Effects of Curcumin on Changes in Spermatogenetic Cells of Rats Treated with Cisplatin

Cisplatin is an effective antineoplastic drug which is used to treat many types of cancer. The most common known side effect of this drug is infertility. Curcumin, also called turmeric, has antioxidant and antitumor activities. This study was designed to investigate the effects of curcumin on the changes in spermatogenetic cells caused by cisplatin, which is used as a chemotherapeutic drug especially in testicular cancers. For this purpose, randomly selected 36 Spraque Dawley rats were seperated to 4 groups that of control, cisplatin, curcumin and curcumin+cisplatin and each group was seperated to 3 subgroups, each of them have 3 rats, so total 12 subgroups were obtained. The testicular tissues obtained from rats were evaluated histochemically, immunohistochemically and ultrastructually. In the results of this study, it is observed that the rate of apoptosis increased significantly in the experimental groups given curcumin together with cisplatin injection, and the transition-1 protein which is involved in DNA packaging in the elongated spermatids belonging to stages of XII, XIII an XIV, immunopositivity is increased statistically in the cisplatin-administered experimental groups compared to control groups. Both light and electron microscopic findings showed that intense degeneration, vacuolization, germ cell loss and spermatogenetic arrest occurred especially in the group given curcumin together with cisplatin. The results of our study showed that cisplatin can cause problems in infertility through DNA packaging and dragging cells to apoptosis and necrosis. Physicians who use cisplatin for cancer treatment are advised not to use curcumin together with cisplatin because it exacerbates the side effects of the cancer drug

Gebe olmayan bir kadında kalçanın idiopatik geçici osteoporozu: vaka çalışması

Kalçanın geçici osteoporozu (KGO) öncelikle orta yaşlı erkekleri ve ge- beliğin üçüncü trimestrindeki dönemindeki kadınları etkileyen nadir bir hastalıktır. KGO kalça ağrısı ve radyolojik olarak eklem aralığında daralma veya destrüksiyon olmaksızın ortaya çıkan geçici osteopeni ile ilişkilidir. Kadınlar için tanımlanmış tek risk faktörü gebeliktir. Tipik olarak semp- tomların kendiliğinden rezolüsyonu ile benign bir seyir gösterir. Radyog- rafiler erken dönemde belirti vermeyebilir. Bu nedenle, geçici osteoporoz avasküler nekroz gibi çok sayıda diğer hastalıklarla karışabilir. Erken dö- nemlerde bu iki hastalığın birbirinden ayırt edilmesi uygun tedavi planı- nın seçilebilmesi için önemlidir. Bu yazıda, gebelik de dahil olmak üzere herhangi bir risk faktörü olmayan ve konserevatif tedavi ile yeterli iyileşme gösteren KGO’lu 35 yaşındaki kadın hasta sunulmuştur.Türk Fiz T›p Re­hab Derg 2013;59:157-60.Transient osteoporosis of the hip (TOH) is a rare disease affecting women in the third trimester of pregnancy as well as middle-aged men. TOH is associated with hip pain and temporary osteopenia apparent on radiology without joint space narrowing or destruction of the hip. Pregnancy is the only recognized risk factor for women. It typically runs a benign course with eventual resolution of symptoms. Radiographs may be unrevealing early in its course. Therefore, transient osteoporosis may be confused with many other conditions such as avascular necrosis. In early stages, it is important to distinguish between these two conditions to order to decide on an appropriate treatment plan. In this report, we present a 35-year-old woman who had TOH, without any risk factor including pregnancy, and showed sufficient improvement with conservative treatment. Turk J Phys Med Rehab 2013;59:157-60

Synthesis, characterization and cyclization reactions of some new bisthiosemicarbazones

