Working Across Time Zones in Cross-Cultural Student Teams

The ability to collaborate with fellow workers from different cultures on international projects is a key asset in today's job market. International projects add new dimensions to student teamwork. These types of projects give students the opportunity to participate in collaboration that is remote, cross-cultural, and linguistically challenging. This proposal examines an international term project completed by the computing students of Rose-Hulman Institute of Technology and Bilkent University

Use of Intuitive Tools to Enhance Student Learning and User Experience

Most user interfaces today present system functions by use of verbal or iconic symbols on static 2D menu pages organized in a hierarchical system. This is unnatural to all human beings and must be learned, thus being a barrier between the full use and understanding of computer systems. With this problem in mind we set out to build a website and collaborative application for International Children's Center (ICC) which could be used not only across languages but across ages as well. This effort was tested on a daily basis by a multinational team consisting of students from the United States and Turkey as well as children from the respective countries. This attention to usability will not only lead to an intuitive tool for the client but also teach the students in the course how to build intuitive user interfaces

The effect of cerebral microbleeds on prognosis in intracerebral hematomas and analysis of risk factors

INTRODUCTION: Cerebral microbleeds (CMB) are hypointense lesions detected in T2 gradient ECO sequences, smaller than 5 mm in diameter, and are sensitive to blood-degradation products such as hemosiderin. We investigated the effects of CMK on hematoma volume and prognosis in patients with intracerebral hematoma. METHODS: Fifty patients with intracerebral hemorrhage who underwent gradient EKO and SWI sequences and hospitalized in neurology clinic between 2012 -2016 were included. Patients with surgical intervention, aneurysm hemorrhages, and subarachnoid, subdural, and epidural hemorrhages were excluded. Hematomas due to hypertension and unknown etiology were included. Hospitalization duration, NIHSS scores at admission and discharge, vascular risk factors, use of antithrombotic and anticoagulants were recorded. RESULTS: 27 patients had foci of microbleeds, and 23 patients did not have any. Female /Male ratio was 19/31. The mean age of those with microbleeds was 67.07 ± 12.64, and those without microbleeds was 65.65 ± 14.65. Hematoma localizations were determined as lobar (n: 19), basal ganglion (n: 15) and thalamus (n: 10) respectively. Sixteen had subcortical and 11 had cortical localization of CMB. DISCUSSION AND CONCLUSION: We suggested that CMB has no significant effect on prognosis and is independent of HT, DM, smoking and antithrombotic or anticoagulant therapy. There was no correlation between hematoma localization and existence of CMBs. Hematoma volumes were similar in both groups. There was no difference between groups in terms of CMBs’ localization. Although it was concluded that CMB had no effect on hematoma prognosis and not affected by other risk factors, studies are needed to elucidate their etiology with large group prospective randomized trials

Does the Level of WT1 Expression Predict the Outcome in Philadelphia-Negative Myeloproliferative Neoplasms?

Aims: Despite the clinical importance of the leukemic transformation of chronic myeloproliferative neoplasms (MPNs), very little is known about markers that predict leukemic transformation. We studied WT1 expression in 37 MPN patients diagnosed as bcr-abl negative and JAK2 (V617F) positive with a molecular genetic test, and 23 healthy controls. Results: WT1 expression is higher in MPN patients compared with normal controls (p=0.002). According to the WT1 expression levels, patients were divided into two groups: high (>= 0.205) and low (0-0.205) WT1 expression. Two out of six patients with a high WT1 expression level transformed to myelodysplastic syndrome at a 42- and 46-month follow-up, respectively. Conclusions: Our results suggest that the overexpression of WT1 may play an important role in the leukemic transformation of MPNs

Relationship of CD95 and COX-2 in renal cell carcinomas with survival and other prognostic parameters: A tissue microarray study

WOS: 000360441800004PubMed: 26060153Objective: To investigate the expression of cyclooxygenase-2 and cluster of differentiation 95 in renal cell carcinomas having different clinico-pathological characteristics. Methods: The study entailed histopathological diagnoses carried out on paraffin blocks at the Department of Pathology of the Medical Hospital of Duzce University, Turkey, between 2005 and 2011. Immunohistochemical staining for cyclooxygenase-2 and cluster of differentiation 95 was performed on tissue microarray using standard procedures. Each patient's age and gender as well as the tumour's grade, stage, diameter, ureteral surgical margins, vascular invasion, capsule invasion and subtype were assessed. In order to determine if the cases were still alive, relatives were telephoned and identity registration records were checked. SPSS 18 was used for statistical analysis. Results: There were 49 paraffin blocks in the study. Significant correlations were found between cyclooxygenase-2 and tumour subtype (p=0.044) as well as between cyclooxygenase-2 and tumour diameter (p=0.026). There was a significant correlation between cluster of differentiation 95 and the Fuhrman grade (p=0.050). Conclusion: Expression of cluster of differentiation 95 and cyclooxygenase-2 may be correlated with prognostic parameters in renal cell carcinoma and may also be associated with tumour progression