Design and Synthesis of Naphthoylhydrazones Fluorescent Receptors for Molecular Recognition

分子识别是超分子化学的核心研究内容之一，包括离子客体和中性分子的识别。荧光检测的高灵敏度、可实时及远程检测等优越性，使其在分子识别与传感的应用得到蓬勃发展。金属离子在环境和生命科学中发挥着重要的作用，设计合成高灵敏、高选择性的荧光化学传感分子近年来备受关注。阴离子在化学、生物、医药、环境等领域的重要作用已为人们所共知。受制于阴离子独特的结构特性，如半径较大、几何构型各异以及对环境pH极为敏感的特点，阴离子受体的设计合成以及新的识别体系的建立更具挑战性，已成为超分子化学研究领域活跃的课题之一。 一般地，过渡金属与重金属离子，由于它们多存在空轨道，可发生从荧光团到过渡金属离子的电子转移或能量转移...Molecular recognition is a core research area in supramolecular chemistry which is composed of ionic and neutral species recognition. Due to high sensitivity, intrinsic simplicity and remote sensing capacity, fluorescent sensors have been rapidly developed in molecular recognition and sensing. Heavy and transition metal ions play important roles in many biological and environmental processes. To d...学位：理学硕士院系专业：化学化工学院化学系_分析化学学号：X20042500

Highly Selective Recognition of Zinc Ion by Salicylaldehyde-2-phenylacetylhydraonde

设计合成了用于识别锌离子的荧光传感分子——水杨醛缩苯乙酰腙(1),通过红外光谱、核磁共振谱和质谱表征其结构;利用其荧光性质研究了该物质对几种过渡金属离子的识别性质,初步探讨了其结合模式。实验表明:在乙腈介质中,主体分子1表现出对zn2+良好的选择性,zn2+的加入导致1的长波长荧光增强437倍,而其它过渡金属只引起1的荧光略微增强,JOb法实验揭示1与zn2+的结合比为1∶1。A fluorescent chemosensor,salicylaldehyde-2-phenylacetylhydrazone(1),was designed and synthesized.1 was confirmed by IR,--1H NMR and ESI-MS.1 was found to recognize transition metal ions such as Zn--(2+)、Cu--(2+)、Hg--(2+)、Pb--(2+) and Ni--(2+) via its fluorescence spectra.Mechanism of enhancement of 1's fluorescence by Zn--(2+) was briefly discussed.It was found that 1 showed a highly selective response to Zn--(2+).In acetonitrile Zn--(2+) induced a dramatic enhancement in the fluorescence of 1 by 437 folds,whereas the other transition metal ions had little influence.Job's test showed 1 coordinated with Zn--(2+) to form 1∶1 model complex.国家自然科学基金资助项目(20675069

Progress in Fluorescence Sensors for Hg(Ⅱ) Cations

荧光传感提供了方便,快捷,廉价的分析检测重金属离子的方法,并具有很高的灵敏度和选择性。它在环境科学,分析化学以及生命科学等领域有着广泛的应用前景。综述了Hg2+荧光传感的最新研究进展,并展望了该领域的发展趋势。Chemical sensors are valuable in a valuable in a variety of fields such as environmental chemistry,analytic chemistry,and bio-medicinal science.They provide accurate,convenient inexpensive ways of detecting and toxic heavy metal ions with high selectivity and sensitivity.The progress that has been achieved for the chemical sensors of Hg~(2+) is reviewed.国家自然科学基金(20525518,20675069

Membrane software and its applications

本文简述了膜软件的概念及其内涵 ,介绍膜应用软件开发过程中应注意的问题和几例膜软件的应用研究概况。The conception and meaning of membrane software(process)were reviewed.The problems for membrane software and several examlpes were discussed

8-氨基喹啉取代苯甲酰胺衍生物对汞离子和铜离子的识别

设计合成了可识别金属离子的荧光传感分子8-氨基喹啉取代苯甲酰胺衍生物,通过核磁共振谱和质谱表征其结构;利用其光谱性质研究了该系列物质对过渡金属离子Cu2+,Hg2+,Pb2+,Zn2+,Ni2+和Cd2+的识别性质,初步探讨了其识别机理。实验表明:在乙腈中,8-氨基喹啉苯甲酰胺的吸收光谱在509nm处对Cu2+有响应,溶液由无色变成红色;而其荧光光谱对Hg2+和Cu2+有良好的选择性,荧光增强倍率分别高达368和192,与金属离子形成结合比为1:1配合物

Study on Selective Recognition of Anion by Salicylaldehyde-2-phenylacetohydrazide

