DESIGN AND IMPLEMENTATION of EMBEDDED SofTWARE IN EXPRESS ELEVATOR MAIN CONTROLLER

针对高速电梯控制系统不断增加的功能需求以及电梯智能化、安全性、可靠性等方面不断提高的要求,用ArM构建电梯主控制器硬件平台并完成了bOOTlOAdEr及uClInuX操作系统的移植;编写了CAn总线等相关驱动程序;设计了高速电梯的跑层逻辑控制算法以及基于多目标规划和支持向量机的电梯群控算法;采用SQlITE实时数据库快速实现电梯运行参数的存储与读取;同时采用CPld和AVr单片机设计主、辅两套高速计数电路,保证了电梯在高速运行状态下的稳定性与可靠性。在电梯模拟控制台上的实际测试验证了该电梯主控制器设计的合理性与可靠性。In order to meet the increasing function needs of express elevator control system and the growing improved requirements of the elevator in intelligence,security and reliability,in this paper the ARM chip is used for the construction of hardware platform of elevator's main controller.Bootloader and uCLinux operating system are ported on this platform,and corresponding drivers such as CAN-bus are designed as well.Express elevator's operation logical control algorithm and elevator group control algorithm based on multi-objective programming and support vector machine are designed.SQLite real-time database is introduced into this system to implement rapid store and access of elevator operation parameters.CPLD-based main high speed counter is designed while the auxiliary one is implemented with AVR MCU,this redundant architecture of high speed counter guarantees the stability and reliability of elevator system.Practical tests carried out on elevator simulation platform verify the correctness and reliability of the design of elevator's main controller.福建省科技计划重点项目(2008H0060

MLICP-CNN:基于CNN与ICP的多标记胸片置信诊断模型

针对胸片的多标记预测集缺少可校准性的缺陷,提出一种基于卷积神经网络(Convolutional Neural Networks,CNN)与归纳一致性预测器(Inductive Conformal Prediction,ICP)的多标记胸片置信诊断模型MLICP-CNN。该模型将学习数据划分为训练集和校准集,通过使用CNN从训练集中学习出规则D。基于规则D和校准集使用算法随机性对被测数据进行置信预测,即为每个被测数据提供附带置信度的多标记预测集。在对Chest X-ray14胸片数据集的实验结果表明,该模型在临床常用的95%置信度下,模型准确率为95%,体现了置信度评估的恰好可校准性。在CNN架构为Resenet50并采用LS-MLICP为奇异值映射函数下,模型性能最好,其确定预测率为96.43%,理想预测率为92.31%。另外,CNN架构对预测效率的影响程度远远小于奇异值映射函数。国家自然科学基金面上项目(61673186);;\n福建省自然科学基金面上项目(2012J01274

动脉粥样硬化性肾动脉狭窄的早期发现

探讨冠状动脉造影同时行肾动脉造影的必要性及动脉粥样硬化性肾动脉狭窄的相关危险因素分析。共 4 91例临床疑似冠心病患者行冠状动脉造影同时行非选择性或选择性肾动脉造影 ,并对相关的临床因素进行评价 ,筛选出动脉粥样硬化性肾动脉狭窄的独立危险因素。冠心病组患者中动脉粥样硬化性肾动脉狭窄的发病率为2 0 % ,显著高于非冠心病组 (2 .6 % )。冠心病、外周血管疾病是动脉粥样硬化性肾动脉狭窄的独立危险因素 (多元Logistic回归分析示 ,P <0 .0 0 1、P =0 .0 0 3) ,是其早期发现的指标。对怀疑有冠心病的患者 ,在冠状动脉造影同时行肾动脉造影有助于动脉粥样硬化性肾动脉狭窄的早期发现

Photo-generated dinuclear {Eu(II)}2 active sites for selective CO2 reduction in a photosensitizing metal-organic framework