The reaction of trans-1, 4-dichloro-2-butene 1 with selected phenols affords (E)-1, 4-bis(aryloxy)-2-butenes 2a-d which are converted into bis-thiosemicarbazones 3a-h via the reactions with thiosemicarbazide and 4-methyl thiosemicarbazide, respectively. Similarly, 4-methyl-5-ethoxycarbonyl- 2, 3-dihydro-1, 3-thiazoles 4a-h are synthesized via the reaction of bis-thiosemicarbazones 3a-h with ethyl 2-chloroacetoacetate. trans-1, 4-Dithiocyanato-2-butene 5 is obtained from the reaction of KSCN and trans-1, 4-dichloro-2-butene 1. Furthermore, the bis-2-amino-1, 3, 4-thiadiazoles 6k and l are obtained from the reaction of trans-1, 4-dithiocyanato-2-butene 5 with thiosemicarbazide and 4-methyl thiosemicarbazide, respectively. These compounds are characterized by elemental analyses, infrared, 1H-, 13C-NMR and mass spectrometry. Finally, the microbial features of all compounds are determined. Some of them exhibited microbial activities at low level, and the electronic absorption spectra of the compounds 3b, d, f and h are measured in organic solvents (MeOH, DMF, DMSO and 1, 4-dioxane) with various polarities

Which out-of-office measurement technique should be used for diagnosing hypertension in prehypertensives?

Hypertension (HT) is diagnosed with high office blood pressure (BP), although confirmation with the addition of out-of-office measurements is currently recommended. However, insufficient data are available concerning the use of out-of-office BP measurement techniques for the diagnosis of HT in the prehypertensive population. The aim of the present study was to determine which out-of-office measurements yielded earlier and more frequent detection of development of HT in prehypertensive patients. Two hundred seven prehypertensive patients under monitoring in the Cappadocia cohort were included in the study. Office BP was measured five times at 1-min intervals, followed by 24-h ambulatory BP monitoring (24-h ABPM). Home BP measurement (HBPM) was performed five times, at the same times in the morning and evening, at 1-min intervals for 1 week. The same procedure was carried out at 4-6-month intervals for ~2 years. HT was diagnosed in 25.6% of subjects, masked HT in 11.1%, and white coat HT in 2.9%, while 23.7% remained prehypertensive and 36.7% became normotensive. Briefly, 56.6% of the patients with HT were diagnosed with office plus 24-h ABPM, 13.2% with office plus HBPM, and 30.2% with office plus HBPM and 24-h ABPM. Office with 24-h ABPM yielded statistically significantly more diagnoses (p < 0.001). In conclusion, our prospective observational study evaluated the usefulness of out-of-office BP measurements in confirming diagnosis of HT in prehypertensive patients. The findings show that 24-h ABPM detected HT earlier and more frequently in this high-risk population

İnce malzeme miktarı ve cinsi ile iri agrega boyutunun kendiliğinden yerleşen betonların işlenebilirlik özelliklerine etkisi

Self-compacting concretes (SCC) were prepared with 10 mm and 16 mm coarse aggregate sizes and using limestone powder (LS) and fly ash (FA) as fine material. The amount of fines in concrete, where the amount of cement and the water / cement ratio were kept constant, was increased in 36 dm3 increments up to 108 dm3. The effect of the type and amount of fines and coarse aggregate size on flowing, passing, segregation and blocking properties of SCCs were examined. Experimental results indicated that slump flow increases with increasing fines content. Opposite to this, V-funnel times increased with increasing fines content, however, they were shorter for FA than those of LS, which can be attributed the balling and lubrication effect of the former and arching effect of the latter particles. For both fines, higher segregation was obtained for SCCs with 16 mm than those of 10 mm. The SCCs with low amount of fines displayed higher blocking step in general and FA-added concretes had higher segregation than those of LS. The difference in the behaviors of LS and UK added concretes is most probably due to the differences in the particle shape and surface properties.Kendiliğinden yerleşen betonlar (KYB), 10 mm ve 16 mm iri agrega boyutlarında ve ince malzeme olarak kalker tozu (KT) ve uçucu kül (UK) kullanılarak hazırlanmıştır. Çimento miktarı ve su/çimento oranının sabit tutulduğu betonlardaki ince malzeme miktarı 36 dm3 'lük artışlarla 108 dm3 'e kadar çıkarılmıştır. İnce malzeme tipi ve miktarının ve iri agrega boyutunun KYB'lerin akma, dar açıklıktan geçme, ayrışma, bloke olma gibi özelliklerine etkisi incelenmiştir. Deneysel sonuçlar, artan ince malzeme içeriği ile çökme akışının arttığını göstermiştir. Bunun tersine, artan ince tane içeriği ile V-hunisi süreleri artmıştır, ancak UK için KT'den daha kısa süreler elde edilmiştir. UK küresel tanecik yapısında olduğu için beton karışımı içinde yağlayıcı etki gösterir. Her iki ince malzeme için de 16 mm'lik KYB'ler için 10 mm'lik olanlardan daha yüksek segregasyon elde edilmiştir. Düşük miktarda ince malzeme içeren KYB'ler genel olarak daha yüksek blokaj adımı sergilemiştir ve UK katkılı betonlar KT'ye göre daha yüksek ayrışma göstermiştir. KT'li ve UK’lı KYB’lerde gözlenen bu farklı davranış muhtemelen tane şekli ve yüzey özelliklerindeki farklılıklardan kaynaklanmaktadır

