Fermionic currents in topologically nontrivial braneworlds

We investigate the influence of a brane on the vacuum expectation value (VEV) of the current density for a charged fermionic field in background of locally AdS spacetime with an arbitrary number of toroidally compact dimensions and in the presence of a constant gauge field. Along compact dimensions the field operator obeys quasiperiodicity conditions with arbitrary phases and on the brane it is constrained by the bag boundary condition. The VEVs for the charge density and the components of the current density along uncompact dimensions vanish. The components along compact dimensions are decomposed into the brane-free and brane-induced contributions. The behavior of the latter in various asymptotic regions of the parameters is investigated. It particular, it is shown that the brane-induced contribution is mainly located near the brane and vanishes on the AdS boundary and on the horizon. An important feature is the finiteness of the current density on the brane. Applications are given to $Z_2$-symmetric braneworlds of the Randall-Sundrum type with compact dimensions for two classes of boundary conditions on the fermionic field. In the special case of three-dimensional spacetime, the corresponding results are applied for the investigation of the edge effects on the ground state current density induced in curved graphene tubes by an enclosed magnetic flux.Comment: 32 pages, 9 figures, PACS numbers: 04.62.+v, 03.70.+k, 98.80.-k, 61.46.F

Model of creation and management of the process of technological projects development

The purpose of the article is to determine and describe main principles and model of development of regional business accelerator on the basis of technical university for development of innovational startups. The research included the work on identification of the problems of the process of commercialization of technological developments, which business accelerator should solve. One of the basic purposes of creation of business accelerator is increase of the flow of prepared projects for consideration by investment committees of funds of early stages. Accelerator can be a full-scale unified mechanism of formation of deals flow from diversified mass of completed R&D. As a result of the research, the authors come to a conclusion that the process of creation of value and movement from prototype to entering a market supposes long chain with formation of various risks at each stage – scientific, financial, administrative, etc. Minimization of such risks requires from partners, involved with the work of business accelerator, solving emerging problems together. Such motivation could be formed by development of business accelerator by the principles of partnership and creation of equal access and rights for basic members.peer-reviewe

Student motivation for professional self-improvement

Problems of arousing student motivation in vocational education are discussed. The authors suggest dealing with these problems by specifying the learner’s vocational self-determination and stimulating their professional growth. The notion of “professional self-improvement of students in the system of secondary vocational education” is introduced. Relations between students’ and teachers’ motivation problems are revealed.Раскрываются проблемы формирования мотивации студентов к профессиональному обучению. Предлагается методика разрешения этих проблем средствами уточнения профессионального самоопределения и профессионального самосовершенствования. Вводится определение понятия «профессиональное саморазвитие студентов профессиональных образовательных организаций среднего профессионального образования». Обозначаются связи между проблемами мотивации у студентов и преподавателей

Formation of the system of management of supporting university on the basis of strengthening of communication component

The article deals with changes in the system of management of educational establishments of higher education caused by creation of supporting universities. The program of creation of such universities supposes formation of universities-leaders in regions, which can consolidate educational and scientific basis for training of personnel in Russian subjects. During creation of supporting regional universities, the emphasis is made on the fact that they are to become the centers of innovational development, being a part of economy and region’s infrastructure at the same time. At that, creation of new engineering and implemental centers and R&D laboratories requires complex realization of projects for creation of high-tech production and necessary conditions for development of interface of regional supporting universities and enterprises. The article views functions and organizational structure of management of technical university; establishes dependence of intensity of organizational transformations on various factors. The authors show a process of formation of matrix organizational structure of technical supporting university with the use of mobile informational and communicational structures, which is formed by placement of horizontal connections on existing linear and functional structure.peer-reviewe

Single Shot Temporal Action Detection

Temporal action detection is a very important yet challenging problem, since videos in real applications are usually long, untrimmed and contain multiple action instances. This problem requires not only recognizing action categories but also detecting start time and end time of each action instance. Many state-of-the-art methods adopt the "detection by classification" framework: first do proposal, and then classify proposals. The main drawback of this framework is that the boundaries of action instance proposals have been fixed during the classification step. To address this issue, we propose a novel Single Shot Action Detector (SSAD) network based on 1D temporal convolutional layers to skip the proposal generation step via directly detecting action instances in untrimmed video. On pursuit of designing a particular SSAD network that can work effectively for temporal action detection, we empirically search for the best network architecture of SSAD due to lacking existing models that can be directly adopted. Moreover, we investigate into input feature types and fusion strategies to further improve detection accuracy. We conduct extensive experiments on two challenging datasets: THUMOS 2014 and MEXaction2. When setting Intersection-over-Union threshold to 0.5 during evaluation, SSAD significantly outperforms other state-of-the-art systems by increasing mAP from 19.0% to 24.6% on THUMOS 2014 and from 7.4% to 11.0% on MEXaction2.Comment: ACM Multimedia 201