设计合成了用于识别阴离子的荧光传感分子水杨醛缩苯乙酰腙(1),通过红外光谱、核磁共振谱和质谱表征其结构;利用其光谱性质研究了该物质对几种阴离子的识别性质,初步探讨了其结合模式。实验表明:在乙腈介质中,受体分子1表现出对f-良好的选择性,f-的加入导致1在478 nM处荧光增强44倍,而其它阴离子只引起1的荧光略微增强,JOb法实验得出1与f-的结合比为1∶1。A kind of fluorescent chemosensor for anions,salicylaldehyde-2-phenylacetohydrazide(signed by 1),was designed and synthesized.The structure of the chemosensor was confirmed by IR,1H NMR and ESI-MS.The recogniation of anions such as F-,AcO-and H2PO-4 was investigated via its absorption and fluorescence spectra,and their coordinating models were discussed briefly.It was found that the receptor 1 showed highly selective response to F-in acetonitrile.In acetonitrile F-induced dramatic enhancement of the fluorescence of receptor 1 by 44 folds at 478 nm,whereas the other anions had little influence on the fluorescence of receptor 1.Job's test showed that receptor 1 coordinated with F-to form a complex with 1∶1 model.国家自然科学基金(No.20675069

Study on Synthesis and Anion Recognition of N-(Orthohydroxynaphthamido)-N′-Phenylthioureas

设计合成了3种n-邻羟基萘甲酰胺基-n′-苯基硫脲类化合物,通过核磁共振谱和质谱表征了其结构。应用吸收光谱和荧光光谱考察了在乙腈中其与f-、CH3CO2-、H2PO4-、HSO4-、Cl-和br-等阴离子的相互作用。结果表明,该类主体分子与阴离子形成结合比为1∶1氢键配合物,通过改变萘环上酰基和羟基的相邻位置可调控识别作用的选择性,它们与阴离子作用分别在355、367nM和372nM出现最大吸收峰,荧光光谱显示它们对f-有突出的响应灵敏度,可选择性识别f-。The N-(orthohydroxynaphthamido)-N′-phenylthioureas were designed and synthesized and their structure were characterized by 1HNMR and ESI-MS.Their interaction with anions such as F-、CH3CO-2、H2PO-4、HSO-4、Cl-and Br-in acetonitrile were investigated by absorption and fluorescence spectra.The hydrogen bonding of 1∶1 complexes were formed between receptors and anions.The selectivity of receptors to anion could be efficiently tuned by altering substituent site of acyl and hydroxyl at N-naphtyl moiety.The receptors interaction with anions induced maximal new peaks at 355nm,367nm and 372nm in the absorption spectra,respectively.The F-induced enhancement of the receptors could be applied as selective fluorescent sensors for fluoride

Study on selective recognition of Hg--(2+) by N-(2-hydroxy-1-naphtalamido)-N'-phenyl-thiourea

设计合成了用于识别汞离子的ICT荧光传感分子n-(2-羟基-1-萘甲酰胺基)-n’-苯基硫脲(1),通过红外光谱、核磁共振谱和质谱表征了其结构。利用其荧光性质研究了该物质对几种重金属离子的识别性质,初步探讨了其结合模式。实验表明:在50%水-乙腈介质中主体分子1表现出对Hg2+良好的选择性,其结合比为1∶2。A novel fluorophore,N-(2-hydroxy-1-naphtalamido)-N'-phenyl-thiourea was synthesized and the structure were characterized by IR,1H NMR and ESI-MS.It showed fluorescence in acetonitrile in the presence of some transition metal ions,the highest sensitivity was observed with Hg2+.It was also found that the receptor 1 show sensitive and selective response toward Hg2+ in water-acetonitrile(50/50,v/v).Preliminary investigations were carried out to understand the selective signaling mechanism for Hg2+,which was shown to form a 2∶1 complex with the ligand.国家自然科学基金项目(20675069

Progress of Aerobic Oxidation of Alcohols Catalyzed by Transition Metals

醛酮是重要的化工原料,由醇氧化生成醛或酮是一类重要的化学反应。在诸多关于醇的氧化反应研究中,以环境友好的氧化剂替代传统氧化剂的研究尤为引人注目,特别是以空气/氧气为最终氧化剂的过渡金属催化的氧化反应由于具有价廉、清洁等优点而备受人们青睐。介绍了包括钯、钌、金、锇等贵金属以及钴、钒、铜、铁等廉价金属催化的空气/氧气氧化反应在醇的氧化及动力学拆分领域的应用。The oxidation of alcohols to aldehydes or ketones is a kind of important chemical transformation.The oxidation using molecular oxygen as terminal oxidant is favored for its advantages in economy and environment.In this paper,the progress in several kinds of transition metal catalyzed aerobic oxidations of alcohols is summarized.科技部国际合作中新联合课题(JRP10;S2014GR0448/1418324001); 福建省海洋中心课题(14GYY023NF23); 龙岩学院国家基金培育计划(LG2014010

α-呋喃甲醛缩对苯二甲酰腙对铜离子的高选择性识别研究

设计合成了荧光传感分子α-呋喃甲醛缩对苯二甲酰腙(p-PB-Fu),采用1HNMR对其结构进行了表征,应用吸收和荧光光谱初步探讨了在乙腈中其对Cu2+的响应。结果表明,p-PB-Fu与Cu2+存在两个结合过程,首先是其与Cu2+以2:1的方式形成普通配合物;而随着Cu2+的继续加入,所形成的配合物之间通过自簇集而形成金属配位聚合物/寡聚物。光谱数据初步表明后者对Cu2+具有较高的识别选择性