渤海海峡区域地壳稳定性评价

区域地壳稳定性评价在我国主要作为工程建设的决策和规划的重要参考。这一方法是在我国的大型工程的建设活动中得到了广泛地应用,其应用范围包括大坝、核电站的决策和选址以及城市规划、铁路、隧道等工程的建设等。近年来,随着工程活动规模的扩大,对区域地壳稳定性评价也提出了新的要求:一是需要更加贴近工程实践,实现由场地评价向地质工程设计的转变;二是需要将评价区域由传统的陆地区域扩展到海域。本文即是一次进行海域工程区域地壳稳定性评价的尝试,利用所采集到的渤海海峡及邻区最新的GPS 数据、重磁场数据、高分辨率地震数据和地应力数据等资料,对该区域的断裂活动性、地震活动性、地形变特征、地球物理场和地应力特征等方面进行综合分析,采用基于层次分析法的模糊综合评价方法,按照稳定、较稳定、较不稳定、不稳定四个等级,将渤海海峡跨海通道工程区划分为1600 个5 km×5 km 的评价小区域进行了区域地壳稳定性评价。结果表明,在1600 个评价区中,稳定区和较稳定区较少,分别为204 个和141 个,主要集中在北黄海区域;而研究区大部分区域处于较不稳定和不稳定状态,其数量分别为775 和480 个,且主要位于渤海南部和渤海海峡南部,这明显是因为受到了NNE 向郯庐断裂和NW 向张家口蓬莱断裂的影响。这种评价结果对即将开展的渤海海峡跨海通道工程的规划和建设是十分不利的,需要采用更加详细的工程地质调查手段对这一区域进行进一步的调查和研究

The Effect of Capital on Bank Risk-Taking and Lending Behavior ——Discuss the Effectiveness of the New Capital Regulation Framework

在新资本监管改革对银行资本的质与量都提出更高要求，经济结构进入转型发展的关键时期，普惠金融发展逐步走上历史舞台的大背景下，本文深入探讨了资本对银行风险承担与贷款行为的影响。关于资本与银行风险承担行为的关系，本文从直接与间接两个方面进行探讨，并且在直接效应测度中深入分析了银行监督努力的中介作用。同时，本文还对不同监管时期的作用效果进行了对比分析。关于资本与银行贷款行为的关系，本文一方面从贷款总额，贷款结构与典型行业贷款三方面出发，并且重点分析了金融危机时期以及新资本监管改革预期时期，不同监管工具作用的差异；另一方面立足于普惠金融，本文从新资本监管给予普惠金融贷款相应的风险权重优惠出发，测度了资本...New capital regulation requires higher amount and quality of bank capital than before. Economic structure adjustment goes to the critical period. Inclusive Finance takes to the stage. This dissertation studies the effect of capital on bank risk-taking and lending behavior. This thesis researches the relationship between capital and bank risk-taking behavior from direct and indirect aspects. For di...学位：经济学博士院系专业：经济学院_金融学学号：1562014015406

移植免疫与器官再生的研究进展

在临床移植手术和免疫抑制取得巨大成功后的数十年间,同种移植免疫领域堪称突破的进展较少。异种移植由于排斥和感染等障碍举步维艰,令很多研究者失去兴趣。器官再生研究尽管方兴未艾,但距离解决人类的实际问题还有相当长的路要走。近年来,随着干细胞技术和基因编辑技术的发展,移植与再生领域取得了巨大发展。在此,我们对科学意义和应用前景较为突出的进展加以评述,挂一漏万乃至谬误之处,恳请同行指正。国家自然科学基金(81401318

A Research into the Expert Conclusion

内容摘要鉴定结论作为我国三大诉讼法中规定的证据种类之一，在诉讼中起着十分重要的作用。鉴定结论并非与案件事实一同生成，而是由鉴定人在诉讼过程中对已有的专门性问题进行分析、推理所得出的判断性意见。鉴定结论从鉴定的启动到鉴定结论作为定案依据，大致经历了鉴定结论的启动程序、制作程序、质证程序以及认证程序等四个阶段。笔者在本文中重点研究鉴定结论的制作主体制度、启动制度、质证制度以及认证制度。第一章、鉴定结论的制作主体。鉴定主体制度是整个鉴定制度的核心，是保证鉴定制度科学性的根本基础。两大法系国家的鉴定主体制度在立法和实践层面都存在较大差异。本章通过对两大法系国家鉴定主体制度的比较分析，指出我国现行鉴定人...ABSTRACT The expert conclusion, as one of the legal evidence defined in the procedural law, plays a significant character in the judgment. The expert conclusion isn’t appeared together with the fact of case but a estimated consequence made by the appraiser in the process of analysis and discursion based on specific affairs. From the launch of identification to the expert conclusion becomes the e...学位：法律硕士院系专业：法学院法律系_法律硕士(JM)学号：X200512012

Transcriptional regulation of PEN-2, a key component of the γ-secretase complex, by CREB

