Synthesis and Performance of Glucose-Responsive Microgels

糖尿病（diabetes）是一种以高血糖为特征的代谢性疾病，在全球范围内的患病率高达8.3%以上，已成为严重威胁人类健康的疾病之一。 目前糖尿病的治疗手段主要是注射胰岛素及饮食控制，但是注射的胰岛素能到达肝脏（正常生理学作用部位）的量仅有不到20%，并且胰岛素在体内易失活，因此难以准确控制注射的胰岛素剂量。若加大胰岛素剂量并频繁给药，又可能会使体内的胰岛素过剩，从而导致低血糖、胰岛素抗性及其他副作用。因此，开发一种可由体内血糖水平作为开关来调控胰岛素释放的体系尤为重要。 本论文通过合理设计，发展了三类葡萄糖响应性微凝胶。主要研究内容如下： （1）合成了Ag@聚(3-丙烯酰胺苯硼酸-co-...Diabetes is a kind of metabolic diseases characterized by hyperglycemia, its rapidly increasing worldwide prevalence has been recognized as a serious global health threat. Current standard care for diabetic patients requires subsequent self-injection of insulin. It is reported that only approximately 20% of insulin reaches the liver following the insulin injection. Excess insulin in the body can ...学位：理学硕士院系专业：化学化工学院_高分子化学与物理学号：2052013115166

Factors Influencing The Decision To Outsourcing Public Service –Based On The Inspiration Of Outsourcing Public Service Experience In U.S.

我国现处于经济社会全面转型的关键时期，公众对公共服务的需求急剧增加和多元化，而政府公共服务的供给仍存在多方面的问题：供给不足、分配不均、供给结构失衡等等。供需矛盾日益加剧，促使政府开始借鉴国外行政改革的成功经验，在公共部门中引入市场机制，以提高政府的行政效率。公共服务外包是其中一种重要的制度安排。从20世纪90年代以来，公共服务外包开始在我国得到初步应用。但是我国公共服务外包实践的深度和广度还远远不及西方国家，国内相关的理论研究尚不全面和具体，尤其缺乏对我国公共服务外包中具体问题的研究，这进一步限制了我国公共服务外包的发展。公共服务外包成功与否取决于多种宏观因素和微观因素。在对相关影响因素的一...Chinese economy and society is in total transformation now, it makes the public service capability cannot fulfill the constant raised and heterogeneous need of the public. Many local governments begin to learn the successful experience of the government’s reform in western countries and bring the market mechanism into public sectors in order to provide better public service. Outsourcing is one of ...学位：经济学硕士院系专业：经济学院财政系_财政学(含税收学)学号：1552008115190

Research on the influence of individual career management on the employment behaviors of higher vocational college students

随着高校毕业生人数的增加，高职生就业形势越发严峻，通过职业生涯管理能提高毕业生就业竞争力，提高就业成功率。而要职业生涯管理发挥其最广泛作用，必须激发个人管理与自我管理的欲望，探讨自我职业生涯管理对高职生就业行为的影响作用，对改善学生消极就业行为，提高高职生就业率有深远的意义。本文通过了解学生在接受自我职业生涯管理团体干预后就业行为改变情况，并针对此提出相应的对策与建议。 目前，高职生自我职业生涯管理已成为当今社会研究的热点问题。但就从目前已发表的现有文献来看，大部分对高职生自我职业生涯管理的研究都只涉及到理论层面，而在自我职业生涯管理对就业行为的影响方面的研究相对较少，并且大多没有进行实证研...With the increase in the number of graduate from higher institution, the employment situation of higher vocational college students is increasingly severe. Individual career management can improve the employment competence of graduates. In order to fulfill the most extensive function of career management, the desire of individual management and self management must be stimulated. Exploring the e...学位：教育学硕士院系专业：体育教学部_高等教育学学号：X200929001

The Development and Prospects of Theoretical Research on Women's Studies

女性学理论体系是女性学的重要知识内核和学科支撑。系统梳理近年来女性学理论研究的成果对推动女性学学科的进一步发展意义重大。2006年以来,女性学理论研究的基本特点是:跨学科性逐渐增强,但“理论预设“的痕迹过于突出;实证支撑不断丰富,但存在将社会性别分析夸大化的倾向;多元综合趋势明显,但没能从根本上克服简单糅合的弊端。为了加快女性学理论建设的发展,促使中国女性学学科的真正成熟,应从以下几方面着手:促进学术队伍和研究对象的性别多元化;在中国女性学学者中倡导学派意识;强化理论研究的合作精神和全球视野。The theoretical system is important knowledge core and academic support of women's studies,and the systematic survey of theoretical research on women's studies has great significance on promoting further development of women's studies.Since 2006,the basic characteristics of the theoretical study on women's studies is that interdisciplinary gradually increased,but the "default theory" traces too prominently;empirical support is enriched,but there is a tendency to exaggerate social gender analysis;multiple integrated tendency is evident,but it does not overcome the drawbacks of a simple blend.To speed up the development of women's studies,to promote true maturity of women's studies,the following aspects should be done: promoting gender diversity of academic team and research objects;advocating school awareness among Chinese scholars;strengthening cooperative spirit and global perspective of theoretical studies

