitates multidimensional education, training, and competency-based assessments.&lt;/p&gt; &lt;p&gt;Results: To systematically promote holistic care, accompanied by appropriate and consistent assessment standards, health care providers must continue to learn about the main components of holistic care, including its required knowledge and competencies, professional medical care empathy and psychological support, the praxeology of healthcare seeking, family care, and end-of-life and hospice care.&lt;/p&gt; &lt;p&gt;Conclusion: This article discusses the core values of holistic care; how to promote holistic care; and how to implement education, training, and assessments in the field of holistic care and may therefore serve as a reference for holistic care training in medical settings.&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt; </jats:p

一种MAX相陶瓷涂层及其制备方法和制备装置

本发明公开了一种MAX相陶瓷涂层，此涂层组成为V2AlxC2‑x，x＝0.7～1.5，涂层为柱状晶生长结构，每一个柱状晶由一层Al原子层和两层V原子层交替排列形成，且C原子层位于两层V原子层之间，涂层密度为4.5～5.2g-cm3。本发明还公开了所述MAX相陶瓷涂层的制备方法，采用双靶磁控溅射法并辅助射频叠加中频的电源施加方式，在制备温度为550～650℃的情况下，在非晶基体上非外延生长出所述MAX相陶瓷涂层。该制备条件下获得的V2AlxC2‑x涂层纯度达到了99.9％，涂层硬度在13～16GPa。此方法一步合成，成本较低，可控制性强，有利于MAX相涂层低温制备和多领域应用

谐波减速器柔轮疲劳寿命及其力学性能分析

柔轮作为谐波减速器中最薄弱的环节之一，一直是谐波减速器可靠性研究中备受关注的对象。以CSG-32-80型谐波减速器为对象，利用Ansys Workbench对其柔轮进行了瞬态分析，得出了柔轮应力、应变的分布情况；将有限元分析结果导入Ncode Designlife疲劳分析模块，结合柔轮材料的S-N应力—寿命曲线，得出了柔轮的疲劳寿命。并通过正交实验的方式探究了柔轮最大应力与柔轮长度、柔轮壁厚、柔轮齿宽3种参数之间的关系，为柔轮结构的最优化设计提供了一定理论参考