長野県内における透析患者様の通院状況について

Article長野県透析研究会誌 30(1): 132-133(2007)journal articl

定年退職者あいさつ

素粒子から情報まで／小柳義夫先生との記憶／26年間の研究・教育に没頭した本郷を去るに当たって／I have two questions. : 小林孝嘉先生のご退職にあたって／東京大学を退職するにあたって／山岸晧彦先生を送る／定年を迎えて／太田俊明先生を送る／退職にあたって／東江昭夫先生を送る／東大理学部・理学系研究科における思い出／小林昭子先生を送る／Born to be an Astronomer／祖父江義明先生の退職によせて／43年のまとめ／渡邊さんを送る／やればできる？／お別れに寄せ

Clinical early phase II study of bicalutamide (Casodex) in patients with prostatic cancer

ビカルタミド1日1回50mg群, 80mg及び100mgを12週間投与する3群比較の無作為化非盲検試験を実施した. 1)登録症例は124例で, 適格例は122例であった. 2)総合効果における奏効率は50mg群, 80mg群及び100mg群でそれぞれ50.5%, 61.0%及び53.7%であった. 3)PSAに対する奏効率は50mg群, 80mg群及び100mg群でそれぞれ84.2%, 92.7%及び97.6%であった. 4)副作用発現率は3群ほぼ6割で副作用による中止例は80mg群の1例のみで, 安全度において3群間に有意差はなかった.主な副作用は乳房腫脹, 乳房圧痛等であったTo investigate the efficacy and safety of bicalutamide (Casodex(R)) with its clinically recommended dose, the randomized early phase II study was performed in 124 patients with prostatic cancer (stage C, D). The patients were given 50, 80 or 100 mg of bicalutamide orally once a day in fixed doses for 12 weeks ; 122 patients were eligible for evaluation. The overall response rate was 50.0% (20/40); 61.0% (25/41) and 53.7% (22/41) in the 50 mg, 80 mg and 100 mg groups, respectively. The response rate in prostate lesion, bone and lymph node metastases was slightly higher in the 80 mg group than in the 50 mg and 100 mg groups. The proportion of patients showing a response with regard to serum PSA (CR and PR) was 84.2, 92.7 and 97.6% in the 50, 80 and 100 mg groups, respectively. The incidence of adverse reactions was 65.0, 61.0 and 61.0% in the 50, 80 and 100 mg groups, respectively, and there was no significant difference in overall safety rating in the three groups. Frequent adverse reactions were gynecomastia and breast pain. Only one patient in the 80 ing group was withdrawn due to shortness of breath. Serum concentrations of LH, testosterone and estradiol increased significantly after treatment. Bicalutamide was concluded to be effective and well tolerated in patients with prostatic cancer, and its recommended dose was 80 mg once daily

運動方向の違いが到達把持運動時の指先距離に与える影響

本研究は、運動方向の違いが到達把持運動時の指先距離に与える影響を検討する事を目的とした。対象は、健常成人12名である。大球・中球・小球の3種類の物品を、正面(以下;F)、右45°(以下;R)、左45°(以下;L)に設置し、各物品に対する"F"・"R"・"L"の運動方向へ到達把持運動を実施し、動作解析法を用いて、動作開始から物品接触までの指先距離を抽出し,3群間で比較検討した。結果、大球の比較では、60～90%の時点において、"F"が、"L"より、指間距離は有意に広く、さらに"L"が"R"においても指先距離は有意に広かった。中球比較では、70～90%の時点で、"F"が"L"より、有意に指先距離が広く、さらに"R"が"L"より有意に広かった。小球では、60～95%の時点で、"L"が"F"より有意に指先距離が広く、さらに"L"が"R"より有意に広かった。これらのことから、"L"への到達把持運動では"F"・"L"と異なったパターンを示し、これらの要因として、肩関節・手関節における関節の自由度に対する方向調整と適応調整による動作パターンの違いが考えられ、運動方向の違いでの手指の形成パターンは異なることが明らかとなった。This study was intended to examine whether the difference in the movement direction affects the distance of the fingertip at the time of reaching the gripping movement. The subject is a healthy adult 12 people. Target is the large ball, medium ball and small ball, which is the three types. Placed of the target is a Front("F") and Right45°("R"), left 45 °("L") . Between three groups by extracting the distance of the fingertip with reach and grasping motion is compared motion analysis to each target. Result, In the comparison of large ball, "L" is significantly wider distance of the fingertip at time of 65-90% than the "F". "L" was more significantly wider than "R". In the comparison of medium ball, "F" is significantly wider distance of the fingertip at the time of 20-40% than the "L", "L" was significantly wider than "R". In the comparison of small ball, "L" is significantly wider distance of the fingertip at the time of 60-95% than the "F". "L" was significantly wider than "R". From these things, this study showed that the difference in the movement direction affects the fingers forming the pattern