Effects of sedimentation thickness of shrimp pond cleaning discharges on Acanthus ilicifolius seedlings

模拟直接排入红树林的虾池清塘排出物在林地的不同沉积厚度(0、2、4、8 CM),研究其对培养424 d的红树植物老鼠簕(ACAnTHuS IlICIfOlIuS)幼苗生长和生理的影响。清塘排出物的加入对老鼠簕幼苗茎高、基径、叶片数、叶面积、生物量和相对生长率等生长指标都有显著促进作用。总体长势表现为沉积厚度8 CM>4 CM>2 CM>0 CM。生长指标显示只需少量清塘排出物的沉积(沉积厚度2 CM、4 CM)就能对幼苗的生长产生明显的促进作用,但大量排出物沉积的积累并不会带来更明显的促进作用。清塘排出物沉积的加入能显著提高叶片光合能力,尤其利于叶绿素A的合成。沉积厚度2 CM和4 CM时,幼苗叶片游离脯氨酸的积累并不显著,但丙二醛、可溶性糖、可溶性蛋白含量显著高于正常水平;沉积厚度8 CM则使叶片中游离脯氨酸、丙二醛和水溶性化合物均有大量积累;而叶片中抗氧化酶活性只有在大量沉积物加入(沉积厚度8 CM)时才显著低于对照组水平。总之,老鼠簕幼苗对清塘排出物沉积厚度4 CM以下具有较强的抗逆性和适应力,沉积厚度8 CM会使老鼠簕幼苗受到一定程度的逆境伤害,但本实验期间还未影响其生长。In landward coastal zones of most mangrove swamps in China,there are many shrimp ponds with surface sediments rich in nutrients such as N and P.During pond cleaning periods,some of these surface sediments are usually directly discharged into mangrove swamps after being flushed by using high-pressure hydraulic giants.Gradually,these sediments from shrimp ponds will accumulate on the floor of mangrove swamps,resulting in the increase in sedimentation thickness.However,the effects of sedimentation of shrimp pond cleaning discharges on mangrove ecosystems are still unknown.Therefore,to study their responses and endurances in growth and physiological characteristics,four thickness treatments(0,2,4,8 cm) were applied to simulate the sedimentation condition of shrimp pond discharges into the mangrove swamp,and Acanthus ilicifolius seedlings were cultivated under these treatments for 424 days.In terms of growth indexes,including stem diameter,stem height,leaf number,leaf area,total biomass and relative growth rate,growths of A.ilicifolius seedlings were promoted due to the sedimentation of shrimp pond cleaning discharges.The growth condition of A.ilicifolius seedlings under four treatments followed the order of 8 cm > 4 cm > 2 cm > 0 cm.Results also indicated that a small quantity of cleaning discharges(sedimentation thickness of only 2 cm) could obviously enhance the growth of A.ilicifolius seedlings,and this enhancement would not be stronger comparing with the increasing of the sedimentation thickness.The sedimentation of shrimp pond cleaning discharges enhanced the leaf photosynthetic capacity,especially synthesized more chlorophyll a.With 2 and 4 cm sedimentation thicknesses,contents of MDA,soluble protein and soluble sugar in leaves were significantly higher than normal levels,but there was no significant accumulation of free proline in leaves;8 cm sedimentation thickness resulted in abundant accumulation of MDA,soluble protein,soluble sugar and free proline in the leaves;only in the 8 cm sedimentation thickness group,activities of antioxidant enzymes in leaves were significantly lower than the control group.In a conclusion,A.ilicifolius seedlings had strong endurance and adaptability to shrimp pond cleaning discharges with the sedimentation thickness less than 4 cm;a sedimentation thickness of over 8 cm resulted in stress damages to seedling physiology,but the damage to seedling growth was not obvious during this experiment period.Impacts of sedimentation of shrimp pond cleaning discharges on mangrove ecosystems will be long and profound.Related government departments should attach great importance to it,enhance the management and monitor of mangroves nearby aquaculture areas,and balance the relationship between the development of aquaculture and the ecological restoration of mangroves.In addition,shrimp pond cleaning discharges may contain a variety of residual drugs such as disinfectants and antibiotics used for pond disinfection and disease prevention,which may be toxic to the environment.However,the toxic mechanisms and processes of these substances to mangrove ecosystems are still unclear.Therefore,further studies should be focused on the long-term effects of sedimentation and chemical pollution of shrimp pond discharges on mangrove ecosystems.国家自然科学基金资助项目(41076049