EVALUATION OF ASPHALT PAVEMENT PERFORMANCE FOR DIFFERENT DIATOMITE CONTENT

The majority of steel and reinforced concrete bridges are produced with asphalt pavement. The reason for this is to protect steel and concrete structures from the effects of water and degrading salt additives and to increase their durability. Asphalt bridge superstructures are mostly manufactured with four layers. These layers are the primer bonding layer, waterproofing layer, protection layer and surface asphalt wearing layers. The superstructure must protect the supporting substructure. It should protect the life of the structure and ensure the integrity of the structure against permanent deformation, aging, raveling, water damage and chemical effects. Diatomite additive is used as a performance enhancer in various aspects. It is generally preferred in the region of 5%-15% according to the bitumen mass. The granulometric size and chemical properties of the diatomite additive are other effective factors. In this study, the rutting resistance of conventional and diatomite-modified asphalt pavement for 5% and 10% ratios for selected diatomite additive gradation is investigated. The rutting resistance of the pavements is investigated by repeated creep tests for two different additive ratios on water-damaged and control mixtures. In unconditioned samples, 5% diatomite-modified mixtures; in conditioned samples, 10% diatomite-modified mixtures showed the greatest deformation resistance

Türk kolon ve rektum cerrahisi derneği (TKRCD) terminoloji komisyonu çalışma raporu

