LITHIUM-INDUCED NEPHROGENIC DIABETES INSIPIDUS RESPONSIVE TO DESMOPRESSIN

WOS: 000485206400020PubMed: 31508188Nephrogenic diabetes insipidus (NDI) is the most common renal side effect seen with lithium therapy. Persisting cases after the cessation of the therapy may be seen when lithium therapy is continued for too long. Although desmopressin treatment is not one of the accepted treatment modalities for NDI, there are few reports using desmopressin treatment in unresponsive cases. Herein, we reported the fourth lithium-induced NDI case in the literature responsive to desmopressin therapy

Preparation and bioevaluation of 99mTc-carbonyl complex of guanine

The aim of this study is to prepare radiolabeled guanine with 99mTc(CO) 3 + core. For this purpose, guanine has been radiolabeled with 99mTc(CO) 3 + core. Quality control study of radiolabeled guanine molecule with 99mTc(CO) 3 + core was performed by thin layer radio chromatography (TLRC) and high performance liquid radio chromatography (HPLRC). The results showed that the radiolabeling yield was quite high (94 ± 3%). Beside that 99mTc(CO) 3-Gua complex has showed good in vitro stability during the 24 h period. Radiopharmaceutical potential of this complex was evaluated in Wistar Albino Rats. It was concluded that 99mTc(CO) 3-Gua could be used as a nucleotide radiopharmaceutical for in vivo applications. © 2011 Akadémiai Kiadó, Budapest, Hungary.Firat University Scientific Research Projects Management Unit: 2007NBE003Acknowledgment This study was financially supported by the Ege University Scientific Research Project numbered 2007NBE003 (Bornova Izmir, Turkey). -

Bioevaluation of 99mTc(CO) 3-Guanine in vitro and in vivo

The aim of this study is to examine biological behaviour of radiolabeled guanine with [Tc(CO) 3] + core in vitro and in vivo. In vitro biological behavior of 99mTc(CO) 3-Gua was evaluated on Lung (A-549), Breast (MCF-7), Colonic (Caco) carcinoma cell lines and normal human bronchial epithelial (NHBE). 99mTc(CO) 3-Gua compound showed high uptake on A-549 cell line when compared to NHBE cell line. Biodistribution characteristics of 99mTc(CO) 3-Gua was evaluated using New Zeland Rabbits. Scintigraphic results showed that a high level of radioactivity was observed in the lungs and liver shortly after administration of the 99mTc(CO) 3-Gua and excretion takes place via both renal and hepatobiliary route. It was concluded that 99mTc(CO) 3-Gua could be used as a nucleotide radiopharmaceutical for imaging purposes. © 2012 Akadémiai Kiadó, Budapest, Hungary