母乳喂养结合音乐播放对新生儿足跟采血疼痛缓解的观察

目的:观察母乳喂养结合音乐播放对足月健康新生儿足跟采血的止痛效果。方法:于2014年8月至2015年2月期间在厦门市某三甲医院抽取292例足月新生儿,随机分为对照组、母乳喂养组、音乐组、音乐联合母乳喂养组共4组,每组73人。在足跟采血接受新生儿疾病筛查时,对照组新生儿给予常规足跟采血,干预组在采血前2 MIn到采血结束5 MIn分别给予纯母乳喂养、音乐疗法、以及音乐联合母乳喂养的相应干预。采血疼痛评分采用新生儿面部编码系统(nfCS)。结果:给予母乳喂养结合音乐播放干预的新生儿采血中和采血后1 MIn的nfCS明显低于音乐组和对照组,痛苦面容开始时间显著晚于对照组和音乐组,痛苦面容持续时间显著短于对照组和音乐组,差异均具有统计学意义(P0.05)。音乐组和对照组新生儿之间在上述各项指标差异无统计学意义(P>0.05)。结论:母乳喂养可以有效缓解新生儿足跟采血的疼痛程度,单纯音乐疗法不能够加强母乳喂养的止痛效果

Mechanism of geniposide in improving free fatty acid metabolism in rats with non-alcoholic fatty liver disease

观察栀子苷改善非酒精性脂肪性肝病的效果,从游离脂肪酸探讨栀子苷调节非酒精性脂肪性肝病的作用机制。健康雄性Wistar大鼠40只,随机分为4组:正常组、模型组、栀子苷组和血脂康组,每组大鼠10只,正常组大鼠给予正常大鼠饲料喂养,其余3组大鼠均采用高脂饲料喂养以诱导非酒精性脂肪性肝病,造模时间为8周,从第5周起至第8周末,栀子苷组和血脂康组分别灌服相应的药物。记录大鼠体重、肝湿重、脂肪质量;用相应方法检测肝组织TG,FFA,FAS,AMPK,ACCase及Malonyl-Co A含量,血清CHO,LDL-C的含量,血清AST,ALT的活性;观察肝脏组织肉眼及病理变化(HE染色法)。结果显示,与正常组相比,模型组大鼠的体重;肝湿重;脂肪重;血清CHO,LDL-C,ALT,AST;肝组织TG,FFA,FAS,ACCase及Malonyl-Co A含量皆显著升高(P<0.01);肝组织AMPK活性显著降低(P<0.01),肝组织肉眼外观及病理切片脂肪变性明显,并出现炎症损伤;与模型组相比,栀子苷组大鼠体重、脂肪质量、肝组织FFA含量、血清ALT,AST活性均显著降低(P<0.01),肝湿重,肝组织TG,FAS,ACCase及Malonyl-Co A含量明显降低(P<0.05),肝组织AMPK活性明显增多(P<0.05),肝脏肉眼外观及病理学表现均有所改善;与模型组相比,血脂康组大鼠的肝湿重、脂肪质量、肝组织TG,FFA和血清LDL-C水平明显降低(P<0.05);与血脂康组相比,栀子苷组大鼠的体重、脂肪质量、肝组织FFA含量均显著降低(P<0.01),其他方面无明显差异。结果表明,栀子苷具有显著的改善高脂饮食诱导的大鼠非酒精性脂肪性肝病的药理效应;其改善大鼠非酒精性脂肪性肝病的游离脂肪酸代谢是通过调节"AMPK-ACCase-Malonyl-Co A-FFA"轴来实现的。To observe the effect of geniposide on non-alcoholic fatty liver disease( NAFLD),and discuss the mechanism of geniposide for NAFLD from the aspect of free fatty acid,forty healthy Wistar male rats were randomly divided into normal group,model group,geniposide and Xuezhikang group. The rats in normal group were fed with normal diets,and the rats in other 3 groups were given with high-fat diet for 8 weeks to induce the NAFLD models. From the week 5 to end of week 8,the rats in geniposide and Xuezhikang group were intervened with corresponding medicines. The body weight,liver wet weight,and fat weight of the rats were recorded.Visual and pathological changes in hepatic tissues were observed with HE staining. The contents of TG,FFA,FAS,AMPK,ACCase and Malonyl-Co A in hepatic tissue,contents of CHO and LDL-C in serum and activities of AST and ALT in serum were detected by using corresponding methods. The results showed that the body weight,liver wet weight,and fat weight of the rats,CHO,LDL-C,ALT and AST levels in serum,TG,FFA,FAS,ACCase and Malonyl-Co A levels in hepatic tissues of the rats in model group were significantly higher than those in normal group( P < 0. 01),while AMPK activity was significantly lower than that of the normal group( P < 0. 01),with obvious visual and pathological steatosis in hepatic tissues,and inflammatory injury occurred in model group. Compared with the model group,body weight of the rat,fat weight,levels of FFA in hepatic tissues,ALT and AST activities in serum,liver wet weight,TG,FAS,ACCase and Malonyl-Co A levels were significantly decreased in geniposide group( P < 0. 01),while the AMPK activity in hepatic tissues was significantly increased( P < 0. 05),with improvement in visual and pathological performance.Compared with the model group,liver wet weight,fat weight,TG and FFA levels in hepatic tissues,and LDL-C level in serum were significantly decreased in Xuezhikang group( P < 0. 05). Compared with Xuezhikang group,the body weight of rat,fat weight and FFA level in hepatic tissues were significantly lower in geniposide group( P < 0. 01),but with no significant difference in other aspects. These findings indicated that geniposide was highly effective in improving the pharmacological effect of NAFLD induced by highfat diet,and the mechanism was achieved through AMPK-ACCase-Malonyl-Co A-FFA axis.国家自然科学基金项目(81274155;81503529);; 福建省自然科学基金项目(2014J01374);; 福建省高等学校新世纪人才计划项目;; 厦门市科技计划项目(3502Z20134020);; 福建省中医药科研项目(WZPW201308