This study aimed to explain the working order of the Terminology Commission, which was established at the workshop of the Turkish Society of Colon and Rectal Surgery (TKRCD) on February 22, 2020, the criteria and results in the preparation of the terminology report. The commission prepared a work plan to complete in three main steps. The working process continued in a way that the members expressed their opinions with equal rights and the decisions were taken by consensus or by majority vote. The main purpose of the commission study was determined as “determining the terms that need to be explained and agreed in colorectal surgery, and to define them in a way that is compatible with the literature and contributes to daily practice”. The first meeting of the commission was held on February 22, 2020, and the report was accepted by the TKRCD Board of Directors on May 25, 2021. A total of 20 meetings were held during this period. In the first step, five headings were determined for writing the terms: Anatomy, symptoms and diagnostic tools, diseases, treatments and complications. There was a consensus that the terms met the following three conditions: 1) the need for explanation and consensus in colorectal surgery, 2) literature support, and 3) use in daily practice. The terms were written in the following format: Terms and synonyms, English equivalents, definition, explanation and bibliography. In the second step, each commissioner wrote an average of 10.8±4.3 terms. The distribution of 89 terms in the final report was as follows: Anatomy (n=26, 29.2%), symptoms and diagnostic tools (n=8, 8.9%), diseases (n=20, 22.4%), treatments (n=28, 31.4%), and complications (n=7, 7.8%). Figures (n=7), all from the archives of the commission members, and figures drawn by a new commission member (n=53) were also added to the report. In the third step, the report was submitted to the TKRCD Management with the approval of the TKRCD President. The preparation process of the Terminology Commission report of TKRCD was presented. The final report is open to changes and expansions with future studies.Bu çalışma Türk Kolon ve Rektum Cerrahisi Derneği’nin (TKRCD) 22 Şubat 2020 tarihinde yaptığı çalıştayda kurulan Terminoloji Komisyonu’nun çalışma düzenini, terminoloji raporunun hazırlanmasındaki kriterleri ve sonuçlarını açıklamayı amaçlamaktadır. Komisyon üç ana basamakta tamamlayacak iş planı hazırlamıştır. Çalışma süreci üyelerin eşit haklarla görüş belirttiği ve kararların uzlaşı veya oy çokluğuyla alındığı bir şekilde sürdürülmüştür. Komisyon çalışmasının temel amacı “kolorektal cerrahide açıklanması ve uzlaşı sağlanması gerekli terimlerin belirlenmesi, literatüre uygun ve günlük pratiğe katkı sağlayacak bir şekilde tanımlanması” olarak saptanmıştır. Komisyon ilk toplantısı 22 Şubat 2020’de yapılmış, rapor ise TKRCD Yönetim Kurulu’nda 25 Mayıs 2021’de kabul edilmiştir. Bu dönemde toplam 20 toplantı yapılmıştır. İlk basamakta terimlerin yazılması için beş adet üst başlık belirlenmiştir: anatomi, semptomlar ve tanı gereçleri, hastalıklar, tedaviler ve komplikasyonlar. Terimlerin şu üç şartı sağlaması konusunda karar birliği oluşmuştur: 1) kolorektal cerrahide açıklanması ve uzlaşı sağlanması gerekliliği, 2) literatür desteği ve 3) günlük pratikte kullanılması. Terimler şu formatta yazılmıştır: terim ve eş anlamlıları, İngilizce karşılıkları, tanım, açıklama ve kaynakça. İkinci basamakta her bir komisyon üyesi ortalama 10,8±4,3 terim yazmıştır. Sonuç raporunda yer alan 89 terimin üst başlıklara dağılımı şu şekildedir: anatomi (n=26, %29,2), semptomlar ve tanı gereçleri (n=8, %8,9), hastalıklar (n=20, %22,4), tedaviler (n=28, %31,4) ve komplikasyonlar (n=7, %7,8). Tamamı komisyon üyelerinin arşivlerinden gelen resimler (n=7) ve yeni bir komisyon üyesi tarafından çizilen şekiller de (n=53) rapora eklenmiştir. Üçüncü basamakta rapor TKRCD Başkanının onayıyla TKRCD Yönetimi’ne sunulmuştur. TKRCD’nin Terminoloji Komisyonu raporunun hazırlık süreci sunulmuştur. Sonuç raporu ileride yapılacak çalışmalarla değişiklik ve genişletmelere açıktır

Relationship Between Sleep Duration and Coronary Artery Disease in Older Adults

Purpose: Insomnia, a frequent geriatric syndrome, is thought to be linked with coronary artery disease and increased mortality. The aim of our study was to examine the relationship between sleep duration and coronary artery disease (CAD) and cardiovascular risk factors. Materials and Methods: In this study, patients who applied to the geriatric outpatient clinic for comprehensive geriatric assessment were retrospectively evaluated. Patients were divided into two groups according to the six hours of ideal sleep assumption: those who slept less than six hours and those who slept six hours or more. Results: A total of 2255 patients (age 72±6 years, 63.3% female) were included in this study. Patients who were sleeping less than 6 hours were older (14.4% vs. 10.3%; p=0.005) and most of them were female (69.5% vs. 60.2%; p<001). Coronary artery disease (31.9% vs. 25.9%; p= 0.003), falls (31.8% vs. 25.3%; p=0.002) and depression (25.7% vs. 21.3%; p=0.022) were more common, while hypertension ( 68.5% and 72.5%; p=0.049) were less common in the short sleep duration group. The regression analysis showed that short sleep duration was significantly associated with CAD (OR:1.39; 95% CI:1.14-1.7; p=0.001), falls history (OR:1.25; 95% CI:1.02-1.5; p=0.026), age (OR:1.01; 95% CI:1.01-1.04; p=0.001), male gender (OR:0.63; 95% CI:0.51-0.76; p<0.001), and hypertension (OR:0.74; %95 CI:0.6-0.9; p=0.003). Conclusion: Similar to the literature, CAD was observed more frequently in patients who slept less than 6 hours in our results. Considering this relationship between short sleep duration and CAD, it is important to question sleep duration in comprehensive geriatric assessment