Surface Activation of Amino Polystyrene Microbeads Using Bromoacetic Acid for Immobilization of Antibodies

E-mail:[email protected][中文文摘]分子固定化技术[1]是构造化学、生物敏感元件的重要内容。本文研究氨基聚苯乙烯微珠表面的溴乙酸活化及抗体固定化效率。在pH4.5 条件下，溴乙酸与氨基聚苯乙烯微珠混合反应，制备成表面溴乙酰化的微珠。然后活化的氨基微珠与抗体分子进行偶联。抗体微珠与荧光标记二抗作用后，在荧光显微镜下拍摄微珠的荧光图像，考察活化微珠连接抗体分子的效果。进一步工作将应用抗体微珠开展实际血清样品中的抗原检测。[英文文摘]In this work, surface activation of amino polystyrene microbeads using bromoacetic acid for immobilization of antibodies is presented. The activation efficiency was investigated via microscopic fluorescent imaging.论文工作得到了国家自然科学基金（No.20775065）、教育部高校博士点基金（No.20070384023）、 化学生物传感与计量学国家重点实验室（湖南大学）开放课题（No.2006021）、国家基础科学人才培 养基金（No.J0630429）项目资助

Estimating parameters of hyperbolic modulation frequency signal based on cascade dictionary

为降低水下通信中出现的多径和多普勒效应,提高水下目标探测精度,采用双曲调频信号作为探测信号,利用双曲调频信号(hyperbolic modulation frequency,HFM)时频变化具有双曲线的特征,通过建立HFM信号时间-尺度级联原子库模型,在原子库中寻找最优解,进而对HFM信号的两个频率变化因子进行估计。计算机仿真和水池实验的结果均证明,相较于现在常用的小波-拉东变换(wavelet-Radon)估计方法,本方法的均方根误差小于1%,因此在水下目标探测中有较大的应用价值。To reduce the multi-path and Doppler effects occurring in underwater communications and to increase the precision of underwater target detection,we employ a modulation frequency signal as the detection signal. A hyperbolic modulation frequency( HFM) signal is hyperbolic in the time-frequency domain. In view of this feature,we establish a time-scale cascade dictionary model to find the optimal solution; furthermore,two frequency variation factors of the HFM signal are estimated. The simulation results and the pool trials show that the proposed algorithm performs well,and its accuracy is superior to that of the commonly used wavelet-Radon transform. The root mean square error of the frequency variation factors is 1% lower than that achieved using the wavelet Radon transform.This demonstrates the potential of the suggested algorithm for underwater target detection.国家自然科学基金项目(61471309,61107023);; 国家教育部博士点基金项目(20110121120020);; 福建省自然科学基金项目(2013J01258);福建省自然科学基金项目(2010J01344);; 福建省重点基金项目(2012H1012

古琴减字谱的编码与编辑方法

减字谱是古琴艺术传承的主要载体, 减字谱的编码与编辑软件系统的开发, 对于古琴艺术的传承与保护有着极为重要的意义。本文在张维城和苏文钰教授研究的基础上,充分考虑古琴减字谱自身特点, 给出一种减字谱的编码与编辑方法, 并介绍减字谱编辑软件系统。希望通过在减字谱数 字化方面的努力,推动古琴艺术的传播

靶向人类免疫缺陷病毒1型(HIV-1)整合酶多肽药物表达载体的构建

目的构建人类免疫缺陷病毒1型(HIV-1)整合酶(IN)表达载体用于双分子荧光互补技术筛选多肽药物。方法PCR扩增HIV-1 IN的全长基因序列,将目的片段插入至pBiFc-VN173载体中,并对重组质粒pBiFc-VN173-IN进行双酶切及测序鉴定。将重组质粒pBiFc-VN173-IN和对照组质粒pBiFc-VN173分别转染HEK293T细胞,采用Western blot法和免疫荧光细胞化学染色法检测IN的表达。结果通过高保真PCR、载体构建和鉴定,成功获得IN表达载体pBiFc-VN173-IN。与对照组相比,通过Western blot法和免疫荧光细胞化学染色法证实转染质粒pBiFc-VN173-IN载体的HEK293T细胞表达IN。结论成功构建了IN表达载体,该载体可用于和IN相互作用的多肽药物的双分子荧光互补技术筛选。福建省教育厅中青年教师教育科研项目(JAT171033