利用太阳光驱动CO2还原不仅可降低大气中CO2浓度，而且可以生成重要的化工原料，是缓解气候变暖和开发新能源的理想途径之一。然而如何制备高效光催化剂将CO2高选择性地转化为高附加值的化学产品极具挑战性。课题组巧妙地将具有催化活性的稀土簇合物与光敏配体组装在一起，合成了具有大孔结构的稀土Eu-Ru(phen)3-MOF催化剂，实现了可见光驱动的CO2到甲酸盐的高效选择性转化。研究表明，该材料光催化生成甲酸盐的反应速率可达到321.9 μmol h−1 mmolMOF−1，这是至今为止报道的光催化还原CO2转化为甲酸盐活性最高的MOFs催化剂。 该项研究工作由博士生闫志浩完成，博士生杜明浩参与部分表征工作；中国科学院大连化学物理研究所金盛烨研究员、刘俊学博士在瞬态光谱表征中给予了支持；我校化学化工学院汪骋教授在数据分析过程中给予大量帮助；理论计算由浙江工业大学庄桂林副教授完成。【Abstract】Photocatalytic reduction of CO2 is a promising approach to achieve solar-to-chemical energy conversion. However, traditional catalysts usually suffer from low efficiency, poor stability, and selectivity. Here we demonstrate that a large porous and stable metal-organic framework featuring dinuclear Eu(Ⅲ)2 clusters as connecting nodes and Ru(phen)3 -derived ligands as linkers is constructed to catalyze visible-light-driven CO2 reduction. Photo-excitation of the metalloligands initiates electron injection into the nodes to generate dinuclear {Eu(Ⅱ)} 2 active sites, which can selectively reduce CO2 to formate in a two-electron process with a remarkable rate of 321.9μmolh −1 mmol MOF −1 . The electron transfer from Ru metalloligands to Eu(Ⅲ)2 catalytic centers are studied via transient absorption and theoretical calculations, shedding light on the photocatalytic mechanism. This work highlights opportunities in photo- generation of highly active lanthanide clusters stabilized in MOFs, which not only enables efficient photocatalysis but also facilitates mechanistic investigation of photo-driven charge separation processes.We are grateful for the financial support from the 973 project (Grant 2014CB845601) of the Ministry of Science and Technology of China, the National Natural Science Foundation of China (Grants no. 21422106, 21673184, 21431005, 21721001, and 21390391) and the Fok Ying Tong Education Foundation (151013). We thank Dr. Wen-Ming Qin and the staffs from the BL17B beamline of National Center for Protein Sciences Shanghai at Shanghai Synchrotron Radiation Facility for assistance during data collection; we also thank Miss Ying-Zi Han for helpful measurement on ESI-MS. We also gratefully acknowledge Mr Xuefu Hu for helpful measurement on time-resolved PL and Miss Rong Chen for her assistance on CV measurement and analysis. 研究工作得到科技部（项目批准号：2014CB845601）、国家自然科学基金委（项目批准号：21422106、21673184、21431005、21721001、21390391）、教育部霍英东基金会青年教师基金（项目批准号：151013）等资助

Y型聚乙二醇干扰素琢-2b注射液治疗HCV基因2/3型慢性丙型肝炎患者疗效和安全性的多中心随机对照试验研究

目的以标准剂量的聚乙二醇干扰素(Peg IFN)α-2a联合利巴韦林作为阳性对照,评价新型试验药物Y型Peg IFNα-2b注射液联合利巴韦林治疗2型/3型慢性丙型肝炎(CHC)患者的疗效和安全性。方法采用多中心、随机开放、阳性药对照的Ⅲ期临床试验,筛选符合要求的2型/3型CHC患者,按照2:1的比例随机分配到Y型Peg IFNα-2b组和Peg IFNα-2a组,同时口服利巴韦林,疗程24 w,停药随访24 w。采用Abbott Real Time HCV Genotype II检测HCV基因型,采用Cobas Taq Man实时定量PCR法检测血清HCV RNA水平。详细记录不良事件。主要疗效指标为持续病毒学应答(SVR),并进行非劣效检验。结果本试验实际入组2型/3型CHC患者255例,实际治疗241例。全分析集(FAS)数据显示,158例试验组和83例对照组患者SVR分别为85.4%(95%CI 79.94%~90.94%)和79.5%(95%CI 70.84%~88.20%,P=0.2402);对符合方案分析集(PPS)人群分析显示,试验组和对照组患者SVR分别为87.9%(95%CI 82.45%~93.27%)和85.9%(95%CI 77.82%~94.01%,P=0.7060),率差的95%可置信区间均符合非劣效标准;对PPS人群分析显示,85.8%受试者获得了早期病毒学应答(RVR),RVR的阳性预测值为90.1%;试验组和对照组不良事件发生率相似,分别为95.6%和95.2%,严重不良事件发生率分别为3.8%和3.6%。结论应用Peg IFNα联合利巴韦林治疗2型/3型CHC患者,新型试验药物Y型Peg IFNα-2b具有与对照药物Peg IFNα-2a相似的疗效和安全性。国家科技部“十二五”重大专项(编号:2012ZX10002-003)；“重大新药创制”十二五科技重大专项(编号:2012ZX09303019)