Influenza and pneumonia vaccination rates and factors affecting vaccination among patients with chronic obstructive pulmonary disease

Background: Influenza and pneumococcal vaccinations are recommended in chronic obstructive pulmonary disease patients to decrease associated risks at all stages. Although the prevalence of chronic obstructive pulmonary disease is high in our country, as previously reported, vaccination rates are low. Aims: To assess the vaccination rates of chronic obstructive pulmonary disease patients and factors that may affect these. Study Design: Multi-centre cross-sectional study. Methods: Patients admitted to the chest diseases clinics of six different centres between 1 February 2013 and 1 January 2014 with a pre-diagnosis of Chronic obstructive pulmonary disease according to the Global initiative for chronic obstructive lung disease criteria, who were in a stable condition were included in the study. The survey, which included demographic characteristics, socioeconomic status, severity of disease and vaccination information, was first tested on a small patient population before the study. The survey was completed by the investigators after obtaining written informed consent. Results: The average age of the 296 included patients was 66.3 +/- 9.3 years and 91.9% were male. Of these, 36.5% had the influenza vaccination and 14.1% had the pneumococcal vaccination. The most common reason for not being vaccinated was 'no recommendation by doctors': 57.2% in the case of influenza vaccinations, and 46.8% in the case of pneumococcal vaccinations. Both vaccination rates were significantly higher in those patients with comorbidities (influenza vaccination p0.05). Vaccination rates were significantly higher in those with a white-collar occupation and higher education level, and who presented to a university hospital (p<0.001). Conclusion: Medical professionals do not request vaccinations as often as the International Guidelines suggest for chronic obstructive pulmonary disease patients. Awareness of the importance of these vaccinations among both doctors and patients needs to be addressed

The evaluation of some writing skills according to various factors in the primary school arabic curriculum - Bartin province

06.03.2018 tarih ve 30352 sayılı Resmi gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması, Düzenlenmesi ve Erişime Açılmasına İlişkin Yönerge” gereğince tam metin erişime açılmıştır.Bu araştırmada Bartın ilinde bulunan imam hatip ortaokullarında öğrenim gören 5. sınıf öğrencilerinin İlköğretim (2-8. sınıflar) Arapça Dersi Öğretim Programında bulunan 5. sınıf ilk üç tema (Tema 1: Sesler ve Harfler, Tema 2: Okuyorum ve Yazıyorum, Tema 3: Selamlaşma ve Tanışma) içerisindeki temel yazma becerisi kazanımlarının (Kazanım 1: Arapçanın harflerini ortografik şekilleriyle yazar. Kazanım 2: Tanıdığı Harf ve İfadeleri Gördüğü Şekliyle Yazar. Kazanım 3: Tanıdığı ifadeleri gördüğü şekliyle yazar.) ulaşılabilirliğidir. Arapça dersinde temel yazma becerilerinin öğrenciye kazandırılması esnasında öğrencilerin yaş durumları, cinsiyetleri, okullarına taşımalı olarak ulaşmaları ya da yerleşim yeri (il, ilçe, belde) merkezinde ikamet etmeleri, Arapça çalışırken aileden destek alıp almama durumları ve Arapça dersine ilgi duyup duymamaları kriterlerine göre karşılaştırma yapılarak belirtilen durumlar arasındaki kazanım edinme farklarının ortaya çıkartılması amaçlanmıştır.In this study, the basic writing skills (Acquisition 1: He / She writes Arabic letters in orthographic forms, Acquisition 2: Author as he sees familiar letters and expressions, Acquisition 3: He writes the statements he knows as he sees them) of 5th grade students in primary school (2-8th grade) Arabic Language Teaching Program in the first three themes((Theme 1: Sounds and Letters, Theme 2: I Read and Write, Theme 3: Greetings and Meetings) were examined. In addition, the students' age status, gender, access to their schools by carriage or residence in the center of the settlement (province, district, town), whether they receive support from the family while working in Arabic and whether they are interested in the Arabic course were taken into consideration