Intramolecular Charge Transfer in Supramolecular Systems: Reaction Mechanism and Application

The all-pervasive nature of chemical species means that their observation is of critical importance if we are to understand what is around and within us. Since atoms and molecules operate on a space-scale which is far smaller than ours, we need specially equipped molecules positioned at the scene to report on the action. Among their special capabilities, the reporter molecules must have a means ...学位：理学博士院系专业：化学化工学院化学系_分析化学学号：B20012501

Chiral Separation of Rosiglitazone Sodium by Aqueous/Nonaqueous Capillary Electrophoresis

以环糊精及其衍生物为手性选择剂,通过优化缓冲液的浓度、酸度以及采用环糊精的种类和浓度等,建立了罗格列酮钠对映体的水介质和非水介质两种毛细管电泳拆分方法。最佳条件为:150 mmol/LTris-H3PO4缓冲液,pH=2.0,含有1 mmol/Lβ_CD或DM_β_CD,10%(φ)甲醇的运行液,分离电压为25 kV,检测波长215 nm。也可以使用含有9 mmol/L HDMS_β_CD,20 mmol/L磷酸和10 mmol/L NaOH的甲醇电泳液。两种拆分体系均实现了罗格列酮钠对映体的基线分离,而且拆分效率基本相当。方法简便、快速,可作为罗格列酮钠的手性分离方法。HPCE methods for separating and determining the rosiglitazone sodium enantiomers were estabˉlished.The effects of buffer concentration,pH,and the type and concentrations of CDs in the chiral separaˉtion of rosiglitazone sodium were investigated.The buffer solution used in aqueous capillary electrophoresis(ACE)was150mmol/L Tris-H 3 PO 4 solution,pH=2.0,containing1mmol/Lβ-CD or DM-β-CD,and10%(φ)methanol.The voltage applied was25kV,and the detective wavelength was215nm.In addiˉtion,a simple method for the separation of rosiglitazone sodiumenantiomers was described by nonaqueous capˉillary electrophoresis(NACE)after establishing suitable separation conditions.Under the experiment condiˉtions adopted,the baseline separation of rosiglitazone sodium enantiomers was obtained by the two methods.The proposed methods were simple,rapid and accurate,and could be used for the chiral separation of rosiglitaˉzone sodium

BENZANILIDES: A KIND OF INTRAMOLECULAR CHARGE TRANSFER FLUORESCENCE PROBE

[中文文摘]评述了苯甲酰苯胺及其衍生物的发光行为和电荷转移 /质子转移光物理模型的研究进展 ,并展望了该类新型分子内电荷转移荧光体在化学及生物分子识别与传感中的潜在应用前景。[英文文摘]The research developments in the luminescence behavior and photophysics of benzanilide and its derivatives were reviewed in terms of the PT/ICT and TICT models that have been proposed to interpret the abnormal long-wavelength fluorescence emission. The potential applications of this class of novel intramolecular charge transfer fluorescence probes for chemo- and bio-molecular recognition and sensing were discussed. Forty-three important references were cited.国家自然科学基金资助项目 ( 2 0 1 75 0 2 0 );教育部优秀年轻教师基金;优秀青年教师奖励计划

design and implementation of a model-driven mes data integration platform for petrochemical enterprises

首先分析了企业对数据集成的需求,并指出数据集成所面临的主要问题.针对这些问题,提出了以企业核心数据模型为驱动的数据集成方法,而且给出了该集成方法的一种实现,称之为企业数据集成平台,并以炼化企业的具体应用为例,论述了该方法对于解决企业数据集成问题的有效性

Automatic submarine topography generating method

本发明公开一种海底地形数据自动生成的方法，该发明将无人无缆潜器（AUV）获得的水深数据自动生成海底地形。该发明分成2个阶段，第1阶段是使用AUV获得水深数据，第2阶段是根据AUV获得的水深数据自动生成海底地形。本发明操作简单，能够有效实现根据AUV获得的水深数据自动生成海底地形，生成的地形结果更加真实地反应海底地形特点。</p

CTD data processing method based on AUV (Autonomous Underwater Vehicle)

本发明公开一种无人无缆潜器（AUV）的CTD数据处理的方法。该发明适用于基于AUV获得的CTD数据处理。该发明分成2个阶段，第1阶段是使用AUV获得CTD测量数据，第2阶段是根据AUV获得的CTD数据进行数据处理。本发明操作简单，能够有效实现根据AUV获得的CTD数据自动处理，具有方便高效的优点

