Measurement of the Mechanical Properties of Breast Cancer Cells (MCF-7) Using the Atomic Force Microscopy

提出了一种基于Hertz模型的最优化方法,并研究了不同质量浓度(0,50,100,150和200μg/mL)的白藜芦醇培养36 h后的乳腺癌细胞(MCF-7)的杨氏模量和能量耗散变化情况。实验结果表明:基于Hertz模型的最优化方法相比于基于Hertz模型的高斯拟合法能使理论压痕曲线和实验压痕曲线更吻合;综合考虑细胞的杨氏模量与能量耗散比仅考虑细胞的杨氏模量,更能把不同状态的细胞之间的差异综合地表示出来。实验结果验证了基于Hertz模型的最优化方法相比于基于Hertz模型的高斯拟合法在计算杨氏模量上的优越性,并揭示了综合考虑杨氏模量与能量耗散的必要性

Discrimination of the state of MCF-7 cells by multiple cell mechanics

Cell mechanics indicating the state of cell play an important role in critical activities of the cells. However in recent cell mechanics research, most of researchers only considered the young's modulus and energy dissipation is seldom considered. The existing method of the computation of young's modulus can't also make sure the distance between experimental indentation curve and the theory experimental indentation curve is small. To solve the problems described above, an optimization method of computation of young's modulus has been proposed and an experiment has been carried out. In the experiment force curves were obtained from the MCF-7 cells which has been treated with different concentrations (0ug/ml, 50ug/ml, 100ug/ml, 150ug/ml, 200ug/ml) of resveratrol for 36 hours. Young's modulus and energy dissipation could be obtained from the force curves. The experiment results not only shown that compared with the existing method the proposed method has its superiority in the computation of young's modulus, but also indicated that there is a necessity of considering both Young's modulus and energy dissipation. The results provide an effective method for the computation of cell mechanics and lay a foundation for the drug selection and personalized treatment of diseases

高压静电沥青烟净化除尘装置

本实用新型涉及一种高压静电沥青烟净化除尘装置，含有烟气管、中箱体、高压电场；在烟气管与中箱体之间设有一喷淋管道，在喷淋管道与烟气管相接处的管道壁上设有高压喷嘴：喷淋管道通过进口扩散管与中箱体相接；在进口扩散管内装有气流均布板；该装置可收集比电阻高、尘粒小于１０微米的尘粒，其除尘净化效率高、沥青烟排放浓度低于国家标准