Immunotropic effects of vitamin D3 in original rectal suppositories in experimental ulcerative colitis

Increased incidence of ulcerative colitis (UC) is a prerequisite for searching new therapeutic approaches, primarily with an opportunity of site-directed impact on the colon lesion. UC pathogenesis is associated with dysregulated immune response, and limited effectiveness of basic therapy for the disorder. Vitamin D3 exhibits antioxidant, anti-inflammatory, immunomodulatory and other properties, it has been shown to be effective in some autoimmune diseases, thus prompting us to study its effect on immune status in UC. We aimed for studying the effect of vitamin D3, as a component of original rectal suppositories, upon clinical course and indexes of immune status in experimental UC. UC in rats was modeled with 3% oxazolone solution. The vitamin D3-containing suppositories (1500 IU) weighing 300 mg were administered per rectum every 12 hours for 6 days. On days 2, 4 and 6 of UC, the clinical features were assessed as well as blood leukocyte counts, numbers of CD3+, CD45RA+; absorbing and NBT-reducing abilities of blood neutrophils were determined; IgM, IgG, IL-6 and IL-8 concentrations in serum were also studied.The DAI index increased in non-treated UC, along with raised neutrophil numbers in blood, their absorption and NBT-reducing activity was also increased, the total number of lymphocytes, including CD3+, CD45RA+ became higher, serum concentrations of IgM, IgG, IL-6, IL-8 increased. Local use of vitamin D3 in UC reduces DAI parameters, causes decrease in blood neutrophil counts, reducing and partially restoring absorptive and NBT-reducing abilities of neutrophils, decline of total lymphocyte counts in blood, partially restoring the CD3+ and CD45RA+ numbers, causing decline and partial restoration of serum IgM, IgG, IL-6, IL-8 concentrations. An association between clinical signs and indexes of immune status in UC was established under the conditions of vitamin D3 use. Conclusions: The protective effect of vitamin D3 in UC can be mediated by its antioxidant effect, changes in production of immunoregulatory cytokines, modulation of Th1-, Th2-, Th17-dependent reactions and Treg activity, being a pre-requisite for further studies to clarify the mechanism of vitamin D3 immunotropic action in UC,with an opportunity of using it in clinical practice

Bose-Einstein Condensation of Helium and Hydrogen inside Bundles of Carbon Nanotubes

Helium atoms or hydrogen molecules are believed to be strongly bound within the interstitial channels (between three carbon nanotubes) within a bundle of many nanotubes. The effects on adsorption of a nonuniform distribution of tubes are evaluated. The energy of a single particle state is the sum of a discrete transverse energy Et (that depends on the radii of neighboring tubes) and a quasicontinuous energy Ez of relatively free motion parallel to the axis of the tubes. At low temperature, the particles occupy the lowest energy states, the focus of this study. The transverse energy attains a global minimum value (Et=Emin) for radii near Rmin=9.95 Ang. for H2 and 8.48 Ang.for He-4. The density of states N(E) near the lowest energy is found to vary linearly above this threshold value, i.e. N(E) is proportional to (E-Emin). As a result, there occurs a Bose-Einstein condensation of the molecules into the channel with the lowest transverse energy. The transition is characterized approximately as that of a four dimensional gas, neglecting the interactions between the adsorbed particles. The phenomenon is observable, in principle, from a singular heat capacity. The existence of this transition depends on the sample having a relatively broad distribution of radii values that include some near Rmin.Comment: 21 pages, 9 figure

Melatonin in the dermal film limits the blood lymphocyte death in experimental thermal trauma