专案管理于校园摇滚音乐节的应用

为了丰富大学生的课外生活，鼓励同学们尽情释放激情与才华的目的，我校计划于一个半月内，以不超过200,000元的预算，举办一场校园摇滚音乐节。由于校园音乐节活动流程较为复杂，项目资金费用较高，本文将运用专案管理相关的知识，希望更有效地对此次活动进行管理。本文主要从时间管理、成本管理和风险管理这三个部分进行探讨。在进行专案任务描述之后，制作了责任矩阵，创建了WBS工作分解结构和作业划分表。在时间管理方面做了AON网络图，在进行时间估算之后确定了关键路径，以达到优化工期、提高效率的目的。在成本管理方面制作了管制账户，将复杂的项目预算分解成更小的预算项目，以便更好地进行单独个别预算的监控。风险管理部分主要是输出风险登记册，记录风险项、各个风险项的可能性和影响以及风险的对策。在有限资源的约束下，本文运用系统的方法和理论，对项目涉及的全部工作进行有效的管理，从项目决策开始到项目结束的全过程进行计划、组织、指挥、协调、控制和评价，以实现项目的目标。</jats:p

Parenting：The Genetics*Environment-Endocrine-Brain Mechanism

基于积极和消极养育研究，构建遗传*环境-内分泌-脑模型。父母基因可直接影响养育，也可通过调控激素敏感性间接影响养育，如催产素、睾酮、皮质醇。积极养育脑区涉及动机奖赏、唤醒警觉、内感、镜像、心理化、共情、执行和情绪调节八部分；消极养育体现于脑区激活异常、体积改变、功能连接失调和亲子脑区同步低，并有性别特异性。未来可考察中国父母养育遗传度，探讨多基因和环境交互影响，分析父母自发养育与脑区功能的相关性，基于全基因组关联分析和机器学习，了解影响养育的其他遗传变异以及各变量解释度。</p

培养条件下发菜的形态建成

固体培养基培养的发菜(Nostoc flagelliforme)在黑暗与低光强(<1μmol/m2·s)条件下细胞发育受到抑制,在光强10、20、30、60μmol/m2·s条件下细胞生长良好,但在60μmol/m2·s条件下藻丝体易变黄;液体充气培养的发菜在光强20、60、180μmol/m2·s条件下生长速率、类胡萝卜素与多糖含量均随光强升高而增加。发菜在低营养水平时形成的异形胞较多,异形胞的发生位置也多样,有端生、间生和连生。当琼脂浓度为0.5%—4%时发菜具有相同的形态发育特征,从藻殖段发育至丝

