Hamile kadınlarda COVID-19 pandemisinin depresyon, anksiyete ve stres düzeyleri üzerine etkisi

Objective: Coronavirus disease-2019 (COVID-19) pandemic has negatively affected the psychology of the society. In this study, it was aimed to determine the stress, anxiety and depression levels in pregnant women during the COVID-19 pandemic and to investigate the delivery method attitudes using various scales. Method: The study included 151 pregnant women admitted to the obstetrics and gynecology clinic of our tertiary hospital for follow-up. A 31-question questionnaire containing demographic information and questions about COVID-19, impact of event scale (IES-R), depression anxiety stress scale-21 (DASS-21) and revised pregnancy-related anxiety questionnaire-revised (PRAQ-R) scales were applied. Results: According to the classifications made in DASS-21 subgroups, 16.5% of the pregnant women had severe or extreme depression, 35.1% had severe or extreme anxiety, 11.2% had severe or extreme stress level. The mean IES-R and PRAQ-R scores were found to be significantly higher in those under 35 years of age than those aged 35 years and over (p=0.02 and p=0.01, respectively). PRAQ-R (p<0.001), DASS-21 total (p=0.019), DASS-21 anxiety (p=0.012) and DASS-21 stress (p=0.014) scores were significantly higher in those who had their first pregnancy compared to experienced pregnant women. Conclusion: In the present study, it was determined that the pandemic had a negative effect on the depression, anxiety and stress levels of pregnant women, and this effect was higher especially in younger pregnant women and in those experiencing their first pregnancy.Amaç: Koronavirüs hastalığı-2019 (COVID-19) salgını toplumun psikolojisini olumsuz etkilemiştir. Bu çalışmada, gebelerde COVID-19 salgını sırasında yaşanan stres, anksiyete ve depresyon düzeylerinin belirlenmesi ve çeşitli ölçeklerle doğum yöntemi tutumlarının incelenmesi amaçlanmıştır. Yöntem: Çalışmaya üçüncü basamak hastanemizin kadın hastalıkları ve doğum kliniğine takip için başvuran 151 gebe dahil edildi. Gebelerin hepsine demografik bilgilerini içeren ve COVID-19, olay etkisi ölçeği (IES-R), depresyon anksiyetesi stres ölçeği-21 (DASS-21) ve gözden geçirilmiş gebelikle ilgili anksiyete anketi (PRAQ-R) ile ilgili soruları içeren 31 soruluk bir anket uygulandı. Bulgular: DASS-21 alt gruplarında yapılan sınıflandırmalara göre, gebelerin %16,5’i şiddetli veya aşırı depresyon, %35,1’i şiddetli veya aşırı anksiyete, %11,2’si şiddetli veya aşırı stres düzeyine sahipti. Otuz beş yaşın altındakilerde ortalama IES-R ve PRAQ-R puanları 35 yaş ve üzerindekilere göre anlamlı derecede yüksek bulundu (sırasıyla p=0,02 ve p=0,01). İlk defa hamile olanlarda PRAQ-R (p<0,001), DASS-21 toplam (p=0,019), DASS-21 anksiyete (p=0,012) ve DASS-21 stres (p=0,014) puanları daha önce gebelik geçiren kadınlara göre yüksekti. Sonuç: Bu çalışmada, salgının gebelerin depresyon, anksiyete ve stres düzeylerini olumsuz etkilediği, bu etkinin özellikle genç gebelerde ve ilk gebeliğini yaşayanlarda daha da yüksek olduğu tespit edilmiştir

Usability of Postbiotics in Ruminant Nutrition and Health

Since the ban on the use of antibiotics to promote growth in animal production in 2006, there has been a growing interest in alternative feed additives for animal production. Postbiotics, which have been utilized for this purpose in recent years, are highly promising feed additives that substitute banned substances like antibiotics. In recent years, there have been numerous studies on the utilization of postbiotics in ruminant animal nutrition. This article includes the definition of postbiotics, their properties, methods of obtaining them, and their potential applications in ruminant animal nutrition and health

Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders

BackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are abundant in the central nervous system (CNS), playing critical roles in brain function. Antigenicity of nAChRs has been well demonstrated with antibodies to ganglionic AChR subtypes (i.e., subunit α3 of α3β4-nAChR) and muscle AChR autoantibodies, thus making nAChRs candidate autoantigens in autoimmune CNS disorders. Antibodies to several membrane receptors, like NMDAR, have been identified in autoimmune encephalitis syndromes (AES), but many AES patients have yet to be unidentified for autoantibodies. This study aimed to develop of a cell-based assay (CBA) that selectively detects potentially pathogenic antibodies to subunits of the major nAChR subtypes (α4β2- and α7-nAChRs) and its use for the identification of such antibodies in “orphan” AES cases.MethodsThe study involved screening of sera derived from 1752 patients from Greece, Turkey and Italy, who requested testing for AES-associated antibodies, and from 1203 “control” patients with other neuropsychiatric diseases, from the same countries or from Germany. A sensitive live-CBA with α4β2-or α7-nAChR–transfected cells was developed to detect antibodies against extracellular domains of nAChR major subunits. Flow cytometry (FACS) was performed to confirm the CBA findings and indirect immunohistochemistry (IHC) to investigate serum autoantibodies’ binding to rat brain tissue.ResultsThree patients were found to be positive for serum antibodies against nAChR α4 subunit by CBA and the presence of the specific antibodies was quantitatively confirmed by FACS. We detected specific binding of patient‐derived serum anti‐nAChR α4 subunit antibodies to rat cerebellum and hippocampus tissue. No serum antibodies bound to the α7-nAChR-transfected or control-transfected cells, and no control serum antibodies bound to the transfected cells. All patients positive for serum anti‐nAChRs α4 subunit antibodies were negative for other AES-associated antibodies. All three of the anti‐nAChR α4 subunit serum antibody-positive patients fall into the AES spectrum, with one having Rasmussen encephalitis, another autoimmune meningoencephalomyelitis and another being diagnosed with possible autoimmune encephalitis.ConclusionThis study lends credence to the hypothesis that the major nAChR subunits are autoimmune targets in some cases of AES and establishes a sensitive live-CBA for the identification of such patients

VOCATIONAL HIGH SCHOOL STUDENTS and MATH ANXIETY

DergiPark: 417370ejovocBu araştırmanın amacı Ahi Evran Üniversitesinin farklıMeslek Yüksekokullarında öğrenim gören öğrencilerin matematik kaygı düzeylerinibazı demografik değişkenler açısından incelemektir. &amp;nbsp;Araştırmanın evreni2015-2016 Eğitim-Öğretim Yılı Bahar döneminde Ahi Evran Üniversitesinin farklıMeslek Yüksekokullarında birinci sınıfta öğrenim gören ve matematik dersinialan/almış 2236 öğrencinin tamamından oluşmaktadır. Verilerin toplanmasıaşamasında araştırmacı tarafından oluşturulan Kişisel Bilgi Formu, Erol (1989)tarafından geliştirilmiş ve Bekdemir (2009)’in &amp;nbsp;Meslek Yüksekokulu öğrencilerininmatematik kaygılarını belirlemek için kullandığı toplam 45 sorudan oluşan&amp;nbsp;Matematik Kaygı Ölçeği kullanılmıştır. Veriler analiz edilirken frekans,yüzde, t-testi, Varyans analizi, Bonferroni ve Games Howell testindenyararlanılmıştır. Araştırmanın sonuçlarına göre; doğum tarihi, cinsiyet,&amp;nbsp;mezun olunan okul türü, sınavla veya sınavsız yerleşme durumu, ailesininortalama aylık geliri ve algılanan matematik düzeyi değişkenlerine göreöğrencilerin matematik kaygı düzeyleri arasında istatistiksel açıdan anlamlıfarklılıkların olduğu, birinci veya ikinci öğretim olma durumu, anne-babamesleği, anne-baba tutumuna göre matematik kaygı düzeyleri arasındaistatistiksel olarak anlamlı bir farklılık olmadığı tespit edilmiştir.The purpose of this research toinvestigate the Maths anxiety levels of the students from the differentvocational high schools of Ahi Evran University in terms of some demographicvariants. The population of the study consist of 2236 freshman class studentswho are studying and reseived/reseiving Math class from different vocationalhigh school of Ahi Evran University in the Spring term of 2015-2016 AcademicYear. In this research "Personal Information Form" and"Mathematics Anxiety Scale" were used. "Personal InformationForm" developed by the researcher, "Mathematics Anxiety Scale"developed by Erol (1989) and used by Bekdemir (2009) to define Maths anxiety ofvocational high school students. Data were analyzed by frequency, percentage,t-test, variance analyze, Bonferroni and Games Howell test. There were differences between theMaths anxiety levels of the students in terms of date of birth, gender,graduated high school, family income level, open admission or entering by anexamination and Maths level they perceive themselves. There weren't differencesbetween the Maths anxiety levels of the students in terms of situation ofdaytime of evening education, profession of the father, profession of themother and parent attitude