According to WHO data, about 11 million people need medical care after burns every year. In the overall structure of burns, the share of thermal trauma (TT) is 80%. Lymphocytopenia in TT is a risk factor for infectious complications and limited repair, and the development of new tools for TT therapy using dermal films is demanded in combustiology. The aim of the study was to evaluate changes in blood lymphocyte parameters, i.e., quantitative composition and their death during experimental thermal damage under the influence of the originally developed dermal film with melatonin (MT) in 49 inbred rats. The grade IIIA TT of 3.5% body surface was modeled by contact with boiling water for 12 s. Dermal films based on sodium carboxymethylcellulose supplemented with MT at a concentration of 0.005 g/g were applied daily for 5 days. The total numbers of lymphocytes, CD45RA+ and CD3+ cells, counts of lymphocytes with signs of partial necrosis, early and late apoptosis were assessed in blood. Relative decrease in the area and rate of the burn wound epithelization were also calculated. In animals with TT, the number of blood lymphocytes decreased on days 5, 10 and 20, including CD45RA+ and CD3+, along with increased amounts of lymphocytes with signs of necrosis, late and early apoptosis. By the term of 20 days, the burn wound area was reduced by 11.5%. Usage of dermal films with MT increased the amount of CD3+ cells in blood on days 5 and 10, CD45RA+ on days 5, 10 and 20, being associated with decreased number of lymphocytes showing signs of early apoptosis on days 5, 10 and 20, as well as features of necrosis and late apoptosis on days 5 following TT, accelerates the healing of a burn wound on days 5, 10 and 20 after TT. with a 20 cent reduction of its area by the day 20. Epithelization rate of the burn wound when applying MT-supplemented dermal film on days 5, 10 and 20 increases, along with higher amounts of CD3+ in the blood, and reduced counts of lymphocytes with signs of early apoptosis

Immunotropic effects of Curcuma longa extract as a component of original rectal suppositories in the dynamics of experimental Сrohn’s disease

Crohn’s disease is an urgent problem of modern gastroenterology due to increasing prevalence, severity of complications and side effects of the basic therapy, in particular upon treatment with 5-aminosalicylic acid (5-ASA). Searching, development and trials of new effective drugs with minimal side effects in Crohn’s disease is an urgent task. Curcuma longa is one of the initial substances containing curcumin with antioxidant, cytoprotective, anti-inflammatory properties. Its effectiveness has been demonstrated in few studies with its systemic use in Crohn’s disease treatment. Our aim was to perform a comparative analysis of curcumin and 5-ASA effect applied as a composition of rectal suppositories, studying clinical signs and indices of immune status in experimental Crohn’s disease. The study was performed on 70 Wistar male rats. Crohn’s disease was modeled by introduction of a 50% alcohol solution of trinitrobenzene sulfonic acid (TNBS) per rectum, and verified by clinical and morphological methods. Rectal suppositories, each containing 50 mg of 5-ASA and original suppositories containing 0.075 mg of curcumin were used over 12 hours during 7 days. The studies were performed on the 3rd , 5th and 7th days of Crohn’s disease.In the course of experimental TNBS-induced Crohn’s disease in animals, an increased frequency of bowel motility, appearance of blood in the stool, decreased body weight progressed from the 3rd to the 7th days of observation, along with increased number in CD3+, CD45RA+ lymphocytes in blood, higher number of segmented neutrophils, lower absorption and NBT-reducing activity of blood neutrophils, increased serum concentrations of IL-23, IgM, IgG. Composition of the new medication form was justified; production technology and standardization of the suppositories containing curcumin for the treatment for Crohn’s disease were developed. Usage of rectal suppositories with curcumin is associated with decreased severity of clinical signs, decrease and partial restoration of segmented neutrophils, CD3+ lymphocyte numbers in blood, recovery of absorption and NBT-reducing ability of blood neutrophils, and decrease of IL-23, IgM, IgG concentrations in serum. The effectiveness of rectal suppositories with curcumin is compared to the effectiveness of the use of rectal suppositories with 5-ASA in terms of disease activity index, the number of neutrophils and CD3+ lymphocytes in the blood, serum concentrations of IL-23, IgM and IgG, in, at lesser extent, in terms of absorption and NBT- reducing ability of blood neutrophils.The composition and production technology of rectal suppositories with curcuminwas developed; the leukocyte populations, CD3+, CD45RA+ lymphocytesin blood were assesed, neutrophil absorption and NBT-reducing ability, IL-23, IgM and IgG concentrations were determined; the use of rectal suppositories with curcumin in experimental Crohn’s disease is comparable with the effectiveness of rectal suppositories with 5-ASA