Room-temperature quantum interference in single perovskite quantum dot junctions

钙钛矿材料由于其高量子产率、载流子迁移率和独特的光致发光特性而在光电材料领域存在诸多潜在的重要应用。研究钙钛矿材料在纳米尺度下电荷输运的独特尺寸效应对钙钛矿光电器件的设计和开发具有重要的指导意义。洪文晶教授课题组基于机械可控裂结技术自主研发了具有皮米级位移调控灵敏度和飞安级电学测量精度的精密科学仪器，对南开大学李跃龙副教授团队合成的钙钛矿量子点进行了深入表征，研究工作成功将量子干涉的研究体系拓展至在光电领域具有重要应用的钙钛矿材料领域，为未来制备基于量子干涉效应的新型钙钛矿器件提供了一种全新的思路。 这一跨学科国际合作研究工作是在化学化工学院洪文晶教授、英国Lancaster 大学物理系Colin J. Lambert教授以及南开大学电子信息与光电工程学院李跃龙副教授的共同指导下完成的。化工系硕士研究生郑海宁、Lancaster University大学Songjun Hou博士、南开大学硕士研究生辛晨光为论文第一作者。博士后林禄春，博士研究生谭志冰、郑珏婷，硕士研究生蒋枫、张珑漪，本科生何文翔、李庆民等参与了论文的研究工作。刘俊扬特任副研究员、师佳副教授和萨本栋微纳米研究院杨扬副教授也参与了部分指导工作。The studies of quantum interference effects through bulk perovskite materials at the Ångstrom scale still remain as a major challenge. Herein, we provide the observation of roomtemperature quantum interference effects in metal halide perovskite quantum dots (QDs) using the mechanically controllable break junction technique. Single-QD conductance measurements reveal that there are multiple conductance peaks for the CH3NH3PbBr3 and CH3NH3PbBr2.15Cl0.85 QDs, whose displacement distributions match the lattice constant of QDs, suggesting that the gold electrodes slide through different lattice sites of the QD via Auhalogen coupling. We also observe a distinct conductance ‘jump’ at the end of the sliding process, which is further evidence that quantum interference effects dominate charge transport in these single-QD junctions. This conductance ‘jump’ is also confirmed by our theoretical calculations utilizing density functional theory combined with quantum transport theory. Our measurements and theory create a pathway to exploit quantum interference effects in quantum-controlled perovskite materials.This work was supported by the National Key R&D Program of China (2017YFA0204902, 2014DFE60170, 2018YFB1500105), the National Natural Science Foundation of China (Nos. 21673195, 21503179, 21490573, 61674084, 61874167), the Open Fund of the Key Laboratory of Optical Information Science & Technology (Nankai University) of China, the Fundamental Research Funds for the Central Universities of China (63181321, 63191414, 96173224), and the 111 Project (B16027), the Tianjin Natural Science Foundation (17JCYBJC41400), FET Open project 767187—QuIET, the EU project BAC-TO-FUEL and the UK EPSRC projects EP/N017188/1, EP/M014452/1. 该工作得到国家重点研发计划课题（2017YFA0204902）、国家自然科学基金（21673195、21503179、21490573）、厦门大学“人工智能分析引擎”双一流重大专项等项目的资助，也得到了固体表面物理化学国家重点实验室、能源材料化学协同创新中心的支持