准双曲面齿轮热处理畸变及接触区影响研究

准双曲面齿轮作为主减速器的重要零部件之一,其齿廓的畸变程度直接影响着齿面误差和齿轮接触区质量及一致性的好坏。针对齿轮热处理变形不受控的问题,研究了齿轮热处理的畸变机理。应用45点拓扑网格误差分析接触区偏移规律,以专用锥齿轮检测设备Gleason GMM350和600HTT滚检机为载体,通过实验对比齿轮热处理前后齿面精度变化和接触印痕偏移规律,验证了接触区偏移理论分析结果的正确性,且实验表明,齿轮热处理接触区从大端稍偏齿顶位置向齿面中间移动

液固分离实验中的一些进展

本文介绍中科院力学所在液固分离技术方面开展的研究工作。通过有关文献总结、专利调研和国内现场考察,在几种液固分离技术中选用离心方法,建设了相应的模拟试验设备。在实验中,进行了纯油-砂分离、不同比例的油-水-砂分离实验,总结了几个方面的影响因素,选择了一种合理的除砂方法,在胜利油田、华北油田进行了工业现场应用实验,取得了良好结果。十五期间,从发展海上油气混输特殊工艺要求出发,作为混相增压技术的配套技术,采用离心分离除砂技术,最大限度地减少对多相混输泵的伤害,保证混输工艺的可靠实现

Study on the dose ratio of Chlorogenic acid-Geniposide to treat rats with experimental fatty liver based on uniform design

目的:运用均匀设计法优化绿原酸-栀子苷组合治疗实验性脂肪肝大鼠的最佳剂量配比,探讨中药有效成分配伍配比规律。方法:运用数学模型均匀设计法对绿原酸; -栀子苷组合中的2种中药有效成分进行分组设计,分为6种组合对高脂饮食诱导的实验性脂肪肝大鼠模型进行治疗,观察各组大鼠肝脏的病理变化,并以肝组织甘; 油三酯(TG)、血清低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(CHO)、谷丙转氨酶(ALT)、谷草转氨酶(A; ST)测定作为筛选指标,优选二者的最优剂量配比,并根据所得重新分组验证。结果:与正常组比较,模型组脂肪肝大鼠肝组织TG、血清LDL-C、CHO含; 量明显升高(P<0.01),血清HDL-C含量明显降低(P<0.01),血清ALT、AST活性明显升高(P<0.01),肝组织存在明显脂肪变性。; 经多元逐步回归分析,绿原酸-栀子苷组合治疗脂肪肝的最佳剂量配比是绿原酸90mg+栀子苷90mg。结论:应用均匀设计与药效学分析的方法可有效优化中; 药有效成分组合的最佳剂量配比。Objective: To explore the active ingredients and dose ratio of medicine,; combined with the optimal dose ratio of Chlorogenic acid-Geniposide to; treat rats with experimental fatty liver. Methods: The active; ingredients and optimized prescription were screened out, adopting; uniform design to divide Chlorogenic acid-Geniposide into six; combinations, by using experiment on high fat diet-induced fatty liver; rat models, and the pathological results were observed. The serum LDL-C,; HDL-C, CHO, ALT, AST and liver TG were taken as the screening-indexes.; Results: Compared with the normal groups, the serum LDL-C, CHO, ALT, AST; and liver TG in model groups were significantly higher (P<0.01), the; serum HDL-C in model group was significantly decreased (P<0.01), and the; pathology of liver tissue got obvious steatosis. According to stepwise; regression analysis of uniform design, the best ratio of Chlorogenic; acid-Geniposide to anti-NAFLD were Chlorogenic acid 90mg with Geniposide; 90mg. Conclusion: Uniform design is the appropriate way to confirm the; optimized prescription for active ingredient of Chinese medicine.国家自然科学基金面上项目; 福建省自然科学基金面上项目; 福建省高等学校新世纪人才计划项