特殊时期的“亲子”与“师生”

此次疫情从健康角度而言,对人类生命和生活而言是个威胁,而对亲子关系而言,却是个机会,可以有更多的对话、更多的互动、更多的理解,只要把握得好,完全有可能拥有更融洽的关系。首先,有了时间。城里、乡下,其实很多孩子都是隔代抚养、&ldquo;留守&rdquo;儿童,父母曾经都太忙。如今不得</p

The Interaction Mechanism Between Paclitaxel and HSA

以人血清白蛋白(HSA)为实验材料,通过荧光光谱、等温滴定量热及紫外-可见吸收光谱等技术研究化疗药物紫杉醇与其的结合机理.荧光光谱检测结果表明:紫杉醇主要通过氢键和范德华力与HSA结合,并引起其内源荧光的猝灭.在温度为303k下,二者间的结合常数为10.7x103 l/MOl.紫外-可见吸收光谱检测发现,随着紫杉醇浓度的增加,HSA在278nM处的吸收峰增大,证明二者结合后HSA的构象发生了改变.等温滴定量热实验则进一步说明二者的结合是一个自发进行的放热反应,在温度为303k下结合常数为8.8x103 l/MOl,焓变、熵变及吉布斯自由能分别为-99.1kJ/MOl,-183.6J/(MOl·k)和-43.5kJ/MOl.本研究为紫杉醇在血液中的运输及传递提供理论支持.The interaction mechanism of chemotherapy drugs paclitaxel with human serum albumin(HSA)was studied using fluorescence spectroscopy,isothermal titration calorimetry,and UV spectroscopy.The result of fluorescence experiment showed that the intrinsic fluorescence of HSA was quenched by the binding of paclitaxel,with an binding constant of 10.7×103 L/mol at 303K,and the main forces were hydrogen bonds and van der Waals forces.The result of UV-visible spectroscopy experiment showed that the absorption peak of HSA at 278nm increased with the increase of concentrations of paclitaxel.Such phenomenon implied that the interaction might lead to the conformation change of HSA.Isothermal titration calorimetry experiment further confirmed that the interaction between HSA and paclitaxel is a spontaneous process of exothermic reaction,of which the binding constant,enthalpy change,entropy,and Gibbs free energy are 8.8×103 L/mol,-9.9kJ/mol,-183.6J/(mol·K)and-19.1kJ/mol,respectively at 303K.Our current study provides a theoretical explanation for processes of transport and delivery of paclitaxel in the blood.中央高校基本科研业务费专项资金项

Synthesis and Antitumor Activities of 4-Substituted Phenoxybenzamide Derivatives

以4-羟基苯甲酸乙酯为原料,经烃化、水解、缩合反应,合成了6个酰胺类衍生物。其结构经核磁共振氢谱、碳谱和高分辨质谱进行了表征,并对人体肿瘤细胞株进行了初步体外抗肿瘤活性评价。结果表明化合物n-(4-氟苯基)-4-苯氧基苯甲酰胺具有良好的抗肿瘤活性。Six amide derivatives were synthesized via4-hydroxybenzoic acid as start material and alkylation,hydrolysis and condensation reactions.The structure was confirmed by1 HNMR,13CNMR and HRMS.The antitumor effect of all thenewly synthesized compounds on the in vitro growth of tumor celllines was evaluated.The results show that the N-(4-fluorophenyl)-4-phenoxybenzamide has good anti-tumor activity.厦门大学中央高校基本科研业务费资助项

Working Model of Psychological Assistance by Professional Organizations During the COVID-19 Outbreak in China: Experience of the Clinical Psychology Registration Working Committee

新型冠状病毒肺炎疫情发生以来，各专业组织以及专业人员积极投入到心理援助的工作中。文章探讨和 总结了中国心理学会临床心理学注册工作委员会作为专业学术组织在抗疫心理援助中的工作实践，主要包括做 好顶层设计，找准抗疫工作定位，搭建组织框架，确立工作模式，整合资源整体性运作，利用专家资源就抗 疫心理援助向国家政府建言献策，制定和发布心理援助专业规范，组织注册人员专业队伍投入一线心理援助， 以及对专业学术组织规范、有序、有效地开展心理援助的工作范式进行了重要的实践与探索。 &nbsp;</p