Gamma-secretase, which is responsible for the intramembranous cleavage of Alzheimer's P-amyloid precursor protein (APP), the signaling receptor Notch, and many other substrates, is a multiprotein complex consisting of at least four components: presenilin (PS), nicastrin, APH-1, and PEN-2. Despite the fact that PEN-2 is known to mediate endoproteolytic cleavage of full-length PS and APH-1 and nicastrin are required for maintaining the stability of the complex, the detailed physiological function of each component remain elusive. Unlike that of PS, the transcriptional regulation of PEN-2, APH-1, and nicastrin has not been investigated. Here, we characterized the upstream regions of the human PEN-2 gene and identified a 238-bp fragment located 353 bp upstream of the translational start codon as the key region necessary for the promoter activity. Further analysis revealed a CREB binding site located in the 238-bp region that is essential for the transcriptional activity of the PEN-2 promoter. Mutation of the CREB site abolished the transcriptional activity of the PEN-2 promoter. Electrophoretic mobility shift assays and chromatin immunoprecipitation analysis showed the binding of CREB to the PEN-2 promoter region both in vitro and in vivo. Activation of the CREB transcriptional factor by forskolin dramatically promoted the expression of PEN-2 mRNA and protein, whereas the other components of the gamma-secretase complex remained unaffected. Forskolin treatment slightly increases the secretion of soluble APP alpha and A beta without affecting Notch cleavage. These results demonstrate that expression of PEN-2 is regulated by CREB and suggest that the specific control of PEN-2 expression may imply additional physiological functions uniquely assigned to PEN-2

Coil tuning detection module design of magnetic resonance imaging

线圈作为磁共振成像系统的重要组成部分,其性能直接影响成像质量。为了尽可能保证信噪比和图像质量,探测前需进行线圈调谐。调谐时,通过微调线圈的共振频率和阻抗两个参数,使线圈共振频率与拉莫尔频率一致,线圈和前放电路阻抗匹配。本文设计了一种线圈调谐的检测模块,阐述了模块的工作原理和软硬件设计。模块包括测量、处理两个部分,其中采用STM32采集电压数据,通过数据转换后用液晶屏显示实时波形。实际结果表明,此检测模块不仅延续了上位机调谐显示直观清晰的优点,而且兼具独立数码显示表的操作便捷的优点。Coil as an important part of magnetic resonance imaging system,its performance directly effects the imaging quality.In order to ensure the signal-to-noise and image quality as much as possible,it must tune before detect.When tuning,it make the coil resonance frequency is consistent whit the larmor frequency,coil and the circuit impedance matching by tuning the coli frequency and impedance.In this paper,we design a coil tuning detection module,elaborated the principle of module and design of software and hardware.This module includes two parts:measurement and processing. Use STM32 to collect the data of voltage,and display real-time waveform by LCD screen.It turned out that this module not only has the advantage of intuitive and clear by upper machine tuning,and both has the advantage of convenient operation.国家自然科学基金(11175149)资助项

The Issues and Principles of Natural Science Methods Used in Educational Research

教育研究对象的复杂性决定了自然科学方法在教育研究中既有价值,又需要注意其运用的限度。目前,在将自然科学方法具体运用于教育研究的过程中,还存在着用得乱、用得少、用得肤浅和用得盲目等问题。因此,做到合理规范地运用自然科学方法,使其在教育研究中发挥应有的作用,需要遵循适用范围明确、追求合理有效、明确主从秩序和综合系统运用等原则。Because of complexity of the object of education,the natural science methods can be valuably used in educational research,and it also has limits of usage.At present,there are a lot of problems when the natural science methods are used in educational research,such as used too messy,too less,too shallow and too blind,etc.Therefore,to rationally make use of natural scientific method in educational research,researchers should clear the scope of usage,pursue rational and effective,clear the master- slave order and use systematically,etc

The Research of the Balanced Scorecard Application in Medium-sized Manufacturing Enterprise

平衡计分卡是上世纪九十年代初开始兴起的新型战略和绩效管理理论。通过运用平衡计分卡可以建立战略性的企业绩效管理体系，围绕战略，把各个分散的管理工具整合成一体化的管理体系，使企业的战略行动和财力物力共同服务于公司战略。该管理理论迅速在全球范围得到广泛的运用，在中国企业界的运用也是方兴未艾。本论文以一家中型制造业公司为例，记录了平衡计分卡的研究与实际运用过程，并力图结合中国企业的现状，进行运用创新。 本论文以理论联系实际的方法，在充分研究了战略管理、绩效管理和平衡计分卡理论的基础上，结合中国中型制造企业的管理现状与平衡计分卡的优点和局限，着重对平衡计分卡在中国中小型企业运用的合理性、有效性及适用条...The balanced scorecard is a new theory of strategy and performance management, which rose since early 1990s. A strategic enterprise performance management system could be established by applying the balanced scorecard, the decentralized management tools could be integrated into a management system around the strategy, it makes the enterprise strategic action and resources together to serve the com...学位：工程管理硕士院系专业：管理学院高级经理教育中心（EMBA项目）_高级管理人员工商管理硕士(EMBA)学号：X200615609