The expression of polysialylated neural cell adhesion molecule in throat cancer, breast cancer and lung cancer

多聚唾液酸(Polysialicacid，PSA)是以α2，8键连接唾液酸残基形成的线性均一多聚的碳水化合物，主要附着在神经细胞黏附分子(neuralcelladhesionmolecule，NCAM)上，在调节细胞间黏附、细胞迁移、神经发育和重塑过程中发挥关键作用。正常成人组织中的NCAM缺乏PSA表达，但在一些肿瘤组织中存在PSA的再表达，其促进癌细胞的分离、浸润和远端转移，且具有向脑部转移的倾向。 近年来，关于多聚唾液酸在肿瘤中表达研究逐渐增多，研究表明PSA的表达与肺癌、成神经细胞瘤、神经胶质瘤、垂体瘤、横纹肌瘤的恶性程度、浸润、转移相关，认为其可作为肺癌、成神经细胞瘤诊断和判断预后...Polysialic acid (PSA) is a carbohydrate composed of a linear homopolymer of α2,8 linked sialic acid residues and is mainly attached to the neural cell adhesion molecule (NCAM). PSA plays important roles in intercellular adhesion, cell migration, formation and remodeling of the neural system through regulation of the adhesive property of NCAM. Although PSA is lost from NCAM in most adult tissues, v...学位：理学硕士院系专业：海洋与环境学院环境科学与工程系_环境科学学号：2262007115238

综合化学实验——DMB的绝对不对称合成和表征

介绍一个可用于化学系本科生开设的综合化学实验。该实验构思源于手性对二甲氨基苯甲醛缩氨基苯硫脲(DMB)的绝对不对称合成。学生可通过实验发现、观察和探究手性对称性破缺的奇妙现象,并掌握标题化合物组成、结构和手性性质的各种表征方法,特别是固体圆二色(CD)光谱方法

Synthesis and chiral crystal structure of 1-[4-(dimethylamino)benzylidene]-4-phenylthiosemicarbazide

The reaction of 4-phenylthiosemicarbazide with p-dimethylaminobenzaldehyde produced 1-[4-(dimethylamino)benzylidene]-4-phenylthiosemicarbazide which was characterized by elemental analysis, IR, UV, H-1 NMR and XRD. The crystal belongs to orthorhombic system with space group P2(1)2(1)2(1) and a=0.77038(14) nm, b=1.1428(2) nm, c=1.6726 nm, V=1.4726(5) nm(3), Z=4, D-c= 1.346 g/cm(3), F(000)=632, mu=0.219 mm(-1), the final R=0.0407 and wR=0.1157 for 2807 observed reflections [I>2 sigma(I)]. The crystal structure and the solid-state circular dichroism spectrum showed that an enantiomer of the compound packs into the chiral crystal

Another chiral crystal structure of 1-[4-(Dimethylamino)benzylidene]-4-phenylthiosemicarbazide

Another chiral crystal of 1-[4-(dimethylamino)benzylidenel-4-phenylthiosemicarbazide (DMB) was obtained, and its absolute structure was determined by X-ray single crystal diffraction and the solid circular dichroism (CD) spectrum. The crystal belongs to orthorhombic system with space group P2(1)2(1)2(1) and a = 0.7870(2), b = 1. 1560(2), c = 1.6668(3) nm(3), V = 1.5164(5) nm, Z= 4, D-c=1.307 g/cm(3), F(000)=632, mu=0.213 mm(-1), the final R=0.0409 and wR=0.1061 for 2577 observed reflections [I > 2 sigma(I)]. The absolute structure can be determined well with the Flack parameter 0.00(9). The crystal structure and CD spectrum show that an enantiomer of the compound packs into the chiral crystal

1-[4-(二甲氨基)苯亚甲基氨基]-4-苯基硫脲的合成及手性晶体结构

对二甲氨基苯甲醛和苯基氨基硫脲缩合反应生成1-[4-(二甲氨基)苯亚甲基氨基]-4-苯基硫脲{1-[4-(dimethyl-amino)benzylidene]-4-phenylthiosemicarbazide},并从溶液中析出手性晶体.元素分析、红外光谱、紫外光谱、核磁谱、质谱和X射线衍射测定其组成和结构.晶体属正交晶系,P212121空间群,a=0.77038(14)nm,b=1.1428(2)nm,c=1.6726(3)nm,V=1.4726(5)nm3,Z=4,Dc=1.346g/cm3,F(000)=632,μ=0.219mm-1,可观测点精修最终偏离因子:R=0.0407,wR=0.1157.化合物的晶体结构和固态圆二色谱表明化合物在结晶过程中发生单一对映体的手性堆积

1-[4-(二甲氨基)苯亚甲基氨基]-4-苯基硫脲的另一个手性对映体晶体结构

对-二甲氨基苯甲醛和苯基氨基硫脲缩合反应生成1-[4-(二甲氨基)苯亚甲基氨基]-4-苯基硫脲(DMB),产物能从溶液中析出单一手性对映体晶体.用单晶X射线衍射技术测定了它的绝对构型,晶体属正交晶系,P212121空间群,a=0.7870(2)nm,b=1.1560(2)nm,c=1.6668(3)nm,V=1.5164(5)nm3,Z=4,Dc=1.307g/cm3,F(000)=632,μ=0.213mm-1,2557个可观测点[I>2σ(I)]精修的最终残差因子:R=0.0409,wR=0.1061,Flack参数为0.00(9),能够确定绝对构型.化合物的晶体结构和大宗粉末样品的固体圆二色谱表明化合物在结晶过程中发生单一对映体的手性堆积

转炉脱磷脱硫与相关参数的灰色关联分析

应用灰色系统理论对酒钢50t转炉脱磷、脱硫效果进行灰色关联分析,客观地揭示了脱磷、脱硫效果与生产工艺参数的关系。研究结果简便实用,同时也为实际生产及实现脱磷、脱硫同时优化提供了新的思路和理论依据