54/07/15 8:55AM, Jessie Dill

Jessie Dill gave a statement to the police regarding an encounter she had with Marilyn Sheppard at the beach in Fairport Harbor, Ohio. Dill stated that she had spoken with a woman who would not give her name but said she had a son named Chip. The woman stated that her husband had been having affairs and that she wanted to divorce him, but she was four months pregnant. The woman also stated that she had been having an affair with another man, but if she divorced her husband and married this other man, her baby would be a month old after she remarried. Dill described the woman, her wallet, and her purse. She stated that when she read of Marilyn\u27s death, she called the Sheppard house and spoke to Marilyn\u27s sister-in-law, who advised her to forget about their conversation on the beach

UA12/8 WKU Police - Campus Security Report, 2009

This report is designed to provide students, potential students, parents, facility and staff with crime statistics and information on university services and crime prevention programs. These programs are designed to help inform our campus communities about safety practices that will help you reduce the risk of being a crime victim. I feel that these lessons can give people information that they can carry with them beyond college and will help keep them safe for the rest of their lives

UA12/8 Annual Report

A statement of current campus policies regarding procedures for students and others to report criminal actions or other emergencies occurring on campus and policies concerning the institution\u27s response to such reports

UA12/8 WKU Police - Annual Security Report

This report is designed to provide students, potential students, parents, facility and staff with crime statistics and information on university services and crime prevention programs. These programs are designed to help inform our campus communities about safety practices that will help you reduce the risk of being a crime victim. I feel hat these lessons can give people information that they can carry with them beyond college and will help keep them safe for the rest of their lives

UA12/8 Annual Campus Security and Fire Report

This report is designed to provide students, prospective students, parents, faculty, and staff with accurate crime statistics, information on university services, and crime prevention programs. These programs are designed to help inform our campus community about safety practices that will help reduce the risk of becoming a victim of crime. These safe practices can provide individuals with vital information that they can carry with them through college and beyond, keeping them safe for the rest of their lives

UA12/8 Campus Security Report

A statement of current campus policies regarding procedures for students and others to report criminal actions or other emergencies occurring on campus and policies concerning the institution\u27s response to such reports

UA12/8 WKU Police - Campus Security Report, 2008

This report is designed to provide students, potential students, parents, facility and staff with crime statistics and information on university services and crime prevention programs. These programs are designed to help inform our campus communities about safety practices that will help you reduce the risk of being a crime victim. I feel hat these lessons can give people information that they can carry with them beyond college and will help keep them safe for the rest of their lives

Approaches To Alleviate The Vigabatrin Induced Retinal Toxicity

Safety of therapeutics is one of the primary concerns during the treatment of any ailments. Most of the toxic effects of drugs occurs due to accumulation of drug in organs, which is dependent on the dosage of the drug. The ideal therapy should minimize the risk of causing adverse events at the same time elicit intended therapeutic effects. Vigabatrin (VGB) is an antiepileptic drug used primarily in the treatment of infantile spasms and it acts by inhibiting gamma amino butyric acid (GABA) transaminase thereby increasing inhibitory neurotransmitter GABA levels. At therapeutic doses, VGB accumulates in retina leading to peripheral visual field defects and retinal degeneration. To alleviate retinal toxicity of VGB, different approaches have been explored to decrease the ocular accumulation of VGB and to protect retina from deleterious effects of VGB. Intranasal administration approach was investigated to deliver VGB directly to brain via olfactory region. The in vivo acute, sub-acute and pharmacodynamic studies were performed in Sprague Dawley rats by administering VGB through intraperitoneal and intranasal routes. The mechanism of VGB transport across blood retinal barrier was studied using retinal epithelial cells (ARPE-19) cells. The in vitro and in vivo studies were performed to evaluate the mechanism involved in retinal uptake of VGB and identify approach to decrease VGB retinal uptake. The effects of VGB on retinal neuronal (R28) and ARPE-19 cells were studied. The cytoprotective effect of silymarin and taurine on VGB induced retinal toxicity was investigated. The subacute intranasal administration decreased retinal VGB levels and histological changes compared to intraperitoneal administration. Intranasal pharmacodynamic study demonstrated smaller dose produced significant antiepileptic activity with prolonged duration of VGB action. The ARPE19 cellular transport studies shoNa+/Cl- dependent transporter, TauT was involved in retinal VGB uptake. Further, in vitro cell uptake and in vivo SD rat studies demonstrated TauT inhibitors decreased VGB retinal uptake, thus confirming role of TauT in retinal uptake of VGB. The in vitro cell toxicity studies demonstrated, VGB treatment produced cell death in ARPE19 and R28 cells are due to apoptosis and necrosis, respectively. Further, studies demonstrated antioxidants silymarin and taurine constituents decreased VGB induced cell toxicity. The study results demonstrate intranasal administration of VGB along with a safe TauT inhibitor and an antioxidant as a supplement would be beneficial to prevent the VGB induced retinal toxicity