The Effect of COVID-19 Pandemic on Depression, Anxiety and Stress Levels of Pregnant Women

Objective:Coronavirus disease-2019 (COVID-19) pandemic has negatively affected the psychology of the society. In this study, it was aimed to determine the stress, anxiety and depression levels in pregnant women during the COVID-19 pandemic and to investigate the delivery method attitudes using various scales.Method:The study included 151 pregnant women admitted to the obstetrics and gynecology clinic of our tertiary hospital for follow-up. A 31-question questionnaire containing demographic information and questions about COVID-19, impact of event scale (IES-R), depression anxiety stress scale-21 (DASS-21) and revised pregnancy-related anxiety questionnaire-revised (PRAQ-R) scales were applied.Results:According to the classifications made in DASS-21 subgroups, 16.5% of the pregnant women had severe or extreme depression, 35.1% had severe or extreme anxiety, 11.2% had severe or extreme stress level. The mean IES-R and PRAQ-R scores were found to be significantly higher in those under 35 years of age than those aged 35 years and over (p=0.02 and p=0.01, respectively). PRAQ-R (p<0.001), DASS-21 total (p=0.019), DASS-21 anxiety (p=0.012) and DASS-21 stress (p=0.014) scores were significantly higher in those who had their first pregnancy compared to experienced pregnant women.Conclusion:In the present study, it was determined that the pandemic had a negative effect on the depression, anxiety and stress levels of pregnant women, and this effect was higher especially in younger pregnant women and in those experiencing their first pregnancy

Effect of local and systemic dimethylsulfoxide on peripheral nerve repair: A controlled randomized experimental study

Introduction: We investigated the possible beneficial effect of dimethylsulfoxide (DMSO) on peripheral nerve repair in rats. Methods: Seventy rats were divided into four groups: control, sham, DMSO-L, and DMSO-IP. Except in the control group, nerve repair was done at the right sciatic nerve. DMSO was administered locally and intraperitoneally for 12 weeks to the DMSO-L and DMSO-IP groups, respectively. No therapeutic agent was administered to the other groups. Nerve regeneration was assessed by behavioral, electrophysiological, histopathological, and immunohistochemical tests. Results: With the exception of S-100 protein expression, all results indicate that DMSO has a beneficial effect on peripheral nerve regeneration. Functional nerve recovery was notably more evident in the DMSO-L than in the DMSO-IP group. Under macroscopic examination, nerve scores of the regeneration area in the DMSO-L group was also better than in the others. Discussion: We believe that DMSO can improve peripheral nerve regeneration in rats

Effect of local and systemic dimethylsulfoxide on peripheral nerve repair: A controlled randomized experimental study

*Dinçel, Güngör Çağdaş ( Aksaray, Yazar )Introduction: We investigated the possible beneficial effect of dimethylsulfoxide (DMSO) on peripheral nerve repair in rats. Methods: Seventy rats were divided into four groups: control, sham, DMSO-L, and DMSO-IP. Except in the control group, nerve repair was done at the right sciatic nerve. DMSO was administered locally and intraperitoneally for 12 weeks to the DMSO-L and DMSO-IP groups, respectively. No therapeutic agent was administered to the other groups. Nerve regeneration was assessed by behavioral, electrophysiological, histopathological, and immunohistochemical tests. Results: With the exception of S-100 protein expression, all results indicate that DMSO has a beneficial effect on peripheral nerve regeneration. Functional nerve recovery was notably more evident in the DMSO-L than in the DMSO-IP group. Under macroscopic examination, nerve scores of the regeneration area in the DMSO-L group was also better than in the others. Discussion: We believe that DMSO can improve peripheral nerve regeneration in rats...