Enantioseparation of Nateglinide by Micellar Electrokinetic Chromatography

目的:选择合适的环糊精作手性选择剂,建立那格列奈对映体的胶束电动毛细管色谱拆分方法。方法:使用Tris- H3PO4缓冲液研究了运行液pH、背景电解质浓度、表面活性剂浓度、环糊精种类和浓度及有机添加剂对分离的影响,确定了拆分那格列奈的最佳实验条件:200 mmol·L-1Tris-H3PO4缓冲液,pH=7.8,含40 mmol·L-1 SDS,5 mmol·L-1 HP-β-CD, 10%(v/v)正丙醇,检测波长215 nm。结果:在所建立的最佳条件下,那格列奈对映体达到基线分离,分离度为1.68。结论:方法简单、快速,可作为那格列奈的手性分离方法。Objective:To develop a simple, rapid method for enantioseparation of nateglinide by cyclodextrin (CD)-modified micellar electrokinetic chromatography (MEKC), Method:Using Tris-H3PO4 buffer solution, 215 nm as the detective wavelength, the influence of several factors, such as Tris concentration, pH, anionic surfactant sodium dedecyl sulfate (SDS) concentration, CDs types and their concentration, and organic additive, on the enantimeric separation of nateglinide was investigated and the optimal condition for the separation was established. The buffer solution was 200 mmol·L-1 Tris - H3PO4 at pH 7. 8 containing40mmol·L-1 SDS,5 mmol·L-1 HP-P-CD and 10% (v/v)n-propanol. Result:Under the experiment conditions adopted, the baseline separation of nateglinide enantiomers was obtained, with the resolution 1.68. Conclusion:The proposed method is simple and can be used for the chiral separation of nateglinide

Chiral separation of zolmitriptan with capillary zone electrophoresis

目的:以环糊精及其衍生物为手性选择剂,通过优化缓冲液的浓度、酸度以及采用环糊精的种类和浓度以达到佐米曲坦的基线分离,并将建立方法应用于实际样品的质量控制中。方法:用20mmol·L~(-1)的磷酸二氢钾-磷酸缓冲液,pH=2.0,含有10mmol·L~(-1)羟丙基-β-环糊精(HP-β-CD)的运行液,分离电压为25kV,检测波长226nm。结果:佐米曲坦对映体的分离度达到3.1,本方法可以灵敏检出限量为0.5%的 R 构型光学异构体。结论:方法简便,快速,准确,可有效控制本品中R对映体杂质含量。Objective:To establish HPCE methods for separating and determining the zolmitriptan enantiomers and to investigate the influence of relative factors,such as buffer concentration,pH,CDs types and their concentration, on the chiral separation of zolmitriptan.Methods:The buffer solution adopted was 20 mmol·L~(-1)phosphate solu- tion,pH=2.0,with 10 mmol·L~(-1)HP-β-CD as chiral selector.Applied voltage was 25 kV,and the detection wavelength was 226 nm.Results:Under the optimum experiment conditions,the baseline separation of zolmitriptan enantiomers was obtained,with the resolution better than 3.1.Conclusion:The proposed method is simple,rapid and accurate,and can be used for the quality control of the chiral purity

神经元网络技术和偏最小二乘法在定量分析和构效关系方面的比较

在光度计／计算机联机系统上利用人工神经网络反向传递算法和偏最小二乘法对五组分有机物混合体系的紫外光谱数据和芬太尼构效关系数据同时进行了定性定量分析，对比和研究，结果表明，反向传递模型具有良好的定性分类能力和定量预测能力；偏最小二乘算法的定性分类效果稍差，但定量预测能力优于反向传递算法

Online software updating method of intelligent nodes in AUV

本发明涉及水下机器人和在线控制技术领域，尤其涉及一种AUV中智能节点在线更新软件的方法。本发明分为3个阶段：第1阶段是通过人机交互计算机的以太网将目标程序文件下载到控制计算机中；第2阶段是控制计算机将目标程序文件读取并分解，拆解成按预先规定格式的数据包，通过CAN总线将数据包发送给智能节点；第3阶段是智能节点接收数据包并通过校验后，将软件程序更新到自身的程序存储器中。本发明操作简单，安全实用，可令智能节点自行更新自身软件程序，以避免AUV对外形结构拆卸，再重新组装的过程，提高工作效率，节约时间和人工成本