支撑应力对骨小梁分布的影响及股骨头坏死因素的研究

目的通过犬股骨颈骨折螺钉内固定模型的力学检测及组织学观察,从微观角度认识骨小梁重建对股骨头坏死的影响。方法选取18只成年田园犬制作成股骨颈骨折螺钉内固定模型,于造模后12周确认所有股骨颈骨折已愈合随机分为取钉组、取钉植骨组及不取钉组,于造模后20周分离所有犬的股骨并进行股骨颈力学测试及组织学观察。结果取钉组、取钉植骨组及不取钉组断裂点载荷、最大载荷差异有统计学意义(P0.05),不取钉组与取钉植骨组断裂点载荷大于取钉组;不取钉组最大载荷大于取钉植骨组与取钉组,取钉植骨组最大载荷大于取钉组。取钉组、取钉植骨组及不取钉组骨小梁宽度与新鲜骨面积差异有统计学意义(P<0.05);不取钉组骨小梁宽度、新鲜骨面积大于取钉植骨组,且取钉植骨组大于取钉组。结论支撑应力的改变将导致骨小梁重新分布,骨小梁再分布是影响股骨头坏死塌陷的重要因素。福建省卫生系统中青年骨干人才培养项目(2014-ZQNJC-34

补骨颗粒含药血清对大鼠软骨细胞凋亡及Trx2信号通路的影响

目的观察补骨颗粒含药血清对体外培养的大鼠膝关节软骨细胞凋亡及对Trx2、ASK1及Caspase3表达的影响,从而探讨补骨颗粒预防骨性关节炎发生发展的作用机制。方法采用两步酶消化法分离培养大鼠软骨细胞,并进行传代培养。应用膜联蛋白V-FITC/PI染色后经流式细胞仪检测软骨细胞的凋亡情况。同时,通过电泳分离蛋白并通过蛋白质印迹分析Trx2、ASK1及Caspase3的表达情况。结果软骨细胞培养15 d左右铺满80%～90%的培养皿,大部分细胞呈梭形。流式细胞检测结果显示空白血清组的细胞凋亡率为22.80%,明显高于含药血清组(P<0.05),而20%含药血清组(15.91%)与30%含药血清组(17.93%)的细胞凋亡率又明显低于10%含药血清组(21.58%),各组间比较差异具有统计学意义(P<0.05)。蛋白质印迹分析结果显示含药血清组Trx2的表达量都明显增多,以10%含药血清组的表达量最多;空白组与10%含药血清组的ASK1与Caspase3的表达量比20%与30%含药血清组多。结论补骨颗粒可以通过激活Trx2信号通路而抑制软骨细胞的凋亡,从而起到预防骨性关节炎发生发展的作用

术中自体血回输在骨盆骨折中的应用研究

目的通过分析自体血回输技术在骨盆骨折手术中的应用情况,为自体血回输技术在临床骨科应用的有效性及安全性提供一定参考。方法通过收集2015年2月至2018年2月期间骨盆骨折术中单纯使用自体血回输或异体血输血的患者,对符合纳入标准患者的基本信息、术中出血量、输血量、血常规、ATP酶活性、TNF-α及C3b,并使用SPSS 20.0软件进行统计学分析。结果自体血回输组与异体血输血组均为20例,其中自体血回输组术中出血量为1 127.50 ml,回输自体血量为464.00 ml;异体血输血组术中出血量为745.00 ml,异体血输血量为300.00 ml。术前自体血回输组的血红蛋白及红细胞比容（Hb:112.80 g/L,Hct:32.9%）与异体血输血组（Hb:112.00 g/L,Hct:33.4%）比较差异无统计学意义（Hb:P=0.908,Hct:P=0.510）;输血后2 h及术后第3天两组的血红蛋白及红细胞比容有所下降,但组间比较差异无统计学意义。通过对比自体血回输与异体血输血后发现两组患者在输血后ATP酶活性都有所降低,但是采用自体血回输方法能够抑制ATP酶活性的降低,组间比较发现自体血回输组ATP酶活性明显高于异体血输血组（P=0.002）。输血后两组TNF-α与C3b值都有所升高,输血前后组间比较差异均无统计学意义。结论术中自体血回输可以提高患者红细胞水平,且与异体血回输相比有更高的ATP酶活性,但并不会明显增加机体的炎症反应,是一种值得推广应用的血液管理方法。福建省自然科学基金资助项目(2016J01597);;\n福州市卫生计生科技计划项目(2016-S-wq2);;\n福州市科技计划项目(2017-S-130-5

漳浦县石寨窑发掘简报

漳浦县石寨窑址是闽南一处专门仿烧龙泉青瓷的窑场,从元代开始,一直延续到明初。其产品种类较少,釉色比较丰富。窑业技术颇具特色,出现了介于分室龙窑和横室阶级窑之间的窑炉结构,对研究闽南地区横室阶级窑的起源与发展具有重要意义

