Synthesis and Antitumor Activities of 4-Substituted Phenoxybenzamide Derivatives

Abstract

以4-羟基苯甲酸乙酯为原料,经烃化、水解、缩合反应,合成了6个酰胺类衍生物。其结构经核磁共振氢谱、碳谱和高分辨质谱进行了表征,并对人体肿瘤细胞株进行了初步体外抗肿瘤活性评价。结果表明化合物n-(4-氟苯基)-4-苯氧基苯甲酰胺具有良好的抗肿瘤活性。Six amide derivatives were synthesized via4-hydroxybenzoic acid as start material and alkylation,hydrolysis and condensation reactions.The structure was confirmed by1 HNMR,13CNMR and HRMS.The antitumor effect of all thenewly synthesized compounds on the in vitro growth of tumor celllines was evaluated.The results show that the N-(4-fluorophenyl)-4-phenoxybenzamide has good anti-tumor activity.厦门大学中央高校基本科研业务费资助项