A Study on the relationship between the changes of lymphocyte subgroups and chronic kidney disease and mineral and bone disorder in maintenance hemodialysis patients with HBV infection

Objective To compare the changes of lymphocyte subgroup percentages,mineral and bone metabolism levels and microinflammation status in maintenance hemodialysis(MHD)patients with and without hepatitis B virus(HBV)infection,and to observe the correlation between lymphocyte subgroup changes and chronic kidney disease and mineral and bone disorder(CKD-MBD)in patients with HBV infection.Methods A total of 62 patients with end-stage renal disease who had been treated with MHD for more than 3 months were divided into two groups:HD group(33 cases)and HBV-HD group(29 cases).The percentage of lymphocyte subgroups was detected by monoclonal antibody flow cytometry,the level of parathyroid hormone(PTH)was detected by radioisotope method,and microinflammatory factors were detected by enzyme-linked immunosorbent assay.Results In routine blood examination,16.13%(10/62)patients were observed to show a decrease in white blood cell count with an increase in 5 cases,53.23%(33/62)patients had a decrease in lymphocyte percentage with an increase in 3 cases.Compared with the HD group,the percentage and absolute value of lymphocyte in the HBV-HD group were significantly decreased(P0.05).Compared with the HD group,the percentage of B lymphocytes in the HBV-HD group had no significant difference(P>0.05),and the percentage of NK lymphocytes decreased significantly(P0.05).The correlation analysis showed that there was a negative correlation between Th cell percentage,CD4~+/CD8~+ ratio,NK lymphocyte percentage and the level of PTH and calcium-phosphorus product in the two groups.Conclusions In MHD patients,the number of lymphocyte subgroups decreases to different degrees,and the numbers of T lymphocyte and NK lymphocyte subgroups decrease to a greater extent after HBV infection.CKD-MBD is more likely to occur in patients with HBV infection.CKD-MBD may be involved in the suppression of immune function of T lymphocytes.Since immune deficiency can induce and aggravate infection,the microinflammation of MHD patients infected with HBV may be more serious

社会转型与文化转型·海峡两岸圆桌论坛·实录

徐新建(四川大学教授、人类学高级论坛副秘书长):大家好。今天的话题围绕"文化转型"展开。据我所知这既是人类学圈的一个新提法,也是一个有争议的话题。我想请徐杰舜教授首先交代一下议题的来源和这次圆桌对话的意义。虽然在座有部分学者参与谋划了很久,但多数人是没有参与的。今天上午周大鸣教授做了简短的表态,强调提"文化转型"的目的是一种抗争,也就是人类学和社会学的抗争,后者提出的"社会转型"几乎主导了现实社会的思想和实践。我想,这已涉及了知识生产和学术政治,值得各位关注。下面就请徐杰舜老师做简要说明

Measurement of integrated luminosity of data collected at 3.773 GeV by BESIII from 2021 to 2024

We present a measurement of the integrated luminosity e+e- of collision data collected by the BESIII detector at the BEPCII collider at a center-of-mass energy of Ecm = 3.773 GeV. The integrated luminosities of the datasets taken from December 2021 to June 2022, from November 2022 to June 2023, and from October 2023 to February 2024 were determined to be 4.995±0.019 fb-1, 8.157±0.031 fb-1, and 4.191±0.016 fb-1, respectively, by analyzing large angle Bhabha scattering events. The uncertainties are dominated by systematic effects, and the statistical uncertainties are negligible. Our results provide essential input for future analyses and precision measurements