PROGRESS IN ELECTROCHEMICAL PROTECTION FOR STEEL REINFORCING CONCRETE STRUCTURES

作者简介:邱富荣,男,1940年出生,副研[中文文摘]综述了钢筋混凝土构筑物电化学保护的发展和现状 ,包括牺牲阳极系统和外加电流系统 .内容涉及对不同类型、不同龄期构筑物的保护标准、保护参数选择、保护效果的评价以及检测、监测等诸方面 .认为有必要加强电化学驱氯、电化学再碱化等新技术的研究 ;根据构筑物的不同使用环境 ,采用多种有效的、综合的保护措施.[英文文摘]The electrochemical protection mostly in terms of cathodic protection for steel reinforcing concrete structures aims to restrain or prevent the premature failure or damage of the structure due to corrosion of rebar. The research and development of the protection have been more and more attached great importance to control the corrosion since 1973. In this paper, progress in cathodic protection for concrete structures in the last 25 years is reviewed, and concentrated on practical sections, such as cathodic protection criteria ,engineering design , assessment of protection effectiveness , inspection and monitoring of the system both in impressed current method and in sacrificial anode method. Suggestions are that diverse and comprehensive measures for corrosion control should be taken in accordance with the condition of structure situated and new electrochemical techniques to remove chloride from concrete structures and to realkalize the environment at steelPconcrete interface which are to be useful protective treatments , particularly,for existing structures should be extensively developed.国家自然科学基金!资助项目(59871043

Synthesis and Characterization of Epoxidized Styrene-butadiene-styrene Triblock Copolymer

以H2O2为氧化剂,利用原位反应生成的磷钨杂多酸铵盐为催化剂在水/有机溶剂两相体系中使SbS环氧化,研究了反应条件对环氧化反应的影响,并用1H-nMr、fT-Ir、gPC对环氧化SbS(ESbS)的结构进行表征.研究结果表明该环氧化方法具有反应条件温和、反应速度快、新生成的环氧基不发生开环水解反应等优点;但反应中伴随有SbS交联和降解副反应,严重影响ESbS性能.通过添加0.3%--0.6%抗氧剂、选择甲苯/三苯基磷酸酯混合溶剂为有机相可以抑制交联和降解副反应,提高反应选择性,使制得的ESbS具有良好的性能.SBS epoxidation reaction was preformed in water/solvent biphasic system in the presence of in-situ prepared methyltrioctylammoniumtetrakis(diperoxotungstate)phosphate,using H2O2 as oxidant.The effect of reaction conditions on epoxidized SBS properties was investigated.The epoxidized SBS structures and molecular weight distribution were also characterized by 1H-NMR,FT-IR and GPC.It was demonstrated that epoxidation method used in this paper had many advantages,such as mild reaction condition,fast epoxidation speed,free of epoxy group hydrolysis reaction.But serious crosslinking reaction also occurred during epoxidation reaction,which could result in reduced solubility of epoxidized SBS.In order to improve selectivity of epoxidation reaction,0.3%--0.6%(by mass) antioxidant was used,toluene/triphenyl phosphate mixture was chosen as organic phase solvent.Under these reaction conditions,high epoxy degree and well solubility of epoxidized SBS can be gained

Investigation on Heat Resistance of Epoxy Resin Modified with Diphenylsilandiol

为改善双酚A型环氧树脂的耐热性,采用二苯基硅二醇单体与环氧树脂E-44直接开环加成聚合的方法.以辛酸亚锡作催化剂、4,4′-二氨基二苯基砜(ddS)为固化剂,研究了反应条件和E-44与二苯基硅二醇的物质的量配比对改性产物耐热性能的影响.通过傅立叶红外光谱仪(fT-Ir)、动态热机械仪(dMTA)、热失重分析仪(TgA)进行分析,得出最佳反应条件是150℃/2H,配比为3∶1时,改性环氧树脂的玻璃化转变温度(Tg)为147.45℃,分解温度(Td)达到490.5℃(热失重50%).实验结果表明:二苯基硅二醇改性可以提高环氧树脂的耐热性能.In order to enhance the heat resistance of diglycidyl ethers of bisphenol A type epoxy resin,in this paper,epoxy resin(E-44) was modified with diphenylsilandiol monomer through direct ring-opening addition.With stannous octanoate as the catalyst and 4,4′-diaminodiphenylsulfone(DDS) as the curing agent,we studied the influence of reaction conditions and the molar ratio of resin and diphenylsilandiol on the heat resistance of modified products.Through fourier transform infrared spectroscopy analysis(FT-IR),dynamic thermal mechanical analysis(DMTA)and thermogravimetric analyzer(TGA),the best reaction conditions and molar ratio were obtained to be 150℃/2 h and 3∶1,respectively.Glass transition temperature(Tg) is 147.45℃,and temperature at 50% loss is 490.5℃.The results reveal modification by diphenylsilandiol can enhance the heat resistance of epoxy resin

考虑速度过冲的单载流子光探测器特性

通过在器件模拟中引入考虑了速度过冲效应的水动力学模型,对单载流子光探测器 (UTC-PD)的传统漂移扩散模型进行了改进. 结果表明,电子的速度过冲有效地减小了空间电荷效应,从而提高了器件的带宽. 同时,通过对器件的直流和交流特性分析,研究了吸收层和收集层参数对器件性能的影响